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Spontaneous pneumomediastinum in patients with severe acute respiratory syndrome

Identifieur interne : 005A62 ( Main/Curation ); précédent : 005A61; suivant : 005A63

Spontaneous pneumomediastinum in patients with severe acute respiratory syndrome

Auteurs : C. M. Chu [Hong Kong] ; Y. Y. Leung [Hong Kong] ; J. Y. H. Hui [Hong Kong] ; I. F. N. Hung [Hong Kong] ; V. L. Chan [Hong Kong] ; W. S. Leung [Hong Kong] ; K. I. Law [Hong Kong] ; C. S. Chan [Hong Kong] ; K. S. Chan [Hong Kong] ; K. Y. Yuen [Hong Kong]

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RBID : Pascal:04-0358995

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Abstract

Spontaneous pneumomediastinum (SP) unrelated to assisted ventilation is a newly recognised complication of severe acute respiratory syndrome (SARS). The objective of the present study was to examine the incidence, risk factors and the outcomes of SP in a cohort of SARS victims from a community outbreak. Data were retrieved from a prospectively collected database of virologically confirmed SARS patients. One hundred and twelve cases were analysable, with 13 patients developing SP (11.6%) at a mean±SD of 19.6±4.6 days from symptom onset. Peak lactate dehydrogenase level was associated with the development of SP. SP was associated with increased intubation and a trend towards death. Drainage was required in five cases. For patients who survived, the SP and/or the associated pneumothoraces took a median of 28 days (interquartile range: 15-45 days) to resolve completely. In conclusion, spontaneous pneumomediastinum appeared to be a frequent complication of severe acute respiratory syndrome. Further research is needed to investigate its pathogenesis.

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Pascal:04-0358995

Le document en format XML

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<div type="abstract" xml:lang="en">Spontaneous pneumomediastinum (SP) unrelated to assisted ventilation is a newly recognised complication of severe acute respiratory syndrome (SARS). The objective of the present study was to examine the incidence, risk factors and the outcomes of SP in a cohort of SARS victims from a community outbreak. Data were retrieved from a prospectively collected database of virologically confirmed SARS patients. One hundred and twelve cases were analysable, with 13 patients developing SP (11.6%) at a mean±SD of 19.6±4.6 days from symptom onset. Peak lactate dehydrogenase level was associated with the development of SP. SP was associated with increased intubation and a trend towards death. Drainage was required in five cases. For patients who survived, the SP and/or the associated pneumothoraces took a median of 28 days (interquartile range: 15-45 days) to resolve completely. In conclusion, spontaneous pneumomediastinum appeared to be a frequent complication of severe acute respiratory syndrome. Further research is needed to investigate its pathogenesis.</div>
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