A randomized prospective trial of radiation therapy for AIDS-associated Kaposi's sarcoma
Identifieur interne : 001C58 ( Istex/Corpus ); précédent : 001C57; suivant : 001C59A randomized prospective trial of radiation therapy for AIDS-associated Kaposi's sarcoma
Auteurs : Keith J. Stelzer ; Thomas W. GriffinSource :
- International Journal of Radiation Oncology, Biology, Physics [ 0360-3016 ] ; 1993.
English descriptors
- Teeft :
- Acute toxicity, Aids patients, Anatomical location, Chemotherapy, Complete response, Cosmetic reasons, Crude incidence, Cutaneous, Cutaneous kaposi, Cytotoxic chemotherapy, Epidemic kaposi, Exact test, First manifestation, Good response, High performance status, Higher dose, Higher proportion, Immune deficiency syndrome, Individual lesions, Individual patients, Kaposi, Late toxicity, Lesion, Lesion characteristics, Lesion control, Lesion failure, Lesion size, Median, Median time, Objective response, Oncol, Other sites, Palpable tumor, Partial response, Patient performance status, Proportional differences, Protracted treatment course, Radiation dose, Radiation oncology, Radiation regimens, Radiation therapy, Radiotherapy, Randomized study, Regimen, Sarcoma, Single dose, Skin erythema, Toxicity, Treatment intent, Tumor control, Tumor response.
Abstract
Abstract: Purpose: The optimal dose of radiation in the treatment of AIDS-associated Kaposi's sarcoma has been controversial based on previous nonrandomized retrospective studies.Methods and Materials: Seventy-one cutaneous AIDS-associated Kaposi's sarcoma lesions were randomly assigned to 1 of 3 radiation dose regimens-8 Gy in 1 fraction, 20 Gy in 10 fraction. and 40 Gy in 20 fractions. Lesions were measured prior to and following treatment. Complete resolution of palpable tumor was considered a complete response, regardless of residual purple pigmentation. Reduction in palpable tumor to less than 50% of pretreatment area was considered an objective response. Less than 50% reduction in tumor size was considered a nonresponse.Results: Complete response was higher (p = .04) with 40 Gy (83%) and 20 Gy (79%) than with 8 Gy (50%). Absence of residual purple pigmentation was greater (p = .005) with 40 Gy (43%) than with 20 Gy (8%) or 8 Gy (8%). Lesion failure was lower (p = .03) with 40 Gy (52%) than with 20 Gy (67%) or 8 Gy (88%). Median time to failure was 43 weeks with 40 Gy, 26 weeks with 20 Gy, and 13 weeks with 8 Gy (p = .003).Conclusion: Fractionated radiotherapy to higher total doses resulted in improved response and control of cutaneous Kaposi's sarcoma. This dose-dependence should be considered in determining the optimal radiotherapeutic regimen for individual patients treated for epidemic Kaposi's sarcoma.
Url:
DOI: 10.1016/0360-3016(93)90523-X
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: Purpose: The optimal dose of radiation in the treatment of AIDS-associated Kaposi's sarcoma has been controversial based on previous nonrandomized retrospective studies.Methods and Materials: Seventy-one cutaneous AIDS-associated Kaposi's sarcoma lesions were randomly assigned to 1 of 3 radiation dose regimens-8 Gy in 1 fraction, 20 Gy in 10 fraction. and 40 Gy in 20 fractions. Lesions were measured prior to and following treatment. Complete resolution of palpable tumor was considered a complete response, regardless of residual purple pigmentation. Reduction in palpable tumor to less than 50% of pretreatment area was considered an objective response. Less than 50% reduction in tumor size was considered a nonresponse.Results: Complete response was higher (p = .04) with 40 Gy (83%) and 20 Gy (79%) than with 8 Gy (50%). Absence of residual purple pigmentation was greater (p = .005) with 40 Gy (43%) than with 20 Gy (8%) or 8 Gy (8%). Lesion failure was lower (p = .03) with 40 Gy (52%) than with 20 Gy (67%) or 8 Gy (88%). Median time to failure was 43 weeks with 40 Gy, 26 weeks with 20 Gy, and 13 weeks with 8 Gy (p = .003).Conclusion: Fractionated radiotherapy to higher total doses resulted in improved response and control of cutaneous Kaposi's sarcoma. This dose-dependence should be considered in determining the optimal radiotherapeutic regimen for individual patients treated for epidemic Kaposi's sarcoma.</div>
