4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2- a ]pyrimidine-3-carboxylic acids
Identifieur interne : 001935 ( Istex/Corpus ); précédent : 001934; suivant : 0019364-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2- a ]pyrimidine-3-carboxylic acids
Auteurs : I. V. Ukrainets ; N. L. Bereznyakova ; I. A. TuraibeiSource :
- Chemistry of Heterocyclic Compounds [ 0009-3122 ] ; 2008-01-01.
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Abstract
Abstract: Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.
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DOI: 10.1007/s10593-008-0012-x
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ISTEX:52550D902E9F63015B6CDC0D98F1B3379565D73CLe document en format XML
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A." last="Turaibei">I. A. Turaibei</name><affiliation><mods:affiliation>Kharkiv Medical Academy of Postgraduate Education, 61176, Kharkiv, Ukraine</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: igor_doctor@rambler.ru</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:52550D902E9F63015B6CDC0D98F1B3379565D73C</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1007/s10593-008-0012-x</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-HG4V9WX8-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001935</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001935</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2- a ]pyrimidine-3-carboxylic acids</title><author><name sortKey="Ukrainets, I V" sort="Ukrainets, I V" uniqKey="Ukrainets I" first="I. V." last="Ukrainets">I. V. Ukrainets</name><affiliation><mods:affiliation>National University of Pharmacy, 61002, Kharkiv, Ukraine</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: uiv@kharkov.ua</mods:affiliation></affiliation></author><author><name sortKey="Bereznyakova, N L" sort="Bereznyakova, N L" uniqKey="Bereznyakova N" first="N. L." last="Bereznyakova">N. L. Bereznyakova</name><affiliation><mods:affiliation>National University of Pharmacy, 61002, Kharkiv, Ukraine</mods:affiliation></affiliation></author><author><name sortKey="Turaibei, I A" sort="Turaibei, I A" uniqKey="Turaibei I" first="I. A." last="Turaibei">I. A. Turaibei</name><affiliation><mods:affiliation>Kharkiv Medical Academy of Postgraduate Education, 61176, Kharkiv, Ukraine</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: igor_doctor@rambler.ru</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Chemistry of Heterocyclic Compounds</title><title level="j" type="abbrev">Chem Heterocycl Comp</title><idno type="ISSN">0009-3122</idno><idno type="eISSN">1573-8353</idno><imprint><publisher>Springer US; http://www.springer-ny.com</publisher><pubPlace>Boston</pubPlace><date type="published" when="2008-01-01">2008-01-01</date><biblScope unit="volume">44</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="50">50</biblScope><biblScope unit="page" to="63">63</biblScope></imprint><idno type="ISSN">0009-3122</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0009-3122</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>2-hydroxy-4-oxo-4H-pyrido[1,2- a ]pyrimidines</term><term>X-ray structural analysis</term><term>amides</term><term>antiviral activity</term><term>coronavirus</term><term>herpes</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. 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Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-<Emphasis Type="Italic">a</Emphasis>]pyrimidine-3-carboxylic acids</ArticleTitle><ArticleFirstPage>50</ArticleFirstPage><ArticleLastPage>63</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2008</Year><Month>4</Month><Day>21</Day></RegistrationDate><Received><Year>2007</Year><Month>3</Month><Day>22</Day></Received><OnlineDate><Year>2008</Year><Month>5</Month><Day>31</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer Science+Business Media, Inc.</CopyrightHolderName><CopyrightYear>2008</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>I.</GivenName><GivenName>V.</GivenName><FamilyName>Ukrainets</FamilyName></AuthorName><Contact><Email>uiv@kharkov.ua</Email></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>N.</GivenName><GivenName>L.</GivenName><FamilyName>Bereznyakova</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2"><AuthorName DisplayOrder="Western"><GivenName>I.</GivenName><GivenName>A.</GivenName><FamilyName>Turaibei</FamilyName></AuthorName><Contact><Email>igor_doctor@rambler.ru</Email></Contact></Author><Affiliation ID="Aff1"><OrgName>National University of Pharmacy</OrgName><OrgAddress><City>Kharkiv</City><Postcode>61002</Postcode><Country Code="UA">Ukraine</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Kharkiv Medical Academy of Postgraduate Education</OrgName><OrgAddress><City>Kharkiv</City><Postcode>61176</Postcode><Country Code="UA">Ukraine</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para TextBreak="No">Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>amides</Keyword><Keyword>2-hydroxy-4-oxo-4H-pyrido[1,2-<Emphasis Type="Italic">a</Emphasis>]pyrimidines</Keyword><Keyword>herpes</Keyword><Keyword>coronavirus</Keyword><Keyword>antiviral activity</Keyword><Keyword>X-ray structural analysis</Keyword></KeywordGroup><ArticleNote Type="Misc"><SimplePara>__________</SimplePara><SimplePara>Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 61–77, January, 2008.</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>4-Hydroxy-2-quinolones 139. 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Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2- a ]pyrimidine-3-carboxylic acids</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">I.</namePart><namePart type="given">V.</namePart><namePart type="family">Ukrainets</namePart><affiliation>National University of Pharmacy, 61002, Kharkiv, Ukraine</affiliation><affiliation>E-mail: uiv@kharkov.ua</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="given">L.</namePart><namePart type="family">Bereznyakova</namePart><affiliation>National University of Pharmacy, 61002, Kharkiv, Ukraine</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="given">A.</namePart><namePart type="family">Turaibei</namePart><affiliation>Kharkiv Medical Academy of Postgraduate Education, 61176, Kharkiv, Ukraine</affiliation><affiliation>E-mail: igor_doctor@rambler.ru</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer US; http://www.springer-ny.com</publisher><place><placeTerm type="text">Boston</placeTerm></place><dateCreated encoding="w3cdtf">2007-03-22</dateCreated><dateIssued encoding="w3cdtf">2008-01-01</dateIssued><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. 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