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Classification of carcinogens: Polemics, pedantics, or progress?

Identifieur interne : 006619 ( Main/Curation ); précédent : 006618; suivant : 006620

Classification of carcinogens: Polemics, pedantics, or progress?

Auteurs : David B. Clayson [Canada] ; David J. Clegg [Canada]

Source :

RBID : ISTEX:D99A93E19933D2E7312DEECC046E7D148CAA81FB

English descriptors

Abstract

Abstract: Rodent carcinogens may, for physiological or other reasons, induce cancer by a variety of mechanisms which vary in their ability to affect humans. While the current approach of some regulatory agencies to carcinogen risk assessment and regulation may possibly be justified with most genotoxic carcinogens, this is not true with all nongenotoxic carcinogens. Mechanisms attributable to high dose toxicity occasioned by misuse of the maximum tolerated dose concept, imbalancing of homeostasis, unphysiological conditions, and induced cellular proliferation are reviewed. The greatest present need for meaningful regulation of carcinogens is to obtain public acceptance of the fact that some carcinogens are species specific and probably will not exert their effects in humans.

Url:
DOI: 10.1016/0273-2300(91)90003-E

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ISTEX:D99A93E19933D2E7312DEECC046E7D148CAA81FB

Le document en format XML

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<div type="abstract" xml:lang="en">Abstract: Rodent carcinogens may, for physiological or other reasons, induce cancer by a variety of mechanisms which vary in their ability to affect humans. While the current approach of some regulatory agencies to carcinogen risk assessment and regulation may possibly be justified with most genotoxic carcinogens, this is not true with all nongenotoxic carcinogens. Mechanisms attributable to high dose toxicity occasioned by misuse of the maximum tolerated dose concept, imbalancing of homeostasis, unphysiological conditions, and induced cellular proliferation are reviewed. The greatest present need for meaningful regulation of carcinogens is to obtain public acceptance of the fact that some carcinogens are species specific and probably will not exert their effects in humans.</div>
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