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<abstract>Abstract: Purpose: The optimal dose of radiation in the treatment of AIDS-associated Kaposi's sarcoma has been controversial based on previous nonrandomized retrospective studies.Methods and Materials: Seventy-one cutaneous AIDS-associated Kaposi's sarcoma lesions were randomly assigned to 1 of 3 radiation dose regimens-8 Gy in 1 fraction, 20 Gy in 10 fraction. and 40 Gy in 20 fractions. Lesions were measured prior to and following treatment. Complete resolution of palpable tumor was considered a complete response, regardless of residual purple pigmentation. Reduction in palpable tumor to less than 50% of pretreatment area was considered an objective response. Less than 50% reduction in tumor size was considered a nonresponse.Results: Complete response was higher (p = .04) with 40 Gy (83%) and 20 Gy (79%) than with 8 Gy (50%). Absence of residual purple pigmentation was greater (p = .005) with 40 Gy (43%) than with 20 Gy (8%) or 8 Gy (8%). Lesion failure was lower (p = .03) with 40 Gy (52%) than with 20 Gy (67%) or 8 Gy (88%). Median time to failure was 43 weeks with 40 Gy, 26 weeks with 20 Gy, and 13 weeks with 8 Gy (p = .003).Conclusion: Fractionated radiotherapy to higher total doses resulted in improved response and control of cutaneous Kaposi's sarcoma. This dose-dependence should be considered in determining the optimal radiotherapeutic regimen for individual patients treated for epidemic Kaposi's sarcoma.</abstract>
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<abstract xml:lang="en"><p>Abstract: Purpose: The optimal dose of radiation in the treatment of AIDS-associated Kaposi's sarcoma has been controversial based on previous nonrandomized retrospective studies.Methods and Materials: Seventy-one cutaneous AIDS-associated Kaposi's sarcoma lesions were randomly assigned to 1 of 3 radiation dose regimens-8 Gy in 1 fraction, 20 Gy in 10 fraction. and 40 Gy in 20 fractions. Lesions were measured prior to and following treatment. Complete resolution of palpable tumor was considered a complete response, regardless of residual purple pigmentation. Reduction in palpable tumor to less than 50% of pretreatment area was considered an objective response. Less than 50% reduction in tumor size was considered a nonresponse.Results: Complete response was higher (p = .04) with 40 Gy (83%) and 20 Gy (79%) than with 8 Gy (50%). Absence of residual purple pigmentation was greater (p = .005) with 40 Gy (43%) than with 20 Gy (8%) or 8 Gy (8%). Lesion failure was lower (p = .03) with 40 Gy (52%) than with 20 Gy (67%) or 8 Gy (88%). Median time to failure was 43 weeks with 40 Gy, 26 weeks with 20 Gy, and 13 weeks with 8 Gy (p = .003).Conclusion: Fractionated radiotherapy to higher total doses resulted in improved response and control of cutaneous Kaposi's sarcoma. This dose-dependence should be considered in determining the optimal radiotherapeutic regimen for individual patients treated for epidemic Kaposi's sarcoma.</p>
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</math>
: Seventy-one cutaneous AIDS-associated Kaposi's sarcoma lesions were randomly assigned to 1 of 3 radiation dose regimens-8 Gy in 1 fraction, 20 Gy in 10 fraction. and 40 Gy in 20 fractions. Lesions were measured prior to and following treatment. Complete resolution of palpable tumor was considered a complete response, regardless of residual purple pigmentation. Reduction in palpable tumor to less than 50% of pretreatment area was considered an objective response. Less than 50% reduction in tumor size was considered a nonresponse.</ce:simple-para>
<ce:simple-para><math altimg="si3.gif"><rm><unl type="bar">Results</unl>
</rm>
</math>
: Complete response was higher (<ce:italic>p</ce:italic>
= .04) with 40 Gy (83%) and 20 Gy (79%) than with 8 Gy (50%). Absence of residual purple pigmentation was greater (<ce:italic>p</ce:italic>
= .005) with 40 Gy (43%) than with 20 Gy (8%) or 8 Gy (8%). Lesion failure was lower (<ce:italic>p</ce:italic>
= .03) with 40 Gy (52%) than with 20 Gy (67%) or 8 Gy (88%). Median time to failure was 43 weeks with 40 Gy, 26 weeks with 20 Gy, and 13 weeks with 8 Gy (<ce:italic>p</ce:italic>
= .003).</ce:simple-para>
<ce:simple-para><math altimg="si4.gif"><rm><unl type="bar">Conclusion</unl>
</rm>
</math>
: Fractionated radiotherapy to higher total doses resulted in improved response and control of cutaneous Kaposi's sarcoma. This dose-dependence should be considered in determining the optimal radiotherapeutic regimen for individual patients treated for epidemic Kaposi's sarcoma.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:keywords><ce:section-title>Keywords</ce:section-title>
<ce:keyword><ce:text>Kaposi's sarcoma</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Radiation therapy</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Acquired immune deficiency syndrome</ce:text>
</ce:keyword>
</ce:keywords>
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<mods version="3.6"><titleInfo><title>A randomized prospective trial of radiation therapy for AIDS-associated Kaposi's sarcoma</title>
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<titleInfo type="alternative" contentType="CDATA"><title>A randomized prospective trial of radiation therapy for AIDS-associated Kaposi's sarcoma</title>
</titleInfo>
<name type="personal"><namePart type="given">Keith J.</namePart>
<namePart type="family">Stelzer</namePart>
<namePart type="termsOfAddress">M.D., Ph.D.</namePart>
<affiliation>Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA 98195, USA</affiliation>
<description>Reprint requests to: Keith J. Stelzer, M.D., Ph.D., Dept. of Radiation Oncology, University of Washington Medical Center, 1959 Pacific St., RC-08, Seattle, WA 98195.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Thomas W.</namePart>
<namePart type="family">Griffin</namePart>
<namePart type="termsOfAddress">M.D.</namePart>
<affiliation>Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA 98195, USA</affiliation>
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<dateIssued encoding="w3cdtf">1993</dateIssued>
<copyrightDate encoding="w3cdtf">1993</copyrightDate>
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<abstract lang="en">Abstract: Purpose: The optimal dose of radiation in the treatment of AIDS-associated Kaposi's sarcoma has been controversial based on previous nonrandomized retrospective studies.Methods and Materials: Seventy-one cutaneous AIDS-associated Kaposi's sarcoma lesions were randomly assigned to 1 of 3 radiation dose regimens-8 Gy in 1 fraction, 20 Gy in 10 fraction. and 40 Gy in 20 fractions. Lesions were measured prior to and following treatment. Complete resolution of palpable tumor was considered a complete response, regardless of residual purple pigmentation. Reduction in palpable tumor to less than 50% of pretreatment area was considered an objective response. Less than 50% reduction in tumor size was considered a nonresponse.Results: Complete response was higher (p = .04) with 40 Gy (83%) and 20 Gy (79%) than with 8 Gy (50%). Absence of residual purple pigmentation was greater (p = .005) with 40 Gy (43%) than with 20 Gy (8%) or 8 Gy (8%). Lesion failure was lower (p = .03) with 40 Gy (52%) than with 20 Gy (67%) or 8 Gy (88%). Median time to failure was 43 weeks with 40 Gy, 26 weeks with 20 Gy, and 13 weeks with 8 Gy (p = .003).Conclusion: Fractionated radiotherapy to higher total doses resulted in improved response and control of cutaneous Kaposi's sarcoma. This dose-dependence should be considered in determining the optimal radiotherapeutic regimen for individual patients treated for epidemic Kaposi's sarcoma.</abstract>
<note>Presented at the 75th Annual Meeting of the American Radium Society, Aruba, April 27, 1993.</note>
<note type="content">Section title: Clinical original contribution</note>
<subject><genre>Keywords</genre>
<topic>Kaposi's sarcoma</topic>
<topic>Radiation therapy</topic>
<topic>Acquired immune deficiency syndrome</topic>
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<relatedItem type="host"><titleInfo><title>International Journal of Radiation Oncology, Biology, Physics</title>
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<dateIssued encoding="w3cdtf">1993</dateIssued>
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<identifier type="ISSN">0360-3016</identifier>
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<part><date>1993</date>
<detail type="volume"><number>27</number>
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<detail type="issue"><number>5</number>
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