Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan
Identifieur interne : 001066 ( Istex/Corpus ); précédent : 001065; suivant : 001067Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan
Auteurs : Yu-Ching Lan ; Tarek Elbeik ; Joann Dileanis ; Valerie Ng ; Yen-Ju Chen ; Hsieh-Shong Leu ; Shu-Hsing Cheng ; Jen-Chien Wong ; Wing-Wai Wong ; Yi-Ming A. ChenSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2008-02.
Abstract
The Taiwanese government has provided free highly active antiretroviral therapy since April 1997. Previously, we have reported on the molecular epidemiology of HIV‐1 in Taiwan from 1988 to 1998. In addition, an outbreak of circulating recombinant form (CRF) 07_BC among intravenous drug users was noted in 2004. Therefore, the purposes of this study were to elucidate the distribution of HIV‐1 subtypes among different high‐risk groups in Taiwan from 1999 to 2000 and to conduct surveillance on drug resistance among treatment naïve patients from 1997 to 2000. Blood samples from 239 HIV‐1/AIDS patients and their subtypes were examined using DNA sequencing and phylogenetic analysis. The results showed that among 226 male patients, 213 (94.2%) had subtype B, 11 (4.9%) had CRF01_AE, 1 had unique recombinant strain related to both CRF07_BC and CRF08_BC (strain T12‐99TW) and 1 had CRF08_BC (strain L9312‐00TW). The patients infected with T12‐99TW and L9312‐00TW were intravenous drug users and had needle‐sharing experiences in Yunnan Province, China. Of the 13 HIV‐1‐infected females, 7 (53.8%) had subtype B, 5 (38.5%) had CRF01_AE, and 1 (7.7%) had subtype C. Phylogenetic analysis demonstrated that the neither strain T12‐99TW nor L9312‐00TW clustered with CRF07_BC strains isolated from Taiwanese intravenous drug users in 2004. In addition, 126 treatment naïve patients were selected for genotypic DR analysis and the results showed that 4.3% (2/47) homosexual males had M184V mutations. This is the first report on the identification of CRF08_BC and a unique recombinant strain related to both CRF07_BC and CRF08_BC in Taiwan. J. Med. Virol. 80:183–191, 2008. © 2007 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.21065
Links to Exploration step
ISTEX:5D42273C171AD3003D2A55BE0DAE6AE699513D32Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan</title><author><name sortKey="Lan, Yu Hing" sort="Lan, Yu Hing" uniqKey="Lan Y" first="Yu-Ching" last="Lan">Yu-Ching Lan</name><affiliation><mods:affiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Health Risk Management, China Medical University, Taichung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Elbeik, Tarek" sort="Elbeik, Tarek" uniqKey="Elbeik T" first="Tarek" last="Elbeik">Tarek Elbeik</name><affiliation><mods:affiliation>Department of Laboratory Medicine, University of California, San Francisco, California</mods:affiliation></affiliation><affiliation><mods:affiliation>Clinical Laboratories at San Francisco General Hospital, San Francisco, California</mods:affiliation></affiliation></author><author><name sortKey="Dileanis, Joann" sort="Dileanis, Joann" uniqKey="Dileanis J" first="Joann" last="Dileanis">Joann Dileanis</name><affiliation><mods:affiliation>Celera Diagnostics, Alameda, California</mods:affiliation></affiliation></author><author><name sortKey="Ng, Valerie" sort="Ng, Valerie" uniqKey="Ng V" first="Valerie" last="Ng">Valerie Ng</name><affiliation><mods:affiliation>Department of Laboratory Medicine, University of California, San Francisco, California</mods:affiliation></affiliation><affiliation><mods:affiliation>Clinical Laboratories at San Francisco General Hospital, San Francisco, California</mods:affiliation></affiliation></author><author><name sortKey="Chen, Yen U" sort="Chen, Yen U" uniqKey="Chen Y" first="Yen-Ju" last="Chen">Yen-Ju Chen</name><affiliation><mods:affiliation>Institute of Public Health, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Leu, Hsieh Hong" sort="Leu, Hsieh Hong" uniqKey="Leu H" first="Hsieh-Shong" last="Leu">Hsieh-Shong Leu</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital and University, Tao‐Yuan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Cheng, Shu Sing" sort="Cheng, Shu Sing" uniqKey="Cheng S" first="Shu-Hsing" last="Cheng">Shu-Hsing Cheng</name><affiliation><mods:affiliation>Infection Control Committee, Tao‐Yuan General Hospital, Tao‐Yuan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Wong, Jen Hien" sort="Wong, Jen Hien" uniqKey="Wong J" first="Jen-Chien" last="Wong">Jen-Chien Wong</name><affiliation><mods:affiliation>Department of Infectious Disease, China Medical University Hospital, Taichung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Wong, Wing Ai" sort="Wong, Wing Ai" uniqKey="Wong W" first="Wing-Wai" last="Wong">Wing-Wai Wong</name><affiliation><mods:affiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Branch of Communicable Disease Control and Prevention, Taipei City Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chen, Yi Ing A" sort="Chen, Yi Ing A" uniqKey="Chen Y" first="Yi-Ming A." last="Chen">Yi-Ming A. Chen</name><affiliation><mods:affiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: arthur@ym.edu.tw</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: AIDS Prevention and Research Center, National Yang‐Ming University, No. 155, Li‐Nong Street, Sec. 2, Taipei, Taiwan.===</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5D42273C171AD3003D2A55BE0DAE6AE699513D32</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/jmv.21065</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-LV07GDJL-N/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001066</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001066</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan</title><author><name sortKey="Lan, Yu Hing" sort="Lan, Yu Hing" uniqKey="Lan Y" first="Yu-Ching" last="Lan">Yu-Ching Lan</name><affiliation><mods:affiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Health Risk Management, China Medical University, Taichung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Elbeik, Tarek" sort="Elbeik, Tarek" uniqKey="Elbeik T" first="Tarek" last="Elbeik">Tarek Elbeik</name><affiliation><mods:affiliation>Department of Laboratory Medicine, University of California, San Francisco, California</mods:affiliation></affiliation><affiliation><mods:affiliation>Clinical Laboratories at San Francisco General Hospital, San Francisco, California</mods:affiliation></affiliation></author><author><name sortKey="Dileanis, Joann" sort="Dileanis, Joann" uniqKey="Dileanis J" first="Joann" last="Dileanis">Joann Dileanis</name><affiliation><mods:affiliation>Celera Diagnostics, Alameda, California</mods:affiliation></affiliation></author><author><name