The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks
Identifieur interne : 001A81 ( Istex/Corpus ); précédent : 001A80; suivant : 001A82The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks
Auteurs : Nicol Patroniti ; Alberto Zangrillo ; Federico Pappalardo ; Adriano Peris ; Giovanni Cianchi ; Antonio Braschi ; Giorgio A. Iotti ; Antonio Arcadipane ; Giovanna Panarello ; V. Marco Ranieri ; Pierpaolo Terragni ; Massimo Antonelli ; Luciano Gattinoni ; Fabrizio Oleari ; Antonio PesentiSource :
- Intensive Care Medicine [ 0342-4642 ] ; 2011-09-01.
English descriptors
Abstract
Abstract: Purpose: In view of the expected 2009 influenza A(H1N1) pandemic, the Italian Health Authorities set up a national referral network of selected intensive care units (ICU) able to provide advanced respiratory care up to extracorporeal membrane oxygenation (ECMO) for patients with acute respiratory distress syndrome (ARDS). We describe the organization and results of the network, known as ECMOnet. Methods: The network consisted of 14 ICUs with ECMO capability and a national call center. The network was set up to centralize all severe patients to the ECMOnet centers assuring safe transfer. An ad hoc committee defined criteria for both patient transfer and ECMO institutions. Results: Between August 2009 and March 2010, 153 critically ill patients (53% referred from other hospitals) were admitted to the ECMOnet ICU with suspected H1N1. Sixty patients (48 of the referred patients, 49 with confirmed H1N1 diagnosis) received ECMO according to ECMOnet criteria. All referred patients were successfully transferred to the ECMOnet centers; 28 were transferred while on ECMO. Survival to hospital discharge in patients receiving ECMO was 68%. Survival of patients receiving ECMO within 7 days from the onset of mechanical ventilation was 77%. The length of mechanical ventilation prior to ECMO was an independent predictor of mortality. Conclusions: A network organization based on preemptive patient centralization allowed a high survival rate and provided effective and safe referral of patients with severe H1N1-suspected ARDS.
Url:
DOI: 10.1007/s00134-011-2301-6
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ISTEX:953DF1A32E5323ABDD176BA1641D15EDCC465556Le document en format XML
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Marco Ranieri</name><affiliation><mods:affiliation>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</mods:affiliation></affiliation></author><author><name sortKey="Terragni, Pierpaolo" sort="Terragni, Pierpaolo" uniqKey="Terragni P" first="Pierpaolo" last="Terragni">Pierpaolo Terragni</name><affiliation><mods:affiliation>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</mods:affiliation></affiliation></author><author><name sortKey="Antonelli, Massimo" sort="Antonelli, Massimo" uniqKey="Antonelli M" first="Massimo" last="Antonelli">Massimo Antonelli</name><affiliation><mods:affiliation>Dipartimento di Terapia Intensiva e Anestesiologia, Università Cattolica del Sacro Cuore, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gattinoni, Luciano" sort="Gattinoni, Luciano" uniqKey="Gattinoni L" first="Luciano" last="Gattinoni">Luciano Gattinoni</name><affiliation><mods:affiliation>Dipartimento di Anestesiologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Oleari, Fabrizio" sort="Oleari, Fabrizio" uniqKey="Oleari F" first="Fabrizio" last="Oleari">Fabrizio Oleari</name><affiliation><mods:affiliation>Dipartimento della Prevenzione e Comunicazione, Ministero della Salute, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pesenti, Antonio" sort="Pesenti, Antonio" uniqKey="Pesenti A" first="Antonio" last="Pesenti">Antonio Pesenti</name><affiliation><mods:affiliation>Department of Experimental Medicine, University of Milan-Bicocca, Via Pergolesi 33, 20052, Monza, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:953DF1A32E5323ABDD176BA1641D15EDCC465556</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1007/s00134-011-2301-6</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-DL1SGRR4-0/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001A81</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks</title><author><name sortKey="Patroniti, Nicol" sort="Patroniti, Nicol" uniqKey="Patroniti N" first="Nicol" last="Patroniti">Nicol Patroniti</name><affiliation><mods:affiliation>Department of Experimental Medicine, University of Milan-Bicocca, Via Pergolesi 33, 20052, Monza, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Via Pergolesi 33, 20052, Monza, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: nicolo.patroniti@unimib.it</mods:affiliation></affiliation></author><author><name sortKey="Zangrillo, Alberto" sort="Zangrillo, Alberto" uniqKey="Zangrillo A" first="Alberto" last="Zangrillo">Alberto Zangrillo</name><affiliation><mods:affiliation>Dipartimento di Anestesia Cardiaca e Terapia Intensiva, Università Vita-Salute San Raffaele, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pappalardo, Federico" sort="Pappalardo, Federico" uniqKey="Pappalardo F" first="Federico" last="Pappalardo">Federico Pappalardo</name><affiliation><mods:affiliation>Dipartimento di Anestesia Cardiaca