Nucleic acid amplification-based diagnosis of respiratory virus infections.
Identifieur interne : 002489 ( Main/Exploration ); précédent : 002488; suivant : 002490Nucleic acid amplification-based diagnosis of respiratory virus infections.
Auteurs : James B. Mahony [Canada]Source :
- Expert review of anti-infective therapy [ 1744-8336 ] ; 2010.
Descripteurs français
- KwdFr :
- Charge virale, Grippe humaine (diagnostic), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Infections de l'appareil respiratoire (diagnostic), Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Maladies virales (diagnostic), Maladies virales (virologie), Maladies virales (épidémiologie), Pandémies, Réaction de polymérisation en chaîne, Résistance virale aux médicaments, Techniques d'amplification d'acides nucléiques, Virus (), Virus (génétique), Virus (isolement et purification).
- MESH :
- diagnostic : Grippe humaine, Infections de l'appareil respiratoire, Maladies virales.
- génétique : Virus.
- isolement et purification : Virus.
- virologie : Grippe humaine, Infections de l'appareil respiratoire, Maladies virales.
- épidémiologie : Grippe humaine, Infections de l'appareil respiratoire, Maladies virales.
- Charge virale, Humains, Pandémies, Réaction de polymérisation en chaîne, Résistance virale aux médicaments, Techniques d'amplification d'acides nucléiques, Virus.
English descriptors
- KwdEn :
- Drug Resistance, Viral, Humans, Influenza, Human (diagnosis), Influenza, Human (epidemiology), Influenza, Human (virology), Nucleic Acid Amplification Techniques, Pandemics, Polymerase Chain Reaction, Respiratory Tract Infections (diagnosis), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (virology), Viral Load, Virus Diseases (diagnosis), Virus Diseases (epidemiology), Virus Diseases (virology), Viruses (drug effects), Viruses (genetics), Viruses (isolation & purification).
- MESH :
- diagnosis : Influenza, Human, Respiratory Tract Infections, Virus Diseases.
- drug effects : Viruses.
- epidemiology : Influenza, Human, Respiratory Tract Infections, Virus Diseases.
- genetics : Viruses.
- isolation & purification : Viruses.
- virology : Influenza, Human, Respiratory Tract Infections, Virus Diseases.
- Drug Resistance, Viral, Humans, Nucleic Acid Amplification Techniques, Pandemics, Polymerase Chain Reaction, Viral Load.
Abstract
The appearance of eight new respiratory viruses in the human population in the past 9 years, including two new pandemics (SARS coronavirus in 2003 and swine-origin influenza A/H1N1 in 2009), has tested the ability of virology laboratories to develop diagnostic tests to identify these viruses. Nucleic acid amplification tests (NATs) that first appeared two decades ago have been developed for both conventional and emerging viruses and now form the backbone of the clinical laboratory. NATs provide fast, accurate and sensitive detection of respiratory viruses and have significantly increased our understanding of the epidemiology of these viruses. Multiplex PCR assays have been introduced recently and several commercial tests are now available. The final chapter in the evolution of respiratory virus diagnostics will be the addition of allelic discrimination and detection of single nucleotide polymorphisms associated with antiviral resistance to multiplex assays. These resistance assays together with new viral load tests will enable clinical laboratories to provide physicians with important information for optimal treatment of patients.
DOI: 10.1586/eri.10.121
PubMed: 21073292
Affiliations:
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Mahony</name><affiliation wicri:level="1"><nlm:affiliation>Regional Virology Laboratory, St. Joseph's Healthcare Hamilton, 50 Charlton Ave. East, Hamilton, ON, L8N 4A6, Canada. mahonyj@mcmaster.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Regional Virology Laboratory, St. Joseph's Healthcare Hamilton, 50 Charlton Ave. East, Hamilton, ON, L8N 4A6</wicri:regionArea><wicri:noRegion>L8N 4A6</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:21073292</idno><idno type="pmid">21073292</idno><idno type="doi">10.1586/eri.10.121</idno><idno type="wicri:Area/PubMed/Corpus">001588</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001588</idno><idno type="wicri:Area/PubMed/Curation">001588</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001588</idno><idno type="wicri:Area/PubMed/Checkpoint">001624</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001624</idno><idno type="wicri:Area/Ncbi/Merge">002253</idno><idno type="wicri:Area/Ncbi/Curation">002253</idno><idno type="wicri:Area/Ncbi/Checkpoint">002253</idno><idno type="wicri:Area/Main/Merge">002522</idno><idno type="wicri:Area/Main/Curation">002489</idno><idno type="wicri:Area/Main/Exploration">002489</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nucleic acid amplification-based diagnosis of respiratory virus infections.</title><author><name sortKey="Mahony, James B" sort="Mahony, James B" uniqKey="Mahony J" first="James B" last="Mahony">James B. Mahony</name><affiliation wicri:level="1"><nlm:affiliation>Regional Virology Laboratory, St. Joseph's Healthcare Hamilton, 50 Charlton Ave. East, Hamilton, ON, L8N 4A6, Canada. mahonyj@mcmaster.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Regional Virology Laboratory, St. Joseph's Healthcare Hamilton, 50 Charlton Ave. East, Hamilton, ON, L8N 4A6</wicri:regionArea><wicri:noRegion>L8N 4A6</wicri:noRegion></affiliation></author></analytic><series><title level="j">Expert review of anti-infective therapy</title><idno type="eISSN">1744-8336</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Drug Resistance, Viral</term><term>Humans</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Nucleic Acid Amplification Techniques</term><term>Pandemics</term><term>Polymerase Chain Reaction</term><term>Respiratory Tract Infections (diagnosis)</term><term>Respiratory Tract Infections (epidemiology)</term><term>Respiratory Tract Infections (virology)</term><term>Viral Load</term><term>Virus Diseases (diagnosis)</term><term>Virus Diseases (epidemiology)</term><term>Virus Diseases (virology)</term><term>Viruses (drug effects)</term><term>Viruses (genetics)</term><term>Viruses (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Charge virale</term><term>Grippe humaine (diagnostic)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Infections de l'appareil respiratoire (diagnostic)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Infections de l'appareil respiratoire (épidémiologie)</term><term>Maladies virales (diagnostic)</term><term>Maladies virales (virologie)</term><term>Maladies virales (épidémiologie)</term><term>Pandémies</term><term>Réaction de polymérisation en chaîne</term><term>Résistance virale aux médicaments</term><term>Techniques d'amplification d'acides nucléiques</term><term>Virus ()</term><term>Virus (génétique)</term><term>Virus (isolement et purification)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term><term>Respiratory Tract Infections</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term><term>Infections de l'appareil respiratoire</term><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Respiratory Tract Infections</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections de l'appareil respiratoire</term><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Respiratory Tract Infections</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections de l'appareil respiratoire</term><term>Maladies virales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Resistance, Viral</term><term>Humans</term><term>Nucleic Acid Amplification Techniques</term><term>Pandemics</term><term>Polymerase Chain Reaction</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Charge virale</term><term>Humains</term><term>Pandémies</term><term>Réaction de polymérisation en chaîne</term><term>Résistance virale aux médicaments</term><term>Techniques d'amplification d'acides nucléiques</term><term>Virus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The appearance of eight new respiratory viruses in the human population in the past 9 years, including two new pandemics (SARS coronavirus in 2003 and swine-origin influenza A/H1N1 in 2009), has tested the ability of virology laboratories to develop diagnostic tests to identify these viruses. Nucleic acid amplification tests (NATs) that first appeared two decades ago have been developed for both conventional and emerging viruses and now form the backbone of the clinical laboratory. NATs provide fast, accurate and sensitive detection of respiratory viruses and have significantly increased our understanding of the epidemiology of these viruses. Multiplex PCR assays have been introduced recently and several commercial tests are now available. The final chapter in the evolution of respiratory virus diagnostics will be the addition of allelic discrimination and detection of single nucleotide polymorphisms associated with antiviral resistance to multiplex assays. These resistance assays together with new viral load tests will enable clinical laboratories to provide physicians with important information for optimal treatment of patients.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Mahony, James B" sort="Mahony, James B" uniqKey="Mahony J" first="James B" last="Mahony">James B. Mahony</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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