The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development
Identifieur interne : 001833 ( Main/Exploration ); précédent : 001832; suivant : 001834The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development
Auteurs : Nan Zhou ; Yun Zhang ; Jin-Chun Zhang ; Ling Feng ; Jin-Ku BaoSource :
- Journal of the Formosan Medical Association [ 0929-6646 ] ; 2013.
Descripteurs français
- KwdFr :
- Antiviraux (), Antiviraux (usage thérapeutique), Conception de médicament, Coronavirus (), Coronavirus (immunologie), Coronavirus (métabolisme), Dipeptidyl peptidase 4 (), Dipeptidyl peptidase 4 (immunologie), Dipeptidyl peptidase 4 (métabolisme), Humains, Infections à coronavirus (), Infections à coronavirus (immunologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Récepteurs viraux (), Récepteurs viraux (immunologie), Récepteurs viraux (métabolisme), Vaccins antiviraux ().
- MESH :
- immunologie : Coronavirus, Dipeptidyl peptidase 4, Infections à coronavirus, Récepteurs viraux.
- métabolisme : Coronavirus, Dipeptidyl peptidase 4, Récepteurs viraux.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux.
- virologie : Infections à coronavirus.
- Antiviraux, Conception de médicament, Coronavirus, Dipeptidyl peptidase 4, Humains, Infections à coronavirus, Récepteurs viraux, Vaccins antiviraux.
English descriptors
- KwdEn :
- Antiviral Agents (chemistry), Antiviral Agents (therapeutic use), Coronavirus (chemistry), Coronavirus (immunology), Coronavirus (metabolism), Coronavirus Infections (drug therapy), Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Coronavirus Infections (virology), Dipeptidyl Peptidase 4 (chemistry), Dipeptidyl Peptidase 4 (immunology), Dipeptidyl Peptidase 4 (metabolism), Drug Design, Humans, Receptors, Virus (chemistry), Receptors, Virus (immunology), Receptors, Virus (metabolism), Viral Vaccines (chemistry).
- MESH :
- chemical , chemistry : Antiviral Agents, Dipeptidyl Peptidase 4, Receptors, Virus, Viral Vaccines.
- chemical , immunology : Dipeptidyl Peptidase 4, Receptors, Virus.
- chemical , metabolism : Dipeptidyl Peptidase 4, Receptors, Virus.
- chemical , therapeutic use : Antiviral Agents.
- chemistry : Coronavirus.
- drug therapy : Coronavirus Infections.
- immunology : Coronavirus, Coronavirus Infections.
- metabolism : Coronavirus.
- prevention & control : Coronavirus Infections.
- virology : Coronavirus Infections.
- Drug Design, Humans.
Abstract
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is becoming another “SARS-like” threat to the world. It has an extremely high death rate (∼50%) as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD) and its complex with dipeptidyl peptidase 4 (DPP4), raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor interaction to outline why/how could we use MERS-CoV RBD to develop vaccines and antiviral drugs.
Url:
DOI: 10.1016/j.jfma.2013.11.006
PubMed: 24342026
PubMed Central: 7127315
Affiliations:
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Le document en format XML
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()</term><term>Récepteurs viraux (immunologie)</term><term>Récepteurs viraux (métabolisme)</term><term>Vaccins antiviraux ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term><term>Receptors, Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords 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It has an extremely high death rate (∼50%) as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD) and its complex with dipeptidyl peptidase 4 (DPP4), raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor interaction to outline why/how could we use MERS-CoV RBD to develop vaccines and antiviral drugs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Khan, G" uniqKey="Khan G">G. Khan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, L" uniqKey="Lu L">L. Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. 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Jewison</name></author><author><name sortKey="Liu, P" uniqKey="Liu P">P. Liu</name></author><author><name sortKey="Ly, S" uniqKey="Ly S">S. Ly</name></author><author><name sortKey="Frolkis, A" uniqKey="Frolkis A">A. Frolkis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weisel, M" uniqKey="Weisel M">M. Weisel</name></author><author><name sortKey="Proschak, E" uniqKey="Proschak E">E. Proschak</name></author><author><name sortKey="Schneider, G" uniqKey="Schneider G">G. Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bennet, N" uniqKey="Bennet N">N. Bennet</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bao, Jin Ku" sort="Bao, Jin Ku" uniqKey="Bao J" first="Jin-Ku" last="Bao">Jin-Ku Bao</name><name sortKey="Feng, Ling" sort="Feng, Ling" uniqKey="Feng L" first="Ling" last="Feng">Ling Feng</name><name sortKey="Zhang, Jin Chun" sort="Zhang, Jin Chun" uniqKey="Zhang J" first="Jin-Chun" last="Zhang">Jin-Chun Zhang</name><name sortKey="Zhang, Yun" sort="Zhang, Yun" uniqKey="Zhang Y" first="Yun" last="Zhang">Yun Zhang</name><name sortKey="Zhou, Nan" sort="Zhou, Nan" uniqKey="Zhou N" first="Nan" last="Zhou">Nan Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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