sortKey="Ng, Valerie" sort="Ng, Valerie" uniqKey="Ng V" first="Valerie" last="Ng">Valerie Ng</name><affiliation><mods:affiliation>Department of Laboratory Medicine, University of California, San Francisco, California</mods:affiliation></affiliation><affiliation><mods:affiliation>Clinical Laboratories at San Francisco General Hospital, San Francisco, California</mods:affiliation></affiliation></author><author><name sortKey="Chen, Yen U" sort="Chen, Yen U" uniqKey="Chen Y" first="Yen-Ju" last="Chen">Yen-Ju Chen</name><affiliation><mods:affiliation>Institute of Public Health, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Leu, Hsieh Hong" sort="Leu, Hsieh Hong" uniqKey="Leu H" first="Hsieh-Shong" last="Leu">Hsieh-Shong Leu</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital and University, Tao‐Yuan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Cheng, Shu Sing" sort="Cheng, Shu Sing" uniqKey="Cheng S" first="Shu-Hsing" last="Cheng">Shu-Hsing Cheng</name><affiliation><mods:affiliation>Infection Control Committee, Tao‐Yuan General Hospital, Tao‐Yuan, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Wong, Jen Hien" sort="Wong, Jen Hien" uniqKey="Wong J" first="Jen-Chien" last="Wong">Jen-Chien Wong</name><affiliation><mods:affiliation>Department of Infectious Disease, China Medical University Hospital, Taichung, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Wong, Wing Ai" sort="Wong, Wing Ai" uniqKey="Wong W" first="Wing-Wai" last="Wong">Wing-Wai Wong</name><affiliation><mods:affiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Branch of Communicable Disease Control and Prevention, Taipei City Hospital, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chen, Yi Ing A" sort="Chen, Yi Ing A" uniqKey="Chen Y" first="Yi-Ming A." last="Chen">Yi-Ming A. Chen</name><affiliation><mods:affiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: arthur@ym.edu.tw</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: AIDS Prevention and Research Center, National Yang‐Ming University, No. 155, Li‐Nong Street, Sec. 2, Taipei, Taiwan.===</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">80</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="183">183</biblScope><biblScope unit="page" to="191">191</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-02">2008-02</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Taiwanese government has provided free highly active antiretroviral therapy since April 1997. Previously, we have reported on the molecular epidemiology of HIV‐1 in Taiwan from 1988 to 1998. In addition, an outbreak of circulating recombinant form (CRF) 07_BC among intravenous drug users was noted in 2004. Therefore, the purposes of this study were to elucidate the distribution of HIV‐1 subtypes among different high‐risk groups in Taiwan from 1999 to 2000 and to conduct surveillance on drug resistance among treatment naïve patients from 1997 to 2000. Blood samples from 239 HIV‐1/AIDS patients and their subtypes were examined using DNA sequencing and phylogenetic analysis. The results showed that among 226 male patients, 213 (94.2%) had subtype B, 11 (4.9%) had CRF01_AE, 1 had unique recombinant strain related to both CRF07_BC and CRF08_BC (strain T12‐99TW) and 1 had CRF08_BC (strain L9312‐00TW). The patients infected with T12‐99TW and L9312‐00TW were intravenous drug users and had needle‐sharing experiences in Yunnan Province, China. Of the 13 HIV‐1‐infected females, 7 (53.8%) had subtype B, 5 (38.5%) had CRF01_AE, and 1 (7.7%) had subtype C. Phylogenetic analysis demonstrated that the neither strain T12‐99TW nor L9312‐00TW clustered with CRF07_BC strains isolated from Taiwanese intravenous drug users in 2004. In addition, 126 treatment naïve patients were selected for genotypic DR analysis and the results showed that 4.3% (2/47) homosexual males had M184V mutations. This is the first report on the identification of CRF08_BC and a unique recombinant strain related to both CRF07_BC and CRF08_BC in Taiwan. J. Med. Virol. 80:183–191, 2008. © 2007 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>intravenous</json:string><json:string>heterosexual</json:string><json:string>mutation</json:string><json:string>recombinant</json:string><json:string>intravenous drug user</json:string><json:string>epidemiology</json:string><json:string>phylogenetic</json:string><json:string>virol</json:string><json:string>drug resistance</json:string><json:string>subtypes</json:string><json:string>bisexual</json:string><json:string>genotypic</json:string><json:string>taiwanese</json:string><json:string>subtype</json:string><json:string>phylogenetic analysis</json:string><json:string>molecular epidemiology</json:string><json:string>chang</json:string><json:string>immunodeficiency</json:string><json:string>subtype distribution</json:string><json:string>zhang</json:string><json:string>crfs</json:string><json:string>recombinant form</json:string><json:string>intravenous drug user patient</json:string><json:string>taiwanese molecular epidemiology study</json:string><json:string>human immunodeficiency virus type</json:string><json:string>male patient</json:string><json:string>national university</json:string><json:string>drug patient</json:string><json:string>different group</json:string><json:string>risk group</json:string><json:string>user</json:string><json:string>mainland china</json:string><json:string>yunnan province</json:string><json:string>infectious disease</json:string><json:string>treatment patient</json:string><json:string>hong kong</json:string><json:string>drug resistance program</json:string><json:string>chen</json:string><json:string>taiwan</json:string><json:string>homosexual</json:string><json:string>taipei</json:string><json:string>celera diagnostics</json:string><json:string>disease control</json:string><json:string>unique recombinant strain</json:string><json:string>blood sample</json:string><json:string>subtype determination</json:string><json:string>previous study</json:string><json:string>active antiretroviral therapy</json:string><json:string>study subject</json:string><json:string>male homosexual</json:string><json:string>bisexual group</json:string><json:string>female commercial</json:string><json:string>free access</json:string><json:string>primary mutation</json:string><json:string>research center</json:string><json:string>aid prevention</json:string><json:string>drug user</json:string><json:string>genetic diversity</json:string><json:string>heterosexual male</json:string><json:string>taiwanese government</json:string><json:string>clinical parameter</json:string><json:string>patient plasma sample</json:string><json:string>primer