Pathological Changes in Masked Palm Civets Experimentally Infected by Severe Acute Respiratory Syndrome (SARS) Coronavirus
Identifieur interne : 003064 ( Main/Exploration ); précédent : 003063; suivant : 003065Pathological Changes in Masked Palm Civets Experimentally Infected by Severe Acute Respiratory Syndrome (SARS) Coronavirus
Auteurs : Y. Xiao [République populaire de Chine] ; Q. Meng [République populaire de Chine] ; X. Yin [République populaire de Chine] ; Y. Guan [République populaire de Chine] ; Y. Liu [République populaire de Chine] ; C. Li [République populaire de Chine] ; M. Wang [République populaire de Chine] ; G. Liu [République populaire de Chine] ; T. Tong [République populaire de Chine] ; L.-F. Wang [Australie] ; X. Kong [République populaire de Chine] ; D. Wu [République populaire de Chine]Source :
- Journal of Comparative Pathology [ 0021-9975 ] ; 2008.
Descripteurs français
- KwdFr :
- ARN viral (analyse), Animaux, Apoptose, Cerveau (anatomopathologie), Cerveau (virologie), Chats, Foie (anatomopathologie), Foie (virologie), Hybridation in situ, Intestin grêle (anatomopathologie), Intestin grêle (virologie), Maladies des chats (anatomopathologie), Maladies des chats (virologie), Modèles animaux de maladie humaine, Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (virologie), Poumon (anatomopathologie), Poumon (virologie), Rate (anatomopathologie), Rate (virologie), Rein (anatomopathologie), Rein (virologie), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Techniques immunoenzymatiques, Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité), Viverridae.
- MESH :
- analyse : ARN viral.
- anatomopathologie : Cerveau, Foie, Intestin grêle, Maladies des chats, Noeuds lymphatiques, Poumon, Rate, Rein, Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- pathogénicité : Virus du SRAS.
- virologie : Cerveau, Foie, Intestin grêle, Maladies des chats, Noeuds lymphatiques, Poumon, Rate, Rein, Syndrome respiratoire aigu sévère.
- Animaux, Apoptose, Chats, Hybridation in situ, Modèles animaux de maladie humaine, Techniques immunoenzymatiques, Viverridae.
English descriptors
- KwdEn :
- Animals, Apoptosis, Cat Diseases (pathology), Cat Diseases (virology), Cats, Cerebrum (pathology), Cerebrum (virology), Disease Models, Animal, Immunoenzyme Techniques, In Situ Hybridization, Intestine, Small (pathology), Intestine, Small (virology), Kidney (pathology), Kidney (virology), Liver (pathology), Liver (virology), Lung (pathology), Lung (virology), Lymph Nodes (pathology), Lymph Nodes (virology), RNA, Viral (analysis), SARS Virus (isolation & purification), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Spleen (pathology), Spleen (virology), Viverridae.
- MESH :
- chemical , analysis : RNA, Viral.
- isolation & purification : SARS Virus.
- pathogenicity : SARS Virus.
- pathology : Cat Diseases, Cerebrum, Intestine, Small, Kidney, Liver, Lung, Lymph Nodes, Severe Acute Respiratory Syndrome, Spleen.
- virology : Cat Diseases, Cerebrum, Intestine, Small, Kidney, Liver, Lung, Lymph Nodes, Severe Acute Respiratory Syndrome, Spleen.
- Animals, Apoptosis, Cats, Disease Models, Animal, Immunoenzyme Techniques, In Situ Hybridization, Viverridae.
Abstract
Masked palm civets are highly susceptible to infection with the severe acute respiratory syndrome coronavirus (SARS-CoV). Infected animals become less aggressive and develop pyrexia, lethargy and diarrhoea. The present study describes the spectrum of histopathological changes in the lung, spleen, lymph node, liver, small intestine, kidney and cerebrum of civets infected experimentally with SARS-CoV. In-situ hybridization (ISH) with probes specific for the RNA polymerase gene demonstrated viral RNA in the lung, small intestine and cerebrum only. In-situ labelling was employed in order to demonstrate cellular apoptosis in the cerebrum, but there was no evidence of apoptosis within the myocardium. These results indicate that SARS-CoV causes multi-organ pathology in civets, similar to that observed in human SARS patients. These parallels suggest that civets may be used as an animal model of this infection to gain insight into the pathogenesis of SARS and for evaluation of candidate vaccines and antiviral drugs.
