SARS coronavirus accessory proteins
Identifieur interne : 003609 ( Main/Curation ); précédent : 003608; suivant : 003610SARS coronavirus accessory proteins
Auteurs : Krishna Narayanan ; Cheng Huang ; Shinji MakinoSource :
- Virus Research [ 0168-1702 ] ; 2007.
Descripteurs français
- KwdFr :
- Cadres ouverts de lecture, Humains, Lignée cellulaire, Protéines virales (), Protéines virales (génétique), Protéines virales (métabolisme), Protéines virales non structurales (), Protéines virales non structurales (génétique), Protéines virales non structurales (métabolisme), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- génétique : Protéines virales, Protéines virales non structurales, Virus du SRAS.
- métabolisme : Protéines virales, Protéines virales non structurales, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Cadres ouverts de lecture, Humains, Lignée cellulaire, Protéines virales, Protéines virales non structurales.
English descriptors
- KwdEn :
- Cell Line, Humans, Open Reading Frames, SARS Virus (genetics), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (virology), Viral Nonstructural Proteins (chemistry), Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (metabolism).
- MESH :
- chemical , chemistry : Viral Nonstructural Proteins, Viral Proteins.
- genetics : SARS Virus, Viral Nonstructural Proteins, Viral Proteins.
- metabolism : SARS Virus, Viral Nonstructural Proteins, Viral Proteins.
- virology : Severe Acute Respiratory Syndrome.
- Cell Line, Humans, Open Reading Frames.
Abstract
The emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV) has led to a renewed interest in studying the role of accessory proteins in regulating coronavirus infections in the natural host. A significant body of evidence has accumulated in the area of SARS-CoV and host interactions that indicate that the accessory proteins might play an important role in modulating the host response to virus infection and thereby, contribute to pathogenesis. In this review, we have compiled the current knowledge about SARS-CoV accessory proteins, obtained from studies in cell culture systems, reverse genetics and animal models, to shed some light into the possible role of these proteins in the propagation and virulence of SARS-CoV in its natural host. We conclude by providing some questions for future studies that will greatly advance our knowledge about the biological significance and contributions of the accessory proteins in the development of SARS in humans.
Url:
DOI: 10.1016/j.virusres.2007.10.009
PubMed: 18045721
PubMed Central: 2720074
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PMC:2720074Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>The emergence of the severe acute respiratory syndrome coronavirus (SARS-CoV) has led to a renewed interest in studying the role of accessory proteins in regulating coronavirus infections in the natural host. A significant body of evidence has accumulated in the area of SARS-CoV and host interactions that indicate that the accessory proteins might play an important role in modulating the host response to virus infection and thereby, contribute to pathogenesis. In this review, we have compiled the current knowledge about SARS-CoV accessory proteins, obtained from studies in cell culture systems, reverse genetics and animal models, to shed some light into the possible role of these proteins in the propagation and virulence of SARS-CoV in its natural host. We conclude by providing some questions for future studies that will greatly advance our knowledge about the biological significance and contributions of the accessory proteins in the development of SARS in humans.</p>
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</TEI>
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