Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections
Identifieur interne : 001198 ( Istex/Corpus ); précédent : 001197; suivant : 001199Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections
Auteurs : Juanwen Zhang ; Ying Zhao ; Yu ChenSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2014-05.
Abstract
Reports describing the laboratory findings associated with human H7N9 infections are limited. In this study, the laboratory findings of 39 patients with confirmed H7N9 infection were analyzed retrospectively. Patients were enrolled following admission to The First Affiliated Hospital, College of Medicine, Zhejiang University, the primary hospital for the treatment of patients with H7N9 infections in Zhejiang province in China between March and April in 2013. Hematological abnormalities included leukopenia, lymphopenia, thrombocytopenia with prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) as well as elevation of D‐dimer levels. Biochemical abnormalities included elevated serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK), alanine aminotransferase (ALT) activities, and increased C‐reactive protein (CRP) concentration, as well as hyponatremia, hypokalemia, hypocalcemia, hypoproteinemia, and hypoalbuminemia. Arterial blood gas analysis revealed reduced arterial oxygen (PaO2) and carbon dioxide pressures (PaCO2). The data obtained in this study indicate that such abnormal laboratory features exhibited during the early stage of infection are common but not pathognomonic for the novel avian‐origin influenza A strain H7N9; therefore, these features do not to allow the definitive differentiation of H7N9 infection from those of other viruses. J. Med. Virol. 86:895–898, 2014. © 2013 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/jmv.23780
Links to Exploration step
ISTEX:977DBFFDAB2EE46FE472864ADA7884BD50D8CBCELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections</title><author><name sortKey="Zhang, Juanwen" sort="Zhang, Juanwen" uniqKey="Zhang J" first="Juanwen" last="Zhang">Juanwen Zhang</name><affiliation><mods:affiliation>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Zhao, Ying" sort="Zhao, Ying" uniqKey="Zhao Y" first="Ying" last="Zhao">Ying Zhao</name><affiliation><mods:affiliation>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name><affiliation><mods:affiliation>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to: Prof. Yu Chen, Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: tym2011@yeah.net</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:977DBFFDAB2EE46FE472864ADA7884BD50D8CBCE</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1002/jmv.23780</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-0P17JBMV-N/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001198</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001198</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections</title><author><name sortKey="Zhang, Juanwen" sort="Zhang, Juanwen" uniqKey="Zhang J" first="Juanwen" last="Zhang">Juanwen Zhang</name><affiliation><mods:affiliation>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Zhao, Ying" sort="Zhao, Ying" uniqKey="Zhao Y" first="Ying" last="Zhao">Ying Zhao</name><affiliation><mods:affiliation>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation></author><author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name><affiliation><mods:affiliation>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to: Prof. Yu Chen, Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: tym2011@yeah.net</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">86</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="895">895</biblScope><biblScope unit="page" to="898">898</biblScope><biblScope unit="page-count">4</biblScope><date type="published" when="2014-05">2014-05</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Reports describing the laboratory findings associated with human H7N9 infections are limited. In this study, the laboratory findings of 39 patients with confirmed H7N9 infection were analyzed retrospectively. Patients were enrolled following admission to The First Affiliated Hospital, College of Medicine, Zhejiang University, the primary hospital for the treatment of patients with H7N9 infections in Zhejiang province in China between March and April in 2013. Hematological abnormalities included leukopenia, lymphopenia, thrombocytopenia with prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) as well as elevation of D‐dimer levels. Biochemical abnormalities included elevated serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK), alanine aminotransferase (ALT) activities, and increased C‐reactive protein (CRP) concentration, as well as hyponatremia, hypokalemia, hypocalcemia, hypoproteinemia, and hypoalbuminemia. Arterial blood gas analysis revealed reduced arterial oxygen (PaO2) and carbon dioxide pressures (PaCO2). The data obtained in this study indicate that such abnormal laboratory features exhibited during the early stage of infection are common but not pathognomonic for the novel avian‐origin influenza A strain H7N9; therefore, these features do not to allow the definitive differentiation of H7N9 infection from those of other viruses. J. Med. Virol. 