Url:
DOI: 10.1016/j.jcpa.2007.12.005
PubMed: 18343398
PubMed Central: 7094611
Affiliations:
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Le document en format XML
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Xiao</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Graduate School of CAAS, Beijing 100081, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School of CAAS, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Meng, Q" sort="Meng, Q" uniqKey="Meng Q" first="Q." last="Meng">Q. Meng</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Graduate School of CAAS, Beijing 100081, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School of CAAS, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yin, X" sort="Yin, X" uniqKey="Yin X" first="X." last="Yin">X. Yin</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y." last="Liu">Y. Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Li, C" sort="Li, C" uniqKey="Li C" first="C." last="Li">C. Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Wang, M" sort="Wang, M" uniqKey="Wang M" first="M." last="Wang">M. Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Liu, G" sort="Liu, G" uniqKey="Liu G" first="G." last="Liu">G. Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Graduate School of CAAS, Beijing 100081, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School of CAAS, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Tong, T" sort="Tong, T" uniqKey="Tong T" first="T." last="Tong">T. Tong</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Graduate School of CAAS, Beijing 100081, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School of CAAS, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, L F" sort="Wang, L F" uniqKey="Wang L" first="L.-F." last="Wang">L.-F. Wang</name><affiliation wicri:level="1"><nlm:aff id="aff3">CSIRO Livestock Industries, Australian Animal Health Laboratory, Australian Biosecurity Cooperative Research Centre for Emerging Infectious Diseases, Geelong, Victoria 3220, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>CSIRO Livestock Industries, Australian Animal Health Laboratory, Australian Biosecurity Cooperative Research Centre for Emerging Infectious Diseases, Geelong, Victoria 3220</wicri:regionArea><wicri:noRegion>Victoria 3220</wicri:noRegion></affiliation></author><author><name sortKey="Kong, X" sort="Kong, X" uniqKey="Kong X" first="X." last="Kong">X. Kong</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Graduate School of CAAS, Beijing 100081, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School of CAAS, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wu, D" sort="Wu, D" uniqKey="Wu D" first="D." last="Wu">D. Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences (CAAS), Harbin 150001</wicri:regionArea><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Graduate School of CAAS, Beijing 100081, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School of CAAS, Beijing 100081</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of Comparative Pathology</title><idno type="ISSN">0021-9975</idno><idno type="eISSN">1532-3129</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Cat Diseases (pathology)</term><term>Cat Diseases (virology)</term><term>Cats</term><term>Cerebrum (pathology)</term><term>Cerebrum (virology)</term><term>Disease Models, Animal</term><term>Immunoenzyme Techniques</term><term>In Situ Hybridization</term><term>Intestine, Small (pathology)</term><term>Intestine, Small (virology)</term><term>Kidney (pathology)</term><term>Kidney (virology)</term><term>Liver (pathology)</term><term>Liver (virology)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Lymph Nodes (pathology)</term><term>Lymph Nodes (virology)</term><term>RNA, Viral (analysis)</term><term>SARS Virus (isolation & purification)</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Spleen (pathology)</term><term>Spleen (virology)</term><term>Viverridae</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (analyse)</term><term>Animaux</term><term>Apoptose</term><term>Cerveau (anatomopathologie)</term><term>Cerveau (virologie)</term><term>Chats</term><term>Foie (anatomopathologie)</term><term>Foie (virologie)</term><term>Hybridation in situ</term><term>Intestin grêle (anatomopathologie)</term><term>Intestin grêle (virologie)</term><term>Maladies des chats (anatomopathologie)</term><term>Maladies des chats (virologie)</term><term>Modèles animaux de maladie humaine</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Noeuds lymphatiques (virologie)</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Rate (anatomopathologie)</term><term>Rate (virologie)</term><term>Rein (anatomopathologie)</term><term>Rein (virologie)</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Techniques immunoenzymatiques</term><term>Virus du SRAS (isolement et purification)</term><term>Virus du SRAS (pathogénicité)</term><term>Viverridae</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cerveau</term><term>Foie</term><term>Intestin grêle</term><term>Maladies des chats</term><term>Noeuds lymphatiques</term><term>Poumon</term><term>Rate</term><term>Rein</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cat Diseases</term><term>Cerebrum</term><term>Intestine, Small</term><term>Kidney</term><term>Liver</term><term>Lung</term><term>Lymph Nodes</term><term>Severe Acute Respiratory Syndrome</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cerveau</term><term>Foie</term><term>Intestin grêle</term><term>Maladies des chats</term><term>Noeuds lymphatiques</term><term>Poumon</term><term>Rate</term><term>Rein</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cat Diseases</term><term>Cerebrum</term><term>Intestine, Small</term><term>Kidney</term><term>Liver</term><term>Lung</term><term>Lymph Nodes</term><term>Severe Acute Respiratory Syndrome</term><term>Spleen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>Cats</term><term>Disease Models, Animal</term><term>Immunoenzyme Techniques</term><term>In Situ Hybridization</term><term>Viverridae</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Chats</term><term>Hybridation in situ</term><term>Modèles animaux de maladie humaine</term><term>Techniques immunoenzymatiques</term><term>Viverridae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>Masked palm civets are highly susceptible to infection with the severe acute respiratory syndrome coronavirus (SARS-CoV). Infected animals become less aggressive and develop pyrexia, lethargy and diarrhoea. The present study describes the spectrum of histopathological changes in the lung, spleen, lymph node, liver, small intestine, kidney and cerebrum of civets infected experimentally with SARS-CoV. In-situ hybridization (ISH) with probes specific for the RNA polymerase gene demonstrated viral RNA in the lung, small intestine and cerebrum only. In-situ labelling was employed in order to demonstrate cellular apoptosis in the cerebrum, but there was no evidence of apoptosis within the myocardium. These results indicate that SARS-CoV causes multi-organ pathology in civets, similar to that observed in human SARS patients. These parallels suggest that civets may be used as an animal model of this infection to gain insight into the pathogenesis of SARS and for evaluation of candidate vaccines and antiviral drugs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="He, L" uniqKey="He L">L. He</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z. Huang</name></author><author><name sortKey="Che, X" uniqKey="Che X">X. Che</name></author><author><name sortKey="Hou, J" uniqKey="Hou J">J. Hou</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H. Shen</name></author><author><name sortKey="Qiu, L" uniqKey="Qiu L">L. Qiu</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H. Shen</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author><author><name sortKey="Geng, J" uniqKey="Geng J">J. Geng</name></author><author><name sortKey="Han, H" uniqKey="Han H">H. Han</name></author><author><name sortKey="Cai, J" uniqKey="Cai J">J. Cai</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Kang, W" uniqKey="Kang W">W. Kang</name></author><author><name sortKey="Weng, D" uniqKey="Weng D">D. Weng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T. Kuiken</name></author><author><name sortKey="Schutten, M" uniqKey="Schutten