HLA-A∗0201 T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus nucleocapsid and spike proteins
Identifieur interne : 003E84 ( Main/Curation ); précédent : 003E83; suivant : 003E85HLA-A∗0201 T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus nucleocapsid and spike proteins
Auteurs : Yeou-Ping Tsao ; Jian-Yu Lin [Taïwan] ; Jia-Tsrong Jan [Taïwan] ; Chih-Hsiang Leng [Taïwan] ; Chen-Chung Chu [Taïwan] ; Yuh-Cheng Yang [Taïwan] ; Show-Li Chen [Taïwan]Source :
- Biochemical and Biophysical Research Communications [ 0006-291X ] ; 2006.
Descripteurs français
- KwdFr :
- ADN (immunologie), Agranulocytes (immunologie), Animaux, Antigène HLA-A2 (analyse), Antigènes HLA-A (génétique), Antigènes HLA-A (immunologie), Capside (immunologie), Données de séquences moléculaires, Déterminants antigéniques des lymphocytes T (immunologie), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (immunologie), Humains, Lymphocytes T cytotoxiques (immunologie), Lymphocytes auxiliaires Th2 (immunologie), Oligodésoxyribonucléotides, Peptides (), Peptides (immunologie), Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (immunologie), Protéines nucléocapside (), Protéines nucléocapside (immunologie), Souris, Souris transgéniques, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Vaccins antiviraux (immunologie), Vaccins antiviraux (usage thérapeutique), Virus du SRAS (immunologie).
- MESH :
- analyse : Antigène HLA-A2.
- génétique : Antigènes HLA-A.
- immunologie : ADN, Agranulocytes, Antigènes HLA-A, Capside, Déterminants antigéniques des lymphocytes T, Glycoprotéines membranaires, Lymphocytes T cytotoxiques, Lymphocytes auxiliaires Th2, Peptides, Protéines de l'enveloppe virale, Protéines nucléocapside, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virus du SRAS.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Vaccins antiviraux.
- Animaux, Données de séquences moléculaires, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Humains, Oligodésoxyribonucléotides, Peptides, Protéines de l'enveloppe virale, Protéines nucléocapside, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, Capsid (immunology), DNA (immunology), Epitopes, T-Lymphocyte (immunology), HLA-A Antigens (genetics), HLA-A Antigens (immunology), HLA-A2 Antigen (analysis), Humans, Leukocytes, Mononuclear (immunology), Membrane Glycoproteins (chemistry), Membrane Glycoproteins (immunology), Mice, Mice, Transgenic, Molecular Sequence Data, Nucleocapsid Proteins (chemistry), Nucleocapsid Proteins (immunology), Oligodeoxyribonucleotides, Peptides (chemistry), Peptides (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (immunology), Spike Glycoprotein, Coronavirus, T-Lymphocytes, Cytotoxic (immunology), Th2 Cells (immunology), Viral Envelope Proteins (chemistry), Viral Envelope Proteins (immunology), Viral Vaccines (immunology), Viral Vaccines (therapeutic use).
- MESH :
- chemical , analysis : HLA-A2 Antigen.
- chemical , chemistry : Membrane Glycoproteins, Nucleocapsid Proteins, Peptides, Viral Envelope Proteins.
- chemical , genetics : HLA-A Antigens.
- chemical , immunology : DNA, Epitopes, T-Lymphocyte, HLA-A Antigens, Membrane Glycoproteins, Nucleocapsid Proteins, Peptides, Viral Envelope Proteins, Viral Vaccines.
- drug therapy : Severe Acute Respiratory Syndrome.
- immunology : Capsid, Leukocytes, Mononuclear, SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes, Cytotoxic, Th2 Cells.
- chemical , therapeutic use : Viral Vaccines.
- Animals, Humans, Mice, Mice, Transgenic, Molecular Sequence Data, Oligodeoxyribonucleotides, Spike Glycoprotein, Coronavirus.
