Human Coronavirus Infections in Rural Thailand: A Comprehensive Study Using Real-Time Reverse-Transcription Polymerase Chain Reaction Assays
Identifieur interne : 003817 ( Main/Exploration ); précédent : 003816; suivant : 003818Human Coronavirus Infections in Rural Thailand: A Comprehensive Study Using Real-Time Reverse-Transcription Polymerase Chain Reaction Assays
Auteurs : Ryan K. Dare [Géorgie (pays)] ; Alicia M. Fry [Géorgie (pays), États-Unis] ; Malinee Chittaganpitch [Thaïlande] ; Pathom Sawanpanyalert [Thaïlande] ; Sonja J. Olsen [Géorgie (pays)] ; Dean D. Erdman [Géorgie (pays)]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2007.
Abstract
Background. We sought to determine whether infections with human coronaviruses (HCoVs) 229E, OC43, HKU1, and NL63 are associated with pneumonia and to define the epidemiology of HCoV infection in rural Thailand. Methods. We developed a real-time reverse-transcription polymerase chain reaction (RT-PCR) assay panel for the recognized HCoV types and compared HCoV infections in patients hospitalized with pneumonia, outpatients with influenza-like illness, and asymptomatic control patients between September 2003 and August 2005. Results. During study year 1, 43 (5.9%) of 734 patients with pneumonia had HCoV infections; 72.1% of the infections were with OC43. During study year 2, when control patients were available, 21 (1.8%) of 1156 patients with pneumonia, 12 (2.3%) of 513 outpatients, and 6 (2.1%) of 281 control patients had HCoV infections. Compared with infection in control patients, infection with any HCoV type or with all types combined was not associated with pneumonia (adjusted odds ratio for all HCoV types, 0.67 [95% confidence interval, 0.26–1.75]; P= .40 ). HCoV infections were detected throughout both study years; 93.6% of OC43 infections in the first year occurred from January through March. Conclusions. HCoV infections were infrequently detected in rural Thailand by use of sensitive real-time RTPCR assays. We found no association between HCoV infection and illness. However, we noted year-to-year variation in the prevalence of HCoV strains, which likely influenced our results.
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DOI: 10.1086/521308
Affiliations:
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Dare</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Respiratory and Gastroenteritis Viruses Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Fry, Alicia M" sort="Fry, Alicia M" uniqKey="Fry A" first="Alicia M." last="Fry">Alicia M. Fry</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Epidemiology Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Alicia Fry, 1600 Clifton Rd. NE, Mailstop A20, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Chittaganpitch, Malinee" sort="Chittaganpitch, Malinee" uniqKey="Chittaganpitch M" first="Malinee" last="Chittaganpitch">Malinee Chittaganpitch</name><affiliation wicri:level="1"><country xml:lang="fr">Thaïlande</country><wicri:regionArea>National Institute of Health, Thailand Ministry of Public Health, Nonthaburi</wicri:regionArea><wicri:noRegion>Nonthaburi</wicri:noRegion></affiliation></author><author><name sortKey="Sawanpanyalert, Pathom" sort="Sawanpanyalert, Pathom" uniqKey="Sawanpanyalert P" first="Pathom" last="Sawanpanyalert">Pathom Sawanpanyalert</name><affiliation wicri:level="1"><country xml:lang="fr">Thaïlande</country><wicri:regionArea>National Institute of Health, Thailand Ministry of Public Health, Nonthaburi</wicri:regionArea><wicri:noRegion>Nonthaburi</wicri:noRegion></affiliation></author><author><name sortKey="Olsen, Sonja J" sort="Olsen, Sonja J" uniqKey="Olsen S" first="Sonja J." last="Olsen">Sonja J. Olsen</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Division of Emerging Infections and Surveillance Services, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Erdman, Dean D" sort="Erdman, Dean D" uniqKey="Erdman D" first="Dean D." last="Erdman">Dean D. Erdman</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Respiratory and Gastroenteritis Viruses Branch, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2007</date><biblScope unit="vol">196</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1321">1321</biblScope><biblScope unit="page" to="1328">1328</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background. We sought to determine whether infections with human coronaviruses (HCoVs) 229E, OC43, HKU1, and NL63 are associated with pneumonia and to define the epidemiology of HCoV infection in rural Thailand. Methods. We developed a real-time reverse-transcription polymerase chain reaction (RT-PCR) assay panel for the recognized HCoV types and compared HCoV infections in patients hospitalized with pneumonia, outpatients with influenza-like illness, and asymptomatic control patients between September 2003 and August 2005. Results. During study year 1, 43 (5.9%) of 734 patients with pneumonia had HCoV infections; 72.1% of the infections were with OC43. During study year 2, when control patients were available, 21 (1.8%) of 1156 patients with pneumonia, 12 (2.3%) of 513 outpatients, and 6 (2.1%) of 281 control patients had HCoV infections. Compared with infection in control patients, infection with any HCoV type or with all types combined was not associated with pneumonia (adjusted odds ratio for all HCoV types, 0.67 [95% confidence interval, 0.26–1.75]; P= .40 ). HCoV infections were detected throughout both study years; 93.6% of OC43 infections in the first year occurred from January through March. Conclusions. HCoV infections were infrequently detected in rural Thailand by use of sensitive real-time RTPCR assays. We found no association between HCoV infection and illness. However, we noted year-to-year variation in the prevalence of HCoV strains, which likely influenced our results.</div></front></TEI><affiliations><list><country><li>Géorgie (pays)</li><li>Thaïlande</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Dare, Ryan K" sort="Dare, Ryan K" uniqKey="Dare R" first="Ryan K." last="Dare">Ryan K. Dare</name></noRegion><name sortKey="Erdman, Dean D" sort="Erdman, Dean D" uniqKey="Erdman D" first="Dean D." last="Erdman">Dean D. Erdman</name><name sortKey="Fry, Alicia M" sort="Fry, Alicia M" uniqKey="Fry A" first="Alicia M." last="Fry">Alicia M. Fry</name><name sortKey="Olsen, Sonja J" sort="Olsen, Sonja J" uniqKey="Olsen S" first="Sonja J." last="Olsen">Sonja J. Olsen</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Fry, Alicia M" sort="Fry, Alicia M" uniqKey="Fry A" first="Alicia M." last="Fry">Alicia M. 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