Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome
Identifieur interne : 000457 ( Istex/Curation ); précédent : 000456; suivant : 000458Two-Year Prospective Study of the Humoral Immune Response of Patients with Severe Acute Respiratory Syndrome
Auteurs : Wei Liu ; Arnaud Fontanet [France] ; Pan-He Zhang ; Lin Zhan ; Zhong-Tao Xin [République populaire de Chine] ; Laurence Baril [France] ; Fang Tang ; Hui Lv ; Wu-Chun CaoSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2006.
Abstract
In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16
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DOI: 10.1086/500469
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Wei Liu<affiliation><mods:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation>Le document en format XML
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Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2006</date><biblScope unit="vol">193</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="792">792</biblScope><biblScope unit="page" to="795">795</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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