86:895–898, 2014. © 2013 Wiley Periodicals, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Juanwen Zhang</name><affiliations><json:string>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</json:string></affiliations></json:item><json:item><name>Ying Zhao</name><affiliations><json:string>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</json:string></affiliations></json:item><json:item><name>Yu Chen</name><affiliations><json:string>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</json:string><json:string>Correspondence to: Prof. Yu Chen, Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.E‐mail:</json:string><json:string>E-mail: tym2011@yeah.net</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>avian influenza H7N9</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>laboratory features</value></json:item></subject><articleId><json:string>JMV23780</json:string></articleId><arkIstex>ark:/67375/WNG-0P17JBMV-N</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Reports describing the laboratory findings associated with human H7N9 infections are limited. In this study, the laboratory findings of 39 patients with confirmed H7N9 infection were analyzed retrospectively. Patients were enrolled following admission to The First Affiliated Hospital, College of Medicine, Zhejiang University, the primary hospital for the treatment of patients with H7N9 infections in Zhejiang province in China between March and April in 2013. Hematological abnormalities included leukopenia, lymphopenia, thrombocytopenia with prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) as well as elevation of D‐dimer levels. Biochemical abnormalities included elevated serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK), alanine aminotransferase (ALT) activities, and increased C‐reactive protein (CRP) concentration, as well as hyponatremia, hypokalemia, hypocalcemia, hypoproteinemia, and hypoalbuminemia. Arterial blood gas analysis revealed reduced arterial oxygen (PaO2) and carbon dioxide pressures (PaCO2). The data obtained in this study indicate that such abnormal laboratory features exhibited during the early stage of infection are common but not pathognomonic for the novel avian‐origin influenza A strain H7N9; therefore, these features do not to allow the definitive differentiation of H7N9 infection from those of other viruses. J. Med. Virol. 86:895–898, 2014. © 2013 Wiley Periodicals, Inc.</abstract><qualityIndicators><score>6.321</score><pdfWordCount>1969</pdfWordCount><pdfCharCount>13045</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>4</pdfPageCount><pdfPageSize>593.972 x 792 pts</pdfPageSize><pdfWordsPerPage>492</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>196</abstractWordCount><abstractCharCount>1490</abstractCharCount><keywordCount>2</keywordCount></qualityIndicators><title>Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections</title><genre><json:string>article</json:string></genre><host><title>Journal of Medical Virology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9071</json:string></doi><issn><json:string>0146-6615</json:string></issn><eissn><json:string>1096-9071</json:string></eissn><publisherId><json:string>JMV</json:string></publisherId><volume>86</volume><issue>5</issue><pages><first>895</first><last>898</last><total>4</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Research Article</value></json:item><json:item><value>Research Articles</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-0P17JBMV-N</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2014</publicationDate><copyrightDate>2014</copyrightDate><doi><json:string>10.1002/jmv.23780</json:string></doi><id>977DBFFDAB2EE46FE472864ADA7884BD50D8CBCE</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-0P17JBMV-N/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-0P17JBMV-N/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-0P17JBMV-N/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections</title><title level="a" type="short">Avian Influenza H7N9 Laboratory Findings</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-QW5Q88H5-V">Wiley Publishing Ltd</publisher><availability><licence>© 2013 Wiley Periodicals, Inc.</licence></availability><date type="published" when="2014-05"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections</title><title level="a" type="short">Avian Influenza H7N9 Laboratory Findings</title><author xml:id="author-0000"><persName><forename type="first">Juanwen</forename><surname>Zhang</surname></persName><affiliation><orgName type="division">Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine</orgName><orgName type="institution">Zhejiang University</orgName><address><settlement>Hangzhou</settlement><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Ying</forename><surname>Zhao</surname></persName><affiliation><orgName type="division">Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine</orgName><orgName type="institution">Zhejiang University</orgName><address><settlement>Hangzhou</settlement><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><author xml:id="author-0002" role="corresp"><persName><forename type="first">Yu</forename><surname>Chen</surname></persName><affiliation><orgName type="division">Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine</orgName><orgName type="institution">Zhejiang University</orgName><address><settlement>Hangzhou</settlement><country key="CN" xml:lang="en">CHINA</country></address></affiliation></author><idno type="istex">977DBFFDAB2EE46FE472864ADA7884BD50D8CBCE</idno><idno type="ark">ark:/67375/WNG-0P17JBMV-N</idno><idno type="DOI">10.1002/jmv.23780</idno><idno type="unit">JMV23780</idno><idno type="toTypesetVersion">file:JMV.JMV23780.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="pISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><idno type="book-DOI">10.1002/(ISSN)1096-9071</idno><idno type="book-part-DOI">10.1002/jmv.v86.5</idno><idno type="product">JMV</idno><imprint><biblScope unit="vol">86</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="895">895</biblScope><biblScope unit="page" to="898">898</biblScope><biblScope unit="page-count">4</biblScope><date type="published" when="2014-05"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main"><p>Reports describing the laboratory findings associated with human H7N9 infections are limited. In this study, the laboratory findings of 39 patients with confirmed H7N9 infection were analyzed retrospectively. Patients were enrolled following admission to The First Affiliated Hospital, College of Medicine, Zhejiang University, the primary hospital for the treatment of patients with H7N9 infections in Zhejiang province in China between March and April in 2013. Hematological