Effect of sialodacryoadenitis virus infection on axonal regeneration
Identifieur interne : 002297 ( Main/Curation ); précédent : 002296; suivant : 002298Effect of sialodacryoadenitis virus infection on axonal regeneration
Auteurs : Vivian M. Yu [États-Unis] ; Susan E. Mackinnon [États-Unis] ; Daniel A. Hunter [États-Unis] ; Michael J. Brenner [États-Unis]Source :
- Microsurgery [ 0738-1085 ] ; 2011-09.
English descriptors
- Teeft :
- Active sdav infection, Axonal, Axonal regeneration, Bers, Control animals, Control vehicle, Experimental animals, Functional assessment, Functional recovery, Healthy animals, Hindlimb, Hindlimb function, Histomorphometric data, Historical controls, Inert vehicle, Infection, Mackinnon, Male lewis rats, Microsurgery, Morphometric analysis, Morphometry software, Multiple sclerosis, Muscle nerve, Nerve, Nerve density, Nerve regeneration, Nerve transaction, Neural area, Neural tissue, Neurosci, Neurosci lett, Optimal timing, Percent nerve, Peripheral nerve, Peripheral nerve injury, Peripheral nerve regeneration, Plast reconstr surg, Positive effect, Print length factor, Rat, Reconstr microsurg, Regeneration, Respiratory syndrome, Scant nerve, Sciatic nerve, Sdav, Sdav infection, Sdav outbreak, Sialodacryoadenitis virus, Southern illinois university school, Statistical analysis, Surgical procedures, Tibial, Tibial nerve, Tibial nerves, Time point, Total number, Track analysis, Track data, Viral, Viral infection, Viral model, Wallerian degeneration, Washington university, Weight loss.
Abstract
The effect of sialodacryoadenitis virus (SDAV) infection on axonal regeneration and functional recovery was investigated in male Lewis rats. Animals underwent unilateral tibial nerve transection, immediate repair, and treatment with either FK506 (treated) or control vehicle (untreated). Serial walking track analyses were performed to assess functional recovery. Nerves were harvested for morphometric analysis on postoperative day 18 after an SDAV outbreak occurred that affected the 12 experimental animals. Histomorphometry and walking track data were compared against 36 historical controls. Rats infected with SDAV demonstrated severely impaired axonal regeneration and diminished functional recovery. Total fiber counts, nerve density, and percent neural tissue were all significantly reduced in infected animals (P < 0.05). Active SDAV infection severely impaired nerve regeneration and negated the positive effect of FK506 on nerve regeneration in rats. Immunosuppressive risks must be weighed carefully against the potential neuroregenerative benefits in the treatment of peripheral nerve injuries. © 2011 Wiley‐Liss, Inc. Microsurgery, 2011.
Url:
DOI: 10.1002/micr.20914
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Animals underwent unilateral tibial nerve transection, immediate repair, and treatment with either FK506 (treated) or control vehicle (untreated). Serial walking track analyses were performed to assess functional recovery. Nerves were harvested for morphometric analysis on postoperative day 18 after an SDAV outbreak occurred that affected the 12 experimental animals. Histomorphometry and walking track data were compared against 36 historical controls. Rats infected with SDAV demonstrated severely impaired axonal regeneration and diminished functional recovery. Total fiber counts, nerve density, and percent neural tissue were all significantly reduced in infected animals (P < 0.05). Active SDAV infection severely impaired nerve regeneration and negated the positive effect of FK506 on nerve regeneration in rats. Immunosuppressive risks must be weighed carefully against the potential neuroregenerative benefits in the treatment of peripheral nerve injuries. © 2011 Wiley‐Liss, Inc. Microsurgery, 2011.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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