[Development of peptidic MERS-CoV entry inhibitors].
Identifieur interne : 001204 ( Main/Exploration ); précédent : 001203; suivant : 001205[Development of peptidic MERS-CoV entry inhibitors].
Auteurs : Shuai Xia ; Qian Wang ; Shu-Wen Liu ; Lu Lu ; Shi-Bo JiangSource :
- Yao xue xue bao = Acta pharmaceutica Sinica [ 0513-4870 ] ; 2015.
Descripteurs français
- KwdFr :
- Antiviraux (pharmacologie), Conception de médicament, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Dipeptidyl peptidase 4 (métabolisme), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Infections à coronavirus (traitement médicamenteux), Peptides (pharmacologie), Pénétration virale ().
- MESH :
- métabolisme : Dipeptidyl peptidase 4, Glycoprotéine de spicule des coronavirus.
- pharmacologie : Antiviraux, Peptides.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- Conception de médicament, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Pénétration virale.
English descriptors
- KwdEn :
- Antiviral Agents (pharmacology), Coronavirus Infections (drug therapy), Dipeptidyl Peptidase 4 (metabolism), Drug Design, Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Peptides (pharmacology), Spike Glycoprotein, Coronavirus (metabolism), Virus Internalization (drug effects).
- MESH :
- chemical , metabolism : Dipeptidyl Peptidase 4, Spike Glycoprotein, Coronavirus.
- chemical , pharmacology : Antiviral Agents, Peptides.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Virus Internalization.
- drug therapy : Coronavirus Infections.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- Drug Design, Humans.
Abstract
In 2012, a new SARS-like coronavirus emerged in the Middle East, namely the Middle East respiratory syndrome coronavirus (MERS-CoV). It has caused outbreaks with high mortality. During infection of target cell, MERS-CoV S protein S1 subunit binds to the cellular receptor (DPP4), and its S2 subunit HR1 and HR2 regions intact with each other to form a stable six-helix bundle to mediate the fusion between virus and target cell membranes. Hence, blocking the process of six-helix bundle formation can effectively inhibit MERS-CoV entry into the target cells. This review focuses on the recent advance in the development of peptidic entry inhibitors targeting the MERS-CoV S2 subunit.
PubMed: 27169270
Affiliations:
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Le document en format XML
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<term>Drug Design</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Peptides (pharmacology)</term>
<term>Spike Glycoprotein, Coronavirus (metabolism)</term>
<term>Virus Internalization (drug effects)</term>
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<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
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<term>Glycoprotéine de spicule des coronavirus (métabolisme)</term>
<term>Humains</term>
<term>Infections à coronavirus (traitement médicamenteux)</term>
<term>Peptides (pharmacologie)</term>
<term>Pénétration virale ()</term>
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<front><div type="abstract" xml:lang="en">In 2012, a new SARS-like coronavirus emerged in the Middle East, namely the Middle East respiratory syndrome coronavirus (MERS-CoV). It has caused outbreaks with high mortality. During infection of target cell, MERS-CoV S protein S1 subunit binds to the cellular receptor (DPP4), and its S2 subunit HR1 and HR2 regions intact with each other to form a stable six-helix bundle to mediate the fusion between virus and target cell membranes. Hence, blocking the process of six-helix bundle formation can effectively inhibit MERS-CoV entry into the target cells. This review focuses on the recent advance in the development of peptidic entry inhibitors targeting the MERS-CoV S2 subunit.</div>
</front>
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<tree><noCountry><name sortKey="Jiang, Shi Bo" sort="Jiang, Shi Bo" uniqKey="Jiang S" first="Shi-Bo" last="Jiang">Shi-Bo Jiang</name>
<name sortKey="Liu, Shu Wen" sort="Liu, Shu Wen" uniqKey="Liu S" first="Shu-Wen" last="Liu">Shu-Wen Liu</name>
<name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name>
<name sortKey="Wang, Qian" sort="Wang, Qian" uniqKey="Wang Q" first="Qian" last="Wang">Qian Wang</name>
<name sortKey="Xia, Shuai" sort="Xia, Shuai" uniqKey="Xia S" first="Shuai" last="Xia">Shuai Xia</name>
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