pair</json:string><json:string>final extension</json:string><json:string>reference sequence</json:string><json:string>viroseq genotyping system</json:string><json:string>female patient</json:string><json:string>risk factor</json:string><json:string>disease control taiwan</json:string><json:string>region hxb2 reference sequence nucleotide</json:string><json:string>different subtypes</json:string><json:string>drug resistant strain</json:string><json:string>different aid treatment center</json:string><json:string>general hospital</json:string><json:string>different risk group</json:string><json:string>study participant</json:string><json:string>similar pattern</json:string><json:string>homosexual male</json:string><json:string>male heterosexual</json:string><json:string>various subtypes</json:string><json:string>alamo national laboratory</json:string><json:string>world health organization</json:string><json:string>primary resistant mutation</json:string><json:string>temporal trend</json:string><json:string>grant sponsor</json:string><json:string>genome research center</json:string><json:string>epidemiological link</json:string><json:string>male population</json:string><json:string>female population</json:string><json:string>subtype analysis</json:string><json:string>recombinant virus</json:string><json:string>primary genotypic</json:string><json:string>protease inhibitor</json:string><json:string>collaborative group</json:string><json:string>national yangming university</json:string><json:string>southern china</json:string><json:string>drug resistance surveillance</json:string><json:string>acquir immune defic syndr</json:string><json:string>other subtypes</json:string></teeft></keywords><author><json:item><name>Yu‐Ching Lan</name><affiliations><json:string>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</json:string><json:string>Department of Health Risk Management, China Medical University, Taichung, Taiwan</json:string></affiliations></json:item><json:item><name>Tarek Elbeik</name><affiliations><json:string>Department of Laboratory Medicine, University of California, San Francisco, California</json:string><json:string>Clinical Laboratories at San Francisco General Hospital, San Francisco, California</json:string></affiliations></json:item><json:item><name>JoAnn Dileanis</name><affiliations><json:string>Celera Diagnostics, Alameda, California</json:string></affiliations></json:item><json:item><name>Valerie Ng</name><affiliations><json:string>Department of Laboratory Medicine, University of California, San Francisco, California</json:string><json:string>Clinical Laboratories at San Francisco General Hospital, San Francisco, California</json:string></affiliations></json:item><json:item><name>Yen‐Ju Chen</name><affiliations><json:string>Institute of Public Health, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Hsieh‐Shong Leu</name><affiliations><json:string>Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital and University, Tao‐Yuan, Taiwan</json:string></affiliations></json:item><json:item><name>Shu‐Hsing Cheng</name><affiliations><json:string>Infection Control Committee, Tao‐Yuan General Hospital, Tao‐Yuan, Taiwan</json:string></affiliations></json:item><json:item><name>Jen‐Chien Wong</name><affiliations><json:string>Department of Infectious Disease, China Medical University Hospital, Taichung, Taiwan</json:string></affiliations></json:item><json:item><name>Wing‐Wai Wong</name><affiliations><json:string>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</json:string><json:string>Branch of Communicable Disease Control and Prevention, Taipei City Hospital, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Yi‐Ming A. Chen</name><affiliations><json:string>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</json:string><json:string>Department of Microbiology, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</json:string><json:string>E-mail: arthur@ym.edu.tw</json:string><json:string>Correspondence address: AIDS Prevention and Research Center, National Yang‐Ming University, No. 155, Li‐Nong Street, Sec. 2, Taipei, Taiwan.===</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>HIV drug resistance</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>molecular epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HIV subtype</value></json:item></subject><articleId><json:string>JMV21065</json:string></articleId><arkIstex>ark:/67375/WNG-LV07GDJL-N</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The Taiwanese government has provided free highly active antiretroviral therapy since April 1997. Previously, we have reported on the molecular epidemiology of HIV‐1 in Taiwan from 1988 to 1998. In addition, an outbreak of circulating recombinant form (CRF) 07_BC among intravenous drug users was noted in 2004. Therefore, the purposes of this study were to elucidate the distribution of HIV‐1 subtypes among different high‐risk groups in Taiwan from 1999 to 2000 and to conduct surveillance on drug resistance among treatment naïve patients from 1997 to 2000. Blood samples from 239 HIV‐1/AIDS patients and their subtypes were examined using DNA sequencing and phylogenetic analysis. The results showed that among 226 male patients, 213 (94.2%) had subtype B, 11 (4.9%) had CRF01_AE, 1 had unique recombinant strain related to both CRF07_BC and CRF08_BC (strain T12‐99TW) and 1 had CRF08_BC (strain L9312‐00TW). The patients infected with T12‐99TW and L9312‐00TW were intravenous drug users and had needle‐sharing experiences in Yunnan Province, China. Of the 13 HIV‐1‐infected females, 7 (53.8%) had subtype B, 5 (38.5%) had CRF01_AE, and 1 (7.7%) had subtype C. Phylogenetic analysis demonstrated that the neither strain T12‐99TW nor L9312‐00TW clustered with CRF07_BC strains isolated from Taiwanese intravenous drug users in 2004. In addition, 126 treatment naïve patients were selected for genotypic DR analysis and the results showed that 4.3% (2/47) homosexual males had M184V mutations. This is the first report on the identification of CRF08_BC and a unique recombinant strain related to both CRF07_BC and CRF08_BC in Taiwan. J. Med. Virol. 80:183–191, 2008. © 2007 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>10</score><pdfWordCount>5455</pdfWordCount><pdfCharCount>34600</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>594 x 792 pts</pdfPageSize><pdfWordsPerPage>606</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>256</abstractWordCount><abstractCharCount>1692</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan</title><pmid><json:string>18098141</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Medical Virology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9071</json:string></doi><issn><json:string>0146-6615</json:string></issn><eissn><json:string>1096-9071</json:string></eissn><publisherId><json:string>JMV</json:string></publisherId><volume>80</volume><issue>2</issue><pages><first>183</first><last>191</last><total>9</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Research Article</value></json:item></subject></host><namedEntities><unitex><date><json:string>2000</json:string><json:string>1992</json:string><json:string>1997</json:string><json:string>2001</json:string><json:string>1993</json:string><json:string>1987</json:string><json:string>2002</json:string><json:string>1994</json:string><json:string>1999</json:string><json:string>1988</json:string><json:string>2003</json:string><json:string>1995</json:string><json:string>2008</json:string><json:string>2004</json:string><json:string>1996</json:string></date><geogName></geogName><orgName><json:string>Taiwan and China</json:string><json:string>Prevention and Research Center, National Yang-Ming University, Taipei, Taiwan Department of Health Risk Management, China Medical University, Taichung, Taiwan</json:string><json:string>WHO</json:string><json:string>HIV Drug Resistance Program, WHO and CDC</json:string><json:string>Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan</json:string><json:string>Department of Microbiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan</json:string><json:string>Taiwan Straits</json:string><json:string>Clinical Laboratories</json:string><json:string>Taipei Venereal Disease Control Institute, Tao-Yuan General Hospital, Lin-Kou Chang-Gung Memorial Hospital</json:string><json:string>San Francisco General Hospital, San Francisco, California</json:string><json:string>TaKaRa Bio Inc.</json:string><json:string>Infection Control Committee, Tao-Yuan General Hospital, Tao-Yuan, Taiwan</json:string><json:string>METHODS China Medical University Hospital</json:string><json:string>Taiwan, Republic of China</json:string><json:string>Division of Infectious Diseases</json:string><json:string>UK Collaborative Group on Monitoring the Transmission of HIV Drug Resistance</json:string><json:string>National Registration Dataa</json:string><json:string>Department of Internal Medicine, Chang Gung Memorial Hospital and University</json:string><json:string>Department of Laboratory Medicine, University of California, San Francisco, California</json:string><json:string>Southern China and Southeast Asia</json:string><json:string>Celera Diagnostics</json:string><json:string>Wiley-Liss, Inc</json:string><json:string>Center for Disease Control Taiwan</json:string><json:string>UK Collaborative Group on Monitoring</json:string><json:string>National Taiwan University</json:string><json:string>National Surveillance Program for Study Subjects Enrolled</json:string><json:string>Prevention and Research Center of National Yang-Ming University</json:string><json:string>LISS, INC.</json:string><json:string>Los Alamos National Laboratory</json:string><json:string>World Health Organization</json:string><json:string>Department of Infectious Disease, China Medical University Hospital, Taichung, Taiwan</json:string><json:string>North Carolina State University</json:string><json:string>Taipei City Hospital, Taipei, Taiwan</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Ming A. Chen</json:string><json:string>Celera Diagnostics</json:string><json:string>Valerie Ng</json:string><json:string>Yen-Ju Chen</json:string><json:string>C. Subtype</json:string><json:string>J. Med</json:string><json:string>Tarek Elbeik</json:string><json:string>Kathleen Ahrens</json:string><json:string>V. Determination</json:string><json:string>Nested</json:string></persName><placeName><json:string>Foster City</json:string><json:string>Raleigh</json:string><json:string>Valencia</json:string><json:string>Bangkok</json:string><json:string>Hong Kong</json:string><json:string>Taiwan</json:string><json:string>Madison</json:string><json:string>NC</json:string><json:string>China</json:string><json:string>Japan</json:string><json:string>Taichung</json:string><json:string>Xinjiang Province</json:string><json:string>CA</json:string><json:string>WI</json:string><json:string>Alameda</json:string><json:string>Taipei</json:string></placeName><ref_url><json:string>http://www.mbio.ncsu.edu/bioedit/bioedit.html</json:string></ref_url><ref_bibl><json:string>Chang et al., 2006</json:string><json:string>McClutchan et al., 2002</json:string><json:string>Boden et al., 1999</json:string><json:string>Chen et al., 2001</json:string><json:string>Robertson et al., 2000</json:string><json:string>Fang et al., 2004</json:string><json:string>Lan et al.</json:string><json:string>Chen et al., 2006</json:string><json:string>Lemey et al., 2003</json:string><json:string>Little et al., 2002</json:string><json:string>Zhong et al., 2003</json:string><json:string>Su et al., 2000</json:string><json:string>Chen et al., 1998</json:string><json:string>Korber et al., 2000</json:string><json:string>Yang et al., 2003</json:string><json:string>Travers et al., 2004</json:string><json:string>Ruan et al., 2003</json:string><json:string>Yang et al., 2002</json:string><json:string>Los Alamos National Laboratory, 2004</json:string><json:string>Chen and Kuo, 2007</json:string><json:string>Elbeik et al., 2002</json:string><json:string>Sun et al., 2004</json:string><json:string>Yang et al., 2002, 2003</json:string><json:string>Takebe et al., 2004</json:string><json:string>Sun et al. [2004]</json:string><json:string>Piyasirisilp et al., 2000</json:string><json:string>Ou et al., 1992</json:string><json:string>Zhang et al., 2004</json:string><json:string>Chen et al., 1998, 2001</json:string><json:string>Lim et al., 2004</json:string><json:string>Lin et al., 2007</json:string><json:string>Perez-Olmeda et al., 2001</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-LV07GDJL-N</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1002/jmv.21065</json:string></doi><id>5D42273C171AD3003D2A55BE0DAE6AE699513D32</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LV07GDJL-N/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LV07GDJL-N/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-LV07GDJL-N/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan</title><title level="a" type="short" xml:lang="en">HIV‐1 Subtypes and Drug‐Resistant Strains in Taiwan</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><licence>Copyright © 2007 Wiley‐Liss, Inc.