e Terapia Intensiva, Università Vita-Salute San Raffaele, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Peris, Adriano" sort="Peris, Adriano" uniqKey="Peris A" first="Adriano" last="Peris">Adriano Peris</name><affiliation><mods:affiliation>Anestesia e Rianimazione di Emergenza, Dipartimento DAI e Medicina e Chirurgia Generale e d’Urgenza, Azienda Ospedaliero Universitaria Careggi, Florence, Italy</mods:affiliation></affiliation></author><author><name sortKey="Cianchi, Giovanni" sort="Cianchi, Giovanni" uniqKey="Cianchi G" first="Giovanni" last="Cianchi">Giovanni Cianchi</name><affiliation><mods:affiliation>Anestesia e Rianimazione di Emergenza, Dipartimento DAI e Medicina e Chirurgia Generale e d’Urgenza, Azienda Ospedaliero Universitaria Careggi, Florence, Italy</mods:affiliation></affiliation></author><author><name sortKey="Braschi, Antonio" sort="Braschi, Antonio" uniqKey="Braschi A" first="Antonio" last="Braschi">Antonio Braschi</name><affiliation><mods:affiliation>Dipartimento di Scienze Chirurgiche Rianimatorie-Riabilitative e dei Trapianti d’Organo, Sezione di Anestesia Rianimazione e Terapia Antalgica, Anestesia e Rianimazione I Dipartimento di Emergenza Urgenza, Università degli Studi di Pavia, IRCCS Policlinico San Matteo, Pavia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Iotti, Giorgio A" sort="Iotti, Giorgio A" uniqKey="Iotti G" first="Giorgio A." last="Iotti">Giorgio A. Iotti</name><affiliation><mods:affiliation>Anestesia e Rianimazione II, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy</mods:affiliation></affiliation></author><author><name sortKey="Arcadipane, Antonio" sort="Arcadipane, Antonio" uniqKey="Arcadipane A" first="Antonio" last="Arcadipane">Antonio Arcadipane</name><affiliation><mods:affiliation>Terapia Intensiva, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Palermo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Panarello, Giovanna" sort="Panarello, Giovanna" uniqKey="Panarello G" first="Giovanna" last="Panarello">Giovanna Panarello</name><affiliation><mods:affiliation>Terapia Intensiva, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Palermo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ranieri, V Marco" sort="Ranieri, V Marco" uniqKey="Ranieri V" first="V. Marco" last="Ranieri">V. Marco Ranieri</name><affiliation><mods:affiliation>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</mods:affiliation></affiliation></author><author><name sortKey="Terragni, Pierpaolo" sort="Terragni, Pierpaolo" uniqKey="Terragni P" first="Pierpaolo" last="Terragni">Pierpaolo Terragni</name><affiliation><mods:affiliation>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</mods:affiliation></affiliation></author><author><name sortKey="Antonelli, Massimo" sort="Antonelli, Massimo" uniqKey="Antonelli M" first="Massimo" last="Antonelli">Massimo Antonelli</name><affiliation><mods:affiliation>Dipartimento di Terapia Intensiva e Anestesiologia, Università Cattolica del Sacro Cuore, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gattinoni, Luciano" sort="Gattinoni, Luciano" uniqKey="Gattinoni L" first="Luciano" last="Gattinoni">Luciano Gattinoni</name><affiliation><mods:affiliation>Dipartimento di Anestesiologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Oleari, Fabrizio" sort="Oleari, Fabrizio" uniqKey="Oleari F" first="Fabrizio" last="Oleari">Fabrizio Oleari</name><affiliation><mods:affiliation>Dipartimento della Prevenzione e Comunicazione, Ministero della Salute, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pesenti, Antonio" sort="Pesenti, Antonio" uniqKey="Pesenti A" first="Antonio" last="Pesenti">Antonio Pesenti</name><affiliation><mods:affiliation>Department of Experimental Medicine, University of Milan-Bicocca, Via Pergolesi 33, 20052, Monza, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Intensive Care Medicine</title><title level="j" type="abbrev">Intensive Care Med</title><idno type="ISSN">0342-4642</idno><idno type="eISSN">1432-1238</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2011-09-01">2011-09-01</date><biblScope unit="volume">37</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1447">1447</biblScope><biblScope unit="page" to="1457">1457</biblScope></imprint><idno type="ISSN">0342-4642</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0342-4642</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ARDS</term><term>Extracorporeal membrane oxygenation</term><term>Preparedness plan</term><term>Viral infection</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Purpose: In view of the expected 2009 influenza A(H1N1) pandemic, the Italian Health Authorities set up a national referral network of selected intensive care units (ICU) able to provide advanced respiratory care up to extracorporeal membrane oxygenation (ECMO) for patients with acute respiratory distress syndrome (ARDS). We describe the organization and results of the network, known as ECMOnet. Methods: The network consisted of 14 ICUs with ECMO capability and a national call center. The network was set up to centralize all severe patients to the ECMOnet centers assuring safe transfer. An ad hoc committee defined criteria for both patient transfer and ECMO institutions. Results: Between August 2009 and March 2010, 153 critically ill patients (53% referred from other hospitals) were admitted to the ECMOnet ICU with suspected H1N1. Sixty patients (48 of the referred patients, 49 with confirmed H1N1 diagnosis) received ECMO according to ECMOnet criteria. All referred patients were successfully transferred to the ECMOnet centers; 28 were transferred while on ECMO. Survival to hospital discharge in patients receiving ECMO was 68%. Survival of patients receiving ECMO within 7 days from the onset of mechanical ventilation was 77%. The length of mechanical ventilation prior to ECMO was an independent predictor of mortality. Conclusions: A network organization based on preemptive patient centralization allowed a high survival rate and provided effective and safe referral of patients with severe H1N1-suspected ARDS.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Nicolò Patroniti</name><affiliations><json:string>Department of Experimental Medicine, University of Milan-Bicocca, Via Pergolesi 33, 20052, Monza, Italy</json:string><json:string>Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Via Pergolesi 33, 20052, Monza, Italy</json:string><json:string>E-mail: nicolo.patroniti@unimib.it</json:string></affiliations></json:item><json:item><name>Alberto Zangrillo</name><affiliations><json:string>Dipartimento di Anestesia Cardiaca e Terapia Intensiva, Università Vita-Salute San Raffaele, Milan, Italy</json:string></affiliations></json:item><json:item><name>Federico Pappalardo</name><affiliations><json:string>Dipartimento di Anestesia Cardiaca e Terapia Intensiva, Università Vita-Salute San Raffaele, Milan, Italy</json:string></affiliations></json:item><json:item><name>Adriano Peris</name><affiliations><json:string>Anestesia e Rianimazione di Emergenza, Dipartimento DAI e Medicina e Chirurgia Generale e d’Urgenza, Azienda Ospedaliero Universitaria Careggi, Florence, Italy</json:string></affiliations></json:item><json:item><name>Giovanni Cianchi</name><affiliations><json:string>Anestesia e Rianimazione di Emergenza, Dipartimento DAI e Medicina e Chirurgia Generale e d’Urgenza, Azienda Ospedaliero Universitaria Careggi, Florence, Italy</json:string></affiliations></json:item><json:item><name>Antonio Braschi</name><affiliations><json:string>Dipartimento di Scienze Chirurgiche Rianimatorie-Riabilitative e dei Trapianti d’Organo, Sezione di Anestesia Rianimazione e Terapia Antalgica, Anestesia e Rianimazione I Dipartimento di Emergenza Urgenza, Università degli Studi di Pavia, IRCCS Policlinico San Matteo, Pavia, Italy</json:string></affiliations></json:item><json:item><name>Giorgio A. Iotti</name><affiliations><json:string>Anestesia e Rianimazione II, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy</json:string></affiliations></json:item><json:item><name>Antonio Arcadipane</name><affiliations><json:string>Terapia Intensiva, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Palermo, Italy</json:string></affiliations></json:item><json:item><name>Giovanna Panarello</name><affiliations><json:string>Terapia Intensiva, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Palermo, Italy</json:string></affiliations></json:item><json:item><name>V. Marco Ranieri</name><affiliations><json:string>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</json:string></affiliations></json:item><json:item><name>Pierpaolo Terragni</name><affiliations><json:string>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</json:string></affiliations></json:item><json:item><name>Massimo Antonelli</name><affiliations><json:string>Dipartimento di Terapia Intensiva e Anestesiologia, Università Cattolica del Sacro Cuore, Rome, Italy</json:string></affiliations></json:item><json:item><name>Luciano Gattinoni</name><affiliations><json:string>Dipartimento di Anestesiologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy</json:string></affiliations></json:item><json:item><name>Fabrizio Oleari</name><affiliations><json:string>Dipartimento della Prevenzione e Comunicazione, Ministero della Salute, Rome, Italy</json:string></affiliations></json:item><json:item><name>Antonio Pesenti</name><affiliations><json:string>Department of Experimental Medicine, University of Milan-Bicocca, Via Pergolesi 33, 20052, Monza, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Viral infection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Extracorporeal membrane oxygenation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Preparedness plan</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ARDS</value></json:item></subject><articleId><json:string>2301</json:string><json:string>s00134-011-2301-6</json:string></articleId><arkIstex>ark:/67375/VQC-DL1SGRR4-0</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Purpose: In view of the expected 2009 influenza A(H1N1) pandemic, the Italian Health Authorities set up a national referral network of selected intensive care units (ICU) able to provide advanced respiratory care up to extracorporeal membrane oxygenation (ECMO) for patients with acute respiratory distress syndrome (ARDS). We describe the organization and results of the network, known as