M">M. Schutten</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G. van Amerongen</name></author><author><name sortKey="Van Doornum, G J" uniqKey="Van Doornum G">G.J. van Doornum</name></author><author><name sortKey="Van Den Hoogen, B G" uniqKey="Van Den Hoogen B">B.G. van den Hoogen</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M. Peiris</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K. Stohr</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franks, T J" uniqKey="Franks T">T.J. Franks</name></author><author><name sortKey="Chong, P Y" uniqKey="Chong P">P.Y. Chong</name></author><author><name sortKey="Chui, P" uniqKey="Chui P">P. Chui</name></author><author><name sortKey="Galvin, J R" uniqKey="Galvin J">J.R. Galvin</name></author><author><name sortKey="Lourens, R M" uniqKey="Lourens R">R.M. Lourens</name></author><author><name sortKey="Reid, A H" uniqKey="Reid A">A.H. Reid</name></author><author><name sortKey="Selbs, E" uniqKey="Selbs E">E. Selbs</name></author><author><name sortKey="Mcevoy, C P" uniqKey="Mcevoy C">C.P. McEvoy</name></author><author><name sortKey="Hayden, C D" uniqKey="Hayden C">C.D. Hayden</name></author><author><name sortKey="Fukuoka, J" uniqKey="Fukuoka J">J. Fukuoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenough, T C" uniqKey="Greenough T">T.C. Greenough</name></author><author><name sortKey="Carville, A" uniqKey="Carville A">A. Carville</name></author><author><name sortKey="Coderre, J" uniqKey="Coderre J">J. Coderre</name></author><author><name sortKey="Somasundaran, M" uniqKey="Somasundaran M">M. Somasundaran</name></author><author><name sortKey="Sullivan, J L" uniqKey="Sullivan J">J.L. Sullivan</name></author><author><name sortKey="Luzuriaga, K" uniqKey="Luzuriaga K">K. Luzuriaga</name></author><author><name sortKey="Mansfield, K" uniqKey="Mansfield K">K. Mansfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Zheng, B J" uniqKey="Zheng B">B.J. Zheng</name></author><author><name sortKey="He, Y Q" uniqKey="He Y">Y.Q. He</name></author><author><name sortKey="Liu, X L" uniqKey="Liu X">X.L. Liu</name></author><author><name sortKey="Zhuang, Z X" uniqKey="Zhuang Z">Z.X. Zhuang</name></author><author><name sortKey="Cheung, C L" uniqKey="Cheung C">C.L. Cheung</name></author><author><name sortKey="Luo, S W" uniqKey="Luo S">S.W. Luo</name></author><author><name sortKey="Li, P H" uniqKey="Li P">P.H. Li</name></author><author><name sortKey="Zhang, L J" uniqKey="Zhang L">L.J. Zhang</name></author><author><name sortKey="Guan, Y J" uniqKey="Guan Y">Y.J. Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D. Erdman</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T. Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S. Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S. Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C. Urbani</name></author><author><name sortKey="Comer, J A" uniqKey="Comer J">J.A. Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T. Kuiken</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Schutten, M" uniqKey="Schutten M">M. Schutten</name></author><author><name sortKey="Rimmelzwaan, G F" uniqKey="Rimmelzwaan G">G.F. Rimmelzwaan</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G. van Amerongen</name></author><author><name sortKey="Van Riel, D" uniqKey="Van Riel D">D. van Riel</name></author><author><name sortKey="Laman, J D" uniqKey="Laman J">J.D. Laman</name></author><author><name sortKey="De Jong, T" uniqKey="De Jong T">T. de Jong</name></author><author><name sortKey="Van Doornum, G" uniqKey="Van Doornum G">G. van Doornum</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Li, K S" uniqKey="Li K">K.S. Li</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Tsoi, H W" uniqKey="Tsoi H">H.W. Tsoi</name></author><author><name sortKey="Wong, B H" uniqKey="Wong B">B.H. Wong</name></author><author><name sortKey="Wong, S S" uniqKey="Wong S">S.S. Wong</name></author><author><name sortKey="Leung, S Y" uniqKey="Leung S">S.Y. Leung</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z. Shi</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M. Yu</name></author><author><name sortKey="Ren, W" uniqKey="Ren W">W. Ren</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C. Smith</name></author><author><name