Global virus outbreaks: Interferons as 1st responders.
Identifieur interne : 000B34 ( Main/Exploration ); précédent : 000B33; suivant : 000B35Global virus outbreaks: Interferons as 1st responders.
Auteurs : Ben X. Wang [Canada] ; Eleanor N. Fish [Canada]Source :
- Seminars in immunology [ 1096-3618 ] ; 2019.
Abstract
Outbreaks of severe virus infections with the potential to cause global pandemics are increasing. In many instances these outbreaks have been newly emerging (SARS coronavirus), re-emerging (Ebola virus, Zika virus) or zoonotic (avian influenza H5N1) virus infections. In the absence of a targeted vaccine or a pathogen-specific antiviral, broad-spectrum antivirals would function to limit virus spread. Given the direct antiviral effects of type I interferons (IFNs) in inhibiting the replication of both DNA and RNA viruses at different stages of their replicative cycles, and the effects of type I IFNs on activating immune cell populations to clear virus infections, IFNs-α/β present as ideal candidate broad-spectrum antivirals.
DOI: 10.1016/j.smim.2019.101300
PubMed: 31771760
Affiliations:
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Fish</name><affiliation wicri:level="1"><nlm:affiliation>Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, ON M5G 2M1, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. 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Wang</name><affiliation wicri:level="1"><nlm:affiliation>Princess Margaret Cancer Center, Tumor Immunotherapy Program, University Health Network, Toronto, ON M5G 2M9, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Center, Tumor Immunotherapy Program, University Health Network, Toronto, ON M5G 2M9</wicri:regionArea><wicri:noRegion>ON M5G 2M9</wicri:noRegion></affiliation></author><author><name sortKey="Fish, Eleanor N" sort="Fish, Eleanor N" uniqKey="Fish E" first="Eleanor N" last="Fish">Eleanor N. Fish</name><affiliation wicri:level="1"><nlm:affiliation>Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, ON M5G 2M1, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: en.fish@utoronto.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, ON M5G 2M1, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8</wicri:regionArea><wicri:noRegion>ON M5S 1A8</wicri:noRegion></affiliation></author></analytic><series><title level="j">Seminars in immunology</title><idno type="eISSN">1096-3618</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Outbreaks of severe virus infections with the potential to cause global pandemics are increasing. In many instances these outbreaks have been newly emerging (SARS coronavirus), re-emerging (Ebola virus, Zika virus) or zoonotic (avian influenza H5N1) virus infections. In the absence of a targeted vaccine or a pathogen-specific antiviral, broad-spectrum antivirals would function to limit virus spread. Given the direct antiviral effects of type I interferons (IFNs) in inhibiting the replication of both DNA and RNA viruses at different stages of their replicative cycles, and the effects of type I IFNs on activating immune cell populations to clear virus infections, IFNs-α/β present as ideal candidate broad-spectrum antivirals.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Wang, Ben X" sort="Wang, Ben X" uniqKey="Wang B" first="Ben X" last="Wang">Ben X. Wang</name></noRegion><name sortKey="Fish, Eleanor N" sort="Fish, Eleanor N" uniqKey="Fish E" first="Eleanor N" last="Fish">Eleanor N. Fish</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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