Investigation of immunogenic T-cell epitopes in SARS virus nucleocapsid protein and their role in the prevention and treatment of SARS infection.
Identifieur interne : 003084 ( Main/Curation ); précédent : 003083; suivant : 003085Investigation of immunogenic T-cell epitopes in SARS virus nucleocapsid protein and their role in the prevention and treatment of SARS infection.
Auteurs : Y K Cheung [Hong Kong] ; S C S. Cheng ; F W Y. Sin ; K T Chan ; Y. XieSource :
- Hong Kong medical journal = Xianggang yi xue za zhi [ 1024-2708 ] ; 2008.
Descripteurs français
- KwdFr :
- ADN viral (immunologie), ADN viral (métabolisme), Animaux, Antigène HLA-A2 (immunologie), Antigènes HLA-A (immunologie), Attribution aléatoire, Déterminants antigéniques des lymphocytes T (immunologie), Humains, Lymphocytes T cytotoxiques (immunologie), Modèles animaux de maladie humaine, Probabilité, Protéines nucléocapside (immunologie), Sensibilité et spécificité, Souris, Souris transgéniques, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Vaccins antiviraux (immunologie), Vaccins antiviraux (pharmacologie), Vaccins à ADN (immunologie), Virus du SRAS (immunologie).
- MESH :
- immunologie : ADN viral, Antigène HLA-A2, Antigènes HLA-A, Déterminants antigéniques des lymphocytes T, Lymphocytes T cytotoxiques, Protéines nucléocapside, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Vaccins à ADN, Virus du SRAS.
- métabolisme : ADN viral.
- pharmacologie : Vaccins antiviraux.
- Animaux, Attribution aléatoire, Humains, Modèles animaux de maladie humaine, Probabilité, Sensibilité et spécificité, Souris, Souris transgéniques, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Animals, DNA, Viral (immunology), DNA, Viral (metabolism), Disease Models, Animal, Epitopes, T-Lymphocyte (immunology), HLA-A Antigens (immunology), HLA-A2 Antigen (immunology), Humans, Mice, Mice, Transgenic, Nucleocapsid Proteins (immunology), Probability, Random Allocation, SARS Virus (immunology), Sensitivity and Specificity, Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Severe Acute Respiratory Syndrome (therapy), T-Lymphocytes, Cytotoxic (immunology), Vaccines, DNA (immunology), Viral Vaccines (immunology), Viral Vaccines (pharmacology).
- MESH :
- chemical , immunology : DNA, Viral, Epitopes, T-Lymphocyte, HLA-A Antigens, HLA-A2 Antigen, Nucleocapsid Proteins, Vaccines, DNA, Viral Vaccines.
- chemical , metabolism : DNA, Viral.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes, Cytotoxic.
- chemical , pharmacology : Viral Vaccines.
- prevention & control : Severe Acute Respiratory Syndrome.
- therapy : Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Humans, Mice, Mice, Transgenic, Probability, Random Allocation, Sensitivity and Specificity.
Abstract
1. A novel HLA-A2.1-specific SARS coronavirus (SARS-CoV) nucleocapsid (N) protein epitope (N220-N228 LALLLLDRL) able to activate cytotoxic T cells in vitro has been identified. 2. When used with a single-chain-trimer system, the SARS-CoV N protein epitope (N220-N228 LALLLLDRL) can stimulate a cytotoxic T-cell response against N-protein expressing cells in the HLA-A2.1K(b) transgenic mouse model.
PubMed: 18708671
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pubmed:18708671Le document en format XML
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Sin</name></author><author><name sortKey="Chan, K T" sort="Chan, K T" uniqKey="Chan K" first="K T" last="Chan">K T Chan</name></author><author><name sortKey="Xie, Y" sort="Xie, Y" uniqKey="Xie Y" first="Y" last="Xie">Y. 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Cheng</name></author><author><name sortKey="Sin, F W Y" sort="Sin, F W Y" uniqKey="Sin F" first="F W Y" last="Sin">F W Y. Sin</name></author><author><name sortKey="Chan, K T" sort="Chan, K T" uniqKey="Chan K" first="K T" last="Chan">K T Chan</name></author><author><name sortKey="Xie, Y" sort="Xie, Y" uniqKey="Xie Y" first="Y" last="Xie">Y. Xie</name></author></analytic><series><title level="j">Hong Kong medical journal = Xianggang yi xue za zhi</title><idno type="ISSN">1024-2708</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>DNA, Viral (immunology)</term><term>DNA, Viral (metabolism)</term><term>Disease Models, Animal</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>HLA-A Antigens (immunology)</term><term>HLA-A2 Antigen (immunology)</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term><term>Nucleocapsid Proteins (immunology)</term><term>Probability</term><term>Random Allocation</term><term>SARS Virus (immunology)</term><term>Sensitivity and Specificity</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Severe Acute Respiratory Syndrome (therapy)</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Vaccines, DNA (immunology)</term><term>Viral Vaccines (immunology)</term><term>Viral Vaccines (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (immunologie)</term><term>ADN viral (métabolisme)</term><term>Animaux</term><term>Antigène HLA-A2 (immunologie)</term><term>Antigènes HLA-A (immunologie)</term><term>Attribution aléatoire</term><term>Déterminants antigéniques des lymphocytes T (immunologie)</term><term>Humains</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Modèles animaux de maladie humaine</term><term>Probabilité</term><term>Protéines nucléocapside (immunologie)</term><term>Sensibilité et spécificité</term><term>Souris</term><term>Souris transgéniques</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins antiviraux (pharmacologie)</term><term>Vaccins à ADN (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>DNA, Viral</term><term>Epitopes, T-Lymphocyte</term><term>HLA-A Antigens</term><term>HLA-A2 Antigen</term><term>Nucleocapsid Proteins</term><term>Vaccines, DNA</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA, Viral</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>ADN viral</term><term>Antigène HLA-A2</term><term>Antigènes HLA-A</term><term>Déterminants antigéniques des lymphocytes T</term><term>Lymphocytes T cytotoxiques</term><term>Protéines nucléocapside</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Vaccins à ADN</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ADN viral</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term><term>Probability</term><term>Random Allocation</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attribution aléatoire</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Probabilité</term><term>Sensibilité et spécificité</term><term>Souris</term><term>Souris transgéniques</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. A novel HLA-A2.1-specific SARS coronavirus (SARS-CoV) nucleocapsid (N) protein epitope (N220-N228 LALLLLDRL) able to activate cytotoxic T cells in vitro has been identified. 2. When used with a single-chain-trimer system, the SARS-CoV N protein epitope (N220-N228 LALLLLDRL) can stimulate a cytotoxic T-cell response against N-protein expressing cells in the HLA-A2.1K(b) transgenic mouse model.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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