SrasV1, Main, Curation, bibRecord, 003068

Novel Hypoglycemic Dihydropyridones Serendipitously Discovered from O-versus C-Alkylation in The Synthesis of VMAT2 Antagonists

Identifieur interne : 003068 ( Main/Curation ); précédent : 003067; suivant : 003069

Novel Hypoglycemic Dihydropyridones Serendipitously Discovered from O-versus C-Alkylation in The Synthesis of VMAT2 Antagonists

Auteurs : Yuli Xie [États-Unis] ; Anthony Raffo [États-Unis] ; Masanori Ichise [États-Unis] ; Shixian Deng [États-Unis] ; Paul E. Harris [États-Unis] ; Donald W. Landry [États-Unis]

Source :

Bioorganic & medicinal chemistry letters [ 0960-894X ] ; 2008.

RBID : PMC:3632391

Abstract

Vesicular monoamine transporter type 2 (VMAT2) is a newly emerging target for both diagnostic and therapeutic applications in diabetes mellitus. In pursuit of novel VMAT2 antagonists, we identified a potent hypoglycemic agent with a novel dihydropyridone scaffold. Several analogs were designed and synthesized. A preliminary structure activity relationship (SARs) showed that the dihydropyridone scaffold is required for the activity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632391

DOI: 10.1016/j.bmcl.2008.07.129
PubMed: 18752945
PubMed Central: 3632391

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PMC:3632391

Le document en format XML

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Novel Hypoglycemic Dihydropyridones Serendipitously Discovered from O-versus C-Alkylation in The Synthesis of VMAT2 Antagonists

Novel Hypoglycemic Dihydropyridones Serendipitously Discovered from O-versus C-Alkylation in The Synthesis of VMAT2 Antagonists

Source :

Abstract

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