abnormalities included leukopenia, lymphopenia, thrombocytopenia with prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) as well as elevation of <hi rend="smallCaps">D</hi>‐dimer levels. Biochemical abnormalities included elevated serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK), alanine aminotransferase (ALT) activities, and increased C‐reactive protein (CRP) concentration, as well as hyponatremia, hypokalemia, hypocalcemia, hypoproteinemia, and hypoalbuminemia. Arterial blood gas analysis revealed reduced arterial oxygen (PaO<hi rend="subscript">2</hi>) and carbon dioxide pressures (PaCO<hi rend="subscript">2</hi>). The data obtained in this study indicate that such abnormal laboratory features exhibited during the early stage of infection are common but not pathognomonic for the novel avian‐origin influenza A strain H7N9; therefore, these features do not to allow the definitive differentiation of H7N9 infection from those of other viruses. <hi rend="bold"><hi rend="italic">J. Med. Virol. 86:895–898, 2014</hi>.</hi> © 2013 Wiley Periodicals, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="jmv23780-kwd-0001">avian influenza H7N9</term><term xml:id="jmv23780-kwd-0002">laboratory features</term></keywords><keywords rend="articleCategory"><term>Research Article</term></keywords><keywords rend="tocHeading1"><term>Research Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-0P17JBMV-N/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" xml:lang="en" type="serialArticle" xml:id="jmv23780"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1096-9071</doi><issn type="print">0146-6615</issn><issn type="electronic">1096-9071</issn><idGroup><id type="product" value="JMV"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF MEDICAL VIROLOGY">Journal of Medical Virology</title><title type="short">J. Med. Virol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi registered="yes">10.1002/jmv.v86.5</doi><copyright ownership="publisher">© 2013 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering type="journalVolume" number="86">86</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2014-05">May 2014</coverDate></publicationMeta><publicationMeta level="unit" position="240" type="article" status="forIssue"><doi>10.1002/jmv.23780</doi><idGroup><id type="unit" value="JMV23780"></id></idGroup><countGroup><count type="pageTotal" number="4"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">© 2013 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptAccepted" date="2013-08-21"></event><event type="xmlCreated" agent="Thomson Digital" date="2013-09-23"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.0 mode:FullText" date="2014-03-13"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-10-11"></event><event type="firstOnline" date="2013-10-11"></event><event type="publishedOnlineFinalForm" date="2014-03-13"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-08"></event></eventGroup><numberingGroup><numbering type="pageFirst">895</numbering><numbering type="pageLast">898</numbering></numberingGroup><correspondenceTo><lineatedText><line>Correspondence to: Prof. Yu Chen, Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.</line><line>E‐mail:
<email>tym2011@yeah.net</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JMV.JMV23780.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections</title><title type="short">Avian Influenza H7N9 Laboratory Findings</title><title type="shortAuthors">Zhang et al.</title></titleGroup><creators><creator xml:id="jmv23780-cr-0001" creatorRole="author" affiliationRef="#jmv23780-aff-0001"><personName><givenNames>Juanwen</givenNames> <familyName>Zhang</familyName></personName></creator><creator xml:id="jmv23780-cr-0002" creatorRole="author" affiliationRef="#jmv23780-aff-0001"><personName><givenNames>Ying</givenNames> <familyName>Zhao</familyName></personName></creator><creator xml:id="jmv23780-cr-0003" creatorRole="author" affiliationRef="#jmv23780-aff-0001" corresponding="yes"><personName><givenNames>Yu</givenNames> <familyName>Chen</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="jmv23780-aff-0001" countryCode="CN"><orgDiv>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine</orgDiv><orgName>Zhejiang University</orgName><address><city>Hangzhou</city><country>China</country></address></affiliation></affiliationGroup><keywordGroup type="author" xml:lang="en"><keyword xml:id="jmv23780-kwd-0001">avian influenza H7N9</keyword><keyword xml:id="jmv23780-kwd-0002">laboratory features</keyword></keywordGroup><fundingInfo><fundingAgency>Traditional Chinese Medicine Foundation of Zhejiang Province, China</fundingAgency><fundingNumber>2008CA054</fundingNumber></fundingInfo><abstractGroup><abstract type="main"><section xml:id="jmv23780-sec-0001"><p>Reports describing the laboratory findings associated with human H7N9 infections are limited. In this study, the laboratory findings of 39 patients with confirmed H7N9 infection were analyzed retrospectively. Patients were enrolled following admission to The First Affiliated Hospital, College of Medicine, Zhejiang University, the primary hospital for the treatment of patients with H7N9 infections in Zhejiang province in China between March and April in 2013. Hematological abnormalities included leukopenia, lymphopenia, thrombocytopenia with prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) as well as elevation of <sc>D</sc>‐dimer levels. Biochemical abnormalities included elevated serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK), alanine aminotransferase (ALT) activities, and increased C‐reactive protein (CRP) concentration, as well as hyponatremia, hypokalemia, hypocalcemia, hypoproteinemia, and hypoalbuminemia. Arterial blood gas analysis revealed reduced arterial oxygen (PaO<sub>2</sub>) and carbon dioxide pressures (PaCO<sub>2</sub>). The data obtained in this study indicate that such abnormal laboratory features exhibited during the early stage of infection are common but not pathognomonic for the novel avian‐origin influenza A strain H7N9; therefore, these features do not to allow the definitive differentiation of H7N9 infection from those of other viruses. <b><i>J. Med. Virol. 