Adenine: an important drug scaffold for the design of antiviral agents.
Identifieur interne : 001373 ( Main/Exploration ); précédent : 001372; suivant : 001374Adenine: an important drug scaffold for the design of antiviral agents.
Auteurs : Changyuan Wang [République populaire de Chine] ; Zhendong Song [République populaire de Chine] ; Haiqing Yu [République populaire de Chine] ; Kexin Liu [République populaire de Chine] ; Xiaodong Ma [République populaire de Chine]Source :
- Acta pharmaceutica Sinica. B [ 2211-3835 ] ; 2015.
Abstract
Adenine derivatives, in particular the scaffold bearing the acyclic nucleoside phosphonates (ANPS), possess significant antiviral and cytostatic activity. Till now, several effective adenine derivatives have been marketed for the treatment of HIV, HBV, CMV and other virus-infected diseases. These compounds are represented by tenofovir (PMPA), a medicine for both HIV and HBV, and adefovir as an anti-HBV agent. More than this, other analogs, such as GS9148, GS9131, and GS7340, are also well-known anti-viral agents that have been progressed to the clinical studies for their excellent activity. In general, the structures of these compounds include an adenine nucleobase linked to a phosphonate side chain. Considerable structural modifications on the scaffold itself and the peripheral sections were made. The structure-activity relationships (SARs) of this skeleton will provide valuable clues to identify more effective adenine derivatives as antiviral drugs. Here, we systematically summarized the SARs of the adenine derivatives, and gave important information for further optimizing this template.
DOI: 10.1016/j.apsb.2015.07.002
PubMed: 26579473
Affiliations:
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xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Pharmacy, Dalian Medical University, Dalian 116044</wicri:regionArea><wicri:noRegion>Dalian 116044</wicri:noRegion></affiliation></author></analytic><series><title level="j">Acta pharmaceutica Sinica. B</title><idno type="ISSN">2211-3835</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Adenine derivatives, in particular the scaffold bearing the acyclic nucleoside phosphonates (ANPS), possess significant antiviral and cytostatic activity. Till now, several effective adenine derivatives have been marketed for the treatment of HIV, HBV, CMV and other virus-infected diseases. These compounds are represented by tenofovir (PMPA), a medicine for both HIV and HBV, and adefovir as an anti-HBV agent. More than this, other analogs, such as GS9148, GS9131, and GS7340, are also well-known anti-viral agents that have been progressed to the clinical studies for their excellent activity. In general, the structures of these compounds include an adenine nucleobase linked to a phosphonate side chain. Considerable structural modifications on the scaffold itself and the peripheral sections were made. The structure-activity relationships (SARs) of this skeleton will provide valuable clues to identify more effective adenine derivatives as antiviral drugs. Here, we systematically summarized the SARs of the adenine derivatives, and gave important information for further optimizing this template. </div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Changyuan" sort="Wang, Changyuan" uniqKey="Wang C" first="Changyuan" last="Wang">Changyuan Wang</name></noRegion><name sortKey="Liu, Kexin" sort="Liu, Kexin" uniqKey="Liu K" first="Kexin" last="Liu">Kexin Liu</name><name sortKey="Ma, Xiaodong" sort="Ma, Xiaodong" uniqKey="Ma X" first="Xiaodong" last="Ma">Xiaodong Ma</name><name sortKey="Song, Zhendong" sort="Song, Zhendong" uniqKey="Song Z" first="Zhendong" last="Song">Zhendong Song</name><name sortKey="Yu, Haiqing" sort="Yu, Haiqing" uniqKey="Yu H" first="Haiqing" last="Yu">Haiqing Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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