Discovery and genetic analysis of novel coronaviruses in least horseshoe bats in southwestern China
Identifieur interne : 000E54 ( Main/Exploration ); précédent : 000E53; suivant : 000E55Discovery and genetic analysis of novel coronaviruses in least horseshoe bats in southwestern China
Auteurs : Lihua Wang [République populaire de Chine] ; Shihong Fu [République populaire de Chine] ; Yuxi Cao [République populaire de Chine] ; Hailin Zhang [République populaire de Chine] ; Yun Feng [République populaire de Chine] ; Weihong Yang [République populaire de Chine] ; Kai Nie [République populaire de Chine] ; Xuejun Ma [République populaire de Chine] ; Guodong Liang [République populaire de Chine]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2017.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Animaux, Cadres ouverts de lecture, Chiroptera (), Chiroptera (virologie), Coronavirus (), Coronavirus (génétique), Coronavirus (isolement et purification), Génome viral, Phylogénie, Recombinaison génétique, Rectum (virologie), Taille du génome, Urine (virologie), Évolution moléculaire.
- MESH :
- génétique : ARN viral, Coronavirus.
- isolement et purification : Coronavirus.
- virologie : Chiroptera, Rectum, Urine.
- Animaux, Cadres ouverts de lecture, Chiroptera, Coronavirus, Génome viral, Phylogénie, Recombinaison génétique, Taille du génome, Évolution moléculaire.
English descriptors
- KwdEn :
- Animals, Chiroptera (classification), Chiroptera (virology), Coronavirus (classification), Coronavirus (genetics), Coronavirus (isolation & purification), Evolution, Molecular, Genome Size, Genome, Viral, Open Reading Frames, Phylogeny, RNA, Viral (genetics), Recombination, Genetic, Rectum (virology), Urine (virology).
- MESH :
- chemical , genetics : RNA, Viral.
- classification : Chiroptera, Coronavirus.
- genetics : Coronavirus.
- isolation & purification : Coronavirus.
- virology : Chiroptera, Rectum, Urine.
- Animals, Evolution, Molecular, Genome Size, Genome, Viral, Open Reading Frames, Phylogeny, Recombination, Genetic.
Abstract
To investigate bat coronaviruses (CoVs), we collected 132 rectal swabs and urine samples from five bat species in three countries in southwestern China. Seven CoVs belonging to distinct groups of severe acute respiratory syndrome (SARS)-like CoVs and α-CoVs were detected in samples from least horseshoe bats. Samples from other bat species were negative for these viruses, indicating that the least horseshoe bat represents one of the natural reservoirs and mixers for strains of CoVs and has a pivotal role in the evolution and dissemination of these viruses. The genetic and evolutionary characteristics of these strains were described. Whole-genome sequencing of a new isolate (F46) from a rectal swab from a least horseshoe bat showed that it contained 29 699 nucleotides, excluding the poly (A) tail, with 13 open reading frames (ORFs). Phylogenetic and recombination analyses of F46 provided evidence of natural recombination between bat SARS-like CoVs (Rs3367 and LYRa11) or SARS-CoV (BJ01), suggesting that F46 could be a new recombinant virus from SARS-like CoVs or SARS-CoVs.
Url:
DOI: 10.1038/emi.2016.140
PubMed: 28352124
PubMed Central: 5378919
Affiliations:
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Le document en format XML
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China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Weihong" sort="Yang, Weihong" uniqKey="Yang W" first="Weihong" last="Yang">Weihong Yang</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Yunnan Institute of Endemic Diseases Control and Prevention, Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention of Dali</institution>, Dali 671000, Yunnan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nie, Kai" sort="Nie, Kai" uniqKey="Nie K" first="Kai" last="Nie">Kai Nie</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral 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for Disease Control and Prevention</institution>, Beijing 102206,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>, Hangzhou 310003,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Guodong" sort="Liang, Guodong" uniqKey="Liang G" first="Guodong" last="Liang">Guodong Liang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and 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wicri:level="1"><nlm:aff id="aff2"><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>, Hangzhou 310003,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fu, Shihong" sort="Fu, Shihong" uniqKey="Fu S" first="Shihong" last="Fu">Shihong Fu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>, Hangzhou 310003,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cao, Yuxi" sort="Cao, Yuxi" uniqKey="Cao Y" first="Yuxi" last="Cao">Yuxi Cao</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>, Hangzhou 310003,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hailin" sort="Zhang, Hailin" uniqKey="Zhang H" first="Hailin" last="Zhang">Hailin Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Yunnan Institute of Endemic Diseases Control and Prevention, Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention of Dali</institution>, Dali 671000, Yunnan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Feng, Yun" sort="Feng, Yun" uniqKey="Feng Y" first="Yun" last="Feng">Yun Feng</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Yunnan Institute of Endemic Diseases Control and Prevention, Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention of Dali</institution>, Dali 