Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.
Identifieur interne : 000E17 ( Main/Curation ); précédent : 000E16; suivant : 000E18Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.
Auteurs : Ya-Li Sang ; Wei-Ming Zhang [République populaire de Chine] ; Peng-Cheng Lv ; Hai-Liang Zhu [République populaire de Chine]Source :
- Current topics in medicinal chemistry [ 1873-4294 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Indoles.
- Humains, Polymérisation, Prolifération cellulaire, Tubuline.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Tubulin.
- chemical , pharmacology : Indoles.
- drug effects : Cell Proliferation.
- Humans, Polymerization.
Abstract
Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy. Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest among scientists. This review describes the synthesis, bioactivities and SARs of indole-based agents targeting tubulin polymerization during the past decade.
DOI: 10.2174/1568026616666160530154812
PubMed: 27237326
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pubmed:27237326Le document en format XML
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<author><name sortKey="Zhang, Wei Ming" sort="Zhang, Wei Ming" uniqKey="Zhang W" first="Wei-Ming" last="Zhang">Wei-Ming Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Nanjing Institute for the Comprehensive Utilization of Wild Plant, Nanjing 210042, People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
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<country xml:lang="fr">République populaire de Chine</country>
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<country xml:lang="fr">République populaire de Chine</country>
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<series><title level="j">Current topics in medicinal chemistry</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Proliferation (drug effects)</term>
<term>Humans</term>
<term>Indoles (pharmacology)</term>
<term>Polymerization</term>
<term>Tubulin (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term>
<term>Indoles (pharmacologie)</term>
<term>Polymérisation</term>
<term>Prolifération cellulaire ()</term>
<term>Tubuline ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Tubulin</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Indoles</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Indoles</term>
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<term>Polymerization</term>
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<term>Polymérisation</term>
<term>Prolifération cellulaire</term>
<term>Tubuline</term>
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<front><div type="abstract" xml:lang="en">Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy. Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest among scientists. This review describes the synthesis, bioactivities and SARs of indole-based agents targeting tubulin polymerization during the past decade.</div>
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