The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds
Identifieur interne : 001543 ( Main/Exploration ); précédent : 001542; suivant : 001544The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds
Auteurs : Yahira M. Báez-Santos ; Sarah E. St. John ; Andrew D. MesecarSource :
- Antiviral Research [ 0166-3542 ] ; 2014.
Descripteurs français
- KwdFr :
- Antiviraux (), Antiviraux (pharmacologie), Coronavirus (enzymologie), Coronavirus (génétique), Cysteine endopeptidases (), Cysteine endopeptidases (métabolisme), Cytokines (métabolisme), Génome viral, Humains, Inhibiteurs de la cystéine protéinase (), Inhibiteurs de la cystéine protéinase (pharmacologie), Modèles moléculaires, Protéines virales (), Protéines virales (métabolisme), Réplication virale, Ubiquitine (métabolisme), Ubiquitines (métabolisme), Virus du SRAS (), Virus du SRAS (croissance et développement), Virus du SRAS (enzymologie), Virus du SRAS (génétique).
- MESH :
- croissance et développement : Virus du SRAS.
- enzymologie : Coronavirus, Virus du SRAS.
- génétique : Coronavirus, Virus du SRAS.
- métabolisme : Cysteine endopeptidases, Cytokines, Protéines virales, Ubiquitine, Ubiquitines.
- pharmacologie : Antiviraux, Inhibiteurs de la cystéine protéinase.
- Antiviraux, Cysteine endopeptidases, Génome viral, Humains, Inhibiteurs de la cystéine protéinase, Modèles moléculaires, Protéines virales, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Coronavirus (enzymology), Coronavirus (genetics), Cysteine Endopeptidases (chemistry), Cysteine Endopeptidases (metabolism), Cysteine Proteinase Inhibitors (chemistry), Cysteine Proteinase Inhibitors (pharmacology), Cytokines (metabolism), Genome, Viral, Humans, Models, Molecular, SARS Virus (drug effects), SARS Virus (enzymology), SARS Virus (genetics), SARS Virus (growth & development), Ubiquitin (metabolism), Ubiquitins (metabolism), Viral Proteins (chemistry), Viral Proteins (metabolism), Virus Replication.
- MESH :
- chemical , chemistry : Antiviral Agents, Cysteine Endopeptidases, Cysteine Proteinase Inhibitors, Viral Proteins.
- chemical , metabolism : Cysteine Endopeptidases, Cytokines, Ubiquitin, Ubiquitins, Viral Proteins.
- chemical , pharmacology : Antiviral Agents, Cysteine Proteinase Inhibitors.
- drug effects : SARS Virus.
- enzymology : Coronavirus, SARS Virus.
- genetics : Coronavirus, SARS Virus.
- growth & development : SARS Virus.
- Genome, Viral, Humans, Models, Molecular, Virus Replication.
Abstract
HTS and structure-based design produced naphthalene-based lead compounds with inhibition of SARS-CoV PLpro in the nM range. These naphthalene-based lead compounds have antiviral potency against SARS-CoV in cell culture. SARS-CoV PLpro naphthalene-based inhibitors are non-toxic and highly selective for SARS-CoV PLpro. Designed SARS-CoV PLpro inhibitors act through a non-covalent, competitive mechanism of inhibition. Lessons from design of SARS-CoV PLpro inhibitors have profound implications for other USPs implicated in disease processes.
Url:
DOI: 10.1016/j.antiviral.2014.12.015
PubMed: 25554382
PubMed Central: 5896749
Affiliations:
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xml:lang="fr"><term>Antiviraux</term><term>Cysteine endopeptidases</term><term>Génome viral</term><term>Humains</term><term>Inhibiteurs de la cystéine protéinase</term><term>Modèles moléculaires</term><term>Protéines virales</term><term>Réplication virale</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0235">HTS and structure-based design produced naphthalene-based lead compounds with inhibition of SARS-CoV PLpro in the nM range.</p></list-item><list-item id="o0010"><label>•</label><p id="p0240">These naphthalene-based lead compounds have antiviral potency against SARS-CoV in cell culture.</p></list-item><list-item id="o0015"><label>•</label><p id="p0245">SARS-CoV PLpro naphthalene-based inhibitors are non-toxic and highly selective for SARS-CoV PLpro.</p></list-item><list-item id="o0020"><label>•</label><p id="p0250">Designed SARS-CoV PLpro inhibitors act through a non-covalent, competitive mechanism of inhibition.</p></list-item><list-item id="o0025"><label>•</label><p id="p0255">Lessons from design of SARS-CoV PLpro inhibitors have profound implications for other USPs implicated in disease processes.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Angelini, M M" uniqKey="Angelini M">M.M. Angelini</name></author><author><name sortKey="Akhlaghpour, M" uniqKey="Akhlaghpour M">M. Akhlaghpour</name></author><author><name sortKey="Neuman, B W" uniqKey="Neuman B">B.W. Neuman</name></author><author><name sortKey="Buchmeier, M J" uniqKey="Buchmeier M">M.J. Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author><author><name sortKey="Barraza, S J" uniqKey="Barraza S">S.J. Barraza</name></author><author><name sortKey="Wilson, M W" uniqKey="Wilson M">M.W. Wilson</name></author><author><name sortKey="Agius, M P" uniqKey="Agius M">M.P. Agius</name></author><author><name sortKey="Mielech, A M" uniqKey="Mielech A">A.M. Mielech</name></author><author><name sortKey="Davis, N M" uniqKey="Davis N">N.M. Davis</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Larsen, S D" uniqKey="Larsen S">S.D. Larsen</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author><author><name sortKey="Mielech, A M" uniqKey="Mielech A">A.M. Mielech</name></author><author><name sortKey="Deng, X" uniqKey="Deng X">X. Deng</name></author><author><name sortKey="Baker, S" uniqKey="Baker S">S. Baker</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barrett, A J" uniqKey="Barrett A">A.J. Barrett</name></author><author><name sortKey="Rawlings, N D" uniqKey="Rawlings N">N.D. Rawlings</name></author><author><name sortKey="Woessner, J F" uniqKey="Woessner J">J.F. Woessner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barretto, N" uniqKey="Barretto N">N. Barretto</name></author><author><name sortKey="Jukneliene, D" uniqKey="Jukneliene D">D. Jukneliene</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barretto, N" uniqKey="Barretto N">N. Barretto</name></author><author><name sortKey="Jukneliene, D" uniqKey="Jukneliene D">D. Jukneliene</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borodovsky, A" uniqKey="Borodovsky A">A. Borodovsky</name></author><author><name sortKey="Kessler, B M" uniqKey="Kessler B">B.M. Kessler</name></author><author><name sortKey="Casagrande, R" uniqKey="Casagrande R">R. Casagrande</name></author><author><name sortKey="Overkleeft, H S" uniqKey="Overkleeft H">H.S. Overkleeft</name></author><author><name sortKey="Wilkinson, K D" uniqKey="Wilkinson K">K.D. Wilkinson</name></author><author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H.L. Ploegh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borodovsky, A" uniqKey="Borodovsky A">A. Borodovsky</name></author><author><name sortKey="Ovaa, H" uniqKey="Ovaa H">H. Ovaa</name></author><author><name sortKey="Kolli, N" uniqKey="Kolli N">N. Kolli</name></author><author><name sortKey="Gan Erdene, T" uniqKey="Gan Erdene T">T. Gan-Erdene</name></author><author><name sortKey="Wilkinson, K D" uniqKey="Wilkinson K">K.D. Wilkinson</name></author><author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H.L. Ploegh</name></author><author><name sortKey="Kessler, B M" uniqKey="Kessler B">B.M. Kessler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bredenbeek, P J" uniqKey="Bredenbeek P">P.J. Bredenbeek</name></author><author><name sortKey="Pachuk, C J" uniqKey="Pachuk C">C.J. Pachuk</name></author><author><name sortKey="Noten, A F" uniqKey="Noten A">A.F. Noten</name></author><author><name sortKey="Charite, J" uniqKey="Charite J">J. Charite</name></author><author><name sortKey="Luytjes, W" uniqKey="Luytjes W">W. Luytjes</name></author><author><name sortKey="Weiss, S R" uniqKey="Weiss S">S.R. Weiss</name></author><author><name sortKey="Spaan, W J" uniqKey="Spaan W">W.J. Spaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brian, D A" uniqKey="Brian D">D.A. Brian</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calistri, A" uniqKey="Calistri A">A. Calistri</name></author><author><name sortKey="Munegato, D" uniqKey="Munegato D">D. Munegato</name></author><author><name sortKey="Carli, I" uniqKey="Carli I">I. Carli</name></author><author><name sortKey="Parolin, C" uniqKey="Parolin C">C. Parolin</name></author><author><name sortKey="Palu, G" uniqKey="Palu G">G. Palu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A. Chatterjee</name></author><author><name sortKey="Johnson, M A" uniqKey="Johnson M">M.A. Johnson</name></author><author><name sortKey="Serrano, P" uniqKey="Serrano P">P. Serrano</name></author><author><name sortKey="Pedrini, B" uniqKey="Pedrini B">B. Pedrini</name></author><author><name sortKey="Joseph, J S" uniqKey="Joseph J">J.S. Joseph</name></author><author><name sortKey="Neuman, B W" uniqKey="Neuman B">B.W. Neuman</name></author><author><name sortKey="Saikatendu, K" uniqKey="Saikatendu K">K. Saikatendu</name></author><author><name sortKey="Buchmeier, M J" uniqKey="Buchmeier M">M.J. Buchmeier</name></author><author><name sortKey="Kuhn, P" uniqKey="Kuhn P">P. Kuhn</name></author><author><name sortKey="Wuthrich, K" uniqKey="Wuthrich K">K. Wuthrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author><author><name sortKey="Chang, G G" uniqKey="Chang G">G.G. Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, J K" uniqKey="Cho J">J.K. Cho</name></author><author><name sortKey="Curtis Long, M J" uniqKey="Curtis Long M">M.J. Curtis-Long</name></author><author><name sortKey="Lee, K H" uniqKey="Lee K">K.H. Lee</name></author><author><name sortKey="Kim, D W" uniqKey="Kim D">D.W. Kim</name></author><author><name sortKey="Ryu, H W" uniqKey="Ryu H">H.W. Ryu</name></author><author><name sortKey="Yuk, H J" uniqKey="Yuk H">H.J. Yuk</name></author><author><name sortKey="Park, K H" uniqKey="Park K">K.H. Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author><author><name sortKey="Chien, C H" uniqKey="Chien C">C.H. Chien</name></author><author><name sortKey="Han, Y S" uniqKey="Han Y">Y.S. Han</name></author><author><name sortKey="Prebanda, M T" uniqKey="Prebanda M">M.T. Prebanda</name></author><author><name sortKey="Hsieh, H P" uniqKey="Hsieh H">H.P. Hsieh</name></author><author><name sortKey="Turk, B" uniqKey="Turk B">B. Turk</name></author><author><name sortKey="Chang, G G" uniqKey="Chang G">G.G. Chang</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, C Y" uniqKey="Chou C">C.Y. Chou</name></author><author><name sortKey="Lai, H Y" uniqKey="Lai H">H.Y. Lai</name></author><author><name sortKey="Chen, H Y" uniqKey="Chen H">H.Y. Chen</name></author><author><name sortKey="Cheng, S C" uniqKey="Cheng S">S.C. Cheng</name></author><author><name sortKey="Cheng, K W" uniqKey="Cheng K">K.W. Cheng</name></author><author><name sortKey="Chou, Y W" uniqKey="Chou Y">Y.W. Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chouljenko, V N" uniqKey="Chouljenko V">V.N. Chouljenko</name></author><author><name sortKey="Lin, X Q" uniqKey="Lin X">X.Q. Lin</name></author><author><name sortKey="Storz, J" uniqKey="Storz J">J. Storz</name></author><author><name sortKey="Kousoulas, K G" uniqKey="Kousoulas K">K.G. Kousoulas</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clementz, M A" uniqKey="Clementz M">M.A. Clementz</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Banach, B S" uniqKey="Banach B">B.S. Banach</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L. Sun</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Takayama, J" uniqKey="Takayama J">J. Takayama</name></author><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devaraj, S G" uniqKey="Devaraj S">S.G. Devaraj</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Tseng, M" uniqKey="Tseng M">M. Tseng</name></author><author><name sortKey="Barretto, N" uniqKey="Barretto N">N. Barretto</name></author><author><name sortKey="Lin, R" uniqKey="Lin R">R. Lin</name></author><author><name sortKey="Peters, C J" uniqKey="Peters C">C.J. Peters</name></author><author><name sortKey="Tseng, C T" uniqKey="Tseng C">C.T. Tseng</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egloff, M P" uniqKey="Egloff M">M.P. Egloff</name></author><author><name sortKey="Malet, H" uniqKey="Malet H">H. Malet</name></author><author><name sortKey="Putics, A" uniqKey="Putics A">A. Putics</name></author><author><name sortKey="Heinonen, M" uniqKey="Heinonen M">M. Heinonen</name></author><author><name sortKey="Dutartre, H" uniqKey="Dutartre H">H. Dutartre</name></author><author><name sortKey="Frangeul, A" uniqKey="Frangeul A">A. Frangeul</name></author><author><name sortKey="Gruez, A" uniqKey="Gruez A">A. Gruez</name></author><author><name sortKey="Campanacci, V" uniqKey="Campanacci V">V. Campanacci</name></author><author><name sortKey="Cambillau, C" uniqKey="Cambillau C">C. Cambillau</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Ahola, T" uniqKey="Ahola T">T. Ahola</name></author><author><name sortKey="Canard, B" uniqKey="Canard B">B. Canard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fraile, J M" uniqKey="Fraile J">J.M. Fraile</name></author><author><name sortKey="Quesada, V" uniqKey="Quesada V">V. Quesada</name></author><author><name sortKey="Rodriguez, D" uniqKey="Rodriguez D">D. Rodriguez</name></author><author><name sortKey="Freije, J M" uniqKey="Freije J">J.M. Freije</name></author><author><name sortKey="Lopez Otin, C" uniqKey="Lopez Otin C">C. Lopez-Otin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frieman, M" uniqKey="Frieman M">M. Frieman</name></author><author><name sortKey="Basu, D" uniqKey="Basu D">D. Basu</name></author><author><name sortKey="Matthews, K" uniqKey="Matthews K">K. Matthews</name></author><author><name sortKey="Taylor, J" uniqKey="Taylor J">J. Taylor</name></author><author><name sortKey="Jones, G" uniqKey="Jones G">G. Jones</name></author><author><name sortKey="Pickles, R" uniqKey="Pickles R">R. Pickles</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R. Baric</name></author><author><name sortKey="Engel, D A" uniqKey="Engel D">D.A. Engel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frieman, M" uniqKey="Frieman M">M. Frieman</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Johnston, R E" uniqKey="Johnston R">R.E. Johnston</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Takayama, J" uniqKey="Takayama J">J. Takayama</name></author><author><name sortKey="Aubin, Y" uniqKey="Aubin Y">Y. Aubin</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Chaudhuri, R" uniqKey="Chaudhuri R">R. Chaudhuri</name></author><author><name sortKey="Baez, Y" uniqKey="Baez Y">Y. Baez</name></author><author><name sortKey="Sleeman, K" uniqKey="Sleeman K">K. Sleeman</name></author><author><name sortKey="Coughlin, M" uniqKey="Coughlin M">M. Coughlin</name></author><author><name sortKey="Nichols, D B" uniqKey="Nichols D">D.B. Nichols</name></author><author><name sortKey="Mulhearn, D C" uniqKey="Mulhearn D">D.C. Mulhearn</name></author><author><name sortKey="Prabhakar, B S" uniqKey="Prabhakar B">B.S. Prabhakar</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Johnson, M E" uniqKey="Johnson M">M.E. Johnson</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Takayama, J" uniqKey="Takayama J">J. Takayama</name></author><author><name sortKey="Rao, K V" uniqKey="Rao K">K.V. Rao</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Chaudhuri, R" uniqKey="Chaudhuri R">R. Chaudhuri</name></author><author><name sortKey="Mulhearn, D C" uniqKey="Mulhearn D">D.C. Mulhearn</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H. Lee</name></author><author><name sortKey="Nichols, D B" uniqKey="Nichols