ECMOnet. Methods: The network consisted of 14 ICUs with ECMO capability and a national call center. The network was set up to centralize all severe patients to the ECMOnet centers assuring safe transfer. An ad hoc committee defined criteria for both patient transfer and ECMO institutions. Results: Between August 2009 and March 2010, 153 critically ill patients (53% referred from other hospitals) were admitted to the ECMOnet ICU with suspected H1N1. Sixty patients (48 of the referred patients, 49 with confirmed H1N1 diagnosis) received ECMO according to ECMOnet criteria. All referred patients were successfully transferred to the ECMOnet centers; 28 were transferred while on ECMO. Survival to hospital discharge in patients receiving ECMO was 68%. Survival of patients receiving ECMO within 7 days from the onset of mechanical ventilation was 77%. The length of mechanical ventilation prior to ECMO was an independent predictor of mortality. Conclusions: A network organization based on preemptive patient centralization allowed a high survival rate and provided effective and safe referral of patients with severe H1N1-suspected ARDS.</abstract><qualityIndicators><refBibsNative>false</refBibsNative><abstractWordCount>228</abstractWordCount><abstractCharCount>1542</abstractCharCount><keywordCount>4</keywordCount><score>9.736</score><pdfWordCount>5364</pdfWordCount><pdfCharCount>38432</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>595.276 x 790.866 pts</pdfPageSize></qualityIndicators><title>The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks</title><genre><json:string>research-article</json:string></genre><host><title>Intensive Care 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Medicine</value></json:item></subject></host><ark><json:string>ark:/67375/VQC-DL1SGRR4-0</json:string></ark><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1007/s00134-011-2301-6</json:string></doi><id>953DF1A32E5323ABDD176BA1641D15EDCC465556</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-DL1SGRR4-0/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-DL1SGRR4-0/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/VQC-DL1SGRR4-0/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><licence><p>Copyright jointly held by Springer and ESICM, 2011</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>2011-03-02</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Original</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">Nicolò</forename><surname>Patroniti</surname></persName><email>nicolo.patroniti@unimib.it</email><affiliation>Department of Experimental Medicine, University of Milan-Bicocca, Via Pergolesi 33, 20052, Monza, Italy</affiliation><affiliation>Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Via Pergolesi 33, 20052, Monza, Italy</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Alberto</forename><surname>Zangrillo</surname></persName><affiliation>Dipartimento di Anestesia Cardiaca e Terapia Intensiva, Università Vita-Salute San Raffaele, Milan, Italy</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Federico</forename><surname>Pappalardo</surname></persName><affiliation>Dipartimento di Anestesia Cardiaca e Terapia Intensiva, Università Vita-Salute San Raffaele, Milan, Italy</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Adriano</forename><surname>Peris</surname></persName><affiliation>Anestesia e Rianimazione di Emergenza, Dipartimento DAI e Medicina e Chirurgia Generale e d’Urgenza, Azienda Ospedaliero Universitaria Careggi, Florence, Italy</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Giovanni</forename><surname>Cianchi</surname></persName><affiliation>Anestesia e Rianimazione di Emergenza, Dipartimento DAI e Medicina e Chirurgia Generale e d’Urgenza, Azienda Ospedaliero Universitaria Careggi, Florence, Italy</affiliation></author><author xml:id="author-0005"><persName><forename type="first">Antonio</forename><surname>Braschi</surname></persName><affiliation>Dipartimento di Scienze Chirurgiche Rianimatorie-Riabilitative e dei Trapianti d’Organo, Sezione di Anestesia Rianimazione e Terapia Antalgica, Anestesia e Rianimazione I Dipartimento di Emergenza Urgenza, Università degli Studi di Pavia, IRCCS Policlinico San Matteo, Pavia, Italy</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Giorgio</forename><surname>Iotti</surname></persName><affiliation>Anestesia e Rianimazione II, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy</affiliation></author><author xml:id="author-0007"><persName><forename type="first">Antonio</forename><surname>Arcadipane</surname></persName><affiliation>Terapia Intensiva, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Palermo, Italy</affiliation></author><author xml:id="author-0008"><persName><forename type="first">Giovanna</forename><surname>Panarello</surname></persName><affiliation>Terapia Intensiva, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Palermo, Italy</affiliation></author><author xml:id="author-0009"><persName><forename type="first">V.</forename><surname>Ranieri</surname></persName><affiliation>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</affiliation></author><author xml:id="author-0010"><persName><forename type="first">Pierpaolo</forename><surname>Terragni</surname></persName><affiliation>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</affiliation></author><author xml:id="author-0011"><persName><forename type="first">Massimo</forename><surname>Antonelli</surname></persName><affiliation>Dipartimento di Terapia Intensiva e Anestesiologia, Università Cattolica del Sacro Cuore, Rome, Italy</affiliation></author><author xml:id="author-0012"><persName><forename type="first">Luciano</forename><surname>Gattinoni</surname></persName><affiliation>Dipartimento di Anestesiologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy</affiliation></author><author xml:id="author-0013"><persName><forename type="first">Fabrizio</forename><surname>Oleari</surname></persName><affiliation>Dipartimento della Prevenzione e Comunicazione, Ministero della Salute, Rome, Italy</affiliation></author><author xml:id="author-0014"><persName><forename type="first">Antonio</forename><surname>Pesenti</surname></persName><affiliation>Department of Experimental Medicine, University of Milan-Bicocca, Via Pergolesi 33, 20052, Monza, Italy</affiliation></author><idno type="istex">953DF1A32E5323ABDD176BA1641D15EDCC465556</idno><idno type="ark">ark:/67375/VQC-DL1SGRR4-0</idno><idno type="DOI">10.1007/s00134-011-2301-6</idno><idno type="article-id">2301</idno><idno type="article-id">s00134-011-2301-6</idno></analytic><monogr><title level="j">Intensive Care Medicine</title><title level="j" type="abbrev">Intensive Care Med</title><idno type="pISSN">0342-4642</idno><idno type="eISSN">1432-1238</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">31</idno><idno type="volume-issue-count">12</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2011-09-01"></date><biblScope unit="volume">37</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1447">1447</biblScope><biblScope unit="page" to="1457">1457</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011-03-02</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Purpose: In view of the expected 2009 influenza A(H1N1) pandemic, the Italian Health Authorities set up a national referral network of selected intensive care units (ICU) able to provide advanced respiratory care up to extracorporeal membrane oxygenation (ECMO) for patients with acute respiratory distress syndrome (ARDS). We describe the organization and results of the network, known as ECMOnet. Methods: The network consisted of 14 ICUs with ECMO capability and a national call center. The network was set up to centralize all severe patients to the ECMOnet centers assuring safe transfer. An ad hoc committee defined criteria for both patient transfer and ECMO institutions. Results: Between August 2009 and March 2010, 153 critically ill patients (53% referred from other hospitals) were admitted to the ECMOnet ICU with suspected H1N1. Sixty patients (48 of the referred patients, 49 with confirmed H1N1 diagnosis) received ECMO according to ECMOnet criteria. All referred patients were successfully transferred to the ECMOnet centers; 28 were transferred while on ECMO. Survival to hospital discharge in patients receiving ECMO was 68%. Survival of patients receiving ECMO within 7 days from the onset of mechanical ventilation was 77%. The length of mechanical ventilation prior to ECMO was an independent predictor of mortality. Conclusions: A network organization based on preemptive patient centralization allowed a high survival rate and provided effective and safe referral of patients with severe H1N1-suspected ARDS.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Viral infection</term></item><item><term>Extracorporeal membrane oxygenation</term></item><item><term>Preparedness plan</term></item><item><term>ARDS</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Pain Medicine</term></item><item><term>Anesthesiology</term></item><item><term>Intensive / Critical Care Medicine</term></item><item><term>Pediatrics</term></item><item><term>Pneumology/Respiratory System</term></item><item><term>Emergency Medicine</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2011-03-02">Created</change><change when="2011-09-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-DL1SGRR4-0/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal OutputMedium="All"><JournalInfo JournalProductType="NonStandardArchiveJournal" 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VolumeType="Regular"><VolumeIDStart>37</VolumeIDStart><VolumeIDEnd>37</VolumeIDEnd><VolumeIssueCount>12</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular" OutputMedium="All"><IssueInfo IssueType="Regular" TocLevels="0"><IssueIDStart>9</IssueIDStart><IssueIDEnd>9</IssueIDEnd><IssueArticleCount>31</IssueArticleCount><IssueHistory><OnlineDate><Year>2011</Year><Month>8</Month><Day>13</Day></OnlineDate><PrintDate><Year>2011</Year><Month>8</Month><Day>12</Day></PrintDate><CoverDate><Year>2011</Year><Month>9</Month></CoverDate><PricelistYear>2011</PricelistYear></IssueHistory><IssueCopyright><CopyrightHolderName>Copyright jointly held by Springer and ESICM</CopyrightHolderName><CopyrightYear>2011</CopyrightYear></IssueCopyright></IssueInfo><Article