</licence></availability><date type="published" when="2008-02"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan</title><title level="a" type="short" xml:lang="en">HIV‐1 Subtypes and Drug‐Resistant Strains in Taiwan</title><author xml:id="author-0000"><persName><forename type="first">Yu‐Ching</forename><surname>Lan</surname></persName><affiliation><orgName type="institution">AIDS Prevention and Research Center</orgName><orgName type="institution">National Yang‐Ming University</orgName><address><addrLine>Taipei</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation><affiliation><orgName type="division">Department of Health Risk Management</orgName><orgName type="institution">China Medical University</orgName><address><addrLine>Taichung</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Tarek</forename><surname>Elbeik</surname></persName><affiliation><orgName type="laboratory">Department of Laboratory Medicine</orgName><orgName type="institution">University of California</orgName><address><addrLine>San Francisco</addrLine><addrLine>California</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation><affiliation><orgName type="institution">Clinical Laboratories at San Francisco General Hospital</orgName><address><addrLine>San Francisco</addrLine><addrLine>California</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">JoAnn</forename><surname>Dileanis</surname></persName><affiliation><address><addrLine>Celera Diagnostics</addrLine><addrLine>Alameda, California</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Valerie</forename><surname>Ng</surname></persName><affiliation><orgName type="laboratory">Department of Laboratory Medicine</orgName><orgName type="institution">University of California</orgName><address><addrLine>San Francisco</addrLine><addrLine>California</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation><affiliation><orgName type="institution">Clinical Laboratories at San Francisco General Hospital</orgName><address><addrLine>San Francisco</addrLine><addrLine>California</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Yen‐Ju</forename><surname>Chen</surname></persName><affiliation><orgName type="institution">Institute of Public Health</orgName><orgName type="department">School of Medicine</orgName><orgName type="institution">National Yang‐Ming University</orgName><address><addrLine>Taipei</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Hsieh‐Shong</forename><surname>Leu</surname></persName><affiliation><orgName type="division">Division of Infectious Diseases</orgName><orgName type="division">Department of Internal Medicine</orgName><orgName type="institution">Chang Gung Memorial Hospital and University</orgName><address><addrLine>Tao‐Yuan</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Shu‐Hsing</forename><surname>Cheng</surname></persName><affiliation><address><addrLine>Infection Control Committee</addrLine><addrLine>Tao‐Yuan General Hospital, Tao‐Yuan, Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Jen‐Chien</forename><surname>Wong</surname></persName><affiliation><orgName type="division">Department of Infectious Disease</orgName><orgName type="institution">China Medical University Hospital</orgName><address><addrLine>Taichung</addrLine><addrLine>Taiwan</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Wing‐Wai</forename><surname>Wong</surname></persName><affiliation><orgName type="institution">AIDS Prevention and Research Center</orgName><orgName type="institution">National Yang‐Ming University</orgName><address><addrLine>Taipei</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation><affiliation><orgName type="division">Branch of Communicable Disease Control and Prevention</orgName><orgName type="institution">Taipei City Hospital</orgName><address><addrLine>Taipei</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><author xml:id="author-0009" role="corresp"><persName><forename type="first">Yi‐Ming A.</forename><surname>Chen</surname></persName><email>arthur@ym.edu.tw</email><affiliation><orgName type="institution">AIDS Prevention and Research Center</orgName><orgName type="institution">National Yang‐Ming University</orgName><address><addrLine>Taipei</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation><affiliation><orgName type="department">Department of Microbiology</orgName><orgName type="department">School of Medicine</orgName><orgName type="institution">National Yang‐Ming University</orgName><address><addrLine>Taipei</addrLine><addrLine>Taiwan</addrLine><country key="TW" xml:lang="en">TAIWAN, PROVINCE OF CHINA</country></address></affiliation></author><idno type="istex">5D42273C171AD3003D2A55BE0DAE6AE699513D32</idno><idno type="ark">ark:/67375/WNG-LV07GDJL-N</idno><idno type="DOI">10.1002/jmv.21065</idno><idno type="unit">JMV21065</idno><idno type="toTypesetVersion">file:JMV.JMV21065.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="pISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><idno type="book-DOI">10.1002/(ISSN)1096-9071</idno><idno type="book-part-DOI">10.1002/jmv.v80:2</idno><idno type="product">JMV</idno><imprint><biblScope unit="vol">80</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="183">183</biblScope><biblScope unit="page" to="191">191</biblScope><biblScope unit="page-count">9</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-02"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>The Taiwanese government has provided free highly active antiretroviral therapy since April 1997. Previously, we have reported on the molecular epidemiology of HIV‐1 in Taiwan from 1988 to 1998. In addition, an outbreak of circulating recombinant form (CRF) 07_BC among intravenous drug users was noted in 2004. Therefore, the purposes of this study were to elucidate the distribution of HIV‐1 subtypes among different high‐risk groups in Taiwan from 1999 to 2000 and to conduct surveillance on drug resistance among treatment naïve patients from 1997 to 2000. Blood samples from 239 HIV‐1/AIDS patients and their subtypes were examined using DNA sequencing and phylogenetic analysis. The results showed that among 226 male patients, 213 (94.2%) had subtype B, 11 (4.9%) had CRF01_AE, 1 had unique recombinant strain related to both CRF07_BC and CRF08_BC (strain T12‐99TW) and 1 had CRF08_BC (strain L9312‐00TW). The patients infected with T12‐99TW and L9312‐00TW were intravenous drug users and had needle‐sharing experiences in Yunnan Province, China. Of the 13 HIV‐1‐infected females, 7 (53.8%) had subtype B, 5 (38.5%) had CRF01_AE, and 1 (7.7%) had subtype C. Phylogenetic analysis demonstrated that the neither strain T12‐99TW nor L9312‐00TW clustered with CRF07_BC strains isolated from Taiwanese intravenous drug users in 2004. In addition, 126 treatment naïve patients were selected for genotypic DR analysis and the results showed that 4.3% (2/47) homosexual males had M184V mutations. This is the first report on the identification of CRF08_BC and a unique recombinant strain related to both CRF07_BC and CRF08_BC in Taiwan. J. Med. Virol. 