Viral subversion of nucleocytoplasmic trafficking.
Identifieur interne : 001533 ( Main/Exploration ); précédent : 001532; suivant : 001534Viral subversion of nucleocytoplasmic trafficking.
Auteurs : Melanie L. Yarbrough [États-Unis] ; Miguel A. Mata ; Ramanavelan Sakthivel ; Beatriz M A. FontouraSource :
- Traffic (Copenhagen, Denmark) [ 1600-0854 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Cytoplasme, Noyau de la cellule, Virus.
- pathogénicité : Virus.
- virologie : Cytoplasme, Noyau de la cellule.
- Animaux, Humains, Transport des ARN, Transport nucléaire actif.
English descriptors
- KwdEn :
- MESH :
- metabolism : Cell Nucleus, Cytoplasm, Viruses.
- pathogenicity : Viruses.
- virology : Cell Nucleus, Cytoplasm.
- Active Transport, Cell Nucleus, Animals, Humans, RNA Transport.
Abstract
Trafficking of proteins and RNA into and out of the nucleus occurs through the nuclear pore complex (NPC). Because of its critical function in many cellular processes, the NPC and transport factors are common targets of several viruses that disrupt key constituents of the machinery to facilitate viral replication. Many viruses such as poliovirus and severe acute respiratory syndrome (SARS) virus inhibit protein import into the nucleus, whereas viruses such as influenza A virus target and disrupt host mRNA nuclear export. Current evidence indicates that these viruses may employ such strategies to avert the host immune response. Conversely, many viruses co-opt nucleocytoplasmic trafficking to facilitate transport of viral RNAs. As viral proteins interact with key regulators of the host nuclear transport machinery, viruses have served as invaluable tools of discovery that led to the identification of novel constituents of nuclear transport pathways. This review explores the importance of nucleocytoplasmic trafficking to viral pathogenesis as these studies revealed new antiviral therapeutic strategies and exposed previously unknown cellular mechanisms. Further understanding of nuclear transport pathways will determine whether such therapeutics will be useful treatments for important human pathogens.
DOI: 10.1111/tra.12137
PubMed: 24289861
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001089
- to stream PubMed, to step Curation: 001089
- to stream PubMed, to step Checkpoint: 000E91
- to stream Ncbi, to step Merge: 002791
- to stream Ncbi, to step Curation: 002791
- to stream Ncbi, to step Checkpoint: 002791
- to stream Main, to step Merge: 001535
- to stream Main, to step Curation: 001533
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Viral subversion of nucleocytoplasmic trafficking.</title><author><name sortKey="Yarbrough, Melanie L" sort="Yarbrough, Melanie L" uniqKey="Yarbrough M" first="Melanie L" last="Yarbrough">Melanie L. Yarbrough</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9039, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9039</wicri:regionArea><wicri:noRegion>75390-9039</wicri:noRegion></affiliation></author><author><name sortKey="Mata, Miguel A" sort="Mata, Miguel A" uniqKey="Mata M" first="Miguel A" last="Mata">Miguel A. Mata</name></author><author><name sortKey="Sakthivel, Ramanavelan" sort="Sakthivel, Ramanavelan" uniqKey="Sakthivel R" first="Ramanavelan" last="Sakthivel">Ramanavelan Sakthivel</name></author><author><name sortKey="Fontoura, Beatriz M A" sort="Fontoura, Beatriz M A" uniqKey="Fontoura B" first="Beatriz M A" last="Fontoura">Beatriz M A. Fontoura</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24289861</idno><idno type="pmid">24289861</idno><idno type="doi">10.1111/tra.12137</idno><idno type="wicri:Area/PubMed/Corpus">001089</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001089</idno><idno type="wicri:Area/PubMed/Curation">001089</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001089</idno><idno type="wicri:Area/PubMed/Checkpoint">000E91</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E91</idno><idno type="wicri:Area/Ncbi/Merge">002791</idno><idno type="wicri:Area/Ncbi/Curation">002791</idno><idno type="wicri:Area/Ncbi/Checkpoint">002791</idno><idno type="wicri:Area/Main/Merge">001535</idno><idno type="wicri:Area/Main/Curation">001533</idno><idno type="wicri:Area/Main/Exploration">001533</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Viral subversion of nucleocytoplasmic trafficking.</title><author><name sortKey="Yarbrough, Melanie L" sort="Yarbrough, Melanie L" uniqKey="Yarbrough M" first="Melanie L" last="Yarbrough">Melanie L. Yarbrough</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9039, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390-9039</wicri:regionArea><wicri:noRegion>75390-9039</wicri:noRegion></affiliation></author><author><name sortKey="Mata, Miguel A" sort="Mata, Miguel A" uniqKey="Mata M" first="Miguel A" last="Mata">Miguel A. Mata</name></author><author><name sortKey="Sakthivel, Ramanavelan" sort="Sakthivel, Ramanavelan" uniqKey="Sakthivel R" first="Ramanavelan" last="Sakthivel">Ramanavelan Sakthivel</name></author><author><name sortKey="Fontoura, Beatriz M A" sort="Fontoura, Beatriz M A" uniqKey="Fontoura B" first="Beatriz M A" last="Fontoura">Beatriz M A. Fontoura</name></author></analytic><series><title level="j">Traffic (Copenhagen, Denmark)</title><idno type="eISSN">1600-0854</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active Transport, Cell Nucleus</term><term>Animals</term><term>Cell Nucleus (metabolism)</term><term>Cell Nucleus (virology)</term><term>Cytoplasm (metabolism)</term><term>Cytoplasm (virology)</term><term>Humans</term><term>RNA Transport</term><term>Viruses (metabolism)</term><term>Viruses (pathogenicity)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cytoplasme (métabolisme)</term><term>Cytoplasme (virologie)</term><term>Humains</term><term>Noyau de la cellule (métabolisme)</term><term>Noyau de la cellule (virologie)</term><term>Transport des ARN</term><term>Transport nucléaire actif</term><term>Virus (métabolisme)</term><term>Virus (pathogénicité)</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term><term>Cytoplasm</term><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytoplasme</term><term>Noyau de la cellule</term><term>Virus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cytoplasme</term><term>Noyau de la cellule</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cell Nucleus</term><term>Cytoplasm</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Active Transport, Cell Nucleus</term><term>Animals</term><term>Humans</term><term>RNA Transport</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Transport des ARN</term><term>Transport nucléaire actif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Trafficking of proteins and RNA into and out of the nucleus occurs through the nuclear pore complex (NPC). Because of its critical function in many cellular processes, the NPC and transport factors are common targets of several viruses that disrupt key constituents of the machinery to facilitate viral replication. Many viruses such as poliovirus and severe acute respiratory syndrome (SARS) virus inhibit protein import into the nucleus, whereas viruses such as influenza A virus target and disrupt host mRNA nuclear export. Current evidence indicates that these viruses may employ such strategies to avert the host immune response. Conversely, many viruses co-opt nucleocytoplasmic trafficking to facilitate transport of viral RNAs. As viral proteins interact with key regulators of the host nuclear transport machinery, viruses have served as invaluable tools of discovery that led to the identification of novel constituents of nuclear transport pathways. This review explores the importance of nucleocytoplasmic trafficking to viral pathogenesis as these studies revealed new antiviral therapeutic strategies and exposed previously unknown cellular mechanisms. Further understanding of nuclear transport pathways will determine whether such therapeutics will be useful treatments for important human pathogens. </div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Fontoura, Beatriz M A" sort="Fontoura, Beatriz M A" uniqKey="Fontoura B" first="Beatriz M A" last="Fontoura">Beatriz M A. Fontoura</name><name sortKey="Mata, Miguel A" sort="Mata, Miguel A" uniqKey="Mata M" first="Miguel A" last="Mata">Miguel A. Mata</name><name sortKey="Sakthivel, Ramanavelan" sort="Sakthivel, Ramanavelan" uniqKey="Sakthivel R" first="Ramanavelan" last="Sakthivel">Ramanavelan Sakthivel</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Yarbrough, Melanie L" sort="Yarbrough, Melanie L" uniqKey="Yarbrough M" first="Melanie L" last="Yarbrough">Melanie L. Yarbrough</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001533 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001533 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24289861
|texte= Viral subversion of nucleocytoplasmic trafficking.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24289861" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |