An update on swine-origin influenza virus A/H1N1: a review
Identifieur interne : 001743 ( Istex/Corpus ); précédent : 001742; suivant : 001744An update on swine-origin influenza virus A/H1N1: a review
Auteurs : Sebastian U. Schnitzler ; Paul SchnitzlerSource :
- Virus Genes [ 0920-8569 ] ; 2009-12-01.
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- KwdEn :
Abstract
Abstract: Influenza viruses cause annual epidemics and occasional pandemics that have claimed the lives of millions. The emergence of new strains will continue to pose challenges to public health and the scientific communities. The recent flu pandemic caused by a swine-origin influenza virus A/H1N1 (S-OIV) presents an opportunity to examine virulence factors, the spread of the infection and to prepare for major influenza outbreaks in the future. The virus contains a novel constellation of gene segments, the nearest known precursors being viruses found in swine and it probably arose through reassortment of two viruses of swine origin. Specific markers for virulence can be evaluated in the viral genome, PB1-F2 is a molecular marker of pathogenicity but is not present in the new S-OIV. While attention was focused on a threat of an avian influenza H5N1 pandemic emerging from Asia, a novel influenza virus of swine origin emerged in North America, and is now spreading worldwide. However, S-OIV demonstrates that even serotypes already encountered in past human pandemics may constitute new pandemic threats. There are concerns that this virus may mutate or reassort with existing influenza viruses giving rise to more transmissible or more pathogenic viruses. The 1918 Spanish flu pandemic virus was relatively mild in its first wave and acquired more virulence when it returned in the winter. Thus preparedness on a global scale against a potential more virulent strain is highly recommended. Most isolates of the new S-OIVs are susceptible to neuraminidase inhibitors, and currently a vaccine against the pandemic strain is being manufactured and will be available this fall. This review summarizes the current information on the new pandemic swine-origin influenza virus A/H1N1.
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DOI: 10.1007/s11262-009-0404-8
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The emergence of new strains will continue to pose challenges to public health and the scientific communities. The recent flu pandemic caused by a swine-origin influenza virus A/H1N1 (S-OIV) presents an opportunity to examine virulence factors, the spread of the infection and to prepare for major influenza outbreaks in the future. The virus contains a novel constellation of gene segments, the nearest known precursors being viruses found in swine and it probably arose through reassortment of two viruses of swine origin. Specific markers for virulence can be evaluated in the viral genome, PB1-F2 is a molecular marker of pathogenicity but is not present in the new S-OIV. While attention was focused on a threat of an avian influenza H5N1 pandemic emerging from Asia, a novel influenza virus of swine origin emerged in North America, and is now spreading worldwide. However, S-OIV demonstrates that even serotypes already encountered in past human pandemics may constitute new pandemic threats. There are concerns that this virus may mutate or reassort with existing influenza viruses giving rise to more transmissible or more pathogenic viruses. The 1918 Spanish flu pandemic virus was relatively mild in its first wave and acquired more virulence when it returned in the winter. Thus preparedness on a global scale against a potential more virulent strain is highly recommended. Most isolates of the new S-OIVs are susceptible to neuraminidase inhibitors, and currently a vaccine against the pandemic strain is being manufactured and will be available this fall. This review summarizes the current information on the new pandemic swine-origin influenza virus A/H1N1.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Sebastian U. 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There are concerns that this virus may mutate or reassort with existing influenza viruses giving rise to more transmissible or more pathogenic viruses. The 1918 Spanish flu pandemic virus was relatively mild in its first wave and acquired more virulence when it returned in the winter. Thus preparedness on a global scale against a potential more virulent strain is highly recommended. Most isolates of the new S-OIVs are susceptible to neuraminidase inhibitors, and currently a vaccine against the pandemic strain is being manufactured and will be available this fall. 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DisplayOrder="Western"><GivenName>Sebastian</GivenName><GivenName>U.</GivenName><FamilyName>Schnitzler</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Paul</GivenName><FamilyName>Schnitzler</FamilyName></AuthorName><Contact><Phone>+49-6221-565016</Phone><Fax>+49-6221-565003</Fax><Email>Paul_Schnitzler@med.uni-heidelberg.de</Email></Contact></Author><Affiliation ID="Aff1"><OrgDivision>Department of Virology</OrgDivision><OrgName>Hygiene Institute, University of Heidelberg</OrgName><OrgAddress><Street>Im Neuenheimer Feld 324</Street><Postcode>69120</Postcode><City>Heidelberg</City><Country Code="DE">Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para TextBreak="No">Influenza viruses cause annual epidemics and occasional pandemics that have claimed the lives of millions. The emergence of new strains will continue to pose challenges to public health and the scientific communities. The recent flu pandemic caused by a swine-origin influenza virus A/H1N1 (S-OIV) presents an opportunity to examine virulence factors, the spread of the infection and to prepare for major influenza outbreaks in the future. The virus contains a novel constellation of gene segments, the nearest known precursors being viruses found in swine and it probably arose through reassortment of two viruses of swine origin. Specific