Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
Identifieur interne : 001681 ( Main/Exploration ); précédent : 001680; suivant : 001682Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments
Auteurs : Vineet D. Menachery [États-Unis] ; Kari Debbink [États-Unis] ; Ralph S. Baric [États-Unis]Source :
- Virus Research [ 0168-1702 ] ; 2014.
Descripteurs français
- KwdFr :
- Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Methyltransferases (génétique), Methyltransferases (immunologie), Methyltransferases (métabolisme), Protéines virales non structurales (génétique), Protéines virales non structurales (immunologie), Protéines virales non structurales (métabolisme), Réplication virale, Virus du SRAS (enzymologie), Virus du SRAS (génétique), Virus du SRAS (physiologie).
- MESH :
- enzymologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Methyltransferases, Protéines virales non structurales, Virus du SRAS.
- immunologie : Infections à coronavirus, Methyltransferases, Protéines virales non structurales.
- métabolisme : Methyltransferases, Protéines virales non structurales.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- virologie : Infections à coronavirus.
- Humains, Réplication virale.
English descriptors
- KwdEn :
- Coronavirus Infections (immunology), Coronavirus Infections (virology), Humans, Methyltransferases (genetics), Methyltransferases (immunology), Methyltransferases (metabolism), Middle East Respiratory Syndrome Coronavirus (enzymology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (physiology), SARS Virus (enzymology), SARS Virus (genetics), SARS Virus (physiology), Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (immunology), Viral Nonstructural Proteins (metabolism), Virus Replication.
- MESH :
- chemical , genetics : Methyltransferases, Viral Nonstructural Proteins.
- enzymology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- genetics : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- immunology : Coronavirus Infections, Methyltransferases, Viral Nonstructural Proteins.
- chemical , metabolism : Methyltransferases, Viral Nonstructural Proteins.
- physiology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Coronavirus Infections.
- Humans, Virus Replication.
Abstract
Identifies components required for CoV 2′O-MTase activity including structural motifs and interaction partners. Demonstrates attenuation of NSP16 mutants in multiple CoV strains. Defines innate immune components including MDA5 and IFIT proteins that mediate the attenuation of 2′O-MTase CoV mutants. Provides approaches to exploit 2′O-MTase pathways for antiviral treatment of CoVs and other viruses.
Url:
DOI: 10.1016/j.virusres.2014.09.009
PubMed: 25278144
PubMed Central: 4260984
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">Identifies components required for CoV 2′O-MTase activity including structural motifs and interaction partners.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">Demonstrates attenuation of NSP16 mutants in multiple CoV strains.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">Defines innate immune components including MDA5 and IFIT proteins that mediate the attenuation of 2′O-MTase CoV mutants.</p>
</list-item>
<list-item id="lsti0020"><label>•</label>
<p id="par0020">Provides approaches to exploit 2′O-MTase pathways for antiviral treatment of CoVs and other viruses.</p>
</list-item>
</list>
</p>
</div>
</front>
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</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name>
</region>
<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<name sortKey="Debbink, Kari" sort="Debbink, Kari" uniqKey="Debbink K" first="Kari" last="Debbink">Kari Debbink</name>
<name sortKey="Debbink, Kari" sort="Debbink, Kari" uniqKey="Debbink K" first="Kari" last="Debbink">Kari Debbink</name>
</country>
</tree>
</affiliations>
</record>
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