Indole: A privileged scaffold for the design of anti-cancer agents.
Identifieur interne : 000B21 ( Main/Exploration ); précédent : 000B20; suivant : 000B22Indole: A privileged scaffold for the design of anti-cancer agents.
Auteurs : Yichao Wan [République populaire de Chine] ; Yuanhua Li [République populaire de Chine] ; Chunxing Yan [République populaire de Chine] ; Mi Yan [République populaire de Chine] ; Zilong Tang [République populaire de Chine]Source :
- European journal of medicinal chemistry [ 1768-3254 ] ; 2019.
Descripteurs français
- KwdFr :
- Antinéoplasiques (), Antinéoplasiques (pharmacologie), Antinéoplasiques (synthèse chimique), Conception de médicament, Humains, Indoles (), Indoles (pharmacologie), Indoles (synthèse chimique), Protéine Mcl-1 (antagonistes et inhibiteurs), Protéine Mcl-1 (métabolisme), Protéines proto-oncogènes c-pim-1 (antagonistes et inhibiteurs), Protéines proto-oncogènes c-pim-1 (métabolisme), Tests de criblage d'agents antitumoraux, Tubuline (métabolisme), Tumeurs (métabolisme), Tumeurs (traitement médicamenteux).
- MESH :
- antagonistes et inhibiteurs : Protéine Mcl-1, Protéines proto-oncogènes c-pim-1.
- métabolisme : Protéine Mcl-1, Protéines proto-oncogènes c-pim-1, Tubuline, Tumeurs.
- pharmacologie : Antinéoplasiques, Indoles.
- synthèse chimique : Antinéoplasiques, Indoles.
- traitement médicamenteux : Tumeurs.
- Antinéoplasiques, Conception de médicament, Humains, Indoles, Tests de criblage d'agents antitumoraux.
English descriptors
- KwdEn :
- Antineoplastic Agents (chemical synthesis), Antineoplastic Agents (chemistry), Antineoplastic Agents (pharmacology), Drug Design, Drug Screening Assays, Antitumor, Humans, Indoles (chemical synthesis), Indoles (chemistry), Indoles (pharmacology), Myeloid Cell Leukemia Sequence 1 Protein (antagonists & inhibitors), Myeloid Cell Leukemia Sequence 1 Protein (metabolism), Neoplasms (drug therapy), Neoplasms (metabolism), Proto-Oncogene Proteins c-pim-1 (antagonists & inhibitors), Proto-Oncogene Proteins c-pim-1 (metabolism), Tubulin (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Myeloid Cell Leukemia Sequence 1 Protein, Proto-Oncogene Proteins c-pim-1.
- chemical , chemical synthesis : Antineoplastic Agents, Indoles.
- chemical , chemistry : Antineoplastic Agents, Indoles.
- chemical , metabolism : Myeloid Cell Leukemia Sequence 1 Protein, Proto-Oncogene Proteins c-pim-1, Tubulin.
- chemical , pharmacology : Antineoplastic Agents, Indoles.
- drug therapy : Neoplasms.
- metabolism : Neoplasms.
- Drug Design, Drug Screening Assays, Antitumor, Humans.
Abstract
In general, heterocyclic compounds are a significant source of pharmacologically active compounds. Among them, the indole scaffold widely distributes in natural products and bioactive molecules including anti-cancer agents. In view of its unique physic-chemical and biological properties, it has been used as a privileged scaffold in the anti-cancer agents design. So far, many natural and synthetic indole derivatives have been discovered as promising anti-cancer agents used in clinic or clinical evaluations, suggesting its prominent place in anti-cancer drugs development. This review aimed to provide a clear knowledge on the recent development of indoles as anti-cancer agents, such as myeloid cell leukemia-1 (Mcl-1) inhibitors, proviral insertion site in moloney murine leukemia virus (Pim) inhibitors, histone deacetylase (HDAC) inhibitors, silent mating type information regulation 2 homolog (SIRT) inhibitors and tubulin inhibitors, and made an insight into the corresponding structure-activity relationships (SARs). We hope the review could give a guide to develop new anti-cancer agents with greater potency against drug-sensitive and drug-resistant cancers in the future.