80:183–191, 2008. © 2007 Wiley‐Liss, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">HIV drug resistance</term><term xml:id="kwd2">molecular epidemiology</term><term xml:id="kwd3">HIV subtype</term></keywords><keywords rend="articleCategory"><term>Research Article</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LV07GDJL-N/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1096-9071</doi><issn type="print">0146-6615</issn><issn type="electronic">1096-9071</issn><idGroup><id type="product" value="JMV"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF MEDICAL VIROLOGY">Journal of Medical Virology</title><title type="short">J. Med. Virol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley" registered="yes">10.1002/jmv.v80:2</doi><numberingGroup><numbering type="journalVolume" number="80">80</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2008-02">February 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="10" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jmv.21065</doi><idGroup><id type="unit" value="JMV21065"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title></titleGroup><copyright ownership="publisher">Copyright © 2007 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptAccepted" date="2007-09-13"></event><event type="firstOnline" date="2007-12-20"></event><event type="publishedOnlineFinalForm" date="2007-12-20"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.10 mode:FullText" date="2010-06-29"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-20"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">183</numbering><numbering type="pageLast">191</numbering></numberingGroup><correspondenceTo>AIDS Prevention and Research Center, National Yang‐Ming University, No. 155, Li‐Nong Street, Sec. 2, Taipei, Taiwan.===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JMV.JMV21065.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="5"></count><count type="referenceTotal" number="32"></count><count type="wordTotal" number="1361"></count></countGroup><titleGroup><title type="main" xml:lang="en">Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan<link href="#fn1"></link></title><title type="short" xml:lang="en">HIV‐1 Subtypes and Drug‐Resistant Strains in Taiwan</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Yu‐Ching</givenNames><familyName>Lan</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Tarek</givenNames><familyName>Elbeik</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af5"><personName><givenNames>JoAnn</givenNames><familyName>Dileanis</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Valerie</givenNames><familyName>Ng</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Yen‐Ju</givenNames><familyName>Chen</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Hsieh‐Shong</givenNames><familyName>Leu</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af8"><personName><givenNames>Shu‐Hsing</givenNames><familyName>Cheng</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Jen‐Chien</givenNames><familyName>Wong</familyName></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1 #af10"><personName><givenNames>Wing‐Wai</givenNames><familyName>Wong</familyName></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1 #af11" corresponding="yes"><personName><givenNames>Yi‐Ming A.</givenNames><familyName>Chen</familyName></personName><contactDetails><email>arthur@ym.edu.tw</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="TW" type="organization"><unparsedAffiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="TW" type="organization"><unparsedAffiliation>Department of Health Risk Management, China Medical University, Taichung, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Department of Laboratory Medicine, University of California, San Francisco, California</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Clinical Laboratories at San Francisco General Hospital, San Francisco, California</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Celera Diagnostics, Alameda, California</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="TW" type="organization"><unparsedAffiliation>Institute of Public Health, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="TW" type="organization"><unparsedAffiliation>Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital and University, Tao‐Yuan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="TW" type="organization"><unparsedAffiliation>Infection Control Committee, Tao‐Yuan General Hospital, Tao‐Yuan, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="US" type="organization"><unparsedAffiliation>Department of Infectious Disease, China Medical University Hospital, Taichung, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af10" countryCode="TW" type="organization"><unparsedAffiliation>Branch of Communicable Disease Control and Prevention, Taipei City Hospital, Taipei, Taiwan</unparsedAffiliation></affiliation><affiliation xml:id="af11" countryCode="TW" type="organization"><unparsedAffiliation>Department of Microbiology, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">HIV drug resistance</keyword><keyword xml:id="kwd2">molecular epidemiology</keyword><keyword xml:id="kwd3">HIV subtype</keyword></keywordGroup><fundingInfo><fundingAgency>Genome Research Center of National Yang‐Ming University</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Centers for Disease Control of Taiwan</fundingAgency><fundingNumber>D0H95‐DC‐104.1</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The Taiwanese government has provided free highly active antiretroviral therapy since April 1997. Previously, we have reported on the molecular epidemiology of HIV‐1 in Taiwan from 1988 to 1998. In addition, an outbreak of circulating recombinant form (CRF) 07_BC among intravenous drug users was noted in 2004. Therefore, the purposes of this study were to elucidate the distribution of HIV‐1 subtypes among different high‐risk groups in Taiwan from 1999 to 2000 and to conduct surveillance on drug resistance among treatment naïve patients from 1997 to 2000. Blood samples from 239 HIV‐1/AIDS patients and their subtypes were examined using DNA sequencing and phylogenetic analysis. The results showed that among 226 male patients, 213 (94.2%) had subtype B, 11 (4.9%) had CRF01_AE, 1 had unique recombinant strain related to both CRF07_BC and CRF08_BC (strain T12‐99TW) and 1 had CRF08_BC (strain L9312‐00TW). The patients infected with T12‐99TW and L9312‐00TW were intravenous drug users and had needle‐sharing experiences in Yunnan Province, China. Of the 13 HIV‐1‐infected females, 7 (53.8%) had subtype B, 5 (38.5%) had CRF01_AE, and 1 (7.7%) had subtype C. Phylogenetic analysis demonstrated that the neither strain T12‐99TW nor L9312‐00TW clustered with CRF07_BC strains isolated from Taiwanese intravenous drug users in 2004. In addition, 126 treatment naïve patients were selected for genotypic DR analysis and the results showed that 4.3% (2/47) homosexual males had M184V mutations. This is the first report on the identification of CRF08_BC and a unique recombinant strain related to both CRF07_BC and CRF08_BC in Taiwan. J. Med. Virol. 