SrasV1, Main, Exploration, bibRecord, 001666

Design, synthesis, anti-tobacco mosaic virus (TMV) activity, and SARs of 7-methoxycryptopleurine derivatives.

Identifieur interne : 001666 ( Main/Exploration ); précédent : 001665; suivant : 001667

Design, synthesis, anti-tobacco mosaic virus (TMV) activity, and SARs of 7-methoxycryptopleurine derivatives.

Auteurs : Ziwen Wang [République populaire de Chine] ; Anzheng Feng ; Mingbo Cui ; Yuxiu Liu ; Lizhong Wang ; Qingmin Wang

Source :

Chemical biology & drug design [ 1747-0285 ] ; 2014.

RBID : pubmed:24751111

Descripteurs français

KwdFr :
- Alcaloïdes (), Antiviraux (), Antiviraux (pharmacologie), Antiviraux (synthèse chimique), Conception de médicament, Phénanthrolines (), Quinolizines (), Quinolizines (pharmacologie), Relation structure-activité, Tabac (), Tabac (virologie), Techniques de chimie synthétique, Virus de la mosaïque du tabac (), Évaluation préclinique de médicament ().
MESH :
- pharmacologie : Antiviraux, Quinolizines.
- synthèse chimique : Antiviraux.
- virologie : Tabac.
- Alcaloïdes, Antiviraux, Conception de médicament, Phénanthrolines, Quinolizines, Relation structure-activité, Tabac, Techniques de chimie synthétique, Virus de la mosaïque du tabac, Évaluation préclinique de médicament.

English descriptors

KwdEn :
- Alkaloids (chemistry), Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Chemistry Techniques, Synthetic, Drug Design, Drug Evaluation, Preclinical (methods), Phenanthrolines (chemistry), Quinolizines (chemistry), Quinolizines (pharmacology), Structure-Activity Relationship, Tobacco (drug effects), Tobacco (virology), Tobacco Mosaic Virus (drug effects).
MESH :
- chemical , chemical synthesis : Antiviral Agents.
- chemical , chemistry : Alkaloids, Antiviral Agents, Phenanthrolines, Quinolizines.
- chemical , pharmacology : Antiviral Agents, Quinolizines.
- drug effects : Tobacco, Tobacco Mosaic Virus.
- methods : Drug Evaluation, Preclinical.
- virology : Tobacco.
- Chemistry Techniques, Synthetic, Drug Design, Structure-Activity Relationship.

Abstract

A series of 7-methoxycryptopleurine derivatives 2-23 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited excellent in vivo anti-TMV activity, of which 7-methoxycryptopleurine salt derivatives 16, 19, and 23 displayed significantly higher activity than 7-methoxycryptopleurine (1) and commercial ribavirin and ningnanmycin. Salification, the most commonly employed method for modifying physical-chemical properties, did significantly increase antiviral activity, and different salt forms displayed different antiviral effect. This study provides fundamental support for development and optimization of phenanthroquinolizidine alkaloids as potential inhibitors of plant virus.

DOI: 10.1111/cbdd.12340
PubMed: 24751111

Affiliations:

République populaire de Chine

Le document en format XML

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<term>Antiviral Agents (pharmacology)</term>
<term>Chemistry Techniques, Synthetic</term>
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<term>Drug Evaluation, Preclinical (methods)</term>
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<front><div type="abstract" xml:lang="en">A series of 7-methoxycryptopleurine derivatives 2-23 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited excellent in vivo anti-TMV activity, of which 7-methoxycryptopleurine salt derivatives 16, 19, and 23 displayed significantly higher activity than 7-methoxycryptopleurine (1) and commercial ribavirin and ningnanmycin. Salification, the most commonly employed method for modifying physical-chemical properties, did significantly increase antiviral activity, and different salt forms displayed different antiviral effect. This study provides fundamental support for development and optimization of phenanthroquinolizidine alkaloids as potential inhibitors of plant virus. </div>
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Design, synthesis, anti-tobacco mosaic virus (TMV) activity, and SARs of 7-methoxycryptopleurine derivatives.

Design, synthesis, anti-tobacco mosaic virus (TMV) activity, and SARs of 7-methoxycryptopleurine derivatives.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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