Abstract
The immunogenicity of HLA-A∗0201-restricted cytotoxic T lymphocyte (CTL) peptide in severe acute respiratory syndrome coronavirus (SARS-CoV) nuclear capsid (N) and spike (S) proteins was determined by testing the proteins’ ability to elicit a specific cellular immune response after immunization of HLA-A2.1 transgenic mice and in vitro vaccination of HLA-A2.1 positive human peripheral blood mononuclearcytes (PBMCs). First, we screened SARS N and S amino acid sequences for allele-specific motif matching those in human HLA-A2.1 MHC-I molecules. From HLA peptide binding predictions (
Url:
DOI: 10.1016/j.bbrc.2006.03.152
PubMed: 16630549
PubMed Central: 7092919
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PMC:7092919Le document en format XML
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Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Microbiology and Immunology, National Defense Medical Center, Taipei 114</wicri:regionArea><wicri:noRegion>Taipei 114</wicri:noRegion></affiliation></author><author><name sortKey="Jan, Jia Tsrong" sort="Jan, Jia Tsrong" uniqKey="Jan J" first="Jia-Tsrong" last="Jan">Jia-Tsrong Jan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Institute of Preventive Medicine, National Defense Medical Center, Taipei 114, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Preventive Medicine, National Defense Medical Center, Taipei 114</wicri:regionArea><wicri:noRegion>Taipei 114</wicri:noRegion></affiliation></author><author><name sortKey="Leng, Chih Hsiang" sort="Leng, Chih Hsiang" uniqKey="Leng C" first="Chih-Hsiang" last="Leng">Chih-Hsiang Leng</name><affiliation wicri:level="1"><nlm:aff id="aff3">Vaccine Research and Development Center, National Health Research Institutes, Taipei 115, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Vaccine Research and Development Center, National Health Research Institutes, Taipei 115</wicri:regionArea><wicri:noRegion>Taipei 115</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Chen Chung" sort="Chu, Chen Chung" uniqKey="Chu C" first="Chen-Chung" last="Chu">Chen-Chung Chu</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Medical Research, Mackay Memorial Hospital, Taipei 104, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Mackay Memorial Hospital, Taipei 104</wicri:regionArea><wicri:noRegion>Taipei 104</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Yuh Cheng" sort="Yang, Yuh Cheng" uniqKey="Yang Y" first="Yuh-Cheng" last="Yang">Yuh-Cheng Yang</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Medical Research, Mackay Memorial Hospital, Taipei 104, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Medical Research, Mackay Memorial Hospital, Taipei 104</wicri:regionArea><wicri:noRegion>Taipei 104</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Show Li" sort="Chen, Show Li" uniqKey="Chen S" first="Show-Li" last="Chen">Show-Li Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Microbiology and Immunology, National Defense Medical Center, Taipei 114, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Microbiology and Immunology, National Defense Medical Center, Taipei 114</wicri:regionArea><wicri:noRegion>Taipei 114</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 100</wicri:regionArea><wicri:noRegion>Taipei 100</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochemical and Biophysical Research Communications</title><idno type="ISSN">0006-291X</idno><idno type="eISSN">1090-2104</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Capsid (immunology)</term><term>DNA (immunology)</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>HLA-A Antigens (genetics)</term><term>HLA-A Antigens (immunology)</term><term>HLA-A2 Antigen (analysis)</term><term>Humans</term><term>Leukocytes, Mononuclear (immunology)</term><term>Membrane Glycoproteins (chemistry)</term><term>Membrane Glycoproteins (immunology)</term><term>Mice</term><term>Mice, Transgenic</term><term>Molecular Sequence Data</term><term>Nucleocapsid Proteins (chemistry)</term><term>Nucleocapsid Proteins (immunology)</term><term>Oligodeoxyribonucleotides</term><term>Peptides (chemistry)</term><term>Peptides (immunology)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Spike Glycoprotein, Coronavirus</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Th2 Cells (immunology)</term><term>Viral Envelope Proteins (chemistry)</term><term>Viral Envelope Proteins (immunology)</term><term>Viral Vaccines (immunology)</term><term>Viral Vaccines (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN (immunologie)</term><term>Agranulocytes (immunologie)</term><term>Animaux</term><term>Antigène HLA-A2 (analyse)</term><term>Antigènes HLA-A (génétique)</term><term>Antigènes HLA-A (immunologie)</term><term>Capside (immunologie)</term><term>Données de séquences moléculaires</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires ()</term><term>Glycoprotéines membranaires (immunologie)</term><term>Humains</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Oligodésoxyribonucléotides</term><term>Peptides ()</term><term>Peptides (immunologie)</term><term>Protéines de l'enveloppe virale ()</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>Protéines nucléocapside ()</term><term>Protéines nucléocapside (immunologie)</term><term>Souris</term><term>Souris transgéniques</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins antiviraux (usage thérapeutique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>HLA-A2 Antigen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Membrane Glycoproteins</term><term>Nucleocapsid Proteins</term><term>Peptides</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-A Antigens</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>DNA</term><term>Epitopes, T-Lymphocyte</term><term>HLA-A Antigens</term><term>Membrane Glycoproteins</term><term>Nucleocapsid Proteins</term><term>Peptides</term><term>Viral Envelope Proteins</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigène HLA-A2</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA-A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>ADN</term><term>Agranulocytes</term><term>Antigènes HLA-A</term><term>Capside</term><term>Déterminants antigéniques des lymphocytes T</term><term>Glycoprotéines membranaires</term><term>Lymphocytes T cytotoxiques</term><term>Lymphocytes auxiliaires Th2</term><term>Peptides</term><term>Protéines de l'enveloppe virale</term><term>Protéines nucléocapside</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Capsid</term><term>Leukocytes, Mononuclear</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocytes, Cytotoxic</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term><term>Molecular Sequence Data</term><term>Oligodeoxyribonucleotides</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Données de séquences moléculaires</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires</term><term>Humains</term><term>Oligodésoxyribonucléotides</term><term>Peptides</term><term>Protéines de l'enveloppe virale</term><term>Protéines nucléocapside</term><term>Souris</term><term>Souris transgéniques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The immunogenicity of HLA-A<sup>∗</sup>0201-restricted cytotoxic T lymphocyte (CTL) peptide in severe acute respiratory syndrome coronavirus (SARS-CoV) nuclear capsid (N) and spike (S) proteins was determined by testing the proteins’ ability to elicit a specific cellular immune response after immunization of HLA-A2.1 transgenic mice and in vitro vaccination of HLA-A2.1 positive human peripheral blood mononuclearcytes (PBMCs). First, we screened SARS N and S amino acid sequences for allele-specific motif matching those in human HLA-A2.1 MHC-I molecules. From HLA peptide binding predictions (<ext-link ext-link-type="uri" xlink:href="http://thr.cit.nih.gov/molbio/hla_bind/">http://thr.cit.nih.gov/molbio/hla_bind/</ext-link>), ten each potential N- and S-specific HLA-A2.1-binding peptides were synthesized. The high affinity HLA-A2.1 peptides were validated by T2-cell stabilization assays, with immunogenicity assays revealing peptides N223–231, N227–235, and N317–325 to be the first identified HLA-A<sup>∗</sup>0201-restricted CTL epitopes of SARS-CoV N protein. In addition, previous reports identified three HLA-A<sup>∗</sup>0201-restricted CTL epitopes of S protein (S978–986, S1203–1211, and S1167–1175), here we found two novel peptides S787–795 and S1042–1050 as S-specific CTL epitopes. Moreover, our identified N317–325 and S1042–1050 CTL epitopes could induce recall responses when IFN-γ stimulation of blood CD8<sup>+</sup> T-cells revealed significant difference between normal healthy donors and SARS-recovered patients after those PBMCs were in vitro vaccinated with their cognate antigen. Our results would provide a new insight into the development of therapeutic vaccine in SARS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ksiazek, G" uniqKey="Ksiazek G">G. Ksiazek</name></author><author><name sortKey="Endman, D" uniqKey="Endman D">D. Endman</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T. Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S. 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