Classification of carcinogens: Polemics, pedantics, or progress?
Identifieur interne : 006619 ( Main/Curation ); précédent : 006618; suivant : 006620Classification of carcinogens: Polemics, pedantics, or progress?
Auteurs : David B. Clayson [Canada] ; David J. Clegg [Canada]Source :
- Regulatory Toxicology and Pharmacology [ 0273-2300 ] ; 1991.
English descriptors
- Teeft :
- Academic press, Active metabolite, Adverse effects, Animal carcinogens, Ashby, Assay, Base mispairing, Bioassay, Bladder, Bladder carcinogenesis, Bladder epithelium, Boca raton, Body weight, Butylated, Butylated hydroxyanisole, Butylated hydroxytoluene, Cancer inst, Cancer lett, Carcinogen, Carcinogen curve, Carcinogen risk assessment, Carcinogenesis, Carcinogenesis bioassay, Carcinogenic, Carcinogenicity, Carcinogenicity bioassay, Cell proliferation, Cell tumors, Cellular, Cellular proliferation, Cellular replication, Chem, Chemical carcinogens, Chromosomal aberrations, Clayson, Clegg, Concurrent controls, Considerable numbers, Delaney clause, Different species, Dose effects, Dose response, Elsevier, Excessive safety factor, Extreme conditions, Fetal malformations, Food chem, Food supply, Fukushima, Further studies, Gastric cancer, Genetic changes, Genetic repair mechanisms, Genotoxic, Genotoxic carcinogens, Genotoxic effects, Genotoxicity, Genotoxicity tests, Health perspect, High dose toxicity, High levels, Highest dose, Homeostatic balance, Hormonal control, Human exposure, Human population, Hydrogen peroxide, Hydroxyanisole, Initiation stage, Interdisciplinary panel, Legal mandate, Lesser curvature, Limited evidence, Liver cells, Liver tumors, Male fischer, Male rats, Mammalian cells, Mammary gland, Many rodent carcinogens, Maternal toxicity, Mathematical logic, Metabolic activation, Munro, Mutat, National cancer institute, National toxicology program, Nera, Nongenotoxic, Nongenotoxic agent, Nongenotoxic agents, Nongenotoxic carcinogens, Oncogene, Other substances, Paynter, Peroxisome, Peroxisome proliferator, Peroxisome proliferators, Pesticide residues, Pharmacol, Possible mechanisms, Predictive toxicology, Proliferation, Proliferators, Protooncogene activation, Rat, Regulatory scientist, Relevant evidence, Risk assessment, Rodent, Rodent bioassay, Rodent carcinogens, Saccharin, Scientific counsellors, Scientific literature, Shubik, Sodium chloride, Sodium ions, Sodium saccharin, Specific bases, Specific tissues, Swenberg, Test agent, Test animals, Test chemical, Thyroid hormones, Thyroid tumorigenesis, Toxic agents, Toxicity, Toxicol, Toxicological, Toxicological risk assessment, Toxicology, Tumor induction, Tumor promotion, Tumorigenesis, Unphysiological, Unphysiological conditions, Urinary, Urinary bladder, Urinary tract, Wide variety.
Abstract
Abstract: Rodent carcinogens may, for physiological or other reasons, induce cancer by a variety of mechanisms which vary in their ability to affect humans. While the current approach of some regulatory agencies to carcinogen risk assessment and regulation may possibly be justified with most genotoxic carcinogens, this is not true with all nongenotoxic carcinogens. Mechanisms attributable to high dose toxicity occasioned by misuse of the maximum tolerated dose concept, imbalancing of homeostasis, unphysiological conditions, and induced cellular proliferation are reviewed. The greatest present need for meaningful regulation of carcinogens is to obtain public acceptance of the fact that some carcinogens are species specific and probably will not exert their effects in humans.
Url:
DOI: 10.1016/0273-2300(91)90003-E
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<front><div type="abstract" xml:lang="en">Abstract: Rodent carcinogens may, for physiological or other reasons, induce cancer by a variety of mechanisms which vary in their ability to affect humans. While the current approach of some regulatory agencies to carcinogen risk assessment and regulation may possibly be justified with most genotoxic carcinogens, this is not true with all nongenotoxic carcinogens. Mechanisms attributable to high dose toxicity occasioned by misuse of the maximum tolerated dose concept, imbalancing of homeostasis, unphysiological conditions, and induced cellular proliferation are reviewed. The greatest present need for meaningful regulation of carcinogens is to obtain public acceptance of the fact that some carcinogens are species specific and probably will not exert their effects in humans.</div>
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