Immunotherapy of human immunodeficiency virus infection
Identifieur interne : 001375 ( Istex/Corpus ); précédent : 001374; suivant : 001376Immunotherapy of human immunodeficiency virus infection
Auteurs : John W. HaddenSource :
- Trends in Pharmacological Sciences [ 0165-6147 ] ; 1991.
English descriptors
- Teeft :
- Antiviral, Antiviral therapy, Bone marrow transplantation, Companion viruses, Hadden, Immune response, Immunorestorative therapy, Immunotherapy, Intravenous immunoglobulin therapy, Lymphocyte, Lymphocyte counts, Multicenter, Multicenter trial, Neutralizing antibody, Opportunistic infections, Peptide, Pituitary hormones, Preliminary data, Preliminary results, Symptomatic patients, Thymic, Thymus, Tips march, Vaccine development, Viral, Viral recovery, Viral replication, Zidovudine, Zidovudine treatment.
Abstract
Abstract: HIV infection results in the destruction of the thymus-dependent cellular immune system and death due to opportunistic infection and malignancy. Immunosuppressive influences (other sexually or blood-transmitted viruses, HIV-derived peptides, semen, poor nutrition, drugs, etc.) favor the progression of the disease. Although immunorestorative agents may be expected to delay progression of the disease, John Hadden argues that no agent has yet proven useful in reversing the immunodeficiency in full-blown AIDS. However, two thymomimetic drugs, isoprinosine and diethyldithiocarbamate, inhibit the development of infections in patients with pre-AIDS in large multicenter trials, and preliminary data from trials with two thymomimetic peptides, thymopentin and ImReg-1, in pre-AIDS patients are encouraging.
Url:
DOI: 10.1016/0165-6147(91)90517-V
Links to Exploration step
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