Ethical issues in research on control of the HIV/AIDS epidemic: report from a workshop of the World Federation of Scientists, Erice, Sicily, Italy, 22–24 August 2003
Identifieur interne : 001383 ( Istex/Corpus ); précédent : 001382; suivant : 001384Ethical issues in research on control of the HIV/AIDS epidemic: report from a workshop of the World Federation of Scientists, Erice, Sicily, Italy, 22–24 August 2003
Auteurs : G. De Thé ; F. Buonaguro ; N. Charpak ; Jl Hutton ; R. Thorstensson ; E. Valdas ; R. ZetterströmSource :
- Acta Paediatrica [ 0803-5253 ] ; 2004-08.
English descriptors
- Teeft :
- Acta, Acta paediatr, Antiretroviral drugs, Antiretroviral therapy, Different countries, Ethical issues, European community, Global apathy, Helsinki, Human rights, Human virus, Individual autonomy, Many countries, Medical research, Personal autonomy, Professional ethics, Public health, Statistical methods, Such trials, Treatment programmes, Unethical trials, Urgent need, Vaccine, Vaccine preparations, Vaccine trials, Workshop report, World federation, World health organization.
Abstract
In research on control of the HIV/AIDS epidemic there are many ethical issues to be considered. The problem of personal autonomy versus the interest of society to prevent the spread of the disease in various settings makes it difficult to follow the regulations of the Declaration of Helsinki in all respects. This is particularly clear in the evaluation of trials aimed at preventing mother‐to‐child transmission of HIV. The interest of the child does not always conform to the policy of avoiding stigmatization of the mother. Conclusion: Programmes for the implementation of antiretroviral therapy and vaccine trials may differ in countries with different mean incomes of the inhabitants, and are also influenced by local patterns. For this reason, the Declaration of Helsinki should be changed in such a way that it conforms with the ways in which it may be possible to combat such a disastrous epidemic as that caused by HIV.
Url:
DOI: 10.1111/j.1651-2227.2004.tb02729.x
Links to Exploration step
ISTEX:86F12D8E318DD8FA8D3B74D937559386C40F4C93Le document en format XML
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Zetterström</name><affiliation><mods:affiliation>Karolinska University Hospital, Stockholm, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: rolf.zetterstrom@actapaediatrica.se</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Acta Paediatrica</title><title level="j" type="alt">ACTA PAEDIATRICA</title><idno type="ISSN">0803-5253</idno><idno type="eISSN">1651-2227</idno><imprint><biblScope unit="vol">93</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1125">1125</biblScope><biblScope unit="page" to="1128">1128</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08">2004-08</date></imprint><idno type="ISSN">0803-5253</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0803-5253</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta</term><term>Acta paediatr</term><term>Antiretroviral drugs</term><term>Antiretroviral therapy</term><term>Different countries</term><term>Ethical issues</term><term>European community</term><term>Global apathy</term><term>Helsinki</term><term>Human rights</term><term>Human virus</term><term>Individual autonomy</term><term>Many countries</term><term>Medical research</term><term>Personal autonomy</term><term>Professional ethics</term><term>Public health</term><term>Statistical methods</term><term>Such trials</term><term>Treatment programmes</term><term>Unethical trials</term><term>Urgent need</term><term>Vaccine</term><term>Vaccine preparations</term><term>Vaccine trials</term><term>Workshop report</term><term>World federation</term><term>World health organization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In research on control of the HIV/AIDS epidemic there are many ethical issues to be considered. The problem of personal autonomy versus the interest of society to prevent the spread of the disease in various settings makes it difficult to follow the regulations of the Declaration of Helsinki in all respects. This is particularly clear in the evaluation of trials aimed at preventing mother‐to‐child transmission of HIV. The interest of the child does not always conform to the policy of avoiding stigmatization of the mother. Conclusion: Programmes for the implementation of antiretroviral therapy and vaccine trials may differ in countries with different mean incomes of the inhabitants, and are also influenced by local patterns. For this reason, the Declaration of Helsinki should be changed in such a way that it conforms with the ways in which it may be possible to combat such a disastrous epidemic as that caused by HIV.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>acta</json:string><json:string>vaccine</json:string><json:string>helsinki</json:string><json:string>vaccine trials</json:string><json:string>acta paediatr</json:string><json:string>ethical issues</json:string><json:string>such trials</json:string><json:string>world federation</json:string><json:string>individual autonomy</json:string><json:string>public health</json:string><json:string>different countries</json:string><json:string>world health organization</json:string><json:string>antiretroviral therapy</json:string><json:string>many countries</json:string><json:string>workshop report</json:string><json:string>professional ethics</json:string><json:string>vaccine preparations</json:string><json:string>european community</json:string><json:string>treatment programmes</json:string><json:string>medical research</json:string><json:string>antiretroviral drugs</json:string><json:string>urgent need</json:string><json:string>unethical trials</json:string><json:string>human rights</json:string><json:string>statistical methods</json:string><json:string>global apathy</json:string><json:string>personal autonomy</json:string><json:string>human virus</json:string></teeft></keywords><author><json:item><name>G de Thé</name><affiliations><json:string>Pasteur Institute, Paris, France</json:string></affiliations></json:item><json:item><name>F Buonaguro</name><affiliations><json:string>Viral Oncology, 1st Naz Tumori Fond Pascale, Napoli, Italy</json:string></affiliations></json:item><json:item><name>N Charpak</name><affiliations><json:string>Kangaroo