sortKey="Epstein, J H" uniqKey="Epstein J">J.H. Epstein</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Crameri, G" uniqKey="Crameri G">G. Crameri</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z. Hu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J. Sui</name></author><author><name sortKey="Kuhn, J H" uniqKey="Kuhn J">J.H. Kuhn</name></author><author><name sortKey="Moore, M J" uniqKey="Moore M">M.J. Moore</name></author><author><name sortKey="Luo, S" uniqKey="Luo S">S. Luo</name></author><author><name sortKey="Wong, S K" uniqKey="Wong S">S.K. Wong</name></author><author><name sortKey="Huang, I C" uniqKey="Huang I">I.C. Huang</name></author><author><name sortKey="Xu, K" uniqKey="Xu K">K. Xu</name></author><author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N. Vasilieva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, B H" uniqKey="Liu B">B.H. Liu</name></author><author><name sortKey="Wu, D L" uniqKey="Wu D">D.L. Wu</name></author><author><name sortKey="Zhan, D W" uniqKey="Zhan D">D.W. Zhan</name></author><author><name sortKey="Qin, E D" uniqKey="Qin E">E.D. Qin</name></author><author><name sortKey="Zhu, Q Y" uniqKey="Zhu Q">Q.Y. Zhu</name></author><author><name sortKey="Wang, C E" uniqKey="Wang C">C.E. Wang</name></author><author><name sortKey="Meng, Q W" uniqKey="Meng Q">Q.W. Meng</name></author><author><name sortKey="Peng, W M" uniqKey="Peng W">W.M. Peng</name></author><author><name sortKey="Yin, X N" uniqKey="Yin X">X.N. Yin</name></author><author><name sortKey="Yang, Y H" uniqKey="Yang Y">Y.H. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martina, B E" uniqKey="Martina B">B.E. Martina</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T. Kuiken</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Rimmelzwaan, G F" uniqKey="Rimmelzwaan G">G.F. Rimmelzwaan</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G. Van Amerongen</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcauliffe, J" uniqKey="Mcauliffe J">J. McAuliffe</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Fahle, G" uniqKey="Fahle G">G. Fahle</name></author><author><name sortKey="Fischer, S" uniqKey="Fischer S">S. Fischer</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name></author><author><name sortKey="Butler, E" uniqKey="Butler E">E. Butler</name></author><author><name sortKey="Zaki, S" uniqKey="Zaki S">S. Zaki</name></author><author><name sortKey="St Claire, M" uniqKey="St Claire M">M. St Claire</name></author><author><name sortKey="Murphy, B" uniqKey="Murphy B">B. Murphy</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholls, J M" uniqKey="Nicholls J">J.M. Nicholls</name></author><author><name sortKey="Butany, J" uniqKey="Butany J">J. Butany</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Beh, S L" uniqKey="Beh S">S.L. Beh</name></author><author><name sortKey="Poutanen, S" uniqKey="Poutanen S">S. Poutanen</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Wong, M" uniqKey="Wong M">M. Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholls, J M" uniqKey="Nicholls J">J.M. Nicholls</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Lee, K C" uniqKey="Lee K">K.C. Lee</name></author><author><name sortKey="Ng, W F" uniqKey="Ng W">W.F. Ng</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Leung, C Y" uniqKey="Leung C">C.Y. Leung</name></author><author><name sortKey="Chu, C M" uniqKey="Chu C">C.M. Chu</name></author><author><name sortKey="Hui, P K" uniqKey="Hui P">P.K. Hui</name></author><author><name sortKey="Mak, K L" uniqKey="Mak K">K.L. Mak</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Nicholls, J M" uniqKey="Nicholls J">J.M. Nicholls</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qin, C" uniqKey="Qin C">C. Qin</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Wei, Q" uniqKey="Wei Q">Q. Wei</name></author><author><name sortKey="She, M" uniqKey="She M">M. She</name></author><author><name sortKey="Marasco, W A" uniqKey="Marasco W">W.A. Marasco</name></author><author><name sortKey="Jiang, H" uniqKey="Jiang H">H. Jiang</name></author><author><name sortKey="Tu, X" uniqKey="Tu X">X. Tu</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name></author><author><name sortKey="Ren, L" uniqKey="Ren L">L. Ren</name></author><author><name sortKey="Gao, H" uniqKey="Gao H">H. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Paddock, C" uniqKey="Paddock C">C. Paddock</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Butler, E" uniqKey="Butler E">E. Butler</name></author><author><name sortKey="Zaki, S" uniqKey="Zaki S">S. Zaki</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J. Guarner</name></author><author><name sortKey="Hayes, N" uniqKey="Hayes N">N. Hayes</name></author><author><name sortKey="Murphy, B" uniqKey="Murphy B">B. Murphy</name></author><author><name sortKey="Zaki, S" uniqKey="Zaki S">S. Zaki</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rowe, T" uniqKey="Rowe T">T. Rowe</name></author><author><name sortKey="Gao, G" uniqKey="Gao G">G. Gao</name></author><author><name sortKey="Hogan, R J" uniqKey="Hogan R">R.J. Hogan</name></author><author><name sortKey="Crystal, R G" uniqKey="Crystal R">R.G. Crystal</name></author><author><name sortKey="Voss, T G" uniqKey="Voss T">T.G. Voss</name></author><author><name sortKey="Grant, R L" uniqKey="Grant R">R.L. Grant</name></author><author><name sortKey="Bell, P" uniqKey="Bell P">P. Bell</name></author><author><name sortKey="Kobinger, G P" uniqKey="Kobinger G">G.P. Kobinger</name></author><author><name sortKey="Wivel, N A" uniqKey="Wivel N">N.A. Wivel</name></author><author><name sortKey="Wilson, J M" uniqKey="Wilson J">J.M. Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, H D" uniqKey="Song H">H.D. Song</name></author><author><name sortKey="Tu, C C" uniqKey="Tu C">C.C. Tu</name></author><author><name sortKey="Zhang, G W" uniqKey="Zhang G">G.W. Zhang</name></author><author><name sortKey="Wang, S Y" uniqKey="Wang S">S.Y. Wang</name></author><author><name sortKey="Zheng, K" uniqKey="Zheng K">K. Zheng</name></author><author><name sortKey="Lei, L C" uniqKey="Lei L">L.C. Lei</name></author><author><name sortKey="Chen, Q X" uniqKey="Chen Q">Q.X. Chen</name></author><author><name sortKey="Gao, Y W" uniqKey="Gao Y">Y.W. Gao</name></author><author><name sortKey="Zhou, H Q" uniqKey="Zhou H">H.Q. Zhou</name></author><author><name sortKey="Xiang, H" uniqKey="Xiang H">H. Xiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Mcauliffe, J" uniqKey="Mcauliffe J">J. McAuliffe</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Fahle, G" uniqKey="Fahle G">G. Fahle</name></author><author><name sortKey="Fischer, S" uniqKey="Fischer S">S. Fischer</name></author><author><name sortKey="Tatti, K" uniqKey="Tatti K">K. Tatti</name></author><author><name sortKey="Packard, M" uniqKey="Packard M">M. Packard</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name></author><author><name sortKey="Zaki, S" uniqKey="Zaki S">S. Zaki</name></author><author><name sortKey="Murphy, B" uniqKey="Murphy B">B. Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="To, K F" uniqKey="To K">K.F. To</name></author><author><name sortKey="Tong, J H" uniqKey="Tong J">J.H. Tong</name></author><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author><author><name sortKey="Au, F W" uniqKey="Au F">F.W. Au</name></author><author><name sortKey="Chim, S S" uniqKey="Chim S">S.S. Chim</name></author><author><name sortKey="Chan, K C" uniqKey="Chan K">K.C. Chan</name></author><author><name sortKey="Cheung, J L" uniqKey="Cheung J">J.L. Cheung</name></author><author><name sortKey="Liu, E Y" uniqKey="Liu E">E.Y. Liu</name></author><author><name sortKey="Tse, G M" uniqKey="Tse G">G.M. Tse</name></author><author><name sortKey="Lo, A W" uniqKey="Lo A">A.W. Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tse, G M" uniqKey="Tse G">G.M. Tse</name></author><author><name sortKey="To, K F" uniqKey="To K">K.F. To</name></author><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author><author><name sortKey="Lo, A W" uniqKey="Lo A">A.W. Lo</name></author><author><name sortKey="Ng, K C" uniqKey="Ng K">K.C. Ng</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A. Wu</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N. Lee</name></author><author><name sortKey="Wong, H C" uniqKey="Wong H">H.C. Wong</name></author><author><name sortKey="Mak, S M" uniqKey="Mak S">S.M. Mak</name></author><author><name sortKey="Chan, K F" uniqKey="Chan K">K.F. Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tu, C" uniqKey="Tu C">C. Tu</name></author><author><name sortKey="Crameri, G" uniqKey="Crameri G">G. Crameri</name></author><author><name sortKey="Kong, X" uniqKey="Kong X">X. Kong</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y. Sun</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M. Yu</name></author><author><name sortKey="Xiang, H" uniqKey="Xiang H">H. Xiang</name></author><author><name sortKey="Xia, X" uniqKey="Xia X">X. Xia</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Ren, T" uniqKey="Ren T">T. Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L F" uniqKey="Wang L">L.-F. Wang</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z. Shi</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name></author><author><name sortKey="Field, H" uniqKey="Field H">H. Field</name></author><author><name sortKey="Daszak, P" uniqKey="Daszak P">P. Daszak</name></author><author><name sortKey="Eaton, B T" uniqKey="Eaton B">B.T. Eaton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, D" uniqKey="Wu D">D. Wu</name></author><author><name sortKey="Tu, C" uniqKey="Tu C">C. Tu</name></author><author><name sortKey="Xin, C" uniqKey="Xin C">C. Xin</name></author><author><name sortKey="Xuan, H" uniqKey="Xuan H">H. Xuan</name></author><author><name sortKey="Meng, Q" uniqKey="Meng Q">Q. Meng</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y. Yu</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y. Jiang</name></author><author><name sortKey="Yin, X" uniqKey="Yin X">X. Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J M" uniqKey="Zhao J">J.M. Zhao</name></author><author><name sortKey="Zhou, G D" uniqKey="Zhou G">G.D. Zhou</name></author><author><name sortKey="Sun, Y L" uniqKey="Sun Y">Y.L. Sun</name></author><author><name sortKey="Wang, S S" uniqKey="Wang S">S.S. Wang</name></author><author><name sortKey="Yang, J F" uniqKey="Yang J">J.F. Yang</name></author><author><name sortKey="Meng, E H" uniqKey="Meng E">E.H. Meng</name></author><author><name sortKey="Pan, D" uniqKey="Pan D">D. Pan</name></author><author><name sortKey="Li, W S" uniqKey="Li W">W.S. Li</name></author><author><name sortKey="Zhou, X S" uniqKey="Zhou X">X.S. Zhou</name></author><author><name sortKey="Wang, Y D" uniqKey="Wang Y">Y.D. Wang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xiao, Y" sort="Xiao, Y" uniqKey="Xiao Y" first="Y." last="Xiao">Y. Xiao</name></noRegion><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><name sortKey="Kong, X" sort="Kong, X" uniqKey="Kong X" first="X." last="Kong">X. Kong</name><name sortKey="Kong, X" sort="Kong, X" uniqKey="Kong X" first="X." last="Kong">X. Kong</name><name sortKey="Li, C" sort="Li, C" uniqKey="Li C" first="C." last="Li">C. Li</name><name sortKey="Liu, G" sort="Liu, G" uniqKey="Liu G" first="G." last="Liu">G. Liu</name><name sortKey="Liu, G" sort="Liu, G" uniqKey="Liu G" first="G." last="Liu">G. Liu</name><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y." last="Liu">Y. Liu</name><name sortKey="Meng, Q" sort="Meng, Q" uniqKey="Meng Q" first="Q." last="Meng">Q. Meng</name><name sortKey="Meng, Q" sort="Meng, Q" uniqKey="Meng Q" first="Q." last="Meng">Q. Meng</name><name sortKey="Tong, T" sort="Tong, T" uniqKey="Tong T" first="T." last="Tong">T. Tong</name><name sortKey="Tong, T" sort="Tong, T" uniqKey="Tong T" first="T." last="Tong">T. Tong</name><name sortKey="Wang, M" sort="Wang, M" uniqKey="Wang M" first="M." last="Wang">M. Wang</name><name sortKey="Wu, D" sort="Wu, D" uniqKey="Wu D" first="D." last="Wu">D. Wu</name><name sortKey="Wu, D" sort="Wu, D" uniqKey="Wu D" first="D." last="Wu">D. Wu</name><name sortKey="Xiao, Y" sort="Xiao, Y" uniqKey="Xiao Y" first="Y." last="Xiao">Y. Xiao</name><name sortKey="Yin, X" sort="Yin, X" uniqKey="Yin X" first="X." last="Yin">X. Yin</name></country><country name="Australie"><noRegion><name sortKey="Wang, L F" sort="Wang, L F" uniqKey="Wang L" first="L.-F." last="Wang">L.-F. Wang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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