ID="s00134-011-2301-6" OutputMedium="All"><ArticleInfo ArticleType="OriginalPaper" ContainsESM="Yes" Language="En" NumberingStyle="Unnumbered" TocLevels="0"><ArticleID>2301</ArticleID><ArticleDOI>10.1007/s00134-011-2301-6</ArticleDOI><ArticleCitationID>1447</ArticleCitationID><ArticleSequenceNumber>7</ArticleSequenceNumber><ArticleTitle Language="En" OutputMedium="All">The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks</ArticleTitle><ArticleCategory>Original</ArticleCategory><ArticleFirstPage>1447</ArticleFirstPage><ArticleLastPage>1457</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2011</Year><Month>6</Month><Day>14</Day></RegistrationDate><Received><Year>2011</Year><Month>3</Month><Day>2</Day></Received><Accepted><Year>2011</Year><Month>6</Month><Day>3</Day></Accepted><OnlineDate><Year>2011</Year><Month>7</Month><Day>6</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Copyright jointly held by Springer and ESICM</CopyrightHolderName><CopyrightYear>2011</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1 Aff2" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Nicolò</GivenName><FamilyName>Patroniti</FamilyName></AuthorName><Contact><Phone>+39-39-2333291</Phone><Fax>+39-39-2332297</Fax><Email>nicolo.patroniti@unimib.it</Email></Contact></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Alberto</GivenName><FamilyName>Zangrillo</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Federico</GivenName><FamilyName>Pappalardo</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4"><AuthorName DisplayOrder="Western"><GivenName>Adriano</GivenName><FamilyName>Peris</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff4"><AuthorName DisplayOrder="Western"><GivenName>Giovanni</GivenName><FamilyName>Cianchi</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff5"><AuthorName DisplayOrder="Western"><GivenName>Antonio</GivenName><FamilyName>Braschi</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff6"><AuthorName DisplayOrder="Western"><GivenName>Giorgio</GivenName><GivenName>A.</GivenName><FamilyName>Iotti</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff7"><AuthorName DisplayOrder="Western"><GivenName>Antonio</GivenName><FamilyName>Arcadipane</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff7"><AuthorName DisplayOrder="Western"><GivenName>Giovanna</GivenName><FamilyName>Panarello</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff8"><AuthorName DisplayOrder="Western"><GivenName>V.</GivenName><GivenName>Marco</GivenName><FamilyName>Ranieri</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff8"><AuthorName DisplayOrder="Western"><GivenName>Pierpaolo</GivenName><FamilyName>Terragni</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff9"><AuthorName DisplayOrder="Western"><GivenName>Massimo</GivenName><FamilyName>Antonelli</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff10"><AuthorName DisplayOrder="Western"><GivenName>Luciano</GivenName><FamilyName>Gattinoni</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff11"><AuthorName DisplayOrder="Western"><GivenName>Fabrizio</GivenName><FamilyName>Oleari</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Antonio</GivenName><FamilyName>Pesenti</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Experimental Medicine</OrgDivision><OrgName>University of Milan-Bicocca</OrgName><OrgAddress><Street>Via Pergolesi 33</Street><Postcode>20052</Postcode><City>Monza</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Perioperative Medicine and Intensive Care</OrgDivision><OrgName>San Gerardo Hospital</OrgName><OrgAddress><Street>Via Pergolesi 33</Street><Postcode>20052</Postcode><City>Monza</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Dipartimento di Anestesia Cardiaca e Terapia Intensiva</OrgDivision><OrgName>Università Vita-Salute San Raffaele</OrgName><OrgAddress><City>Milan</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>Anestesia e Rianimazione di Emergenza, Dipartimento DAI e Medicina e Chirurgia Generale e d’Urgenza</OrgDivision><OrgName>Azienda Ospedaliero Universitaria Careggi</OrgName><OrgAddress><City>Florence</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff5"><OrgDivision>Dipartimento di Scienze Chirurgiche Rianimatorie-Riabilitative e dei Trapianti d’Organo, Sezione di Anestesia Rianimazione e Terapia Antalgica, Anestesia e Rianimazione I Dipartimento di Emergenza Urgenza</OrgDivision><OrgName>Università degli Studi di Pavia, IRCCS Policlinico San Matteo</OrgName><OrgAddress><City>Pavia</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff6"><OrgDivision>Anestesia e Rianimazione II</OrgDivision><OrgName>Fondazione IRCCS Policlinico San Matteo</OrgName><OrgAddress><City>Pavia</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff7"><OrgDivision>Terapia Intensiva</OrgDivision><OrgName>Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione</OrgName><OrgAddress><City>Palermo</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff8"><OrgDivision>Dipartimento di Anestesiologia e Medicina degli Stati Critici</OrgDivision><OrgName>Università di Torino</OrgName><OrgAddress><Street>Ospedale S. Giovanni Battista-Molinette</Street><City>Turin</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff9"><OrgDivision>Dipartimento