SrasV1, Main, Exploration, bibRecord, 001E22

Solid‐phase synthesis and screening of a library of C‐terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease

Identifieur interne : 001E22 ( Main/Exploration ); précédent : 001E21; suivant : 001E23

Solid‐phase synthesis and screening of a library of C‐terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease

Auteurs : Nicholas J. Ede [Australie] ; Jeffrey Hill [Singapour] ; Joma K. Joy [Singapour] ; Anne-Marie Ede [Australie] ; Merran L. Koppens [Australie]

Source :

Journal of Peptide Science [ 1075-2617 ] ; 2012-11.

RBID : ISTEX:BD9E692FC34F28635BD5C07CCFE3E4E86CDBCCE0

English descriptors

Teeft :
- Aldehyde, Arginine, Arginine peptide aldehydes, Chem, Cleavage, Copyright, Cysteine proteases, Encephalitis, European peptide society, Fmoc, Inhibition constants, Inhibitor, John wiley sons, Library synthesis, Linker, Mass spectrometry mimotopes sample, Microtitre plate format, Mimotopes, Mmol, Molecular weight, Mvev, Mvev protease, Oxazolidine, Pept, Peptide, Peptide aldehyde library, Peptide aldehydes, Peptide inhibitor, Peptide synthesis, Protease, Protease assay, Reaction mixture, Solid phase, Solid phase synthesis, Spectrometry.

Abstract

Murray Valley encephalitis virus is a member of the flavivirus group, a large family of single‐stranded RNA viruses, which cause serious disease in all regions of the world. Unfortunately, no suitable antivirals are available, and there are commercial vaccines for only three flaviviruses. The solid‐phase synthesis of a library of 400 C‐terminal arginine peptide aldehydes and their screening against Murray Valley encephalitis virus protease are demonstrated. The library was utilised to elucidate several tripeptide sequences that can be used as inhibitors in further SAR studies. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd.

The solid‐phase synthesis of a library of 400 C‐terminal arginine peptide aldehydes and their screening against Murray Valley encephalitis virus protease are demonstrated. The library was utilised to elucidate several tripeptide sequences that can be used as inhibitors in further SAR studies.

Url:

https://api.istex.fr/ark:/67375/WNG-PZT17QGT-P/fulltext.pdf

DOI: 10.1002/psc.2450

Affiliations:

Australie, Singapour

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000D96
to stream Istex, to step Curation: 000D96
to stream Istex, to step Checkpoint: 000532
to stream Main, to step Merge: 001E46
to stream Main, to step Curation: 001E22

