Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus.
Identifieur interne : 004827 ( Main/Curation ); précédent : 004826; suivant : 004828Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus.
Auteurs : Zhinan Chen [République populaire de Chine] ; Li Mi ; Jing Xu ; Jiyun Yu ; Xianhui Wang ; Jianli Jiang ; Jinliang Xing ; Peng Shang ; Airong Qian ; Yu Li ; Peter X. Shaw ; Jianwei Wang ; Shumin Duan ; Jin Ding ; Chunmei Fan ; Yang Zhang ; Yong Yang ; Xiaoling Yu ; Qiang Feng ; Biehu Li ; Xiying Yao ; Zheng Zhang ; Ling Li ; Xiaoping Xue ; Ping ZhuSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- pathogénicité : Virus du SRAS.
- physiologie : Antigènes CD, Cyclophiline A, Effet cytopathogène viral, Protéines nucléocapside, Protéines virales structurales.
- Expression des gènes, Humains, Liaison aux protéines, Lignée cellulaire.
English descriptors
- KwdEn :
- MESH :
- chemical , physiology : Antigens, CD, Cyclophilin A, Nucleocapsid Proteins, Viral Structural Proteins.
- chemical : Basigin.
- pathogenicity : SARS Virus.
- physiology : Cytopathogenic Effect, Viral.
- Cell Line, Gene Expression, Humans, Protein Binding.
Abstract
To identify the function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome (SARS) coronavirus (CoV), we analyzed the protein-protein interaction among HAb18G/CD147, cyclophilin A (CyPA), and SARS-CoV structural proteins by coimmunoprecipitation and surface plasmon resonance analysis. Although none of the SARS-CoV proteins was found to be directly bound to HAb18G/CD147, the nucleocapsid (N) protein of SARS-CoV was bound to CyPA, which interacted with HAb18G/CD147. Further research showed that HAb18G/CD147, a transmembrane molecule, was highly expressed on 293 cells and that CyPA was integrated with SARS-CoV. HAb18G/CD147-antagonistic peptide (AP)-9, an AP of HAb18G/CD147, had a high rate of binding to 293 cells and an inhibitory effect on SARS-CoV. These results show that HAb18G/CD147, mediated by CyPA bound to SARS-CoV N protein, plays a functional role in facilitating invasion of host cells by SARS-CoV. Our findings provide some evidence for the cytologic mechanism of invasion by SARS-CoV and provide a molecular basis for screening anti-SARS drugs.
DOI: 10.1086/427811
PubMed: 15688292
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pubmed:15688292Le document en format XML
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<term>Cell Line</term>
<term>Cyclophilin A (physiology)</term>
<term>Cytopathogenic Effect, Viral (physiology)</term>
<term>Gene Expression</term>
<term>Humans</term>
<term>Nucleocapsid Proteins (physiology)</term>
<term>Protein Binding</term>
<term>SARS Virus (pathogenicity)</term>
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<term>Cyclophiline A (physiologie)</term>
<term>Effet cytopathogène viral (physiologie)</term>
<term>Expression des gènes</term>
<term>Humains</term>
<term>Liaison aux protéines</term>
<term>Lignée cellulaire</term>
<term>Protéines nucléocapside (physiologie)</term>
<term>Protéines virales structurales (physiologie)</term>
<term>Virus du SRAS (pathogénicité)</term>
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<term>Viral Structural Proteins</term>
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<term>Effet cytopathogène viral</term>
<term>Protéines nucléocapside</term>
<term>Protéines virales structurales</term>
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<term>Gene Expression</term>
<term>Humans</term>
<term>Protein Binding</term>
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<front><div type="abstract" xml:lang="en">To identify the function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome (SARS) coronavirus (CoV), we analyzed the protein-protein interaction among HAb18G/CD147, cyclophilin A (CyPA), and SARS-CoV structural proteins by coimmunoprecipitation and surface plasmon resonance analysis. Although none of the SARS-CoV proteins was found to be directly bound to HAb18G/CD147, the nucleocapsid (N) protein of SARS-CoV was bound to CyPA, which interacted with HAb18G/CD147. Further research showed that HAb18G/CD147, a transmembrane molecule, was highly expressed on 293 cells and that CyPA was integrated with SARS-CoV. HAb18G/CD147-antagonistic peptide (AP)-9, an AP of HAb18G/CD147, had a high rate of binding to 293 cells and an inhibitory effect on SARS-CoV. These results show that HAb18G/CD147, mediated by CyPA bound to SARS-CoV N protein, plays a functional role in facilitating invasion of host cells by SARS-CoV. Our findings provide some evidence for the cytologic mechanism of invasion by SARS-CoV and provide a molecular basis for screening anti-SARS drugs.</div>
</front>
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