[Clinical aspects of human infection by the avian influenza virus].
Identifieur interne : 002971 ( Main/Exploration ); précédent : 002970; suivant : 002972[Clinical aspects of human infection by the avian influenza virus].
Auteurs : P. GoubauSource :
- Bulletin et memoires de l'Academie royale de medecine de Belgique [ 0377-8231 ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
- pathogénicité : Virus de la grippe A.
- épidémiologie : Grippe chez les oiseaux, Grippe humaine.
- Animaux, Facteurs de risque, Humains, Oiseaux.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Influenza, Human.
- pathogenicity : Influenza A virus.
- transmission : Influenza in Birds, Influenza, Human.
- Animals, Birds, Humans, Risk Factors.
Abstract
The species barrier is not perfect for Influenza A and numerous transmissions of the virus from pigs or poultry to humans have been described these years. Appearing in 1997 and becoming epidemic in 2003, influenza A/H5N1 provoked many deadly enzootics in poultry batteries (highly pathogenic avian influenza of HPAI). Starting in Asia, many countries throughout Africa and Europe were affected. Sporadic human cases were described in direct contact with diseased chicken or other poultry. Half of the cases are lethal, but human to human transmission occurs with difficulty. From January 2003 to August 11th 2009, 438 cases were declared worldwide with 262 deaths. Many countries declared cases, but recently most cases occurred in Egypt. Measures in hospital were taken which were copied from the measures for SARS (Severe Acute Respiratory Syndrome), but these were probably excessive in this case, considering the low rate of secondary cases with A/H5N1. In many human infections, signs of severe respiratory distress develop and multi organ failure. It was feared that this deadly virus could become easily transmitted between humans, leading to a new pandemic. This was not the case up to now. The strong pathogenicity of the virus is still not completely explained, but the deep location of infection in the lungs and the deregulation of cytokine production by the target cells, particularly macrophages, may be part of the explanation.
PubMed: 20669612
Affiliations:
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Le document en format XML
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Goubau</name><affiliation><nlm:affiliation>Laboratoire de Virologie Médicale, Cliniques Universitaires St. Luc.</nlm:affiliation><wicri:noCountry code="subField">Cliniques Universitaires St</wicri:noCountry></affiliation></author></analytic><series><title level="j">Bulletin et memoires de l'Academie royale de medecine de Belgique</title><idno type="ISSN">0377-8231</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Birds</term><term>Humans</term><term>Influenza A virus (pathogenicity)</term><term>Influenza in Birds (transmission)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (transmission)</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Facteurs de risque</term><term>Grippe chez les oiseaux (transmission)</term><term>Grippe humaine (transmission)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Oiseaux</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza in Birds</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Birds</term><term>Humans</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs de risque</term><term>Humains</term><term>Oiseaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The species barrier is not perfect for Influenza A and numerous transmissions of the virus from pigs or poultry to humans have been described these years. Appearing in 1997 and becoming epidemic in 2003, influenza A/H5N1 provoked many deadly enzootics in poultry batteries (highly pathogenic avian influenza of HPAI). Starting in Asia, many countries throughout Africa and Europe were affected. Sporadic human cases were described in direct contact with diseased chicken or other poultry. Half of the cases are lethal, but human to human transmission occurs with difficulty. From January 2003 to August 11th 2009, 438 cases were declared worldwide with 262 deaths. Many countries declared cases, but recently most cases occurred in Egypt. Measures in hospital were taken which were copied from the measures for SARS (Severe Acute Respiratory Syndrome), but these were probably excessive in this case, considering the low rate of secondary cases with A/H5N1. In many human infections, signs of severe respiratory distress develop and multi organ failure. It was feared that this deadly virus could become easily transmitted between humans, leading to a new pandemic. This was not the case up to now. The strong pathogenicity of the virus is still not completely explained, but the deep location of infection in the lungs and the deregulation of cytokine production by the target cells, particularly macrophages, may be part of the explanation.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Goubau, P" sort="Goubau, P" uniqKey="Goubau P" first="P" last="Goubau">P. Goubau</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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