Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule.
Identifieur interne : 001669 ( Main/Exploration ); précédent : 001668; suivant : 001670Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule.
Auteurs : Michael B A. Oldstone [États-Unis] ; Hugh RosenSource :
- Current topics in microbiology and immunology [ 0070-217X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cytokines (immunologie), Grippe humaine (immunologie), Grippe humaine (mortalité), Grippe humaine (traitement médicamenteux), Grippe humaine (virologie), Humains, Lysophospholipides (agonistes), Lysophospholipides (usage thérapeutique), Orthomyxoviridae (), Orthomyxoviridae (immunologie), Sphingosine (agonistes), Sphingosine (analogues et dérivés), Sphingosine (usage thérapeutique).
- MESH :
- agonistes : Lysophospholipides, Sphingosine.
- analogues et dérivés : Sphingosine.
- immunologie : Cytokines, Grippe humaine, Orthomyxoviridae.
- mortalité : Grippe humaine.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Lysophospholipides, Sphingosine.
- virologie : Grippe humaine.
- Animaux, Humains, Orthomyxoviridae.
English descriptors
- KwdEn :
- Animals, Cytokines (immunology), Humans, Influenza, Human (drug therapy), Influenza, Human (immunology), Influenza, Human (mortality), Influenza, Human (virology), Lysophospholipids (agonists), Lysophospholipids (therapeutic use), Orthomyxoviridae (drug effects), Orthomyxoviridae (immunology), Sphingosine (agonists), Sphingosine (analogs & derivatives), Sphingosine (therapeutic use).
- MESH :
- chemical , agonists : Lysophospholipids, Sphingosine.
- chemical , analogs & derivatives : Sphingosine.
- chemical , immunology : Cytokines.
- drug effects : Orthomyxoviridae.
- drug therapy : Influenza, Human.
- immunology : Influenza, Human, Orthomyxoviridae.
- mortality : Influenza, Human.
- chemical , therapeutic use : Lysophospholipids, Sphingosine.
- virology : Influenza, Human.
- Animals, Humans.
Abstract
Cytokine storm defines a dysregulation of and an excessively exaggerated immune response most often accompanying selected viral infections and several autoimmune diseases. Newly emerging and re-emerging infections of the respiratory tract, especially influenza, SARS, and hantavirus post considerable medical problems. Their morbidities and mortalities are often a direct result of cytokine storm. This chapter visits primarily influenza virus infection and resultant cytokine storm. It provides the compelling evidence that illuminates cytokine storm in influenza pathogenesis and the clear findings that cytokine storm is chemically tractable by therapy directed toward sphingosine-1-phosphate receptor (S1PR) modulation, specifically S1P1R agonist therapy. The mechanism(s) of how S1P1R signaling works and the pathways involved are subjects of this review.
DOI: 10.1007/978-3-319-05879-5_6
PubMed: 24728596
Affiliations:
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Newly emerging and re-emerging infections of the respiratory tract, especially influenza, SARS, and hantavirus post considerable medical problems. Their morbidities and mortalities are often a direct result of cytokine storm. This chapter visits primarily influenza virus infection and resultant cytokine storm. It provides the compelling evidence that illuminates cytokine storm in influenza pathogenesis and the clear findings that cytokine storm is chemically tractable by therapy directed toward sphingosine-1-phosphate receptor (S1PR) modulation, specifically S1P1R agonist therapy. The mechanism(s) of how S1P1R signaling works and the pathways involved are subjects of this review. </div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Rosen, Hugh" sort="Rosen, Hugh" uniqKey="Rosen H" first="Hugh" last="Rosen">Hugh Rosen</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Oldstone, Michael B A" sort="Oldstone, Michael B A" uniqKey="Oldstone M" first="Michael B A" last="Oldstone">Michael B A. Oldstone</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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