SrasV1, Main, Exploration, bibRecord, 002F18

Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection

Identifieur interne : 002F18 ( Main/Exploration ); précédent : 002F17; suivant : 002F19

Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection

Auteurs : MIN ZHUANG [Japon, République populaire de Chine] ; HONG JIANG [République populaire de Chine] ; Yasuhiro Suzuki [Japon] ; XIAOGUANG LI [Japon] ; PENG XIAO [Japon] ; Takashi Tanaka [Japon] ; HONG LING [République populaire de Chine] ; BAOFENG YANG [République populaire de Chine] ; Hiroki Saitoh [Japon] ; LIANFENG ZHANG [République populaire de Chine] ; CHUAN QIN [République populaire de Chine] ; Kazuo Sugamura [Japon] ; Toshio Hattori [Japon]

Source :

Antiviral research [ 0166-3542 ] ; 2009.

RBID : Pascal:09-0210832

Descripteurs français

Pascal (Inist)
- Extrait, Virus syndrome respiratoire aigu sévère, Infection, Origine végétale, Plante médicinale, Transferrine, Récepteur biologique, Activité biologique, Antiviral, Cinnamomum, Lentivirus, In vitro.
Wicri :
- topic : Plante médicinale.

English descriptors

KwdEn :
- Antiviral, Biological activity, Biological receptor, Cinnamomum, Extract, In vitro, Infection, Lentivirus, Medicinal plant, Plant origin, Severe acute respiratory syndrome virus, Transferrin.