86:895–898, 2014</i>.</b> © 2013 Wiley Periodicals, Inc.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Avian Influenza H7N9 Laboratory Findings</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections</title></titleInfo><name type="personal"><namePart type="given">Juanwen</namePart><namePart type="family">Zhang</namePart><affiliation>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ying</namePart><namePart type="family">Zhao</namePart><affiliation>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yu</namePart><namePart type="family">Chen</namePart><affiliation>Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China</affiliation><affiliation>Correspondence to: Prof. Yu Chen, Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.E‐mail:</affiliation><affiliation>E-mail: tym2011@yeah.net</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-05</dateIssued><dateCreated encoding="w3cdtf">2013-09-23</dateCreated><dateValid encoding="w3cdtf">2013-08-21</dateValid><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Reports describing the laboratory findings associated with human H7N9 infections are limited. In this study, the laboratory findings of 39 patients with confirmed H7N9 infection were analyzed retrospectively. Patients were enrolled following admission to The First Affiliated Hospital, College of Medicine, Zhejiang University, the primary hospital for the treatment of patients with H7N9 infections in Zhejiang province in China between March and April in 2013. Hematological abnormalities included leukopenia, lymphopenia, thrombocytopenia with prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) as well as elevation of D‐dimer levels. Biochemical abnormalities included elevated serum lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK), alanine aminotransferase (ALT) activities, and increased C‐reactive protein (CRP) concentration, as well as hyponatremia, hypokalemia, hypocalcemia, hypoproteinemia, and hypoalbuminemia. Arterial blood gas analysis revealed reduced arterial oxygen (PaO2) and carbon dioxide pressures (PaCO2). The data obtained in this study indicate that such abnormal laboratory features exhibited during the early stage of infection are common but not pathognomonic for the novel avian‐origin influenza A strain H7N9; therefore, these features do not to allow the definitive differentiation of H7N9 infection from those of other viruses. J. Med. Virol. 86:895–898, 2014. © 2013 Wiley Periodicals, Inc.</abstract><note type="funding">Traditional Chinese Medicine Foundation of Zhejiang Province, China - No. 2008CA054; </note><subject lang="en"><genre>keywords</genre><topic>avian influenza H7N9</topic><topic>laboratory features</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. Virol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic><topic>Research Articles</topic></subject><identifier type="ISSN">0146-6615</identifier><identifier type="eISSN">1096-9071</identifier><identifier type="DOI">10.1002/(ISSN)1096-9071</identifier><identifier type="PublisherID">JMV</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>895</start><end>898</end><total>4</total></extent></part></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0001"><titleInfo><title>Pathogenesis and transmissibility of highly (H7N1) and low (H7N9) pathogenic avian influenza virus infection in red‐legged partridge (Alectoris rufa)</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Bertran</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Pérez‐Ramírez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Busquets</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Dolz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ramis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Darji</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FX</namePart><namePart type="family">Abad</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Valle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Chaves</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Vergara‐Alert</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Barral</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U</namePart><namePart type="family">Höfle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Majó</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bertran K, Pérez‐Ramírez E, Busquets N, Dolz R, Ramis A, Darji A, Abad FX, Valle R, Chaves A, Vergara‐Alert J, Barral M, Höfle U, Majó N. 2011. Pathogenesis and transmissibility of highly (H7N1) and low (H7N9) pathogenic avian influenza virus infection in red‐legged partridge (Alectoris rufa). Vet Res 42:24.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>24</start></extent></part><relatedItem type="host"><titleInfo><title>Vet Res</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><extent unit="pages"><start>24</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0002"><titleInfo><title>Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: Clinical analysis and characterisation of viral genome</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Liang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Sheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Yao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Cui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Yao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Zheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Diao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Xia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KH</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HW</namePart><namePart type="family">Tsoi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Teng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Song</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SY</namePart><namePart type="family">Lau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Zheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KK</namePart><namePart type="family">To</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KY</namePart><namePart type="family">Yuen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen Y, Liang W, Yang S, Wu N, Gao H, Sheng J, Yao H, Wo J, Fang Q, Cui D, Li Y, Yao X, Zhang Y, Wu H, Zheng S, Diao H, Xia S, Zhang Y, Chan KH, Tsoi HW, Teng JL, Song W, Wang P, Lau SY, Zheng M, Chan JF, To KK, Chen H, Li L, Yuen KY. 2013. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: Clinical analysis and characterisation of viral genome. Lancet 381:1916–1925.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>381</number></detail><extent unit="pages"><start>1916</start><end>1925</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>381</number></detail><extent unit="pages"><start>1916</start><end>1925</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0003"><titleInfo><title>Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease</title></titleInfo><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Cheung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LL</namePart><namePart type="family">Poon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AS</namePart><namePart type="family">Lau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Luk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YL</namePart><namePart type="family">Lau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KF</namePart><namePart type="family">Shortridge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Gordon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Peiris</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cheung CY, Poon LL, Lau AS, Luk W, Lau YL, Shortridge KF, Gordon S, Guan Y, Peiris JS. 2002. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease? Lancet 360:1831–1837.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>360</number></detail><extent unit="pages"><start>1831</start><end>1837</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>360</number></detail><extent unit="pages"><start>1831</start><end>1837</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0004"><titleInfo><title>Clinical factors associated with severity in hospitalized children infected with avian influenza (H5N1)</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Furuya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kawachi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Shigematsu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Furuya H, Kawachi S, Shigematsu M, Suzuki K, Watanabe T. 2011. Clinical factors associated with severity in hospitalized children infected with avian influenza (H5N1). Environ Health Prev Med 16:64–68.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>64</start><end>68</end></extent></part><relatedItem type="host"><titleInfo><title>Environ Health Prev Med</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>64</start><end>68</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0005"><titleInfo><title>Human infection with a novel avian‐origin influenza A (H7N9) virus</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Cao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Feng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Jie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Qiu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Lu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Zhu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Xiang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">He</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Gu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Zhao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Zou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Guo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Dong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Dong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zhu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Bai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Hao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Han</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GF</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Yuan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, Xu X, Lu H, Zhu W, Gao Z, Xiang N, Shen Y, He Z, Gu Y, Zhang Z, Yang Y, Zhao X, Zhou L, Li X, Zou S, Zhang Y, Li X, Yang L, Guo J, Dong J, Li Q, Dong L, Zhu Y, Bai T, Wang S, Hao P, Yang W, Zhang Y, Han J, Yu H, Li D, Gao GF, Wu G, Wang Y, Yuan Z, Shu Y. 2013. Human infection with a novel avian‐origin influenza A (H7N9) virus. N Engl J Med 368:1888–1897.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>368</number></detail><extent unit="pages"><start>1888</start><end>1897</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>368</number></detail><extent unit="pages"><start>1888</start><end>1897</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0006"><titleInfo><title>Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG‐I signaling</title></titleInfo><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Graham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KM</namePart><namePart type="family">Hilmer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Zickovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JJ</namePart><namePart type="family">Obar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Graham AC, Hilmer KM, Zickovich JM, Obar JJ. 2013. Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG‐I signaling. J Immunol 90:4676–4684.