markers for virulence can be evaluated in the viral genome, PB1-F2 is a molecular marker of pathogenicity but is not present in the new S-OIV. While attention was focused on a threat of an avian influenza H5N1 pandemic emerging from Asia, a novel influenza virus of swine origin emerged in North America, and is now spreading worldwide. However, S-OIV demonstrates that even serotypes already encountered in past human pandemics may constitute new pandemic threats. There are concerns that this virus may mutate or reassort with existing influenza viruses giving rise to more transmissible or more pathogenic viruses. The 1918 Spanish flu pandemic virus was relatively mild in its first wave and acquired more virulence when it returned in the winter. Thus preparedness on a global scale against a potential more virulent strain is highly recommended. Most isolates of the new S-OIVs are susceptible to neuraminidase inhibitors, and currently a vaccine against the pandemic strain is being manufactured and will be available this fall. This review summarizes the current information on the new pandemic swine-origin influenza virus A/H1N1.</Para></Abstract><KeywordGroup Language="En" OutputMedium="All"><Heading>Keywords</Heading><Keyword>Influenza virus</Keyword><Keyword>Swine-origin influenza virus A/H1N1</Keyword><Keyword>Pandemic</Keyword><Keyword>Antiviral therapy</Keyword><Keyword>Vaccine</Keyword><Keyword>Pathogenicity</Keyword><Keyword>Virulence</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>An update on swine-origin influenza virus A/H1N1: a review</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>An update on swine-origin influenza virus A/H1N1: a review</title></titleInfo><name type="personal"><namePart type="given">Sebastian</namePart><namePart type="given">U.</namePart><namePart type="family">Schnitzler</namePart><affiliation>Department of Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Paul</namePart><namePart type="family">Schnitzler</namePart><affiliation>Department of Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany</affiliation><affiliation>E-mail: Paul_Schnitzler@med.uni-heidelberg.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Report" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer US; http://www.springer-ny.com</publisher><place><placeTerm type="text">Boston</placeTerm></place><dateCreated encoding="w3cdtf">2009-08-16</dateCreated><dateIssued encoding="w3cdtf">2009-12-01</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Influenza viruses cause annual epidemics and occasional pandemics that have claimed the lives of millions. The emergence of new strains will continue to pose challenges to public health and the scientific communities. The recent flu pandemic caused by a swine-origin influenza virus A/H1N1 (S-OIV) presents an opportunity to examine virulence factors, the spread of the infection and to prepare for major influenza outbreaks in the future. The virus contains a novel constellation of gene segments, the nearest known precursors being viruses found in swine and it probably arose through reassortment of two viruses of swine origin. Specific markers for virulence can be evaluated in the viral genome, PB1-F2 is a molecular marker of pathogenicity but is not present in the new S-OIV. While attention was focused on a threat of an avian influenza H5N1 pandemic emerging from Asia, a novel influenza virus of swine origin emerged in North America, and is now spreading worldwide. However, S-OIV demonstrates that even serotypes already encountered in past human pandemics may constitute new pandemic threats. There are concerns that this virus may mutate or reassort with existing influenza viruses giving rise to more transmissible or more pathogenic viruses. The 1918 Spanish flu pandemic virus was relatively mild in its first wave and acquired more virulence when it returned in the winter. Thus preparedness on a global scale against a potential more virulent strain is highly recommended. Most isolates of the new S-OIVs are susceptible to neuraminidase inhibitors, and currently a vaccine against the pandemic strain is being manufactured and will be available this fall. This review summarizes the current information on the new pandemic swine-origin influenza virus A/H1N1.</abstract><subject lang="en"><genre>Keywords</genre><topic>Influenza virus</topic><topic>Swine-origin influenza virus A/H1N1</topic><topic>Pandemic</topic><topic>Antiviral therapy</topic><topic>Vaccine</topic><topic>Pathogenicity</topic><topic>Virulence</topic></subject><relatedItem type="host"><titleInfo><title>Virus Genes</title></titleInfo><titleInfo type="abbreviated"><title>Virus Genes</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2009-10-22</dateIssued><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Plant Sciences</topic><topic>Virology</topic><topic>Medical Microbiology</topic></subject><identifier type="ISSN">0920-8569</identifier><identifier type="eISSN">1572-994X</identifier><identifier type="JournalID">11262</identifier><identifier type="IssueArticleCount">18</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>2009</date><detail type="volume"><number>39</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="pages"><start>279</start><end>292</end></extent></part><recordInfo><recordOrigin>Springer Science+Business Media, LLC, 2009</recordOrigin></recordInfo></relatedItem><identifier type="istex">53FF80B72721ADD8B1732FA64D1E3A9E107FDE6D</identifier><identifier type="ark">ark:/67375/VQC-15K8HCB9-T</identifier><identifier type="DOI">10.1007/s11262-009-0404-8</identifier><identifier type="ArticleID">404</identifier><identifier type="ArticleID">s11262-009-0404-8</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer Science+Business Media, LLC, 2009</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer Science+Business Media, LLC, 2009</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-15K8HCB9-T/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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