Abstract

We found that the butanol fraction of Cinnamomi Cortex (CC/Fr.2) showed moderate inhibitory activity in wild-type severe acute respiratory syndrome coronavirus (wtSARS-CoV) and HIV/SARS-CoV S pseudovirus infections. The inhibition on pseudovirus was also seen in cells pretreated with the CC and CC/Fr.2 (IC_50S, 283.4 ± 16.3 and 149.5 ± 13.5 μg/ml, respectively), however the highest activities on wtSARS-CoV were observed when the viruses were treated by the extracts before challenging (IC_50S, 43.1 ±2.8 and 7.8 ± 0.3 μg/ml; SIs, 8.4 and 23.1, respectively). Among the compounds fractionated from CC, procyanidin A2 and procyanidin B1 showed moderate anti-wtSARS-CoV activity (IC_50S, 29.9 ± 3.3 and 41.3 ± 3.4 μM; SIs, 37.35 and 15.69, respectively). We also sought to determine whether they could interfere with the clathrin-dependent endocytosis pathway using transferrin receptor (TfR) as an indicator. CC/Fr.2 inhibited the internalization of TfR but the procyanidins did not. Taken together, CC/Fr.2 contains unknown substances, that could inhibit the infection, probably by interfering with endocytosis, and it also contains procyanidins that did not inhibit the internalization but inhibited the infection. Therefore, CC extracts contain anti-virus activities that act through distinct mechanisms according to differences in the compounds or mixtures.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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</placeName>
<orgName type="university">Université du Tōhoku</orgName>
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<author><name sortKey="Hattori, Toshio" sort="Hattori, Toshio" uniqKey="Hattori T" first="Toshio" last="Hattori">Toshio Hattori</name>
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</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Antiviral research</title>
<title level="j" type="abbreviated">Antivir. res.</title>
<idno type="ISSN">0166-3542</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term>
<term>Biological activity</term>
<term>Biological receptor</term>
<term>Cinnamomum</term>
<term>Extract</term>
<term>In vitro</term>
<term>Infection</term>
<term>Lentivirus</term>
<term>Medicinal plant</term>
<term>Plant origin</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Transferrin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Extrait</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Infection</term>
<term>Origine végétale</term>
<term>Plante médicinale</term>
<term>Transferrine</term>
<term>Récepteur biologique</term>
<term>Activité biologique</term>
<term>Antiviral</term>
<term>Cinnamomum</term>
<term>Lentivirus</term>
<term>In vitro</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Plante médicinale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We found that the butanol fraction of Cinnamomi Cortex (CC/Fr.2) showed moderate inhibitory activity in wild-type severe acute respiratory syndrome coronavirus (wtSARS-CoV) and HIV/SARS-CoV S pseudovirus infections. The inhibition on pseudovirus was also seen in cells pretreated with the CC and CC/Fr.2 (IC<sub>50S</sub>
, 283.4 ± 16.3 and 149.5 ± 13.5 μg/ml, respectively), however the highest activities on wtSARS-CoV were observed when the viruses were treated by the extracts before challenging (IC<sub>50S</sub>
, 43.1 ±2.8 and 7.8 ± 0.3 μg/ml; SIs, 8.4 and 23.1, respectively). Among the compounds fractionated from CC, procyanidin A2 and procyanidin B1 showed moderate anti-wtSARS-CoV activity (IC<sub>50S</sub>
, 29.9 ± 3.3 and 41.3 ± 3.4 μM; SIs, 37.35 and 15.69, respectively). We also sought to determine whether they could interfere with the clathrin-dependent endocytosis pathway using transferrin receptor (TfR) as an indicator. CC/Fr.2 inhibited the internalization of TfR but the procyanidins did not. Taken together, CC/Fr.2 contains unknown substances, that could inhibit the infection, probably by interfering with endocytosis, and it also contains procyanidins that did not inhibit the internalization but inhibited the infection. Therefore, CC extracts contain anti-virus activities that act through distinct mechanisms according to differences in the compounds or mixtures.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
<li>République populaire de Chine</li>
</country>
<region><li>Région de Tōhoku</li>
</region>
<settlement><li>Sendai</li>
</settlement>
<orgName><li>Université du Tōhoku</li>
</orgName>
</list>
<tree><country name="Japon"><region name="Région de Tōhoku"><name sortKey="Min Zhuang" sort="Min Zhuang" uniqKey="Min Zhuang" last="Min Zhuang">MIN ZHUANG</name>
</region>
<name sortKey="Hattori, Toshio" sort="Hattori, Toshio" uniqKey="Hattori T" first="Toshio" last="Hattori">Toshio Hattori</name>
<name sortKey="Peng Xiao" sort="Peng Xiao" uniqKey="Peng Xiao" last="Peng Xiao">PENG XIAO</name>
<name sortKey="Saitoh, Hiroki" sort="Saitoh, Hiroki" uniqKey="Saitoh H" first="Hiroki" last="Saitoh">Hiroki Saitoh</name>
<name sortKey="Sugamura, Kazuo" sort="Sugamura, Kazuo" uniqKey="Sugamura K" first="Kazuo" last="Sugamura">Kazuo Sugamura</name>
<name sortKey="Suzuki, Yasuhiro" sort="Suzuki, Yasuhiro" uniqKey="Suzuki Y" first="Yasuhiro" last="Suzuki">Yasuhiro Suzuki</name>
<name sortKey="Tanaka, Takashi" sort="Tanaka, Takashi" uniqKey="Tanaka T" first="Takashi" last="Tanaka">Takashi Tanaka</name>
<name sortKey="Xiaoguang Li" sort="Xiaoguang Li" uniqKey="Xiaoguang Li" last="Xiaoguang Li">XIAOGUANG LI</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Min Zhuang" sort="Min Zhuang" uniqKey="Min Zhuang" last="Min Zhuang">MIN ZHUANG</name>
</noRegion>
<name sortKey="Baofeng Yang" sort="Baofeng Yang" uniqKey="Baofeng Yang" last="Baofeng Yang">BAOFENG YANG</name>
<name sortKey="Chuan Qin" sort="Chuan Qin" uniqKey="Chuan Qin" last="Chuan Qin">CHUAN QIN</name>
<name sortKey="Hong Jiang" sort="Hong Jiang" uniqKey="Hong Jiang" last="Hong Jiang">HONG JIANG</name>
<name sortKey="Hong Ling" sort="Hong Ling" uniqKey="Hong Ling" last="Hong Ling">HONG LING</name>
<name sortKey="Lianfeng Zhang" sort="Lianfeng Zhang" uniqKey="Lianfeng Zhang" last="Lianfeng Zhang">LIANFENG ZHANG</name>
</country>
</tree>
</affiliations>
</record>

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Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection

Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection

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