80:183–191, 2008. © 2007 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Dr. Yu‐Ching Lan and Dr. Tarek Elbeik contributed equally to this study.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>HIV‐1 Subtypes and Drug‐Resistant Strains in Taiwan</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan</title></titleInfo><name type="personal"><namePart type="given">Yu‐Ching</namePart><namePart type="family">Lan</namePart><affiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</affiliation><affiliation>Department of Health Risk Management, China Medical University, Taichung, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tarek</namePart><namePart type="family">Elbeik</namePart><affiliation>Department of Laboratory Medicine, University of California, San Francisco, California</affiliation><affiliation>Clinical Laboratories at San Francisco General Hospital, San Francisco, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JoAnn</namePart><namePart type="family">Dileanis</namePart><affiliation>Celera Diagnostics, Alameda, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valerie</namePart><namePart type="family">Ng</namePart><affiliation>Department of Laboratory Medicine, University of California, San Francisco, California</affiliation><affiliation>Clinical Laboratories at San Francisco General Hospital, San Francisco, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yen‐Ju</namePart><namePart type="family">Chen</namePart><affiliation>Institute of Public Health, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hsieh‐Shong</namePart><namePart type="family">Leu</namePart><affiliation>Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital and University, Tao‐Yuan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shu‐Hsing</namePart><namePart type="family">Cheng</namePart><affiliation>Infection Control Committee, Tao‐Yuan General Hospital, Tao‐Yuan, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jen‐Chien</namePart><namePart type="family">Wong</namePart><affiliation>Department of Infectious Disease, China Medical University Hospital, Taichung, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wing‐Wai</namePart><namePart type="family">Wong</namePart><affiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</affiliation><affiliation>Branch of Communicable Disease Control and Prevention, Taipei City Hospital, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yi‐Ming A.</namePart><namePart type="family">Chen</namePart><affiliation>AIDS Prevention and Research Center, National Yang‐Ming University, Taipei, Taiwan</affiliation><affiliation>Department of Microbiology, School of Medicine, National Yang‐Ming University, Taipei, Taiwan</affiliation><affiliation>E-mail: arthur@ym.edu.tw</affiliation><affiliation>Correspondence address: AIDS Prevention and Research Center, National Yang‐Ming University, No. 155, Li‐Nong Street, Sec. 2, Taipei, Taiwan.===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-02</dateIssued><dateValid encoding="w3cdtf">2007-09-13</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">5</extent><extent unit="references">32</extent><extent unit="words">1361</extent></physicalDescription><abstract lang="en">The Taiwanese government has provided free highly active antiretroviral therapy since April 1997. Previously, we have reported on the molecular epidemiology of HIV‐1 in Taiwan from 1988 to 1998. In addition, an outbreak of circulating recombinant form (CRF) 07_BC among intravenous drug users was noted in 2004. Therefore, the purposes of this study were to elucidate the distribution of HIV‐1 subtypes among different high‐risk groups in Taiwan from 1999 to 2000 and to conduct surveillance on drug resistance among treatment naïve patients from 1997 to 2000. Blood samples from 239 HIV‐1/AIDS patients and their subtypes were examined using DNA sequencing and phylogenetic analysis. The results showed that among 226 male patients, 213 (94.2%) had subtype B, 11 (4.9%) had CRF01_AE, 1 had unique recombinant strain related to both CRF07_BC and CRF08_BC (strain T12‐99TW) and 1 had CRF08_BC (strain L9312‐00TW). The patients infected with T12‐99TW and L9312‐00TW were intravenous drug users and had needle‐sharing experiences in Yunnan Province, China. Of the 13 HIV‐1‐infected females, 7 (53.8%) had subtype B, 5 (38.5%) had CRF01_AE, and 1 (7.7%) had subtype C. Phylogenetic analysis demonstrated that the neither strain T12‐99TW nor L9312‐00TW clustered with CRF07_BC strains isolated from Taiwanese intravenous drug users in 2004. In addition, 126 treatment naïve patients were selected for genotypic DR analysis and the results showed that 4.3% (2/47) homosexual males had M184V mutations. This is the first report on the identification of CRF08_BC and a unique recombinant strain related to both CRF07_BC and CRF08_BC in Taiwan. J. Med. Virol. 80:183–191, 2008. © 2007 Wiley‐Liss, Inc.</abstract><note type="content">*Dr. Yu‐Ching Lan and Dr. Tarek Elbeik contributed equally to this study.</note><note type="funding">Genome Research Center of National Yang‐Ming University</note><note type="funding">Centers for Disease Control of Taiwan - No. D0H95‐DC‐104.1; </note><subject lang="en"><genre>keywords</genre><topic>HIV drug resistance</topic><topic>molecular epidemiology</topic><topic>HIV subtype</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. Virol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0146-6615</identifier><identifier type="eISSN">1096-9071</identifier><identifier type="DOI">10.1002/(ISSN)1096-9071</identifier><identifier type="PublisherID">JMV</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>183</start><end>191</end><total>9</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>HIV‐1 drug resistance in newly infected individuals</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Boden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hurley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Cao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Guo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Jones</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Tsay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ip</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Farthing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Limoli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Parkin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Markowitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Boden D, Hurley A, Zhang L, Cao Y, Guo Y, Jones E, Tsay J, Ip J, Farthing C, Limoli K, Parkin N, Markowitz M. 1999. HIV‐1 drug resistance in newly infected individuals. JAMA 282: 1135–1141.