Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells.
Identifieur interne : 002B03 ( Main/Exploration ); précédent : 002B02; suivant : 002B04Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells.
Auteurs : Tanya A. Miura [États-Unis] ; Kathryn V. HolmesSource :
- Journal of leukocyte biology [ 1938-3673 ] ; 2009.
Descripteurs français
- KwdFr :
- Alvéoles pulmonaires (immunologie), Alvéoles pulmonaires (physiopathologie), Alvéoles pulmonaires (virologie), Animaux, Cellules épithéliales (anatomopathologie), Cellules épithéliales (immunologie), Cellules épithéliales (physiologie), Cellules épithéliales (virologie), Chimiokines CXC (physiologie), Coronavirus (isolement et purification), Coronavirus (physiologie), Différenciation cellulaire, Humains, Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Infections à coronavirus (immunologie), Infections à coronavirus (physiopathologie), Interactions hôte-pathogène (physiologie), Maladies pulmonaires (virologie), Maladies virales (immunologie), Maladies virales (épidémiologie), Poumon (virologie), Rats, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (physiopathologie), Virus du SRAS (physiologie).
- MESH :
- anatomopathologie : Cellules épithéliales.
- immunologie : Alvéoles pulmonaires, Cellules épithéliales, Infections à coronavirus, Maladies virales, Syndrome respiratoire aigu sévère.
- isolement et purification : Coronavirus.
- physiologie : Cellules épithéliales, Chimiokines CXC, Coronavirus, Interactions hôte-pathogène, Virus du SRAS.
- physiopathologie : Alvéoles pulmonaires, Infections à coronavirus, Syndrome respiratoire aigu sévère.
- virologie : Alvéoles pulmonaires, Cellules épithéliales, Infections de l'appareil respiratoire, Maladies pulmonaires, Poumon.
- épidémiologie : Infections de l'appareil respiratoire, Maladies virales.
- Animaux, Différenciation cellulaire, Humains, Rats.
English descriptors
- KwdEn :
- Animals, Cell Differentiation, Chemokines, CXC (physiology), Coronavirus (isolation & purification), Coronavirus (physiology), Coronavirus Infections (immunology), Coronavirus Infections (physiopathology), Epithelial Cells (immunology), Epithelial Cells (pathology), Epithelial Cells (physiology), Epithelial Cells (virology), Host-Pathogen Interactions (physiology), Humans, Lung (virology), Lung Diseases (virology), Pulmonary Alveoli (immunology), Pulmonary Alveoli (physiopathology), Pulmonary Alveoli (virology), Rats, Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (virology), SARS Virus (physiology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (physiopathology), Virus Diseases (epidemiology), Virus Diseases (immunology).
- MESH :
- chemical , physiology : Chemokines, CXC.
- epidemiology : Respiratory Tract Infections, Virus Diseases.
- immunology : Coronavirus Infections, Epithelial Cells, Pulmonary Alveoli, Severe Acute Respiratory Syndrome, Virus Diseases.
- isolation & purification : Coronavirus.
- pathology : Epithelial Cells.
- physiology : Coronavirus, Epithelial Cells, Host-Pathogen Interactions, SARS Virus.
- physiopathology : Coronavirus Infections, Pulmonary Alveoli, Severe Acute Respiratory Syndrome.
- virology : Epithelial Cells, Lung, Lung Diseases, Pulmonary Alveoli, Respiratory Tract Infections.
- Animals, Cell Differentiation, Humans, Rats.
Abstract
Viruses that infect the lung are a significant cause of morbidity and mortality in animals and humans worldwide. Coronaviruses are being associated increasingly with severe diseases in the lower respiratory tract. Alveolar epithelial cells are an important target for coronavirus infection in the lung, and infected cells can initiate innate immune responses to viral infection. In this overview, we describe in vitro models of highly differentiated alveolar epithelial cells that are currently being used to study the innate immune response to coronavirus infection. We have shown that rat coronavirus infection of rat alveolar type I epithelial cells in vitro induces expression of CXC chemokines, which may recruit and activate neutrophils. Although neutrophils are recruited early in infection in several coronavirus models including rat coronavirus. However, their role in viral clearance and/or immune-mediated tissue damage is not understood. Primary cultures of differentiated alveolar epithelial cells will be useful for identifying the interactions between coronaviruses and alveolar epithelial cells that influence the innate immune responses to infection in the lung. Understanding the molecular details of these interactions will be critical for the design of effective strategies to prevent and treat coronavirus infections in the lung.
DOI: 10.1189/jlb.0209078
PubMed: 19638499
Affiliations:
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Le document en format XML
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Cells</term><term>Lung</term><term>Lung Diseases</term><term>Pulmonary Alveoli</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term><term>Maladies virales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Differentiation</term><term>Humans</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Différenciation cellulaire</term><term>Humains</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viruses that infect the lung are a significant cause of morbidity and mortality in animals and humans worldwide. Coronaviruses are being associated increasingly with severe diseases in the lower respiratory tract. Alveolar epithelial cells are an important target for coronavirus infection in the lung, and infected cells can initiate innate immune responses to viral infection. In this overview, we describe in vitro models of highly differentiated alveolar epithelial cells that are currently being used to study the innate immune response to coronavirus infection. We have shown that rat coronavirus infection of rat alveolar type I epithelial cells in vitro induces expression of CXC chemokines, which may recruit and activate neutrophils. Although neutrophils are recruited early in infection in several coronavirus models including rat coronavirus. However, their role in viral clearance and/or immune-mediated tissue damage is not understood. Primary cultures of differentiated alveolar epithelial cells will be useful for identifying the interactions between coronaviruses and alveolar epithelial cells that influence the innate immune responses to infection in the lung. Understanding the molecular details of these interactions will be critical for the design of effective strategies to prevent and treat coronavirus infections in the lung.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Idaho</li></region></list><tree><noCountry><name sortKey="Holmes, Kathryn V" sort="Holmes, Kathryn V" uniqKey="Holmes K" first="Kathryn V" last="Holmes">Kathryn V. Holmes</name></noCountry><country name="États-Unis"><region name="Idaho"><name sortKey="Miura, Tanya A" sort="Miura, Tanya A" uniqKey="Miura T" first="Tanya A" last="Miura">Tanya A. Miura</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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