Significance of Variation Within HIV, EBV, and KSHV Subtypes
Identifieur interne : 001575 ( Istex/Curation ); précédent : 001574; suivant : 001576Significance of Variation Within HIV, EBV, and KSHV Subtypes
Auteurs : Justin Stebbing ; Tom Powles ; Mark Nelson [Royaume-Uni] ; Mark Bower [Royaume-Uni]Source :
- Journal of the International Association of Physicians in AIDS Care [ 1545-1097 ] ; 2006-09.
English descriptors
- Teeft :
- Active antiretroviral therapy, Amino acid, Antiretroviral, Antiretroviral therapy, Assoc, Assoc physicians aids care, Central africa, Chimpanzee, Clade, Clin virol, Clinical significance, Crfs, Defic syndr, Democratic republic, Drug resistance, Drug users, Epitope, Epstein barr virus, Fulham road, Genetic diversity, Genome, Global scale, Haart, Herpesvirus, Human herpesvirus, Human immunodeficiency virus type, Immune, Immune control, Immune response, Immune responses, Immune system, Immunodeficiency, Important cause, Infection, Intersubtype, Intravenous drug users, Kaposi herpesvirus, Korber, Kshv, Kshv subtypes, Large number, Major histocompatibility, Many studies, Mark bower, Molecular epidemiology, Molecular piracy, Mutation, Natl, Natl cancer inst monogr, Natural host, Nuclear antigen, Proc natl acad, Protease, Recombinant, Recombinant form, Recombinant forms, Recombinant viruses, Recombination, Replication, Retrovirus, Second virus, Selective pressure, Sequence analysis, Sexual contact, Simian immunodeficiency virus, Sooty mangabeys, Stark contrast, Stebbing, Subtype, Subtypes, Superinfection, Therapeutic strategies, Transcriptase, Treatment failure, Vaccine, Vaccine development, Viral, Viral diversity, Viral replication, Virol, Virus, Virus levels, West africa, Westminster hospital.
Abstract
Since their initial transmission to humans, viruses have diversified extensively through recombination and mutation. The presence of intra- and inter-individual viral diversity influences disease progression, drug resistance, and therapy and presumably explains the conflicting results in many studies, including the failure of peptide-based vaccination strategies. Although HIV is a small RNA virus, coin-fection with large DNA viruses, notably the oncogenicγherpesviridae human herpesvirus-8 and Epstein Barr virus, is common. This coinfection occurs secondary to immunosuppression and shared transmission routes with high-risk predisposing behavior. In addition, all 3 of these viruses can lead to chronic infections, long periods of latency, and reactivation characterized by pain and suffering. The efficient targeting of their genetic diversity represents one of the major challenges in their control, both in prophylactic and therapeutic strategies. An understanding of diversity will help delineate whether population-specific vaccine strategies are necessary.
Url:
DOI: 10.1177/1545109706290171
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The presence of intra- and inter-individual viral diversity influences disease progression, drug resistance, and therapy and presumably explains the conflicting results in many studies, including the failure of peptide-based vaccination strategies. Although HIV is a small RNA virus, coin-fection with large DNA viruses, notably the oncogenicγherpesviridae human herpesvirus-8 and Epstein Barr virus, is common. This coinfection occurs secondary to immunosuppression and shared transmission routes with high-risk predisposing behavior. In addition, all 3 of these viruses can lead to chronic infections, long periods of latency, and reactivation characterized by pain and suffering. The efficient targeting of their genetic diversity represents one of the major challenges in their control, both in prophylactic and therapeutic strategies. 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