Profiling of substrate-specificity and rational design of broad-spectrum peptidomimetic inhibitors for main proteases of coronaviruses.
Identifieur interne : 001594 ( Main/Exploration ); précédent : 001593; suivant : 001595Profiling of substrate-specificity and rational design of broad-spectrum peptidomimetic inhibitors for main proteases of coronaviruses.
Auteurs : C P Chuck [Hong Kong] ; Z H Ke [Hong Kong] ; C. Chen [Hong Kong] ; D C C. Wan [Hong Kong] ; H F Chow [Hong Kong] ; K B Wong [Hong Kong]Source :
- Hong Kong medical journal = Xianggang yi xue za zhi [ 1024-2708 ] ; 2014.
Descripteurs français
- KwdFr :
- Acides aminés, Concentration inhibitrice 50, Conception de médicament, Cysteine endopeptidases (), Inhibiteurs de protéases (synthèse chimique), Oligopeptides (synthèse chimique), Peptidomimétiques (synthèse chimique), Protéines virales (), Protéines virales (antagonistes et inhibiteurs), Spécificité du substrat, Structure moléculaire, Virus du SRAS (), Virus du SRAS (enzymologie).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Virus du SRAS.
- synthèse chimique : Inhibiteurs de protéases, Oligopeptides, Peptidomimétiques.
- Acides aminés, Concentration inhibitrice 50, Conception de médicament, Cysteine endopeptidases, Protéines virales, Spécificité du substrat, Structure moléculaire, Virus du SRAS.
English descriptors
- KwdEn :
- Amino Acids, Cysteine Endopeptidases (chemistry), Drug Design, Inhibitory Concentration 50, Molecular Structure, Oligopeptides (chemical synthesis), Peptidomimetics (chemical synthesis), Protease Inhibitors (chemical synthesis), SARS Virus (classification), SARS Virus (enzymology), Substrate Specificity, Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry).
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemical synthesis : Oligopeptides, Peptidomimetics, Protease Inhibitors.
- chemical , chemistry : Cysteine Endopeptidases, Viral Proteins.
- chemical : Amino Acids.
- classification : SARS Virus.
- enzymology : SARS Virus.
- Drug Design, Inhibitory Concentration 50, Molecular Structure, Substrate Specificity.
PubMed: 25224114
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000F29
- to stream PubMed, to step Curation: 000F29
- to stream PubMed, to step Checkpoint: 000F49
- to stream Ncbi, to step Merge: 002961
- to stream Ncbi, to step Curation: 002961
- to stream Ncbi, to step Checkpoint: 002961
- to stream Main, to step Merge: 001599
- to stream Main, to step Curation: 001594
Le document en format XML
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<term>Inhibitory Concentration 50</term>
<term>Molecular Structure</term>
<term>Oligopeptides (chemical synthesis)</term>
<term>Peptidomimetics (chemical synthesis)</term>
<term>Protease Inhibitors (chemical synthesis)</term>
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<term>Oligopeptides (synthèse chimique)</term>
<term>Peptidomimétiques (synthèse chimique)</term>
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<term>Protease Inhibitors</term>
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<term>Inhibitory Concentration 50</term>
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<term>Concentration inhibitrice 50</term>
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<term>Protéines virales</term>
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