DOI: 10.1016/j.ejmech.2019.111691
PubMed: 31536895
Affiliations:
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Electronic address: zltang@hnust.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan, 411201, PR China; Hunan Provincial College Key Laboratory of QSAR/QSPR, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, Hunan University of Science and Technology, Xiangtan, Hunan, 411201</wicri:regionArea><wicri:noRegion>411201</wicri:noRegion></affiliation></author></analytic><series><title level="j">European journal of medicinal chemistry</title><idno type="eISSN">1768-3254</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (chemical synthesis)</term><term>Antineoplastic Agents (chemistry)</term><term>Antineoplastic Agents (pharmacology)</term><term>Drug Design</term><term>Drug Screening Assays, Antitumor</term><term>Humans</term><term>Indoles (chemical synthesis)</term><term>Indoles (chemistry)</term><term>Indoles (pharmacology)</term><term>Myeloid Cell Leukemia Sequence 1 Protein (antagonists & inhibitors)</term><term>Myeloid Cell Leukemia Sequence 1 Protein (metabolism)</term><term>Neoplasms (drug therapy)</term><term>Neoplasms (metabolism)</term><term>Proto-Oncogene Proteins c-pim-1 (antagonists & inhibitors)</term><term>Proto-Oncogene Proteins c-pim-1 (metabolism)</term><term>Tubulin (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques ()</term><term>Antinéoplasiques (pharmacologie)</term><term>Antinéoplasiques (synthèse chimique)</term><term>Conception de médicament</term><term>Humains</term><term>Indoles ()</term><term>Indoles (pharmacologie)</term><term>Indoles (synthèse chimique)</term><term>Protéine Mcl-1 (antagonistes et inhibiteurs)</term><term>Protéine Mcl-1 (métabolisme)</term><term>Protéines proto-oncogènes c-pim-1 (antagonistes et inhibiteurs)</term><term>Protéines proto-oncogènes c-pim-1 (métabolisme)</term><term>Tests de criblage d'agents antitumoraux</term><term>Tubuline (métabolisme)</term><term>Tumeurs (métabolisme)</term><term>Tumeurs (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Myeloid Cell Leukemia Sequence 1 Protein</term><term>Proto-Oncogene Proteins c-pim-1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antineoplastic Agents</term><term>Indoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antineoplastic Agents</term><term>Indoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Myeloid Cell Leukemia Sequence 1 Protein</term><term>Proto-Oncogene Proteins c-pim-1</term><term>Tubulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Indoles</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéine Mcl-1</term><term>Protéines proto-oncogènes c-pim-1</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine Mcl-1</term><term>Protéines proto-oncogènes c-pim-1</term><term>Tubuline</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Indoles</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Antinéoplasiques</term><term>Indoles</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Design</term><term>Drug Screening Assays, Antitumor</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Antinéoplasiques</term><term>Conception de médicament</term><term>Humains</term><term>Indoles</term><term>Tests de criblage d'agents antitumoraux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In general, heterocyclic compounds are a significant source of pharmacologically active compounds. Among them, the indole scaffold widely distributes in natural products and bioactive molecules including anti-cancer agents. In view of its unique physic-chemical and biological properties, it has been used as a privileged scaffold in the anti-cancer agents design. So far, many natural and synthetic indole derivatives have been discovered as promising anti-cancer agents used in clinic or clinical evaluations, suggesting its prominent place in anti-cancer drugs development. This review aimed to provide a clear knowledge on the recent development of indoles as anti-cancer agents, such as myeloid cell leukemia-1 (Mcl-1) inhibitors, proviral insertion site in moloney murine leukemia virus (Pim) inhibitors, histone deacetylase (HDAC) inhibitors, silent mating type information regulation 2 homolog (SIRT) inhibitors and tubulin inhibitors, and made an insight into the corresponding structure-activity relationships (SARs). We hope the review could give a guide to develop new anti-cancer agents with greater potency against drug-sensitive and drug-resistant cancers in the future.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wan, Yichao" sort="Wan, Yichao" uniqKey="Wan Y" first="Yichao" last="Wan">Yichao Wan</name></noRegion><name sortKey="Li, Yuanhua" sort="Li, Yuanhua" uniqKey="Li Y" first="Yuanhua" last="Li">Yuanhua Li</name><name sortKey="Tang, Zilong" sort="Tang, Zilong" uniqKey="Tang Z" first="Zilong" last="Tang">Zilong Tang</name><name sortKey="Yan, Chunxing" sort="Yan, Chunxing" uniqKey="Yan C" first="Chunxing" last="Yan">Chunxing Yan</name><name sortKey="Yan, Mi" sort="Yan, Mi" uniqKey="Yan M" first="Mi" last="Yan">Mi Yan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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