Therapeutic Potential of Spirooxindoles as Antiviral Agents
Identifieur interne : 000F23 ( Main/Exploration ); précédent : 000F22; suivant : 000F24Therapeutic Potential of Spirooxindoles as Antiviral Agents
Auteurs : Na Ye [États-Unis] ; Haiying Chen [États-Unis] ; Eric A. Wold [États-Unis] ; Pei-Yong Shi [États-Unis] ; Jia Zhou [États-Unis]Source :
- ACS infectious diseases [ 2373-8227 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Virus.
- métabolisme : Virus.
- pharmacologie : Antiviraux, Indoles.
- traitement médicamenteux : Maladies virales.
- virologie : Maladies virales.
- Animaux, Antiviraux, Découverte de médicament, Humains, Indoles, Relation structure-activité, Souris, Virus.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Drug Discovery, Humans, Indoles (chemistry), Indoles (pharmacology), Mice, Oxindoles, Structure-Activity Relationship, Virus Diseases (drug therapy), Virus Diseases (virology), Viruses (drug effects), Viruses (genetics), Viruses (metabolism).
- MESH :
- chemical , chemistry : Antiviral Agents, Indoles.
- chemical , pharmacology : Antiviral Agents, Indoles.
- drug effects : Viruses.
- drug therapy : Virus Diseases.
- genetics : Viruses.
- metabolism : Viruses.
- virology : Virus Diseases.
- Animals, Drug Discovery, Humans, Mice, Oxindoles, Structure-Activity Relationship.
Abstract
Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low toxicity remain challenging, and obtaining such agents continues to be an active area of therapeutic development. Due to their unique three-dimensional structural features, spirooxindoles have been identified as privileged chemotypes for antiviral drug development. Among them, spiropyrazolopyridone oxindoles have been recently reported as potent inhibitors of dengue virus NS4B, leading to the discovery of an orally bioavailable preclinical candidate (
Url:
DOI: 10.1021/acsinfecdis.6b00041
PubMed: 27627626
PubMed Central: 5417367
Affiliations:
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Le document en format XML
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xml:lang="fr">États-Unis</country><wicri:regionArea>Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555</wicri:regionArea><wicri:noRegion>Texas 77555</wicri:noRegion></affiliation></author><author><name sortKey="Wold, Eric A" sort="Wold, Eric A" uniqKey="Wold E" first="Eric A." last="Wold">Eric A. 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Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555</wicri:regionArea><wicri:noRegion>Texas 77555</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Jia" sort="Zhou, Jia" uniqKey="Zhou J" first="Jia" last="Zhou">Jia Zhou</name><affiliation wicri:level="1"><nlm:aff id="A1">Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555</wicri:regionArea><wicri:noRegion>Texas 77555</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555</wicri:regionArea><wicri:noRegion>Texas 77555</wicri:noRegion></affiliation></author></analytic><series><title level="j">ACS infectious diseases</title><idno type="eISSN">2373-8227</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Drug Discovery</term><term>Humans</term><term>Indoles (chemistry)</term><term>Indoles (pharmacology)</term><term>Mice</term><term>Oxindoles</term><term>Structure-Activity Relationship</term><term>Virus Diseases (drug therapy)</term><term>Virus Diseases (virology)</term><term>Viruses (drug effects)</term><term>Viruses (genetics)</term><term>Viruses (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Découverte de médicament</term><term>Humains</term><term>Indoles ()</term><term>Indoles (pharmacologie)</term><term>Maladies virales (traitement médicamenteux)</term><term>Maladies virales (virologie)</term><term>Relation structure-activité</term><term>Souris</term><term>Virus ()</term><term>Virus (génétique)</term><term>Virus (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Indoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Indoles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Virus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Indoles</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Virus Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Discovery</term><term>Humans</term><term>Mice</term><term>Oxindoles</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antiviraux</term><term>Découverte de médicament</term><term>Humains</term><term>Indoles</term><term>Relation structure-activité</term><term>Souris</term><term>Virus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low toxicity remain challenging, and obtaining such agents continues to be an active area of therapeutic development. Due to their unique three-dimensional structural features, spirooxindoles have been identified as privileged chemotypes for antiviral drug development. Among them, spiropyrazolopyridone oxindoles have been recently reported as potent inhibitors of dengue virus NS4B, leading to the discovery of an orally bioavailable preclinical candidate (<italic>R</italic>)-<bold>44</bold> with excellent in vivo efficacy in a dengue viremia mouse model. This review highlights recent advances in the development of biologically active spirooxindoles for their antiviral potential, primarily focusing on the structure–activity relationships (SARs) and modes of action, as well as future directions to achieve more potent analogues toward a viable antiviral therapy.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Ye, Na" sort="Ye, Na" uniqKey="Ye N" first="Na" last="Ye">Na Ye</name></noRegion><name sortKey="Chen, Haiying" sort="Chen, Haiying" uniqKey="Chen H" first="Haiying" last="Chen">Haiying Chen</name><name sortKey="Shi, Pei Yong" sort="Shi, Pei Yong" uniqKey="Shi P" first="Pei-Yong" last="Shi">Pei-Yong Shi</name><name sortKey="Shi, Pei Yong" sort="Shi, Pei Yong" uniqKey="Shi P" first="Pei-Yong" last="Shi">Pei-Yong Shi</name><name sortKey="Shi, Pei Yong" sort="Shi, Pei Yong" uniqKey="Shi P" first="Pei-Yong" last="Shi">Pei-Yong Shi</name><name sortKey="Wold, Eric A" sort="Wold, Eric A" uniqKey="Wold E" first="Eric A." last="Wold">Eric A. Wold</name><name sortKey="Zhou, Jia" sort="Zhou, Jia" uniqKey="Zhou J" first="Jia" last="Zhou">Jia Zhou</name><name sortKey="Zhou, Jia" sort="Zhou, Jia" uniqKey="Zhou J" first="Jia" last="Zhou">Jia Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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