Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus
Identifieur interne : 004D85 ( Main/Curation ); précédent : 004D84; suivant : 004D86Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus
Auteurs : Sara Akerström [Suède] ; Mehrdad Mousavi-Jazi [Suède] ; Jonas Klingström [Suède] ; Mikael Leijon [Suède] ; Ake Lundkvist [Suède] ; Ali Mirazimi [Suède]Source :
- Journal of virology [ 0022-538X ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Monoxyde d'azote, Nitric oxide synthase.
- pharmacologie : Monoxyde d'azote, N-Acétyl-S-nitroso-pénicillamine.
- physiologie : Virus du SRAS.
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Coronavirus, Humans, Microbiology, Nitric Oxide (metabolism), Nitric Oxide (pharmacology), Nitric Oxide Synthase (metabolism), Nitric Oxide Synthase Type II, Nitric oxide, Replication, S-Nitroso-N-Acetylpenicillamine (pharmacology), SARS Virus (drug effects), SARS Virus (physiology), Severe acute respiratory syndrome, Vero Cells, Virology, Virus Replication (drug effects).
- MESH :
- chemical , metabolism : Nitric Oxide, Nitric Oxide Synthase.
- chemical , pharmacology : Nitric Oxide, S-Nitroso-N-Acetylpenicillamine.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, Nitric Oxide Synthase Type II, Vero Cells.
Abstract
Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.
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Pascal:05-0134586Le document en format XML
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<term>Chlorocebus aethiops</term>
<term>Coronavirus</term>
<term>Humans</term>
<term>Microbiology</term>
<term>Nitric Oxide (metabolism)</term>
<term>Nitric Oxide (pharmacology)</term>
<term>Nitric Oxide Synthase (metabolism)</term>
<term>Nitric Oxide Synthase Type II</term>
<term>Nitric oxide</term>
<term>Replication</term>
<term>S-Nitroso-N-Acetylpenicillamine (pharmacology)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (physiology)</term>
<term>Severe acute respiratory syndrome</term>
<term>Vero Cells</term>
<term>Virology</term>
<term>Virus Replication (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Humains</term>
<term>Monoxyde d'azote (métabolisme)</term>
<term>Monoxyde d'azote (pharmacologie)</term>
<term>N-Acétyl-S-nitroso-pénicillamine (pharmacologie)</term>
<term>Nitric oxide synthase (métabolisme)</term>
<term>Nitric oxide synthase type II</term>
<term>Réplication virale ()</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (physiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nitric Oxide</term>
<term>Nitric Oxide Synthase</term>
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<term>Virus Replication</term>
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<term>Nitric oxide synthase</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Monoxyde d'azote</term>
<term>N-Acétyl-S-nitroso-pénicillamine</term>
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<term>Nitric oxide synthase type II</term>
<term>Réplication</term>
<term>Microbiologie</term>
<term>Réplication virale</term>
<term>Virologie</term>
<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en">Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.</div>
</front>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus</title>
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<author><name sortKey="Klingstrom, Jonas" sort="Klingstrom, Jonas" uniqKey="Klingstrom J" first="Jonas" last="Klingström">Jonas Klingström</name>
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<author><name sortKey="Lundkvist, Ake" sort="Lundkvist, Ake" uniqKey="Lundkvist A" first="Ake" last="Lundkvist">Ake Lundkvist</name>
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<region nuts="2">Svealand</region>
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<author><name sortKey="Mirazimi, Ali" sort="Mirazimi, Ali" uniqKey="Mirazimi A" first="Ali" last="Mirazimi">Ali Mirazimi</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control</s1>
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<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
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<term>Severe acute respiratory syndrome</term>
<term>Virology</term>
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<term>Azote monoxyde</term>
<term>Réplication</term>
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<term>Virologie</term>
<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en">Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.</div>
</front>
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<author><name sortKey="Mousavi Jazi, Mehrdad" sort="Mousavi Jazi, Mehrdad" uniqKey="Mousavi Jazi M" first="Mehrdad" last="Mousavi-Jazi">Mehrdad Mousavi-Jazi</name>
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<term>Nitric Oxide (pharmacology)</term>
<term>Nitric Oxide Synthase (metabolism)</term>
<term>Nitric Oxide Synthase Type II</term>
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<term>SARS Virus (drug effects)</term>
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<term>Nitric oxide synthase (métabolisme)</term>
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<term>Cellules Vero</term>
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<front><div type="abstract" xml:lang="en">Nitric oxide (NO) is an important signaling molecule between cells which has been shown to have an inhibitory effect on some virus infections. The purpose of this study was to examine whether NO inhibits the replication cycle of the severe acute respiratory syndrome coronavirus (SARS CoV) in vitro. We found that an organic NO donor, S-nitroso-N-acetylpenicillamine, significantly inhibited the replication cycle of SARS CoV in a concentration-dependent manner. We also show here that NO inhibits viral protein and RNA synthesis. Furthermore, we demonstrate that NO generated by inducible nitric oxide synthase, an enzyme that produces NO, inhibits the SARS CoV replication cycle.</div>
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