SrasV1, Main, Exploration, bibRecord, 001551

The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis

Identifieur interne : 001551 ( Main/Exploration ); précédent : 001550; suivant : 001552

The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis

Auteurs : John Mair-Jenkins ; Maria Saavedra-Campos [Royaume-Uni] ; J. Kenneth Baillie ; Paul Cleary ; Fu-Meng Khaw ; Wei Shen Lim ; Sophia Makki ; Kevin D. Rooney [Royaume-Uni] ; Jonathan S. Nguyen-Van-Tam ; Charles R. Beck

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2014.

RBID : PMC:4264590

Descripteurs français

KwdFr :
- Grippe humaine (immunologie), Grippe humaine (traitement médicamenteux), Humains, Immunoglobulines (administration et posologie), Immunoglobulines (immunologie), Infections de l'appareil respiratoire (immunologie), Plasma sanguin (immunologie), Risque, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Virus du SRAS (immunologie), Études prospectives.
MESH :
- administration et posologie : Immunoglobulines.
- immunologie : Grippe humaine, Immunoglobulines, Infections de l'appareil respiratoire, Plasma sanguin, Syndrome respiratoire aigu sévère, Virus du SRAS.
- traitement médicamenteux : Grippe humaine, Syndrome respiratoire aigu sévère.
- Humains, Risque, Études prospectives.

English descriptors

KwdEn :
- Humans, Immunoglobulins (administration & dosage), Immunoglobulins (immunology), Influenza, Human (drug therapy), Influenza, Human (immunology), Plasma (immunology), Prospective Studies, Respiratory Tract Infections (immunology), Risk, SARS Virus (immunology), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (immunology).
MESH :
- chemical , administration & dosage : Immunoglobulins.
- chemical , immunology : Immunoglobulins.
- drug therapy : Influenza, Human, Severe Acute Respiratory Syndrome.
- immunology : Influenza, Human, Plasma, Respiratory Tract Infections, SARS Virus, Severe Acute Respiratory Syndrome.
- Humans, Prospective Studies, Risk.

Abstract

Background. Administration of convalescent plasma, serum, or hyperimmune immunoglobulin may be of clinical benefit for treatment of severe acute respiratory infections (SARIs) of viral etiology. We conducted a systematic review and exploratory meta-analysis to assess the overall evidence.

Methods. Healthcare databases and sources of grey literature were searched in July 2013. All records were screened against the protocol eligibility criteria, using a 3-stage process. Data extraction and risk of bias assessments were undertaken.

Results. We identified 32 studies of SARS coronavirus infection and severe influenza. Narrative analyses revealed consistent evidence for a reduction in mortality, especially when convalescent plasma is administered early after symptom onset. Exploratory post hoc meta-analysis showed a statistically significant reduction in the pooled odds of mortality following treatment, compared with placebo or no therapy (odds ratio, 0.25; 95% confidence interval, .14–.45; I² = 0%). Studies were commonly of low or very low quality, lacked control groups, and at moderate or high risk of bias. Sources of clinical and methodological heterogeneity were identified.

Conclusions. Convalescent plasma may reduce mortality and appears safe. This therapy should be studied within the context of a well-designed clinical trial or other formal evaluation, including for treatment of Middle East respiratory syndrome coronavirus CoV infection.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264590

DOI: 10.1093/infdis/jiu396
PubMed: 25030060
PubMed Central: 4264590

Affiliations:

Le document en format XML

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<author><name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J. Kenneth" last="Baillie">J. Kenneth Baillie</name>
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,<addr-line>Midlothian</addr-line>
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<author><name sortKey="Cleary, Paul" sort="Cleary, Paul" uniqKey="Cleary P" first="Paul" last="Cleary">Paul Cleary</name>
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,<institution>Public Health England</institution>
,<addr-line>Liverpool</addr-line>
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</author>
<author><name sortKey="Khaw, Fu Meng" sort="Khaw, Fu Meng" uniqKey="Khaw F" first="Fu-Meng" last="Khaw">Fu-Meng Khaw</name>
<affiliation><nlm:aff id="af1"><institution>East Midlands Centre, Public Health England</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lim, Wei Shen" sort="Lim, Wei Shen" uniqKey="Lim W" first="Wei Shen" last="Lim">Wei Shen Lim</name>
<affiliation><nlm:aff id="af2"><addr-line>Respiratory Medicine</addr-line>
,<institution>Nottingham University Hospitals NHS Trust</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Makki, Sophia" sort="Makki, Sophia" uniqKey="Makki S" first="Sophia" last="Makki">Sophia Makki</name>
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</affiliation>
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<author><name sortKey="Rooney, Kevin D" sort="Rooney, Kevin D" uniqKey="Rooney K" first="Kevin D." last="Rooney">Kevin D. Rooney</name>
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,<institution>University of the West of Scotland</institution>
,<addr-line>Hamilton</addr-line>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name>
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<series><title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
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<term>Immunoglobulins (administration & dosage)</term>
<term>Immunoglobulins (immunology)</term>
<term>Influenza, Human (drug therapy)</term>
<term>Influenza, Human (immunology)</term>
<term>Plasma (immunology)</term>
<term>Prospective Studies</term>
<term>Respiratory Tract Infections (immunology)</term>
<term>Risk</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
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<term>Grippe humaine (traitement médicamenteux)</term>
<term>Humains</term>
<term>Immunoglobulines (administration et posologie)</term>
<term>Immunoglobulines (immunologie)</term>
<term>Infections de l'appareil respiratoire (immunologie)</term>
<term>Plasma sanguin (immunologie)</term>
<term>Risque</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
<term>Virus du SRAS (immunologie)</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Immunoglobulins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Immunoglobulins</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Immunoglobulines</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Immunoglobulines</term>
<term>Infections de l'appareil respiratoire</term>
<term>Plasma sanguin</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term>
<term>Plasma</term>
<term>Respiratory Tract Infections</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Background.</italic>
</bold>
 Administration of convalescent plasma, serum, or hyperimmune immunoglobulin may be of clinical benefit for treatment of severe acute respiratory infections (SARIs) of viral etiology. We conducted a systematic review and exploratory meta-analysis to assess the overall evidence.</p>
<p><bold><italic>Methods.</italic>
</bold>
 Healthcare databases and sources of grey literature were searched in July 2013. All records were screened against the protocol eligibility criteria, using a 3-stage process. Data extraction and risk of bias assessments were undertaken.</p>
<p><bold><italic>Results.</italic>
</bold>
 We identified 32 studies of SARS coronavirus infection and severe influenza. Narrative analyses revealed consistent evidence for a reduction in mortality, especially when convalescent plasma is administered early after symptom onset. Exploratory post hoc meta-analysis showed a statistically significant reduction in the pooled odds of mortality following treatment, compared with placebo or no therapy (odds ratio, 0.25; 95% confidence interval, .14–.45; I<sup>2</sup>
 = 0%). Studies were commonly of low or very low quality, lacked control groups, and at moderate or high risk of bias. Sources of clinical and methodological heterogeneity were identified.</p>
<p><bold><italic>Conclusions.</italic>
</bold>
 Convalescent plasma may reduce mortality and appears safe. This therapy should be studied within the context of a well-designed clinical trial or other formal evaluation, including for treatment of Middle East respiratory syndrome coronavirus CoV infection.</p>
</div>
</front>
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<name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name>
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   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4264590
   |texte=   The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis
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The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis

The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis

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