671000, Yunnan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Weihong" sort="Yang, Weihong" uniqKey="Yang W" first="Weihong" last="Yang">Weihong Yang</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Yunnan Institute of Endemic Diseases Control and Prevention, Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention of Dali</institution>, Dali 671000, Yunnan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nie, Kai" sort="Nie, Kai" uniqKey="Nie K" first="Kai" last="Nie">Kai Nie</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>, Hangzhou 310003,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ma, Xuejun" sort="Ma, Xuejun" uniqKey="Ma X" first="Xuejun" last="Ma">Xuejun Ma</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>, Hangzhou 310003,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Guodong" sort="Liang, Guodong" uniqKey="Liang G" first="Guodong" last="Liang">Guodong Liang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention</institution>, Beijing 102206,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>, Hangzhou 310003,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Emerging Microbes & Infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chiroptera (classification)</term><term>Chiroptera (virology)</term><term>Coronavirus (classification)</term><term>Coronavirus (genetics)</term><term>Coronavirus (isolation & purification)</term><term>Evolution, Molecular</term><term>Genome Size</term><term>Genome, Viral</term><term>Open Reading Frames</term><term>Phylogeny</term><term>RNA, Viral (genetics)</term><term>Recombination, Genetic</term><term>Rectum (virology)</term><term>Urine (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Chiroptera ()</term><term>Chiroptera (virologie)</term><term>Coronavirus ()</term><term>Coronavirus (génétique)</term><term>Coronavirus (isolement et purification)</term><term>Génome viral</term><term>Phylogénie</term><term>Recombinaison génétique</term><term>Rectum (virologie)</term><term>Taille du génome</term><term>Urine (virologie)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Chiroptera</term><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term><term>Rectum</term><term>Urine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Rectum</term><term>Urine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Evolution, Molecular</term><term>Genome Size</term><term>Genome, Viral</term><term>Open Reading Frames</term><term>Phylogeny</term><term>Recombination, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Chiroptera</term><term>Coronavirus</term><term>Génome viral</term><term>Phylogénie</term><term>Recombinaison génétique</term><term>Taille du génome</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To investigate bat coronaviruses (CoVs), we collected 132 rectal swabs and urine samples from five bat species in three countries in southwestern China. Seven CoVs belonging to distinct groups of severe acute respiratory syndrome (SARS)-like CoVs and α-CoVs were detected in samples from least horseshoe bats. Samples from other bat species were negative for these viruses, indicating that the least horseshoe bat represents one of the natural reservoirs and mixers for strains of CoVs and has a pivotal role in the evolution and dissemination of these viruses. The genetic and evolutionary characteristics of these strains were described. Whole-genome sequencing of a new isolate (F46) from a rectal swab from a least horseshoe bat showed that it contained 29 699 nucleotides, excluding the poly (A) tail, with 13 open reading frames (ORFs). Phylogenetic and recombination analyses of F46 provided evidence of natural recombination between bat SARS-like CoVs (Rs3367 and LYRa11) or SARS-CoV (BJ01), suggesting that F46 could be a new recombinant virus from SARS-like CoVs or SARS-CoVs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Lihua" sort="Wang, Lihua" uniqKey="Wang L" first="Lihua" last="Wang">Lihua Wang</name></noRegion><name sortKey="Cao, Yuxi" sort="Cao, Yuxi" uniqKey="Cao Y" first="Yuxi" last="Cao">Yuxi Cao</name><name sortKey="Cao, Yuxi" sort="Cao, Yuxi" uniqKey="Cao Y" first="Yuxi" last="Cao">Yuxi Cao</name><name sortKey="Feng, Yun" sort="Feng, Yun" uniqKey="Feng Y" first="Yun" last="Feng">Yun Feng</name><name sortKey="Fu, Shihong" sort="Fu, Shihong" uniqKey="Fu S" first="Shihong" last="Fu">Shihong Fu</name><name sortKey="Fu, Shihong" sort="Fu, Shihong" uniqKey="Fu S" first="Shihong" last="Fu">Shihong Fu</name><name sortKey="Liang, Guodong" sort="Liang, Guodong" uniqKey="Liang G" first="Guodong" last="Liang">Guodong Liang</name><name sortKey="Liang, Guodong" sort="Liang, Guodong" uniqKey="Liang G" first="Guodong" last="Liang">Guodong Liang</name><name sortKey="Ma, Xuejun" sort="Ma, Xuejun" uniqKey="Ma X" first="Xuejun" last="Ma">Xuejun Ma</name><name sortKey="Ma, Xuejun" sort="Ma, Xuejun" uniqKey="Ma X" first="Xuejun" last="Ma">Xuejun Ma</name><name sortKey="Nie, Kai" sort="Nie, Kai" uniqKey="Nie K" first="Kai" last="Nie">Kai Nie</name><name sortKey="Nie, Kai" sort="Nie, Kai" uniqKey="Nie K" first="Kai" last="Nie">Kai Nie</name><name sortKey="Wang, Lihua" sort="Wang, Lihua" uniqKey="Wang L" first="Lihua" last="Wang">Lihua Wang</name><name sortKey="Yang, Weihong" sort="Yang, Weihong" uniqKey="Yang W" first="Weihong" last="Yang">Weihong Yang</name><name sortKey="Zhang, Hailin" sort="Zhang, Hailin" uniqKey="Zhang H" first="Hailin" last="Zhang">Hailin Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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