di Terapia Intensiva e Anestesiologia</OrgDivision><OrgName>Università Cattolica del Sacro Cuore</OrgName><OrgAddress><City>Rome</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff10"><OrgDivision>Dipartimento di Anestesiologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico</OrgDivision><OrgName>Università degli Studi di Milano</OrgName><OrgAddress><City>Milan</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation><Affiliation ID="Aff11"><OrgDivision>Dipartimento della Prevenzione e Comunicazione</OrgDivision><OrgName>Ministero della Salute</OrgName><OrgAddress><City>Rome</City><Country Code="IT">Italy</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><AbstractSection ID="ASec1"><Heading>Purpose</Heading><Para TextBreak="No">In view of the expected 2009 influenza A(H1N1) pandemic, the Italian Health Authorities set up a national referral network of selected intensive care units (ICU) able to provide advanced respiratory care up to extracorporeal membrane oxygenation (ECMO) for patients with acute respiratory distress syndrome (ARDS). We describe the organization and results of the network, known as ECMOnet.</Para></AbstractSection><AbstractSection ID="ASec2"><Heading>Methods</Heading><Para TextBreak="No">The network consisted of 14 ICUs with ECMO capability and a national call center. The network was set up to centralize all severe patients to the ECMOnet centers assuring safe transfer. An ad hoc committee defined criteria for both patient transfer and ECMO institutions.</Para></AbstractSection><AbstractSection ID="ASec3"><Heading>Results</Heading><Para TextBreak="No">Between August 2009 and March 2010, 153 critically ill patients (53% referred from other hospitals) were admitted to the ECMOnet ICU with suspected H1N1. Sixty patients (48 of the referred patients, 49 with confirmed H1N1 diagnosis) received ECMO according to ECMOnet criteria. All referred patients were successfully transferred to the ECMOnet centers; 28 were transferred while on ECMO. Survival to hospital discharge in patients receiving ECMO was 68%. Survival of patients receiving ECMO within 7 days from the onset of mechanical ventilation was 77%. The length of mechanical ventilation prior to ECMO was an independent predictor of mortality.</Para></AbstractSection><AbstractSection ID="ASec4"><Heading>Conclusions</Heading><Para TextBreak="No">A network organization based on preemptive patient centralization allowed a high survival rate and provided effective and safe referral of patients with severe H1N1-suspected ARDS.</Para></AbstractSection></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Viral infection</Keyword><Keyword>Extracorporeal membrane oxygenation</Keyword><Keyword>Preparedness plan</Keyword><Keyword>ARDS</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>This article is written for the ECMOnet Italian ECMO network. Members of the network are listed in the Appendix.</SimplePara></ArticleNote><ArticleNote Type="ESMHint"><Heading>Electronic supplementary material</Heading><SimplePara>The online version of this article (doi:<ExternalRef><RefSource>10.1007/s00134-011-2301-6</RefSource><RefTarget Address="10.1007/s00134-011-2301-6" TargetType="DOI"></RefTarget></ExternalRef>) contains supplementary material, which is available to authorized users.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Nicolò</namePart><namePart type="family">Patroniti</namePart><affiliation>Department of Experimental Medicine, University of Milan-Bicocca, Via Pergolesi 33, 20052, Monza, Italy</affiliation><affiliation>Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Via Pergolesi 33, 20052, Monza, Italy</affiliation><affiliation>E-mail: nicolo.patroniti@unimib.it</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alberto</namePart><namePart type="family">Zangrillo</namePart><affiliation>Dipartimento di Anestesia Cardiaca e Terapia Intensiva, Università Vita-Salute San Raffaele, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Federico</namePart><namePart type="family">Pappalardo</namePart><affiliation>Dipartimento di Anestesia Cardiaca e Terapia Intensiva, Università Vita-Salute San Raffaele, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Adriano</namePart><namePart type="family">Peris</namePart><affiliation>Anestesia e Rianimazione di Emergenza, Dipartimento DAI e Medicina e Chirurgia Generale e d’Urgenza, Azienda Ospedaliero Universitaria Careggi, Florence, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Cianchi</namePart><affiliation>Anestesia e Rianimazione di Emergenza, Dipartimento DAI e Medicina e Chirurgia Generale e d’Urgenza, Azienda Ospedaliero Universitaria Careggi, Florence, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Braschi</namePart><affiliation>Dipartimento di Scienze Chirurgiche Rianimatorie-Riabilitative e dei Trapianti d’Organo, Sezione di Anestesia Rianimazione e Terapia Antalgica, Anestesia e Rianimazione I Dipartimento di Emergenza Urgenza, Università degli Studi di Pavia, IRCCS Policlinico San Matteo, Pavia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giorgio</namePart><namePart type="given">A.