Foundation, Bogota, Colombia</json:string></affiliations></json:item><json:item><name>JL Hutton</name><affiliations><json:string>Department of Statistics, University of Warwick, Coventry, United Kingdom</json:string></affiliations></json:item><json:item><name>R Thorstensson</name><affiliations><json:string>Department of Immunology and Vaccinology, Swedish Institute for Infectious Diseases Control, Solna, Sweden</json:string></affiliations></json:item><json:item><name>E Valdas</name><affiliations><json:string>Department of Microbiology and Infectious Diseases, Perinatal Research Unit, University of Witwatersrand, South Africa</json:string></affiliations></json:item><json:item><name>R Zetterström</name><affiliations><json:string>Karolinska University Hospital, Stockholm, Sweden</json:string><json:string>E-mail: rolf.zetterstrom@actapaediatrica.se</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>HIV/AIDS</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ethical issues</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>research</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mother‐to‐child transmission</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>developing countries</value></json:item></subject><articleId><json:string>APA1125</json:string></articleId><arkIstex>ark:/67375/WNG-LC7Q3FX7-2</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>In research on control of the HIV/AIDS epidemic there are many ethical issues to be considered. The problem of personal autonomy versus the interest of society to prevent the spread of the disease in various settings makes it difficult to follow the regulations of the Declaration of Helsinki in all respects. This is particularly clear in the evaluation of trials aimed at preventing mother‐to‐child transmission of HIV. The interest of the child does not always conform to the policy of avoiding stigmatization of the mother. Conclusion: Programmes for the implementation of antiretroviral therapy and vaccine trials may differ in countries with different mean incomes of the inhabitants, and are also influenced by local patterns. 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><p>In research on control of the HIV/AIDS epidemic there are many ethical issues to be considered. The problem of personal autonomy versus the interest of society to prevent the spread of the disease in various settings makes it difficult to follow the regulations of the Declaration of Helsinki in all respects. This is particularly clear in the evaluation of trials aimed at preventing mother‐to‐child transmission of HIV. The interest of the child does not always conform to the policy of avoiding stigmatization of the mother.</p><p><hi rend="italic">Conclusion</hi>: Programmes for the implementation of antiretroviral therapy and vaccine trials may differ in countries with different mean incomes of the inhabitants, and are also influenced by local patterns. For this reason, the Declaration of Helsinki should be changed in such a way that it conforms with the ways in which it may be possible to combat such a disastrous epidemic as that caused by HIV.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">HIV/AIDS</term><term xml:id="k2">ethical issues</term><term xml:id="k3">research</term><term xml:id="k4">mother‐to‐child transmission</term><term xml:id="k5">developing countries</term></keywords><keywords rend="tocHeading1"><term>WORKSHOP REPORT</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LC7Q3FX7-2/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1651-2227</doi><issn type="print">0803-5253</issn><issn type="electronic">1651-2227</issn><idGroup><id type="product" value="APA"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ACTA PAEDIATRICA">Acta Paediatrica</title></titleGroup></publicationMeta><publicationMeta level="part" position="08108"><doi origin="wiley">10.1111/apa.2004.93.issue-8</doi><numberingGroup><numbering type="journalVolume" number="93">93</numbering><numbering type="journalIssue" number="8">8</numbering></numberingGroup><coverDate startDate="2004-08">August 2004</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0112500" status="forIssue"><doi origin="wiley">10.1111/j.1651-2227.2004.tb02729.x</doi><idGroup><id type="unit" value="APA1125"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="tocHeading1">WORKSHOP REPORT</title></titleGroup><eventGroup><event type="firstOnline" date="2007-01-02"></event><event type="publishedOnlineFinalForm" date="2007-01-02"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.3.1 mode:FullText" date="2014-05-22"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.1 mode:FullText" date="2014-05-22"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1125">1125</numbering><numbering type="pageLast" number="1128">1128</numbering></numberingGroup><correspondenceTo>Rolf Zetterström, Acta Pœdiatrica, Karolinska University Hospital, Z6:04, SE‐171 76 Stockholm, Sweden (Tel. +46 8 517 724 87, fax. +46 8 517 740 34, e‐mail. <email>rolf.zetterstrom@actapaediatrica.se</email>)</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:APA.APA1125.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received Mar. 26, 2004; accepted Apr. 13, 2004</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="20"></count><count type="linksCrossRef" number="8"></count></countGroup><titleGroup><title type="main">Ethical issues in research on control of the HIV/AIDS epidemic: report from a workshop of the World Federation of Scientists, Erice, Sicily, Italy, 22–24 August 2003</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>G</givenNames><familyNamePrefix>de</familyNamePrefix><familyName>Thé</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>F</givenNames><familyName>Buonaguro</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>N</givenNames><familyName>Charpak</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a4"><personName><givenNames>JL</givenNames><familyName>Hutton</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a5"><personName><givenNames>R</givenNames><familyName>Thorstensson</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a6"><personName><givenNames>E</givenNames><familyName>Valdas</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a7" corresponding="yes"><personName><givenNames>R</givenNames><familyName>Zetterström</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FR"><unparsedAffiliation>Pasteur