D">D.B. Nichols</name></author><author><name sortKey="Baliji, S" uniqKey="Baliji S">S. Baliji</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Johnson, M E" uniqKey="Johnson M">M.E. Johnson</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Xi, K" uniqKey="Xi K">K. Xi</name></author><author><name sortKey="Johnson, M E" uniqKey="Johnson M">M.E. Johnson</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Xi, K" uniqKey="Xi K">K. Xi</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Santarsiero, B D" uniqKey="Santarsiero B">B.D. Santarsiero</name></author><author><name sortKey="Fu, W T" uniqKey="Fu W">W.T. Fu</name></author><author><name sortKey="Harcourt, B H" uniqKey="Harcourt B">B.H. Harcourt</name></author><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Johnson, M E" uniqKey="Johnson M">M.E. Johnson</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gosert, R" uniqKey="Gosert R">R. Gosert</name></author><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A. Kanjanahaluethai</name></author><author><name sortKey="Egger, D" uniqKey="Egger D">D. Egger</name></author><author><name sortKey="Bienz, K" uniqKey="Bienz K">K. Bienz</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hagemeijer, M C" uniqKey="Hagemeijer M">M.C. Hagemeijer</name></author><author><name sortKey="Verheije, M H" uniqKey="Verheije M">M.H. Verheije</name></author><author><name sortKey="Ulasli, M" uniqKey="Ulasli M">M. Ulasli</name></author><author><name sortKey="Shaltiel, I A" uniqKey="Shaltiel I">I.A. Shaltiel</name></author><author><name sortKey="De Vries, L A" uniqKey="De Vries L">L.A. de Vries</name></author><author><name sortKey="Reggiori, F" uniqKey="Reggiori F">F. Reggiori</name></author><author><name sortKey="Rottier, P J" uniqKey="Rottier P">P.J. Rottier</name></author><author><name sortKey="De Haan, C A" uniqKey="De Haan C">C.A. de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, Y S" uniqKey="Han Y">Y.S. Han</name></author><author><name sortKey="Chang, G G" uniqKey="Chang G">G.G. Chang</name></author><author><name sortKey="Juo, C G" uniqKey="Juo C">C.G. Juo</name></author><author><name sortKey="Lee, H J" uniqKey="Lee H">H.J. Lee</name></author><author><name sortKey="Yeh, S H" uniqKey="Yeh S">S.H. Yeh</name></author><author><name sortKey="Hsu, J T" uniqKey="Hsu J">J.T. Hsu</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harcourt, B H" uniqKey="Harcourt B">B.H. Harcourt</name></author><author><name sortKey="Jukneliene, D" uniqKey="Jukneliene D">D. Jukneliene</name></author><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A. Kanjanahaluethai</name></author><author><name sortKey="Bechill, J" uniqKey="Bechill J">J. Bechill</name></author><author><name sortKey="Severson, K M" uniqKey="Severson K">K.M. Severson</name></author><author><name sortKey="Smith, C M" uniqKey="Smith C">C.M. Smith</name></author><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, M" uniqKey="Hu M">M. Hu</name></author><author><name sortKey="Li, P" uniqKey="Li P">P. Li</name></author><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Yao, T" uniqKey="Yao T">T. Yao</name></author><author><name sortKey="Wu, J W" uniqKey="Wu J">J.W. Wu</name></author><author><name sortKey="Gu, W" uniqKey="Gu W">W. Gu</name></author><author><name sortKey="Cohen, R E" uniqKey="Cohen R">R.E. Cohen</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y. Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imbert, I" uniqKey="Imbert I">I. Imbert</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Dimitrova, M" uniqKey="Dimitrova M">M. Dimitrova</name></author><author><name sortKey="Guillemot, J C" uniqKey="Guillemot J">J.C. Guillemot</name></author><author><name sortKey="Lecine, P" uniqKey="Lecine P">P. Lecine</name></author><author><name sortKey="Canard, B" uniqKey="Canard B">B. Canard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, J" uniqKey="Jacobs J">J. Jacobs</name></author><author><name sortKey="Grum Tokars, V" uniqKey="Grum Tokars V">V. Grum-Tokars</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Turlington, M" uniqKey="Turlington M">M. Turlington</name></author><author><name sortKey="Saldanha, S A" uniqKey="Saldanha S">S.A. Saldanha</name></author><author><name sortKey="Chase, P" uniqKey="Chase P">P. Chase</name></author><author><name sortKey="Eggler, A" uniqKey="Eggler A">A. Eggler</name></author><author><name sortKey="Dawson, E S" uniqKey="Dawson E">E.S. Dawson</name></author><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author><author><name sortKey="Tomar, S" uniqKey="Tomar S">S. Tomar</name></author><author><name sortKey="Mielech, A M" uniqKey="Mielech A">A.M. Mielech</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Lindsley, C W" uniqKey="Lindsley C">C.W. Lindsley</name></author><author><name sortKey="Hodder, P" uniqKey="Hodder P">P. Hodder</name></author><author><name sortKey="Mesecar, A" uniqKey="Mesecar A">A. Mesecar</name></author><author><name sortKey="Stauffer, S R" uniqKey="Stauffer S">S.R. Stauffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, R P" uniqKey="Jain R">R.P. Jain</name></author><author><name sortKey="Pettersson, H I" uniqKey="Pettersson H">H.I. Pettersson</name></author><author><name