A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV
Identifieur interne : 000A34 ( Main/Exploration ); précédent : 000A33; suivant : 000A35A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV
Auteurs : Meng Yuan [États-Unis] ; Nicholas C. Wu [États-Unis] ; Xueyong Zhu [États-Unis] ; Chang-Chun D. Lee [États-Unis] ; Ray T. Y. So [République populaire de Chine] ; Huibin Lv [République populaire de Chine] ; Chris K. P. Mok [République populaire de Chine] ; Ian A. Wilson [États-Unis]Source :
- Science (New York, N.y.) [ 0036-8075 ] ; 2020.
Abstract
The outbreak of COVID-19 caused by SARS-CoV-2 virus has now become a pandemic, but there is currently very little understanding of the antigenicity of the virus. We therefore determined the crystal structure of CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient, in complex with the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein to 3.1 Å. CR3022 targets a highly conserved epitope, distal from the receptor-binding site, that enables cross-reactive binding between SARS-CoV-2 and SARS-CoV. Structural modeling further demonstrates that the binding epitope can only be accessed by CR3022 when at least two RBD on the trimeric S protein are in the “up” conformation and slightly rotated. Overall, this study provides molecular insights into antibody recognition of SARS-CoV-2.
Url:
DOI: 10.1126/science.abb7269
PubMed: 32245784
PubMed Central: 7164391
Affiliations:
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Wu</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zhu, Xueyong" sort="Zhu, Xueyong" uniqKey="Zhu X" first="Xueyong" last="Zhu">Xueyong Zhu</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lee, Chang Chun D" sort="Lee, Chang Chun D" uniqKey="Lee C" first="Chang-Chun D." last="Lee">Chang-Chun D. Lee</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="So, Ray T Y" sort="So, Ray T Y" uniqKey="So R" first="Ray T. Y." last="So">Ray T. Y. So</name><affiliation wicri:level="1"><nlm:aff id="aff2">HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Lv, Huibin" sort="Lv, Huibin" uniqKey="Lv H" first="Huibin" last="Lv">Huibin Lv</name><affiliation wicri:level="1"><nlm:aff id="aff2">HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Mok, Chris K P" sort="Mok, Chris K P" uniqKey="Mok C" first="Chris K. P." last="Mok">Chris K. P. Mok</name><affiliation wicri:level="1"><nlm:aff id="aff2">HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037</wicri:regionArea><wicri:noRegion>92037</wicri:noRegion></affiliation></author></analytic><series><title level="j">Science (New York, N.y.)</title><idno type="ISSN">0036-8075</idno><idno type="eISSN">1095-9203</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The outbreak of COVID-19 caused by SARS-CoV-2 virus has now become a pandemic, but there is currently very little understanding of the antigenicity of the virus. We therefore determined the crystal structure of CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient, in complex with the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein to 3.1 Å. CR3022 targets a highly conserved epitope, distal from the receptor-binding site, that enables cross-reactive binding between SARS-CoV-2 and SARS-CoV. Structural modeling further demonstrates that the binding epitope can only be accessed by CR3022 when at least two RBD on the trimeric S protein are in the “up” conformation and slightly rotated. Overall, this study provides molecular insights into antibody recognition of SARS-CoV-2.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. 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Wilson</name><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name><name sortKey="Wu, Nicholas C" sort="Wu, Nicholas C" uniqKey="Wu N" first="Nicholas C." last="Wu">Nicholas C. Wu</name><name sortKey="Zhu, Xueyong" sort="Zhu, Xueyong" uniqKey="Zhu X" first="Xueyong" last="Zhu">Xueyong Zhu</name></country><country name="République populaire de Chine"><noRegion><name sortKey="So, Ray T Y" sort="So, Ray T Y" uniqKey="So R" first="Ray T. Y." last="So">Ray T. Y. So</name></noRegion><name sortKey="Lv, Huibin" sort="Lv, Huibin" uniqKey="Lv H" first="Huibin" last="Lv">Huibin Lv</name><name sortKey="Mok, Chris K P" sort="Mok, Chris K P" uniqKey="Mok C" first="Chris K. P." last="Mok">Chris K. P. Mok</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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