Institute, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="IT"><unparsedAffiliation>Viral Oncology, 1st Naz Tumori Fond Pascale, Napoli, Italy</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="CO"><unparsedAffiliation>Kangaroo Foundation, Bogota, Colombia</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="GB"><unparsedAffiliation>Department of Statistics, University of Warwick, Coventry, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="a5" countryCode="SE"><unparsedAffiliation>Department of Immunology and Vaccinology, Swedish Institute for Infectious Diseases Control, Solna, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="a6" countryCode="ZA"><unparsedAffiliation>Department of Microbiology and Infectious Diseases, Perinatal Research Unit, University of Witwatersrand, South Africa</unparsedAffiliation></affiliation><affiliation xml:id="a7" countryCode="SE"><unparsedAffiliation>Karolinska University Hospital, Stockholm, Sweden</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">HIV/AIDS</keyword><keyword xml:id="k2">ethical issues</keyword><keyword xml:id="k3">research</keyword><keyword xml:id="k4">mother‐to‐child transmission</keyword><keyword xml:id="k5">developing countries</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>In research on control of the HIV/AIDS epidemic there are many ethical issues to be considered. The problem of personal autonomy versus the interest of society to prevent the spread of the disease in various settings makes it difficult to follow the regulations of the Declaration of Helsinki in all respects. This is particularly clear in the evaluation of trials aimed at preventing mother‐to‐child transmission of HIV. The interest of the child does not always conform to the policy of avoiding stigmatization of the mother.</p><p><i>Conclusion</i>: Programmes for the implementation of antiretroviral therapy and vaccine trials may differ in countries with different mean incomes of the inhabitants, and are also influenced by local patterns. For this reason, the Declaration of Helsinki should be changed in such a way that it conforms with the ways in which it may be possible to combat such a disastrous epidemic as that caused by HIV.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Ethical issues in research on control of the HIV/AIDS epidemic: report from a workshop of the World Federation of Scientists, Erice, Sicily, Italy, 22–24 August 2003</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Ethical issues in research on control of the HIV/AIDS epidemic: report from a workshop of the World Federation of Scientists, Erice, Sicily, Italy, 22–24 August 2003</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">de Thé</namePart><affiliation>Pasteur Institute, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Buonaguro</namePart><affiliation>Viral Oncology, 1st Naz Tumori Fond Pascale, Napoli, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Charpak</namePart><affiliation>Kangaroo Foundation, Bogota, Colombia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Hutton</namePart><affiliation>Department of Statistics, University of Warwick, Coventry, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Thorstensson</namePart><affiliation>Department of Immunology and Vaccinology, Swedish Institute for Infectious Diseases Control, Solna, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Valdas</namePart><affiliation>Department of Microbiology and Infectious Diseases, Perinatal Research Unit, University of Witwatersrand, South Africa</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Zetterström</namePart><affiliation>Karolinska University Hospital, Stockholm, Sweden</affiliation><affiliation>E-mail: rolf.zetterstrom@actapaediatrica.se</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2004-08</dateIssued><edition>Received Mar. 26, 2004; accepted Apr. 13, 2004</edition><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">20</extent><extent unit="linksCrossRef">8</extent></physicalDescription><abstract lang="en">In research on control of the HIV/AIDS epidemic there are many ethical issues to be considered. The problem of personal autonomy versus the interest of society to prevent the spread of the disease in various settings makes it difficult to follow the regulations of the Declaration of Helsinki in all respects. This is particularly clear in the evaluation of trials aimed at preventing mother‐to‐child transmission of HIV. The interest of the child does not always conform to the policy of avoiding stigmatization of the mother. Conclusion: Programmes for the implementation of antiretroviral therapy and vaccine trials may differ in countries with different mean incomes of the inhabitants, and are also influenced by local patterns. For this reason, the Declaration of Helsinki should be changed in such a way that it conforms with the ways in which it may be possible to combat such a disastrous epidemic as that caused by HIV.</abstract><subject lang="en"><genre>keywords</genre><topic>HIV/AIDS</topic><topic>ethical issues</topic><topic>research</topic><topic>mother‐to‐child transmission</topic><topic>developing countries</topic></subject><relatedItem type="host"><titleInfo><title>Acta Paediatrica</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0803-5253</identifier><identifier type="eISSN">1651-2227</identifier><identifier type="DOI">10.1111/(ISSN)1651-2227</identifier><identifier type="PublisherID">APA</identifier><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>93</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1125</start><end>1128</end><total>4</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Human immunodeficiency virus type‐1: mother‐to‐child transmission</title></titleInfo><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Dovie Akue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Babaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Barre‐Sinoussi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Charpak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">De The</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Ferreira Rea</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dovie Akue JP , Babaki P , Barre‐Sinoussi F , Charpak N , De The G , Ferreira Rea M , et al. 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