sortKey="Zhang, J M" uniqKey="Zhang J">J.M. Zhang</name></author><author><name sortKey="Aull, K D" uniqKey="Aull K">K.D. Aull</name></author><author><name sortKey="Fortin, P D" uniqKey="Fortin P">P.D. Fortin</name></author><author><name sortKey="Huitema, C" uniqKey="Huitema C">C. Huitema</name></author><author><name sortKey="Eltis, L D" uniqKey="Eltis L">L.D. Eltis</name></author><author><name sortKey="Parrish, J C" uniqKey="Parrish J">J.C. Parrish</name></author><author><name sortKey="James, M N G" uniqKey="James M">M.N.G. James</name></author><author><name sortKey="Wishart, D S" uniqKey="Wishart D">D.S. Wishart</name></author><author><name sortKey="Vederas, J C" uniqKey="Vederas J">J.C. Vederas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, M A" uniqKey="Johnson M">M.A. Johnson</name></author><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A. Chatterjee</name></author><author><name sortKey="Neuman, B W" uniqKey="Neuman B">B.W. Neuman</name></author><author><name sortKey="Wuthrich, K" uniqKey="Wuthrich K">K. Wuthrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A. Kanjanahaluethai</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Jukneliene, D" uniqKey="Jukneliene D">D. Jukneliene</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knoops, K" uniqKey="Knoops K">K. Knoops</name></author><author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M. Kikkert</name></author><author><name sortKey="Worm, S H" uniqKey="Worm S">S.H. Worm</name></author><author><name sortKey="Zevenhoven Dobbe, J C" uniqKey="Zevenhoven Dobbe J">J.C. Zevenhoven-Dobbe</name></author><author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y. van der Meer</name></author><author><name sortKey="Koster, A J" uniqKey="Koster A">A.J. Koster</name></author><author><name sortKey="Mommaas, A M" uniqKey="Mommaas A">A.M. Mommaas</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lei, J" uniqKey="Lei J">J. Lei</name></author><author><name sortKey="Mesters, J R" uniqKey="Mesters J">J.R. Mesters</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Anemuller, S" uniqKey="Anemuller S">S. Anemuller</name></author><author><name sortKey="Ma, Q" uniqKey="Ma Q">Q. Ma</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindner, H A" uniqKey="Lindner H">H.A. Lindner</name></author><author><name sortKey="Fotouhi Ardakani, N" uniqKey="Fotouhi Ardakani N">N. Fotouhi-Ardakani</name></author><author><name sortKey="Lytvyn, V" uniqKey="Lytvyn V">V. Lytvyn</name></author><author><name sortKey="Lachance, P" uniqKey="Lachance P">P. Lachance</name></author><author><name sortKey="Sulea, T" uniqKey="Sulea T">T. Sulea</name></author><author><name sortKey="Menard, R" uniqKey="Menard R">R. Menard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindner, H A" uniqKey="Lindner H">H.A. Lindner</name></author><author><name sortKey="Lytvyn, V" uniqKey="Lytvyn V">V. Lytvyn</name></author><author><name sortKey="Qi, H" uniqKey="Qi H">H. Qi</name></author><author><name sortKey="Lachance, P" uniqKey="Lachance P">P. Lachance</name></author><author><name sortKey="Ziomek, E" uniqKey="Ziomek E">E. Ziomek</name></author><author><name sortKey="Menard, R" uniqKey="Menard R">R. Menard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Love, K R" uniqKey="Love K">K.R. Love</name></author><author><name sortKey="Catic, A" uniqKey="Catic A">A. Catic</name></author><author><name sortKey="Schlieker, C" uniqKey="Schlieker C">C. Schlieker</name></author><author><name sortKey="Ploegh, H L" uniqKey="Ploegh H">H.L. Ploegh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcnaught, A D" uniqKey="Mcnaught A">A.D. McNaught</name></author><author><name sortKey="Wilkinson, A" uniqKey="Wilkinson A">A. Wilkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melandri, F" uniqKey="Melandri F">F. Melandri</name></author><author><name sortKey="Grenier, L" uniqKey="Grenier L">L. Grenier</name></author><author><name sortKey="Plamondon, L" uniqKey="Plamondon L">L. Plamondon</name></author><author><name sortKey="Huskey, W P" uniqKey="Huskey W">W.P. Huskey</name></author><author><name sortKey="Stein, R L" uniqKey="Stein R">R.L. Stein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mielech, A M" uniqKey="Mielech A">A.M. Mielech</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mielech, A M" uniqKey="Mielech A">A.M. Mielech</name></author><author><name sortKey="Kilianski, A" uniqKey="Kilianski A">A. Kilianski</name></author><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molland, K" uniqKey="Molland K">K. Molland</name></author><author><name sortKey="Zhou, Q" uniqKey="Zhou Q">Q. Zhou</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neuman, B W" uniqKey="Neuman B">B.W. Neuman</name></author><author><name sortKey="Joseph, J S" uniqKey="Joseph J">J.S. Joseph</name></author><author><name sortKey="Saikatendu, K S" uniqKey="Saikatendu K">K.S. Saikatendu</name></author><author><name sortKey="Serrano, P" uniqKey="Serrano P">P. Serrano</name></author><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A. Chatterjee</name></author><author><name sortKey="Johnson, M A" uniqKey="Johnson M">M.A. Johnson</name></author><author><name sortKey="Liao, L" uniqKey="Liao L">L. Liao</name></author><author><name