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>90</number></detail><extent unit="pages"><start>4676</start><end>4684</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>90</number></detail><extent unit="pages"><start>4676</start><end>4684</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0007"><titleInfo><title>Severe acute respiratory syndrome: Clinical and laboratory manifestations</title></titleInfo><name type="personal"><namePart type="given">CW</namePart><namePart type="family">Lam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MH</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CK</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lam CW, Chan MH, Wong CK. 2004. Severe acute respiratory syndrome: Clinical and laboratory manifestations. Clin Biochem Rev 25:121–132.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>121</start><end>132</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Biochem Rev</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>121</start><end>132</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0008"><titleInfo><title>Preliminary report: Epidemiology of the avian influenza A (H7N9) outbreak in China</title></titleInfo><name type="personal"><namePart type="given">Q</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Xiang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Tang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Meng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Tu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Cao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Ding</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Xie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Bai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Zou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">He</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Chai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Jin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Luo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Pang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TM</namePart><namePart type="family">Uyeki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Feng</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Li Q, Zhou L, Zhou M, Chen Z, Li F, Wu H, Xiang N, Chen E, Tang F, Wang D, Meng L, Hong Z, Tu W, Cao Y, Li L, Ding F, Liu B, Wang M, Xie R, Gao R, Li X, Bai T, Zou S, He J, Hu J, Xu Y, Chai C, Wang S, Gao Y, Jin L, Zhang Y, Luo H, Yu H, Gao L, Pang X, Liu G, Shu Y, Yang W, Uyeki TM, Wang Y, Wu F, Feng Z. 2013. Preliminary report: Epidemiology of the avian influenza A (H7N9) outbreak in China. N Engl J Med 1964:4.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>1964</number></detail><extent unit="pages"><start>4</start></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>1964</number></detail><extent unit="pages"><start>4</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0009"><titleInfo><title>Analysis of the clinical characteristics and treatment of two patients with avian influenza virus (H7N9)</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Lu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Xi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Cao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Lu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lu S, Xi X, Zheng Y, Cao Y, Liu X, Lu H. 2013. Analysis of the clinical characteristics and treatment of two patients with avian influenza virus (H7N9). Biosci Trends 7:109–112.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>109</start><end>112</end></extent></part><relatedItem type="host"><titleInfo><title>Biosci Trends</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>109</start><end>112</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0010"><titleInfo><title>Global concerns regarding novel influenza A (H7N9) virus infections</title></titleInfo><name type="personal"><namePart type="given">TM</namePart><namePart type="family">Uyeki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">Cox</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Uyeki TM, Cox NJ. 2013. Global concerns regarding novel influenza A (H7N9) virus infections. N Engl J Med 368:1862–1864.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>368</number></detail><extent unit="pages"><start>1862</start><end>1864</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>368</number></detail><extent unit="pages"><start>1862</start><end>1864</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv23780-cit-0011"><titleInfo><title>Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets</title></titleInfo><name type="personal"><namePart type="given">JM</namePart><namePart type="family">van den Brand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KJ</namePart><namePart type="family">Stittelaar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">van Amerongen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Reperant</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">de Waal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AD</namePart><namePart type="family">Osterhaus</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Kuiken</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">van den Brand JM, Stittelaar KJ, van Amerongen G, Reperant L, de Waal L, Osterhaus AD, Kuiken T. 2012. Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets. PLoS ONE 7:e42343.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>e42343</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS ONE</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>e42343</start></extent></part></relatedItem></relatedItem><identifier type="istex">977DBFFDAB2EE46FE472864ADA7884BD50D8CBCE</identifier><identifier type="ark">ark:/67375/WNG-0P17JBMV-N</identifier><identifier type="DOI">10.1002/jmv.23780</identifier><identifier type="ArticleID">JMV23780</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013 Wiley Periodicals, Inc.© 2013 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-0P17JBMV-N/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001198 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001198 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:977DBFFDAB2EE46FE472864ADA7884BD50D8CBCE
|texte= Laboratory findings in patients with avian‐origin influenza A (H7N9) virus infections
}}
| This area was generated with Dilib version V0.6.33. |  |