Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.
Identifieur interne : 001D00 ( Main/Exploration ); précédent : 001C99; suivant : 001D01Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.
Auteurs : Ali M. Zaki [Arabie saoudite] ; Sander Van Boheemen ; Theo M. Bestebroer ; Albert D M E. Osterhaus ; Ron A M. FouchierSource :
- The New England journal of medicine [ 1533-4406 ] ; 2012.
Descripteurs français
- KwdFr :
- ADN viral (analyse), Adulte d'âge moyen, Azote uréique sanguin, Coronavirus (), Coronavirus (génétique), Coronavirus (isolement et purification), Coronavirus (physiologie), Créatinine (sang), Expectoration (virologie), Génome viral, Humains, Insuffisance rénale (étiologie), Issue fatale, Mâle, Numération formule sanguine, Phylogénie, Pneumopathie virale (), Pneumopathie virale (imagerie diagnostique), Pneumopathie virale (virologie), Poumon (imagerie diagnostique), RT-PCR, Radiographie, Réplication virale (physiologie).
- MESH :
- analyse : ADN viral.
- génétique : Coronavirus.
- imagerie diagnostique : Pneumopathie virale, Poumon.
- isolement et purification : Coronavirus.
- physiologie : Coronavirus, Réplication virale.
- sang : Créatinine.
- virologie : Expectoration, Pneumopathie virale.
- étiologie : Insuffisance rénale.
- Adulte d'âge moyen, Azote uréique sanguin, Coronavirus, Génome viral, Humains, Issue fatale, Mâle, Numération formule sanguine, Phylogénie, Pneumopathie virale, RT-PCR, Radiographie.
English descriptors
- KwdEn :
- Blood Cell Count, Blood Urea Nitrogen, Coronavirus (classification), Coronavirus (genetics), Coronavirus (isolation & purification), Coronavirus (physiology), Creatinine (blood), DNA, Viral (analysis), Fatal Outcome, Genome, Viral, Humans, Lung (diagnostic imaging), Male, Middle Aged, Phylogeny, Pneumonia, Viral (complications), Pneumonia, Viral (diagnostic imaging), Pneumonia, Viral (virology), Radiography, Renal Insufficiency (etiology), Reverse Transcriptase Polymerase Chain Reaction, Sputum (virology), Virus Replication (physiology).
- MESH :
- chemical , analysis : DNA, Viral.
- chemical , blood : Creatinine.
- classification : Coronavirus.
- complications : Pneumonia, Viral.
- diagnostic imaging : Lung, Pneumonia, Viral.
- etiology : Renal Insufficiency.
- genetics : Coronavirus.
- isolation & purification : Coronavirus.
- physiology : Coronavirus, Virus Replication.
- virology : Pneumonia, Viral, Sputum.
- Blood Cell Count, Blood Urea Nitrogen, Fatal Outcome, Genome, Viral, Humans, Male, Middle Aged, Phylogeny, Radiography, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
DOI: 10.1056/NEJMoa1211721
PubMed: 23075143
Affiliations:
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Le document en format XML
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The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li></country></list><tree><noCountry><name sortKey="Bestebroer, Theo M" sort="Bestebroer, Theo M" uniqKey="Bestebroer T" first="Theo M" last="Bestebroer">Theo M. Bestebroer</name><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A M" last="Fouchier">Ron A M. Fouchier</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D M E" last="Osterhaus">Albert D M E. Osterhaus</name><name sortKey="Van Boheemen, Sander" sort="Van Boheemen, Sander" uniqKey="Van Boheemen S" first="Sander" last="Van Boheemen">Sander Van Boheemen</name></noCountry><country name="Arabie saoudite"><noRegion><name sortKey="Zaki, Ali M" sort="Zaki, Ali M" uniqKey="Zaki A" first="Ali M" last="Zaki">Ali M. Zaki</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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