Assembling an ion channel: ORF 3a from SARS-CoV.
Identifieur interne : 001987 ( Main/Curation ); précédent : 001986; suivant : 001988Assembling an ion channel: ORF 3a from SARS-CoV.
Auteurs : Tze-Hsiang Chien [Taïwan] ; Ya-Ling Chiang ; Chin-Pei Chen ; Petra Henklein ; Karen H Nel ; Ing-Shouh Hwang ; Dieter Willbold ; Wolfgang B. FischerSource :
- Biopolymers [ 1097-0282 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Double couche lipidique.
- Canaux ioniques, Séquence d'acides aminés, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Lipid Bilayers.
- chemical : Ion Channels.
- Amino Acid Sequence, SARS Virus.
Abstract
Protein 3a is a 274 amino acid polytopic channel protein with three putative transmembrane domains (TMDs) encoded by severe acute respiratory syndrome corona virus (SARS-CoV). Synthetic peptides corresponding to each of its three individual transmembrane domains (TMDs) are reconstituted into artificial lipid bilayers. Only TMD2 and TMD3 induce channel activity. Reconstitution of the peptides as TMD1 + TMD3 as well as TMD2 + TMD3 in a 1 : 1 mixture induces membrane activity for both mixtures. In a 1 : 1 : 1 mixture, channel like behavior is almost restored. Expression of full length 3a and reconstitution into artificial lipid bilayers reveal a weak cation selective (PK ≈ 2 PCl ) rectifying channel. In the presence of nonphysiological concentration of Ca-ions the channel develops channel activity.
DOI: 10.1002/bip.22230
PubMed: 23483519
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001242
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001242
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001225
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002629
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002629
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002629
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001997
Links to Exploration step
pubmed:23483519Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assembling an ion channel: ORF 3a from SARS-CoV.</title>
<author><name sortKey="Chien, Tze Hsiang" sort="Chien, Tze Hsiang" uniqKey="Chien T" first="Tze-Hsiang" last="Chien">Tze-Hsiang Chien</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biophotonics, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, 112, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biophotonics, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, 112</wicri:regionArea>
<wicri:noRegion>112</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chiang, Ya Ling" sort="Chiang, Ya Ling" uniqKey="Chiang Y" first="Ya-Ling" last="Chiang">Ya-Ling Chiang</name>
</author>
<author><name sortKey="Chen, Chin Pei" sort="Chen, Chin Pei" uniqKey="Chen C" first="Chin-Pei" last="Chen">Chin-Pei Chen</name>
</author>
<author><name sortKey="Henklein, Petra" sort="Henklein, Petra" uniqKey="Henklein P" first="Petra" last="Henklein">Petra Henklein</name>
</author>
<author><name sortKey="H Nel, Karen" sort="H Nel, Karen" uniqKey="H Nel K" first="Karen" last="H Nel">Karen H Nel</name>
</author>
<author><name sortKey="Hwang, Ing Shouh" sort="Hwang, Ing Shouh" uniqKey="Hwang I" first="Ing-Shouh" last="Hwang">Ing-Shouh Hwang</name>
</author>
<author><name sortKey="Willbold, Dieter" sort="Willbold, Dieter" uniqKey="Willbold D" first="Dieter" last="Willbold">Dieter Willbold</name>
</author>
<author><name sortKey="Fischer, Wolfgang B" sort="Fischer, Wolfgang B" uniqKey="Fischer W" first="Wolfgang B" last="Fischer">Wolfgang B. Fischer</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23483519</idno>
<idno type="pmid">23483519</idno>
<idno type="doi">10.1002/bip.22230</idno>
<idno type="wicri:Area/PubMed/Corpus">001242</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001242</idno>
<idno type="wicri:Area/PubMed/Curation">001242</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001242</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001225</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001225</idno>
<idno type="wicri:Area/Ncbi/Merge">002629</idno>
<idno type="wicri:Area/Ncbi/Curation">002629</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002629</idno>
<idno type="wicri:Area/Main/Merge">001997</idno>
<idno type="wicri:Area/Main/Curation">001987</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Assembling an ion channel: ORF 3a from SARS-CoV.</title>
<author><name sortKey="Chien, Tze Hsiang" sort="Chien, Tze Hsiang" uniqKey="Chien T" first="Tze-Hsiang" last="Chien">Tze-Hsiang Chien</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Biophotonics, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, 112, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Institute of Biophotonics, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, 112</wicri:regionArea>
<wicri:noRegion>112</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chiang, Ya Ling" sort="Chiang, Ya Ling" uniqKey="Chiang Y" first="Ya-Ling" last="Chiang">Ya-Ling Chiang</name>
</author>
<author><name sortKey="Chen, Chin Pei" sort="Chen, Chin Pei" uniqKey="Chen C" first="Chin-Pei" last="Chen">Chin-Pei Chen</name>
</author>
<author><name sortKey="Henklein, Petra" sort="Henklein, Petra" uniqKey="Henklein P" first="Petra" last="Henklein">Petra Henklein</name>
</author>
<author><name sortKey="H Nel, Karen" sort="H Nel, Karen" uniqKey="H Nel K" first="Karen" last="H Nel">Karen H Nel</name>
</author>
<author><name sortKey="Hwang, Ing Shouh" sort="Hwang, Ing Shouh" uniqKey="Hwang I" first="Ing-Shouh" last="Hwang">Ing-Shouh Hwang</name>
</author>
<author><name sortKey="Willbold, Dieter" sort="Willbold, Dieter" uniqKey="Willbold D" first="Dieter" last="Willbold">Dieter Willbold</name>
</author>
<author><name sortKey="Fischer, Wolfgang B" sort="Fischer, Wolfgang B" uniqKey="Fischer W" first="Wolfgang B" last="Fischer">Wolfgang B. Fischer</name>
</author>
</analytic>
<series><title level="j">Biopolymers</title>
<idno type="eISSN">1097-0282</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Ion Channels</term>
<term>Lipid Bilayers (metabolism)</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Canaux ioniques</term>
<term>Double couche lipidique (métabolisme)</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lipid Bilayers</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Ion Channels</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Double couche lipidique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Canaux ioniques</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Protein 3a is a 274 amino acid polytopic channel protein with three putative transmembrane domains (TMDs) encoded by severe acute respiratory syndrome corona virus (SARS-CoV). Synthetic peptides corresponding to each of its three individual transmembrane domains (TMDs) are reconstituted into artificial lipid bilayers. Only TMD2 and TMD3 induce channel activity. Reconstitution of the peptides as TMD1 + TMD3 as well as TMD2 + TMD3 in a 1 : 1 mixture induces membrane activity for both mixtures. In a 1 : 1 : 1 mixture, channel like behavior is almost restored. Expression of full length 3a and reconstitution into artificial lipid bilayers reveal a weak cation selective (PK ≈ 2 PCl ) rectifying channel. In the presence of nonphysiological concentration of Ca-ions the channel develops channel activity.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001987 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001987 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Curation |type= RBID |clé= pubmed:23483519 |texte= Assembling an ion channel: ORF 3a from SARS-CoV. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:23483519" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |