Molecular Beacons: A Novel Optical Diagnostic Tool
Identifieur interne : 001E60 ( Main/Exploration ); précédent : 001E59; suivant : 001E61Molecular Beacons: A Novel Optical Diagnostic Tool
Auteurs : Su-Xia Han [République populaire de Chine] ; Xi Jia [République populaire de Chine] ; Jin-Lu Ma [République populaire de Chine] ; Qing Zhu [République populaire de Chine]Source :
- Archivum Immunologiae et Therapiae Experimentalis [ 0004-069X ] ; 2013-04-01.
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Abstract
Abstract: As a result of the efforts of the Human Genome Project and the rise in demand for molecular diagnostic assays, the development and optimization of novel hybridization probes have focused on speed, reliability, and accuracy in the identification of nucleic acids. Molecular beacons (MBs) are single-stranded, fluorophore-labeled nucleic acid probes that are capable of generating a fluorescent signal in the presence of target, but are dark in the absence of target. Because of the high specificity and sensitivity characteristics, MBs have been used in variety of fields. In this review, MBs are introduced and discussed as diagnostic tools in four sections: several technologies of MBs will be illustrated primarily; the limitation of MBs next; the third part is new fashions of MBs; and the last one is to present the application of MBs in disease diagnosis.
Url:
DOI: 10.1007/s00005-012-0209-7
Affiliations:
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Immunol. Ther. Exp.</title><idno type="ISSN">0004-069X</idno><idno type="eISSN">1661-4917</idno><imprint><publisher>SP Birkhäuser Verlag Basel</publisher><pubPlace>Basel</pubPlace><date type="published" when="2013-04-01">2013-04-01</date><biblScope unit="volume">61</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="139">139</biblScope><biblScope unit="page" to="148">148</biblScope></imprint><idno type="ISSN">0004-069X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0004-069X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diagnosis</term><term>Fluorescence resonance energy transfer (FRET)</term><term>Molecular beacons (MBs)</term><term>Nucleic acid probe</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: As a result of the efforts of the Human Genome Project and the rise in demand for molecular diagnostic assays, the development and optimization of novel hybridization probes have focused on speed, reliability, and accuracy in the identification of nucleic acids. Molecular beacons (MBs) are single-stranded, fluorophore-labeled nucleic acid probes that are capable of generating a fluorescent signal in the presence of target, but are dark in the absence of target. Because of the high specificity and sensitivity characteristics, MBs have been used in variety of fields. In this review, MBs are introduced and discussed as diagnostic tools in four sections: several technologies of MBs will be illustrated primarily; the limitation of MBs next; the third part is new fashions of MBs; and the last one is to present the application of MBs in disease diagnosis.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Han, Su Xia" sort="Han, Su Xia" uniqKey="Han S" first="Su-Xia" last="Han">Su-Xia Han</name></noRegion><name sortKey="Jia, Xi" sort="Jia, Xi" uniqKey="Jia X" first="Xi" last="Jia">Xi Jia</name><name sortKey="Ma, Jin Lu" sort="Ma, Jin Lu" uniqKey="Ma J" first="Jin-Lu" last="Ma">Jin-Lu Ma</name><name sortKey="Zhu, Qing" sort="Zhu, Qing" uniqKey="Zhu Q" first="Qing" last="Zhu">Qing Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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