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Solid‐phase synthesis and screening of a library of C‐terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease</title>
<author><name sortKey="Ede, Nicholas J" sort="Ede, Nicholas J" uniqKey="Ede N" first="Nicholas J." last="Ede">Nicholas J. Ede</name>
</author>
<author><name sortKey="Hill, Jeffrey" sort="Hill, Jeffrey" uniqKey="Hill J" first="Jeffrey" last="Hill">Jeffrey Hill</name>
</author>
<author><name sortKey="Joy, Joma K" sort="Joy, Joma K" uniqKey="Joy J" first="Joma K." last="Joy">Joma K. Joy</name>
</author>
<author><name sortKey="Ede, Anne Arie" sort="Ede, Anne Arie" uniqKey="Ede A" first="Anne-Marie" last="Ede">Anne-Marie Ede</name>
</author>
<author><name sortKey="Koppens, Merran L" sort="Koppens, Merran L" uniqKey="Koppens M" first="Merran L." last="Koppens">Merran L. Koppens</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:BD9E692FC34F28635BD5C07CCFE3E4E86CDBCCE0</idno>
<date when="2012" year="2012">2012</date>
<idno type="doi">10.1002/psc.2450</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-PZT17QGT-P/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000D96</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000D96</idno>
<idno type="wicri:Area/Istex/Curation">000D96</idno>
<idno type="wicri:Area/Istex/Checkpoint">000532</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000532</idno>
<idno type="wicri:doubleKey">1075-2617:2012:Ede N:solid:phase:synthesis</idno>
<idno type="wicri:Area/Main/Merge">001E46</idno>
<idno type="wicri:Area/Main/Curation">001E22</idno>
<idno type="wicri:Area/Main/Exploration">001E22</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Solid‐phase synthesis and screening of a library of C‐terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease</title>
<author><name sortKey="Ede, Nicholas J" sort="Ede, Nicholas J" uniqKey="Ede N" first="Nicholas J." last="Ede">Nicholas J. Ede</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Mimotopes Pty Ltd, 11 Duerdin St Clayton, Victoria, 3168</wicri:regionArea>
<wicri:noRegion>3168</wicri:noRegion>
</affiliation>
<affiliation></affiliation>
<affiliation></affiliation>
</author>
<author><name sortKey="Hill, Jeffrey" sort="Hill, Jeffrey" uniqKey="Hill J" first="Jeffrey" last="Hill">Jeffrey Hill</name>
<affiliation wicri:level="1"><country xml:lang="fr">Singapour</country>
<wicri:regionArea>Experimental Therapeutics Centre (ETC), A*STAR, 31 Biopolis WayNanos Level 3, 138669</wicri:regionArea>
<wicri:noRegion>138669</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Joy, Joma K" sort="Joy, Joma K" uniqKey="Joy J" first="Joma K." last="Joy">Joma K. Joy</name>
<affiliation wicri:level="1"><country xml:lang="fr">Singapour</country>
<wicri:regionArea>Experimental Therapeutics Centre (ETC), A*STAR, 31 Biopolis WayNanos Level 3, 138669</wicri:regionArea>
<wicri:noRegion>138669</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ede, Anne Arie" sort="Ede, Anne Arie" uniqKey="Ede A" first="Anne-Marie" last="Ede">Anne-Marie Ede</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Mimotopes Pty Ltd, 11 Duerdin St Clayton, Victoria, 3168</wicri:regionArea>
<wicri:noRegion>3168</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koppens, Merran L" sort="Koppens, Merran L" uniqKey="Koppens M" first="Merran L." last="Koppens">Merran L. Koppens</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Mimotopes Pty Ltd, 11 Duerdin St Clayton, Victoria, 3168</wicri:regionArea>
<wicri:noRegion>3168</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Journal of Peptide Science</title>
<title level="j" type="alt">JOURNAL OF PEPTIDE SCIENCE</title>
<idno type="ISSN">1075-2617</idno>
<idno type="eISSN">1099-1387</idno>
<imprint><biblScope unit="vol">18</biblScope>
<biblScope unit="issue">11</biblScope>
<biblScope unit="page" from="661">661</biblScope>
<biblScope unit="page" to="668">668</biblScope>
<biblScope unit="page-count">8</biblScope>
<date type="published" when="2012-11">2012-11</date>
</imprint>
<idno type="ISSN">1075-2617</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1075-2617</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Aldehyde</term>
<term>Arginine</term>
<term>Arginine peptide aldehydes</term>
<term>Chem</term>
<term>Cleavage</term>
<term>Copyright</term>
<term>Cysteine proteases</term>
<term>Encephalitis</term>
<term>European peptide society</term>
<term>Fmoc</term>
<term>Inhibition constants</term>
<term>Inhibitor</term>
<term>John wiley sons</term>
<term>Library synthesis</term>
<term>Linker</term>
<term>Mass spectrometry mimotopes sample</term>
<term>Microtitre plate format</term>
<term>Mimotopes</term>
<term>Mmol</term>
<term>Molecular weight</term>
<term>Mvev</term>
<term>Mvev protease</term>
<term>Oxazolidine</term>
<term>Pept</term>
<term>Peptide</term>
<term>Peptide aldehyde library</term>
<term>Peptide aldehydes</term>
<term>Peptide inhibitor</term>
<term>Peptide synthesis</term>
<term>Protease</term>
<term>Protease assay</term>
<term>Reaction mixture</term>
<term>Solid phase</term>
<term>Solid phase synthesis</term>
<term>Spectrometry</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Murray Valley encephalitis virus is a member of the flavivirus group, a large family of single‐stranded RNA viruses, which cause serious disease in all regions of the world. Unfortunately, no suitable antivirals are available, and there are commercial vaccines for only three flaviviruses. The solid‐phase synthesis of a library of 400 C‐terminal arginine peptide aldehydes and their screening against Murray Valley encephalitis virus protease are demonstrated. The library was utilised to elucidate several tripeptide sequences that can be used as inhibitors in further SAR studies. Copyright © 2012 European Peptide Society and John Wiley & Sons, Ltd.</div>
<div type="abstract">The solid‐phase synthesis of a library of 400 C‐terminal arginine peptide aldehydes and their screening against Murray Valley encephalitis virus protease are demonstrated. The library was utilised to elucidate several tripeptide sequences that can be used as inhibitors in further SAR studies.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Singapour</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Ede, Nicholas J" sort="Ede, Nicholas J" uniqKey="Ede N" first="Nicholas J." last="Ede">Nicholas J. Ede</name>
</noRegion>
<name sortKey="Ede, Anne Arie" sort="Ede, Anne Arie" uniqKey="Ede A" first="Anne-Marie" last="Ede">Anne-Marie Ede</name>
<name sortKey="Koppens, Merran L" sort="Koppens, Merran L" uniqKey="Koppens M" first="Merran L." last="Koppens">Merran L. Koppens</name>
</country>
<country name="Singapour"><noRegion><name sortKey="Hill, Jeffrey" sort="Hill, Jeffrey" uniqKey="Hill J" first="Jeffrey" last="Hill">Jeffrey Hill</name>
</noRegion>
<name sortKey="Joy, Joma K" sort="Joy, Joma K" uniqKey="Joy J" first="Joma K." last="Joy">Joma K. Joy</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E22 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E22 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:BD9E692FC34F28635BD5C07CCFE3E4E86CDBCCE0
   |texte=   Solid‐phase synthesis and screening of a library of C‐terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Solid‐phase synthesis and screening of a library of C‐terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease

Solid‐phase synthesis and screening of a library of C‐terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri