Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.
Identifieur interne : 001C46 ( Main/Exploration ); précédent : 001C45; suivant : 001C47Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.
Auteurs : Li-Jun Wang [République populaire de Chine] ; Chang-An Geng ; Yun-Bao Ma ; Xiao-Yan Huang ; Jie Luo ; Hao Chen ; Xue-Mei Zhang ; Ji-Jun ChenSource :
- Bioorganic & medicinal chemistry letters [ 1464-3405 ] ; 2012.
Descripteurs français
- KwdFr :
- ADN viral (), ADN viral (biosynthèse), Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Relation structure-activité, Réplication de l'ADN (), Réplication virale (), Virus de l'hépatite B (), Virus de l'hépatite B (génétique), Virus de l'hépatite B (physiologie), Énoxolone (), Énoxolone (pharmacologie), Énoxolone (synthèse chimique).
- MESH :
- biosynthèse : ADN viral.
- génétique : Virus de l'hépatite B.
- pharmacologie : Antiviraux, Énoxolone.
- physiologie : Virus de l'hépatite B.
- synthèse chimique : Antiviraux, Énoxolone.
- ADN viral, Antiviraux, Relation structure-activité, Réplication de l'ADN, Réplication virale, Virus de l'hépatite B, Énoxolone.
English descriptors
- KwdEn :
- Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), DNA Replication (drug effects), DNA, Viral (biosynthesis), DNA, Viral (drug effects), Glycyrrhetinic Acid (chemical synthesis), Glycyrrhetinic Acid (chemistry), Glycyrrhetinic Acid (pharmacology), Hepatitis B virus (drug effects), Hepatitis B virus (genetics), Hepatitis B virus (physiology), Structure-Activity Relationship, Virus Replication (drug effects).
- MESH :
- chemical , biosynthesis : DNA, Viral.
- chemical , chemical synthesis : Antiviral Agents, Glycyrrhetinic Acid.
- chemical , chemistry : Antiviral Agents, Glycyrrhetinic Acid.
- chemical , drug effects : DNA, Viral.
- chemical , pharmacology : Antiviral Agents, Glycyrrhetinic Acid.
- drug effects : DNA Replication, Hepatitis B virus, Virus Replication.
- genetics : Hepatitis B virus.
- physiology : Hepatitis B virus.
- Structure-Activity Relationship.
Abstract
Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC(50) values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.
DOI: 10.1016/j.bmcl.2012.03.081
PubMed: 22520261
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001375
- to stream PubMed, to step Curation: 001375
- to stream PubMed, to step Checkpoint: 001271
- to stream Ncbi, to step Merge: 002487
- to stream Ncbi, to step Curation: 002487
- to stream Ncbi, to step Checkpoint: 002487
- to stream Main, to step Merge: 001C57
- to stream Main, to step Curation: 001C46
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.</title>
<author><name sortKey="Wang, Li Jun" sort="Wang, Li Jun" uniqKey="Wang L" first="Li-Jun" last="Wang">Li-Jun Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201</wicri:regionArea>
<wicri:noRegion>Kunming 650201</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Geng, Chang An" sort="Geng, Chang An" uniqKey="Geng C" first="Chang-An" last="Geng">Chang-An Geng</name>
</author>
<author><name sortKey="Ma, Yun Bao" sort="Ma, Yun Bao" uniqKey="Ma Y" first="Yun-Bao" last="Ma">Yun-Bao Ma</name>
</author>
<author><name sortKey="Huang, Xiao Yan" sort="Huang, Xiao Yan" uniqKey="Huang X" first="Xiao-Yan" last="Huang">Xiao-Yan Huang</name>
</author>
<author><name sortKey="Luo, Jie" sort="Luo, Jie" uniqKey="Luo J" first="Jie" last="Luo">Jie Luo</name>
</author>
<author><name sortKey="Chen, Hao" sort="Chen, Hao" uniqKey="Chen H" first="Hao" last="Chen">Hao Chen</name>
</author>
<author><name sortKey="Zhang, Xue Mei" sort="Zhang, Xue Mei" uniqKey="Zhang X" first="Xue-Mei" last="Zhang">Xue-Mei Zhang</name>
</author>
<author><name sortKey="Chen, Ji Jun" sort="Chen, Ji Jun" uniqKey="Chen J" first="Ji-Jun" last="Chen">Ji-Jun Chen</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:22520261</idno>
<idno type="pmid">22520261</idno>
<idno type="doi">10.1016/j.bmcl.2012.03.081</idno>
<idno type="wicri:Area/PubMed/Corpus">001375</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001375</idno>
<idno type="wicri:Area/PubMed/Curation">001375</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001375</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001271</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001271</idno>
<idno type="wicri:Area/Ncbi/Merge">002487</idno>
<idno type="wicri:Area/Ncbi/Curation">002487</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002487</idno>
<idno type="wicri:Area/Main/Merge">001C57</idno>
<idno type="wicri:Area/Main/Curation">001C46</idno>
<idno type="wicri:Area/Main/Exploration">001C46</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.</title>
<author><name sortKey="Wang, Li Jun" sort="Wang, Li Jun" uniqKey="Wang L" first="Li-Jun" last="Wang">Li-Jun Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201</wicri:regionArea>
<wicri:noRegion>Kunming 650201</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Geng, Chang An" sort="Geng, Chang An" uniqKey="Geng C" first="Chang-An" last="Geng">Chang-An Geng</name>
</author>
<author><name sortKey="Ma, Yun Bao" sort="Ma, Yun Bao" uniqKey="Ma Y" first="Yun-Bao" last="Ma">Yun-Bao Ma</name>
</author>
<author><name sortKey="Huang, Xiao Yan" sort="Huang, Xiao Yan" uniqKey="Huang X" first="Xiao-Yan" last="Huang">Xiao-Yan Huang</name>
</author>
<author><name sortKey="Luo, Jie" sort="Luo, Jie" uniqKey="Luo J" first="Jie" last="Luo">Jie Luo</name>
</author>
<author><name sortKey="Chen, Hao" sort="Chen, Hao" uniqKey="Chen H" first="Hao" last="Chen">Hao Chen</name>
</author>
<author><name sortKey="Zhang, Xue Mei" sort="Zhang, Xue Mei" uniqKey="Zhang X" first="Xue-Mei" last="Zhang">Xue-Mei Zhang</name>
</author>
<author><name sortKey="Chen, Ji Jun" sort="Chen, Ji Jun" uniqKey="Chen J" first="Ji-Jun" last="Chen">Ji-Jun Chen</name>
</author>
</analytic>
<series><title level="j">Bioorganic & medicinal chemistry letters</title>
<idno type="eISSN">1464-3405</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (chemical synthesis)</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>DNA Replication (drug effects)</term>
<term>DNA, Viral (biosynthesis)</term>
<term>DNA, Viral (drug effects)</term>
<term>Glycyrrhetinic Acid (chemical synthesis)</term>
<term>Glycyrrhetinic Acid (chemistry)</term>
<term>Glycyrrhetinic Acid (pharmacology)</term>
<term>Hepatitis B virus (drug effects)</term>
<term>Hepatitis B virus (genetics)</term>
<term>Hepatitis B virus (physiology)</term>
<term>Structure-Activity Relationship</term>
<term>Virus Replication (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral ()</term>
<term>ADN viral (biosynthèse)</term>
<term>Antiviraux ()</term>
<term>Antiviraux (pharmacologie)</term>
<term>Antiviraux (synthèse chimique)</term>
<term>Relation structure-activité</term>
<term>Réplication de l'ADN ()</term>
<term>Réplication virale ()</term>
<term>Virus de l'hépatite B ()</term>
<term>Virus de l'hépatite B (génétique)</term>
<term>Virus de l'hépatite B (physiologie)</term>
<term>Énoxolone ()</term>
<term>Énoxolone (pharmacologie)</term>
<term>Énoxolone (synthèse chimique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>DNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antiviral Agents</term>
<term>Glycyrrhetinic Acid</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term>
<term>Glycyrrhetinic Acid</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>DNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Glycyrrhetinic Acid</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>ADN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>DNA Replication</term>
<term>Hepatitis B virus</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepatitis B virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de l'hépatite B</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Énoxolone</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de l'hépatite B</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hepatitis B virus</term>
</keywords>
<keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antiviraux</term>
<term>Énoxolone</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Structure-Activity Relationship</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>ADN viral</term>
<term>Antiviraux</term>
<term>Relation structure-activité</term>
<term>Réplication de l'ADN</term>
<term>Réplication virale</term>
<term>Virus de l'hépatite B</term>
<term>Énoxolone</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC(50) values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><noCountry><name sortKey="Chen, Hao" sort="Chen, Hao" uniqKey="Chen H" first="Hao" last="Chen">Hao Chen</name>
<name sortKey="Chen, Ji Jun" sort="Chen, Ji Jun" uniqKey="Chen J" first="Ji-Jun" last="Chen">Ji-Jun Chen</name>
<name sortKey="Geng, Chang An" sort="Geng, Chang An" uniqKey="Geng C" first="Chang-An" last="Geng">Chang-An Geng</name>
<name sortKey="Huang, Xiao Yan" sort="Huang, Xiao Yan" uniqKey="Huang X" first="Xiao-Yan" last="Huang">Xiao-Yan Huang</name>
<name sortKey="Luo, Jie" sort="Luo, Jie" uniqKey="Luo J" first="Jie" last="Luo">Jie Luo</name>
<name sortKey="Ma, Yun Bao" sort="Ma, Yun Bao" uniqKey="Ma Y" first="Yun-Bao" last="Ma">Yun-Bao Ma</name>
<name sortKey="Zhang, Xue Mei" sort="Zhang, Xue Mei" uniqKey="Zhang X" first="Xue-Mei" last="Zhang">Xue-Mei Zhang</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Wang, Li Jun" sort="Wang, Li Jun" uniqKey="Wang L" first="Li-Jun" last="Wang">Li-Jun Wang</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C46 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001C46 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:22520261 |texte= Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22520261" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |