Gain-of-Function Research and the Relevance to Clinical Practice.
Identifieur interne : 001021 ( Main/Exploration ); précédent : 001020; suivant : 001022Gain-of-Function Research and the Relevance to Clinical Practice.
Auteurs : Andy Kilianski ; Jennifer B. Nuzzo [États-Unis] ; Kayvon Modjarrad [États-Unis]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Humains, Infections à virus à ARN (), Infections à virus à ARN (virologie), Mutation, Pandémies (), Plan de recherche (normes), Politique de santé, Recherche biomédicale (normes), Souris, Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité), Virus du SRAS (génétique), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus de la grippe A, Virus du SRAS.
- normes : Plan de recherche, Recherche biomédicale.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus de la grippe A, Virus du SRAS.
- virologie : Infections à virus à ARN.
- Animaux, Humains, Infections à virus à ARN, Mutation, Pandémies, Politique de santé, Souris.
English descriptors
- KwdEn :
- Animals, Biomedical Research (standards), Health Policy, Humans, Influenza A virus (genetics), Influenza A virus (pathogenicity), Mice, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Mutation, Pandemics (prevention & control), RNA Virus Infections (prevention & control), RNA Virus Infections (virology), Research Design (standards), SARS Virus (genetics), SARS Virus (pathogenicity).
- MESH :
- genetics : Influenza A virus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- pathogenicity : Influenza A virus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- prevention & control : Pandemics, RNA Virus Infections.
- standards : Biomedical Research, Research Design.
- virology : RNA Virus Infections.
- Animals, Health Policy, Humans, Mice, Mutation.
Abstract
The ongoing moratorium on gain-of-function (GOF) research with highly pathogenic avian influenza virus, severe acute respiratory syndrome coronavirus, and Middle East respiratory syndrome coronavirus has drawn attention to the current debate on these research practices and the potential benefits and risks they present. While much of the discussion has been steered by members of the microbiology and policy communities, additional input from medical practitioners will be highly valuable toward developing a broadly inclusive policy that considers the relative value and harm of GOF research. This review attempts to serve as a primer on the topic for the clinical community by providing a historical context for GOF research, summarizing concerns about its risks, and surveying the medical products that it has yielded.
DOI: 10.1093/infdis/jiv473
PubMed: 26416657
Affiliations:
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