sortKey="Klaus, J P" uniqKey="Klaus J">J.P. Klaus</name></author><author><name sortKey="Yates, J R" uniqKey="Yates J">J.R. Yates</name></author><author><name sortKey="Wuthrich, K" uniqKey="Wuthrich K">K. Wuthrich</name></author><author><name sortKey="Stevens, R C" uniqKey="Stevens R">R.C. Stevens</name></author><author><name sortKey="Buchmeier, M J" uniqKey="Buchmeier M">M.J. Buchmeier</name></author><author><name sortKey="Kuhn, P" uniqKey="Kuhn P">P. Kuhn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nicholson, B" uniqKey="Nicholson B">B. Nicholson</name></author><author><name sortKey="Leach, C A" uniqKey="Leach C">C.A. Leach</name></author><author><name sortKey="Goldenberg, S J" uniqKey="Goldenberg S">S.J. Goldenberg</name></author><author><name sortKey="Francis, D M" uniqKey="Francis D">D.M. Francis</name></author><author><name sortKey="Kodrasov, M P" uniqKey="Kodrasov M">M.P. Kodrasov</name></author><author><name sortKey="Tian, X" uniqKey="Tian X">X. Tian</name></author><author><name sortKey="Shanks, J" uniqKey="Shanks J">J. Shanks</name></author><author><name sortKey="Sterner, D E" uniqKey="Sterner D">D.E. Sterner</name></author><author><name sortKey="Bernal, A" uniqKey="Bernal A">A. Bernal</name></author><author><name sortKey="Mattern, M R" uniqKey="Mattern M">M.R. Mattern</name></author><author><name sortKey="Wilkinson, K D" uniqKey="Wilkinson K">K.D. Wilkinson</name></author><author><name sortKey="Butt, T R" uniqKey="Butt T">T.R. Butt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oostra, M" uniqKey="Oostra M">M. Oostra</name></author><author><name sortKey="Hagemeijer, M C" uniqKey="Hagemeijer M">M.C. Hagemeijer</name></author><author><name sortKey="Van Gent, M" uniqKey="Van Gent M">M. van Gent</name></author><author><name sortKey="Bekker, C P" uniqKey="Bekker C">C.P. Bekker</name></author><author><name sortKey="Te Lintelo, E G" uniqKey="Te Lintelo E">E.G. te Lintelo</name></author><author><name sortKey="Rottier, P J" uniqKey="Rottier P">P.J. Rottier</name></author><author><name sortKey="De Haan, C A" uniqKey="De Haan C">C.A. de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oostra, M" uniqKey="Oostra M">M. Oostra</name></author><author><name sortKey="Te Lintelo, E G" uniqKey="Te Lintelo E">E.G. te Lintelo</name></author><author><name sortKey="Deijs, M" uniqKey="Deijs M">M. Deijs</name></author><author><name sortKey="Verheije, M H" uniqKey="Verheije M">M.H. Verheije</name></author><author><name sortKey="Rottier, P J" uniqKey="Rottier P">P.J. Rottier</name></author><author><name sortKey="De Haan, C A" uniqKey="De Haan C">C.A. de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, J Y" uniqKey="Park J">J.Y. Park</name></author><author><name sortKey="Jeong, H J" uniqKey="Jeong H">H.J. Jeong</name></author><author><name sortKey="Kim, J H" uniqKey="Kim J">J.H. Kim</name></author><author><name sortKey="Kim, Y M" uniqKey="Kim Y">Y.M. Kim</name></author><author><name sortKey="Park, S J" uniqKey="Park S">S.J. Park</name></author><author><name sortKey="Kim, D" uniqKey="Kim D">D. Kim</name></author><author><name sortKey="Park, K H" uniqKey="Park K">K.H. Park</name></author><author><name sortKey="Lee, W S" uniqKey="Lee W">W.S. Lee</name></author><author><name sortKey="Ryu, Y B" uniqKey="Ryu Y">Y.B. Ryu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, J Y" uniqKey="Park J">J.Y. Park</name></author><author><name sortKey="Kim, J H" uniqKey="Kim J">J.H. Kim</name></author><author><name sortKey="Kim, Y M" uniqKey="Kim Y">Y.M. Kim</name></author><author><name sortKey="Jeong, H J" uniqKey="Jeong H">H.J. Jeong</name></author><author><name sortKey="Kim, D W" uniqKey="Kim D">D.W. Kim</name></author><author><name sortKey="Park, K H" uniqKey="Park K">K.H. Park</name></author><author><name sortKey="Kwon, H J" uniqKey="Kwon H">H.J. Kwon</name></author><author><name sortKey="Park, S J" uniqKey="Park S">S.J. Park</name></author><author><name sortKey="Lee, W S" uniqKey="Lee W">W.S. Lee</name></author><author><name sortKey="Ryu, Y B" uniqKey="Ryu Y">Y.B. Ryu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Kilianski, A" uniqKey="Kilianski A">A. Kilianski</name></author><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Pegan, S" uniqKey="Pegan S">S. Pegan</name></author><author><name sortKey="Takayama, J" uniqKey="Takayama J">J. Takayama</name></author><author><name sortKey="Sleeman, K" uniqKey="Sleeman K">K. Sleeman</name></author><author><name sortKey="Coughlin, M" uniqKey="Coughlin M">M. Coughlin</name></author><author><name sortKey="Baliji, S" uniqKey="Baliji S">S. Baliji</name></author><author><name sortKey="Chaudhuri, R" uniqKey="Chaudhuri R">R. Chaudhuri</name></author><author><name sortKey="Fu, W" uniqKey="Fu W">W. Fu</name></author><author><name sortKey="Prabhakar, B S" uniqKey="Prabhakar B">B.S. Prabhakar</name></author><author><name sortKey="Johnson, M E" uniqKey="Johnson M">M.E. Johnson</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Ghosh, A K" uniqKey="Ghosh A">A.K. Ghosh</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratia, K" uniqKey="Ratia K">K. Ratia</name></author><author><name sortKey="Saikatendu, K S" uniqKey="Saikatendu K">K.S. Saikatendu</name></author><author><name sortKey="Santarsiero, B D" uniqKey="Santarsiero B">B.D. Santarsiero</name></author><author><name sortKey="Barretto, N" uniqKey="Barretto N">N. Barretto</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Stevens, R C" uniqKey="Stevens R">R.C. Stevens</name></author><author><name sortKey="Mesecar, A D" uniqKey="Mesecar A">A.D. Mesecar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saikatendu, K S" uniqKey="Saikatendu K">K.S. Saikatendu</name></author><author><name sortKey="Joseph, J S" uniqKey="Joseph J">J.S. Joseph</name></author><author><name sortKey="Subramanian, V" uniqKey="Subramanian V">V. Subramanian</name></author><author><name sortKey="Clayton, T" uniqKey="Clayton T">T. Clayton</name></author><author><name sortKey="Griffith, M" uniqKey="Griffith M">M. Griffith</name></author><author><name sortKey="Moy, K" uniqKey="Moy K">K. Moy</name></author><author><name sortKey="Velasquez, J" uniqKey="Velasquez J">J. Velasquez</name></author><author><name sortKey="Neuman, B W" uniqKey="Neuman B">B.W. Neuman</name></author><author><name sortKey="Buchmeier, M J" uniqKey="Buchmeier M">M.J. Buchmeier</name></author><author><name sortKey="Stevens, R C" uniqKey="Stevens R">R.C. Stevens</name></author><author><name sortKey="Kuhn, P" uniqKey="Kuhn P">P. Kuhn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serrano, P" uniqKey="Serrano P">P. Serrano</name></author><author><name sortKey="Johnson, M A" uniqKey="Johnson M">M.A. Johnson</name></author><author><name sortKey="Almeida, M S" uniqKey="Almeida M">M.S. Almeida</name></author><author><name sortKey="Horst, R" uniqKey="Horst R">R. Horst</name></author><author><name sortKey="Herrmann, T" uniqKey="Herrmann T">T. Herrmann</name></author><author><name sortKey="Joseph, J S" uniqKey="Joseph J">J.S. Joseph</name></author><author><name sortKey="Neuman, B W" uniqKey="Neuman B">B.W. Neuman</name></author><author><name sortKey="Subramanian, V" uniqKey="Subramanian V">V. Subramanian</name></author><author><name sortKey="Saikatendu, K S" uniqKey="Saikatendu K">K.S. Saikatendu</name></author><author><name sortKey="Buchmeier, M J" uniqKey="Buchmeier M">M.J. Buchmeier</name></author><author><name sortKey="Stevens, R C" uniqKey="Stevens R">R.C. Stevens</name></author><author><name sortKey="Kuhn, P" uniqKey="Kuhn P">P. Kuhn</name></author><author><name sortKey="Wuthrich, K" uniqKey="Wuthrich K">K. Wuthrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serrano, P" uniqKey="Serrano P">P. Serrano</name></author><author><name sortKey="Johnson, M A" uniqKey="Johnson M">M.A. Johnson</name></author><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A. Chatterjee</name></author><author><name sortKey="Neuman, B W" uniqKey="Neuman B">B.W. Neuman</name></author><author><name sortKey="Joseph, J S" uniqKey="Joseph J">J.S. Joseph</name></author><author><name sortKey="Buchmeier, M J" uniqKey="Buchmeier M">M.J. Buchmeier</name></author><author><name sortKey="Kuhn, P" uniqKey="Kuhn P">P. Kuhn</name></author><author><name sortKey="Wuthrich, K" uniqKey="Wuthrich K">K. Wuthrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Bredenbeek, P J" uniqKey="Bredenbeek P">P.J. Bredenbeek</name></author><author><name sortKey="Dobbe, J C" uniqKey="Dobbe J">J.C. Dobbe</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Rozanov, M" uniqKey="Rozanov M">M. Rozanov</name></author><author><name sortKey="Spaan, W J" uniqKey="Spaan W">W.J. Spaan</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, L" uniqKey="Sun L">L. Sun</name></author><author><name sortKey="Xing, Y" uniqKey="Xing Y">Y. Xing</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y. Zheng</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Nichols, D B" uniqKey="Nichols D">D.B. Nichols</name></author><author><name sortKey="Clementz, M A" uniqKey="Clementz M">M.A. Clementz</name></author><author><name sortKey="Banach, B S" uniqKey="Banach B">B.S. Banach</name></author><author><name sortKey="Li, K" uniqKey="Li K">K. Li</name></author><author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, J" uniqKey="Tan J">J. Tan</name></author><author><name sortKey="Kusov, Y" uniqKey="Kusov Y">Y. Kusov</name></author><author><name sortKey="Mutschall, D" uniqKey="Mutschall D">D. Mutschall</name></author><author><name sortKey="Tech, S" uniqKey="Tech S">S. Tech</name></author><author><name sortKey="Nagarajan, K" uniqKey="Nagarajan K">K. Nagarajan</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author><author><name sortKey="Schmidt, C L" uniqKey="Schmidt C">C.L. Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, J" uniqKey="Tan J">J. Tan</name></author><author><name sortKey="Vonrhein, C" uniqKey="Vonrhein C">C. Vonrhein</name></author><author><name sortKey="Smart, O S" uniqKey="Smart O">O.S. Smart</name></author><author><name sortKey="Bricogne, G" uniqKey="Bricogne G">G. Bricogne</name></author><author><name sortKey="Bollati, M" uniqKey="Bollati M">M. Bollati</name></author><author><name sortKey="Kusov, Y" uniqKey="Kusov Y">Y. Kusov</name></author><author><name sortKey="Hansen, G" uniqKey="Hansen G">G. Hansen</name></author><author><name sortKey="Mesters, J R" uniqKey="Mesters J">J.R. Mesters</name></author><author><name sortKey="Schmidt, C L" uniqKey="Schmidt C">C.L. Schmidt</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R. Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Ivanov, K A" uniqKey="Ivanov K">K.A. Ivanov</name></author><author><name sortKey="Putics, A" uniqKey="Putics A">A. Putics</name></author><author><name sortKey="Hertzig, T" uniqKey="Hertzig T">T. Hertzig</name></author><author><name sortKey="Schelle, B" uniqKey="Schelle B">B. Schelle</name></author><author><name sortKey="Bayer, S" uniqKey="Bayer S">S. Bayer</name></author><author><name sortKey="Weissbrich, B" uniqKey="Weissbrich B">B. Weissbrich</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, T R" uniqKey="Tong T">T.R. Tong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Hemert, M J" uniqKey="Van Hemert M">M.J. van Hemert</name></author><author><name sortKey="Van Den Worm, S H" uniqKey="Van Den Worm S">S.H. van den Worm</name></author><author><name sortKey="Knoops, K" uniqKey="Knoops K">K. Knoops</name></author><author><name sortKey="Mommaas, A M" uniqKey="Mommaas A">A.M. Mommaas</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilkinson, K D" uniqKey="Wilkinson K">K.D. Wilkinson</name></author><author><name sortKey="Gan Erdene, T" uniqKey="Gan Erdene T">T. Gan-Erdene</name></author><author><name sortKey="Kolli, N" uniqKey="Kolli N">N. Kolli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xue, X Y" uniqKey="Xue X">X.Y. Xue</name></author><author><name sortKey="Yu, H W" uniqKey="Yu H">H.W. Yu</name></author><author><name sortKey="Yang, H T" uniqKey="Yang H">H.T. Yang</name></author><author><name sortKey="Xue, F" uniqKey="Xue F">F. Xue</name></author><author><name sortKey="Wu, Z X" uniqKey="Wu Z">Z.X. Wu</name></author><author><name sortKey="Shen, W" uniqKey="Shen W">W. Shen</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z. Zhou</name></author><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y. Ding</name></author><author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q. Zhao</name></author><author><name sortKey="Zhang, X J C" uniqKey="Zhang X">X.J.C. Zhang</name></author><author><name sortKey="Liao, M" uniqKey="Liao M">M. Liao</name></author><author><name sortKey="Bartlam, M" uniqKey="Bartlam M">M. Bartlam</name></author><author><name sortKey="Rao, Z" uniqKey="Rao Z">Z. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, S" uniqKey="Yang S">S. Yang</name></author><author><name sortKey="Chen, S J" uniqKey="Chen S">S.J. Chen</name></author><author><name sortKey="Hsu, M F" uniqKey="Hsu M">M.F. Hsu</name></author><author><name sortKey="Wu, J D" uniqKey="Wu J">J.D. Wu</name></author><author><name sortKey="Tseng, C T K" uniqKey="Tseng C">C.T.K. Tseng</name></author><author><name sortKey="Liu, Y F" uniqKey="Liu Y">Y.F. Liu</name></author><author><name sortKey="Chen, H C" uniqKey="Chen H">H.C. Chen</name></author><author><name sortKey="Kuo, C W" uniqKey="Kuo C">C.W. Kuo</name></author><author><name sortKey="Wu, C S" uniqKey="Wu C">C.S. Wu</name></author><author><name sortKey="Chang, L W" uniqKey="Chang L">L.W. Chang</name></author><author><name sortKey="Chen, W C" uniqKey="Chen W">W.C. Chen</name></author><author><name sortKey="Liao, S Y" uniqKey="Liao S">S.Y. Liao</name></author><author><name sortKey="Chang, T Y" uniqKey="Chang T">T.Y. Chang</name></author><author><name sortKey="Hung, H H" uniqKey="Hung H">H.H. Hung</name></author><author><name sortKey="Shr, H L" uniqKey="Shr H">H.L. Shr</name></author><author><name sortKey="Liu, C Y" uniqKey="Liu C">C.Y. Liu</name></author><author><name sortKey="Huang, Y A" uniqKey="Huang Y">Y.A. Huang</name></author><author><name sortKey="Chang, L Y" uniqKey="Chang L">L.Y. Chang</name></author><author><name sortKey="Hsu, J C" uniqKey="Hsu J">J.C. Hsu</name></author><author><name sortKey="Peters, C J" uniqKey="Peters C">C.J. Peters</name></author><author><name sortKey="Wang, A H J" uniqKey="Wang A">A.H.J. Wang</name></author><author><name sortKey="Hsu, M C" uniqKey="Hsu M">M.C. Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J M" uniqKey="Zhang J">J.M. Zhang</name></author><author><name sortKey="Pettersson, H I" uniqKey="Pettersson H">H.I. Pettersson</name></author><author><name sortKey="Huitema, C" uniqKey="Huitema C">C. Huitema</name></author><author><name sortKey="Niu, C Y" uniqKey="Niu C">C.Y. Niu</name></author><author><name sortKey="Yin, J" uniqKey="Yin J">J. Yin</name></author><author><name sortKey="James, M N G" uniqKey="James M">M.N.G. James</name></author><author><name sortKey="Eltis, L D" uniqKey="Eltis L">L.D. Eltis</name></author><author><name sortKey="Vederas, J C" uniqKey="Vederas J">J.C. Vederas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Gorbalenya, A E" uniqKey="Gorbalenya A">A.E. Gorbalenya</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Baez Santos, Yahira M" sort="Baez Santos, Yahira M" uniqKey="Baez Santos Y" first="Yahira M." last="Báez-Santos">Yahira M. Báez-Santos</name><name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name><name sortKey="St John, Sarah E" sort="St John, Sarah E" uniqKey="St John S" first="Sarah E." last="St. John">Sarah E. St. John</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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