Lipid charge regulation of non-specific biological ion channels.
Identifieur interne : 001623 ( Main/Exploration ); précédent : 001622; suivant : 001624Lipid charge regulation of non-specific biological ion channels.
Auteurs : Vicente M. Aguilella [Espagne] ; Carmina Verdiá-Báguena ; Antonio AlcarazSource :
- Physical chemistry chemical physics : PCCP [ 1463-9084 ] ; 2014.
Descripteurs français
- KwdFr :
- Alaméthicine (), Alaméthicine (métabolisme), Antibactériens (), Antibactériens (pharmacologie), Canaux ioniques (), Canaux ioniques (métabolisme), Conductivité électrique, Hémolysines (), Hémolysines (métabolisme), Ions (), Ions (métabolisme), Lipides (), Protéines bactériennes (), Protéines bactériennes (métabolisme), Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (métabolisme), Transport des ions (), Virus du SRAS (métabolisme), Électricité statique.
- MESH :
- métabolisme : Alaméthicine, Canaux ioniques, Hémolysines, Ions, Protéines bactériennes, Protéines de l'enveloppe virale, Virus du SRAS.
- pharmacologie : Antibactériens.
- Alaméthicine, Antibactériens, Canaux ioniques, Conductivité électrique, Hémolysines, Ions, Lipides, Protéines bactériennes, Protéines de l'enveloppe virale, Transport des ions, Électricité statique.
English descriptors
- KwdEn :
- Alamethicin (chemistry), Alamethicin (metabolism), Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Bacterial Proteins (chemistry), Bacterial Proteins (metabolism), Electric Conductivity, Hemolysin Proteins (chemistry), Hemolysin Proteins (metabolism), Ion Channels (chemistry), Ion Channels (metabolism), Ion Transport (drug effects), Ions (chemistry), Ions (metabolism), Lipids (chemistry), SARS Virus (metabolism), Static Electricity, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (metabolism).
- MESH :
- chemical , chemistry : Alamethicin, Anti-Bacterial Agents, Bacterial Proteins, Hemolysin Proteins, Ion Channels, Ions, Lipids, Viral Envelope Proteins.
- chemical , metabolism : Alamethicin, Bacterial Proteins, Hemolysin Proteins, Ion Channels, Ions, Viral Envelope Proteins.
- chemical , pharmacology : Anti-Bacterial Agents.
- drug effects : Ion Transport.
- metabolism : SARS Virus.
- Electric Conductivity, Static Electricity.
Abstract
Ion channels are specialized proteins that enable the movement of charges through otherwise impermeable lipidic membranes. Their action is essential in living organisms facilitating electric signaling, muscle contraction or osmotic stress response among other effects. The protein and the lipid charges configure a polarized interface that yields local ionic concentrations and electric potentials that are very different from those of the bulk electrolyte. The combined effect of gradients of ionic concentration and electric potential causes the transport of ions through channels. Here we analyze charge regulation effects in different protein-lipid conformations, stressing how important is the role of electrostatic interactions in the ion channel function that traditionally has been rationalized paying attention mainly to changes in pore size. Tuning lipid charge combined with conductance and selectivity measurements is shown to be a complementary method to evidence lipid involvement in the structure of a biological ion channel.
DOI: 10.1039/c3cp54690j
PubMed: 24452437
Affiliations:
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Le document en format XML
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<term>Protéines bactériennes</term>
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<term>Lipides</term>
<term>Protéines bactériennes</term>
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<front><div type="abstract" xml:lang="en">Ion channels are specialized proteins that enable the movement of charges through otherwise impermeable lipidic membranes. Their action is essential in living organisms facilitating electric signaling, muscle contraction or osmotic stress response among other effects. The protein and the lipid charges configure a polarized interface that yields local ionic concentrations and electric potentials that are very different from those of the bulk electrolyte. The combined effect of gradients of ionic concentration and electric potential causes the transport of ions through channels. Here we analyze charge regulation effects in different protein-lipid conformations, stressing how important is the role of electrostatic interactions in the ion channel function that traditionally has been rationalized paying attention mainly to changes in pore size. Tuning lipid charge combined with conductance and selectivity measurements is shown to be a complementary method to evidence lipid involvement in the structure of a biological ion channel. </div>
</front>
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