</namePart><namePart type="family">Iotti</namePart><affiliation>Anestesia e Rianimazione II, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Arcadipane</namePart><affiliation>Terapia Intensiva, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Palermo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanna</namePart><namePart type="family">Panarello</namePart><affiliation>Terapia Intensiva, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Palermo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="given">Marco</namePart><namePart type="family">Ranieri</namePart><affiliation>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierpaolo</namePart><namePart type="family">Terragni</namePart><affiliation>Dipartimento di Anestesiologia e Medicina degli Stati Critici, Università di Torino, Ospedale S. Giovanni Battista-Molinette, Turin, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Massimo</namePart><namePart type="family">Antonelli</namePart><affiliation>Dipartimento di Terapia Intensiva e Anestesiologia, Università Cattolica del Sacro Cuore, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luciano</namePart><namePart type="family">Gattinoni</namePart><affiliation>Dipartimento di Anestesiologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabrizio</namePart><namePart type="family">Oleari</namePart><affiliation>Dipartimento della Prevenzione e Comunicazione, Ministero della Salute, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Pesenti</namePart><affiliation>Department of Experimental Medicine, University of Milan-Bicocca, Via Pergolesi 33, 20052, Monza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">2011-03-02</dateCreated><dateIssued encoding="w3cdtf">2011-09-01</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Purpose: In view of the expected 2009 influenza A(H1N1) pandemic, the Italian Health Authorities set up a national referral network of selected intensive care units (ICU) able to provide advanced respiratory care up to extracorporeal membrane oxygenation (ECMO) for patients with acute respiratory distress syndrome (ARDS). We describe the organization and results of the network, known as ECMOnet. Methods: The network consisted of 14 ICUs with ECMO capability and a national call center. The network was set up to centralize all severe patients to the ECMOnet centers assuring safe transfer. An ad hoc committee defined criteria for both patient transfer and ECMO institutions. Results: Between August 2009 and March 2010, 153 critically ill patients (53% referred from other hospitals) were admitted to the ECMOnet ICU with suspected H1N1. Sixty patients (48 of the referred patients, 49 with confirmed H1N1 diagnosis) received ECMO according to ECMOnet criteria. All referred patients were successfully transferred to the ECMOnet centers; 28 were transferred while on ECMO. Survival to hospital discharge in patients receiving ECMO was 68%. Survival of patients receiving ECMO within 7 days from the onset of mechanical ventilation was 77%. The length of mechanical ventilation prior to ECMO was an independent predictor of mortality. Conclusions: A network organization based on preemptive patient centralization allowed a high survival rate and provided effective and safe referral of patients with severe H1N1-suspected ARDS.</abstract><note>Original</note><subject lang="en"><genre>Keywords</genre><topic>Viral infection</topic><topic>Extracorporeal membrane oxygenation</topic><topic>Preparedness plan</topic><topic>ARDS</topic></subject><relatedItem type="host"><titleInfo><title>Intensive Care Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Intensive Care Med</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2011-08-13</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Pain Medicine</topic><topic>Anesthesiology</topic><topic>Intensive / Critical Care Medicine</topic><topic>Pediatrics</topic><topic>Pneumology/Respiratory System</topic><topic>Emergency Medicine</topic></subject><identifier type="ISSN">0342-4642</identifier><identifier type="eISSN">1432-1238</identifier><identifier type="JournalID">134</identifier><identifier type="IssueArticleCount">31</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2011</date><detail type="volume"><number>37</number><caption>vol.</caption></detail><detail type="issue"><number>9</number><caption>no.</caption></detail><extent unit="pages"><start>1447</start><end>1457</end></extent></part><recordInfo><recordOrigin>Copyright jointly held by Springer and ESICM, 2011</recordOrigin></recordInfo></relatedItem><identifier type="istex">953DF1A32E5323ABDD176BA1641D15EDCC465556</identifier><identifier type="ark">ark:/67375/VQC-DL1SGRR4-0</identifier><identifier type="DOI">10.1007/s00134-011-2301-6</identifier><identifier type="ArticleID">2301</identifier><identifier type="ArticleID">s00134-011-2301-6</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright jointly held by Springer and ESICM, 2011</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Copyright jointly held by Springer and ESICM, 2011</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-DL1SGRR4-0/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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