Therapeutic and Prophylactic Potential of Small Interfering RNAs against Severe Acute Respiratory Syndrome
Identifieur interne : 003565 ( Main/Exploration ); précédent : 003564; suivant : 003566Therapeutic and Prophylactic Potential of Small Interfering RNAs against Severe Acute Respiratory Syndrome
Auteurs : Zhijie Chang [République populaire de Chine] ; Lorne A. Babiuk ; Jim HuSource :
- Biodrugs [ 1173-8804 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Petit ARN interférent.
- effets indésirables : Petit ARN interférent.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Petit ARN interférent.
- Humains, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : RNA, Small Interfering.
- chemical , adverse effects : RNA, Small Interfering.
- chemical , therapeutic use : RNA, Small Interfering.
- drug therapy : Severe Acute Respiratory Syndrome.
- prevention & control : Severe Acute Respiratory Syndrome.
- Humans.
Abstract
Severe acute respiratory syndrome (SARS), caused by the novel coronavirus SARS-CoV, produced a scare when it appeared in 2003 in China and later quickly spread to other countries around the world. Although it has since disappeared, its threat to human health remains. Therefore, studies on the prevention and treatment of SARS are important for dealing with epidemics of this and other infectious diseases. The most promising newly developed technology for intervention in SARS may be RNA interference, an endogenous cellular process for the inhibition of gene expression mediated by sequence-specific double-stranded RNAs. Numerous studies have reported the therapeutic potential of RNA interference for the treatment of various human diseases ranging from cancers to infectious diseases such as HIV and hepatitis. To date, most studies on inhibition of SARS-CoV replication using small interfering RNAs (siRNAs) have been conducted in cell lines
Url:
DOI: 10.2165/00063030-200721010-00002
PubMed: 17263585
PubMed Central: 7099728
Affiliations:
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Le document en format XML
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Babiuk</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.25152.31</institution-id><institution-id institution-id-type="ISNI">000000012154235X</institution-id><institution>Vaccine & Infectious Disease Organization (VIDO),</institution><institution>University of Saskatchewan,</institution></institution-wrap>Saskatoon, Saskatchewan Canada</nlm:aff><wicri:noCountry code="subfield">Saskatchewan Canada</wicri:noCountry></affiliation></author><author><name sortKey="Hu, Jim" sort="Hu, Jim" uniqKey="Hu J" first="Jim" last="Hu">Jim Hu</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.17063.33</institution-id><institution>Lung Biology Research Program, Hospital for Sick Children Research Institute,</institution><institution>University of Toronto,</institution></institution-wrap>555 University Avenue, Toronto, Toronto, ON M5G 1X8 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">ON M5G 1X8 Ontario Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">Biodrugs</title><idno type="ISSN">1173-8804</idno><idno type="eISSN">1179-190X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>RNA, Small Interfering (administration & dosage)</term><term>RNA, Small Interfering (adverse effects)</term><term>RNA, Small Interfering (therapeutic use)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Petit ARN interférent (administration et posologie)</term><term>Petit ARN interférent (effets indésirables)</term><term>Petit ARN interférent (usage thérapeutique)</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Petit ARN interférent</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS), caused by the novel coronavirus SARS-CoV, produced a scare when it appeared in 2003 in China and later quickly spread to other countries around the world. Although it has since disappeared, its threat to human health remains. Therefore, studies on the prevention and treatment of SARS are important for dealing with epidemics of this and other infectious diseases. The most promising newly developed technology for intervention in SARS may be RNA interference, an endogenous cellular process for the inhibition of gene expression mediated by sequence-specific double-stranded RNAs. Numerous studies have reported the therapeutic potential of RNA interference for the treatment of various human diseases ranging from cancers to infectious diseases such as HIV and hepatitis. To date, most studies on inhibition of SARS-CoV replication using small interfering RNAs (siRNAs) have been conducted in cell lines <italic>in vitro</italic>. One study using siRNAs to inhibit SARS-CoV infection in Rhesus macaques demonstrated that siRNAs were effective both prophylactically and therapeutically with no adverse effects in the animals. Challenges remaining for the application of siRNA <italic>in vivo</italic> for SARS prevention and treatment include the specificity of the siRNAs and the efficiency of delivery. However, with improvements in siRNA design and delivery methods, RNA interference has the potential to become another major weapon for combating dangerous infections due to viruses such as SARS-CoV.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Parry, J" uniqKey="Parry J">J. Parry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skowronski, D M" uniqKey="Skowronski D">D.M. Skowronski</name></author><author><name sortKey="Astell, C" uniqKey="Astell C">C. Astell</name></author><author><name sortKey="Brunham, R C" uniqKey="Brunham R">R.C. 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Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schiffelers, R M" uniqKey="Schiffelers R">R.M. Schiffelers</name></author><author><name sortKey="Storm, G" uniqKey="Storm G">G. Storm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dykxhoorn, D M" uniqKey="Dykxhoorn D">D.M. Dykxhoorn</name></author><author><name sortKey="Lieberman, J" uniqKey="Lieberman J">J. Lieberman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Babiuk, Lorne A" sort="Babiuk, Lorne A" uniqKey="Babiuk L" first="Lorne A." last="Babiuk">Lorne A. Babiuk</name><name sortKey="Hu, Jim" sort="Hu, Jim" uniqKey="Hu J" first="Jim" last="Hu">Jim Hu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Chang, Zhijie" sort="Chang, Zhijie" uniqKey="Chang Z" first="Zhijie" last="Chang">Zhijie Chang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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