Computational approaches for the discovery of cysteine protease inhibitors against malaria and SARS.
Identifieur interne : 002566 ( Main/Exploration ); précédent : 002565; suivant : 002567Computational approaches for the discovery of cysteine protease inhibitors against malaria and SARS.
Auteurs : Falgun Shah [États-Unis] ; Prasenjit Mukherjee ; Prashant Desai ; Mitchell AverySource :
- Current computer-aided drug design [ 1875-6697 ] ; 2010.
Descripteurs français
- KwdFr :
- Animaux, Biologie informatique (), Découverte de médicament (), Humains, Inhibiteurs de la cystéine protéinase (), Inhibiteurs de la cystéine protéinase (usage thérapeutique), Paludisme (enzymologie), Paludisme (traitement médicamenteux), Syndrome respiratoire aigu sévère (enzymologie), Syndrome respiratoire aigu sévère (traitement médicamenteux).
- MESH :
- enzymologie : Paludisme, Syndrome respiratoire aigu sévère.
- traitement médicamenteux : Paludisme, Syndrome respiratoire aigu sévère.
- usage thérapeutique : Inhibiteurs de la cystéine protéinase.
- Animaux, Biologie informatique, Découverte de médicament, Humains, Inhibiteurs de la cystéine protéinase.
English descriptors
- KwdEn :
- Animals, Computational Biology (methods), Cysteine Proteinase Inhibitors (chemistry), Cysteine Proteinase Inhibitors (therapeutic use), Drug Discovery (methods), Humans, Malaria (drug therapy), Malaria (enzymology), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (enzymology).
- MESH :
- chemical , chemistry : Cysteine Proteinase Inhibitors.
- drug therapy : Malaria, Severe Acute Respiratory Syndrome.
- enzymology : Malaria, Severe Acute Respiratory Syndrome.
- methods : Computational Biology, Drug Discovery.
- chemical , therapeutic use : Cysteine Proteinase Inhibitors.
- Animals, Humans.
Abstract
Cysteine proteases are implicated in a variety of human physiological processes and also form an essential component of the life cycle of a number of pathogenic protozoa and viruses. The present review highlights the drug design approaches utilized to understand the mechanism of inhibition and discovery of inhibitors against protozoal cysteine protease, falcipain (a cysteine protease of P. falciparum which causes malaria), and viral cysteine protease, SARS-CoV M(pro) (a cysteine protease of severe acute respiratory syndrome corona virus). The article describes rational approaches for the design of inhibitors and focuses on a variety of structure as well as ligand-based modeling strategies adopted for the discovery of the inhibitors. Also, the key features of ligand recognition against these targets are accentuated. Although no apparent similarities exist between viral and protozoal cysteine proteases discussed here, the goal is to provide examples of rational drug design approaches adopted to design inhibitors against these proteases. The current review would be of interest to scientists engaged in the development of drug design strategies to target the cysteine proteases present in mammals and other lower order organisms.
DOI: 10.2174/157340910790980142
PubMed: 20370692
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Cysteine proteases are implicated in a variety of human physiological processes and also form an essential component of the life cycle of a number of pathogenic protozoa and viruses. The present review highlights the drug design approaches utilized to understand the mechanism of inhibition and discovery of inhibitors against protozoal cysteine protease, falcipain (a cysteine protease of P. falciparum which causes malaria), and viral cysteine protease, SARS-CoV M(pro) (a cysteine protease of severe acute respiratory syndrome corona virus). The article describes rational approaches for the design of inhibitors and focuses on a variety of structure as well as ligand-based modeling strategies adopted for the discovery of the inhibitors. Also, the key features of ligand recognition against these targets are accentuated. Although no apparent similarities exist between viral and protozoal cysteine proteases discussed here, the goal is to provide examples of rational drug design approaches adopted to design inhibitors against these proteases. The current review would be of interest to scientists engaged in the development of drug design strategies to target the cysteine proteases present in mammals and other lower order organisms.</div>
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