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>282</number></detail><extent unit="pages"><start>1135</start><end>1141</end></extent></part><relatedItem type="host"><titleInfo><title>JAMA</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>282</number></detail><extent unit="pages"><start>1135</start><end>1141</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Molecular epidemiology of HIV Type 1 subtypes in Taiwan: Outbreak of HIV type 1 CRF07_BC infection in Intravenous Drug Users 2006</title></titleInfo><name type="personal"><namePart type="given">SY</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WH</namePart><namePart type="family">Sheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CN</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HY</namePart><namePart type="family">Sun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Kao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SF</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WC</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JY</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WW</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Hung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chang SY, Sheng WH, Lee CN, Sun HY, Kao CL, Chang SF, Liu WC, Yang JY, Wong WW, Hung CC, Chang SC. 2006. Molecular epidemiology of HIV Type 1 subtypes in Taiwan: Outbreak of HIV type 1 CRF07_BC infection in Intravenous Drug Users 2006. AIDS Res Hum Retroviruses 22: 1055–1066.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>1055</start><end>1066</end></extent></part><relatedItem type="host"><titleInfo><title>AIDS Res Hum Retroviruses</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>1055</start><end>1066</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>2002 Mortality data of Infectious Disease. [Online in Chinese]</title></titleInfo><name type="corporate"><namePart>Center for Disease Control Taiwan</namePart></name><genre>other</genre><part><date>2002</date></part></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Temporal trends and molecular epidemiology of HIV‐1 infection in Taiwan from 1988 to 1998</title></titleInfo><name type="personal"><namePart type="given">YM</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KL</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Jen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YC</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YC</namePart><namePart type="family">Chuang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JJ</namePart><namePart type="family">Tsai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YC</namePart><namePart type="family">Lan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen YM, Huang KL, Jen I, Chen SC, Liu YC, Chuang YC, Wong JC, Tsai JJ, Lan YC. 2001. Temporal trends and molecular epidemiology of HIV‐1 infection in Taiwan from 1988 to 1998. J Acquir Immune Defic Syndr 26: 274–282.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>274</start><end>282</end></extent></part><relatedItem type="host"><titleInfo><title>J Acquir Immune Defic Syndr</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><extent unit="pages"><start>274</start><end>282</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Molecular epidemiology and trends of HIV‐1 subtypes in Taiwan</title></titleInfo><name type="personal"><namePart type="given">YM</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RY</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HJ</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen YM, Lee CM, Lin RY, Chang HJ. 1998. Molecular epidemiology and trends of HIV‐1 subtypes in Taiwan. J Acquir Immune Defic Syndr Hum Retrovirol 19: 393–402.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>393</start><end>402</end></extent></part><relatedItem type="host"><titleInfo><title>J Acquir Immune Defic Syndr Hum Retrovirol</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>393</start><end>402</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>HIV‐1 CRF07_BC infections, injecting drug users, Taiwan</title></titleInfo><name type="personal"><namePart type="given">YM</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YC</namePart><namePart type="family">Lan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SF</namePart><namePart type="family">Lai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JY</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SF</namePart><namePart type="family">Tsai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HS</namePart><namePart type="family">Kuo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen YM, Lan YC, Lai SF, Yang JY, Tsai SF, Kuo HS. 2006. HIV‐1 CRF07_BC infections, injecting drug users, Taiwan. Emerg Infect Dis 12: 703–705.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>703</start><end>705</end></extent></part><relatedItem type="host"><titleInfo><title>Emerg Infect Dis</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>703</start><end>705</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>HIV‐1 in Taiwan</title></titleInfo><name type="personal"><namePart type="given">YM</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HS</namePart><namePart type="family">Kuo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen YM, Kuo HS. 2007. HIV‐1 in Taiwan. Lancet 369: 623–625.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>369</number></detail><extent unit="pages"><start>623</start><end>625</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>369</number></detail><extent unit="pages"><start>623</start><end>625</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Quantitation of viremia and determination of drug resistance in patients with human immunodeficiency virus infection</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Elbeik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TW</namePart><namePart type="family">Chun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Imamichi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Natarajan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Waters</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RL</namePart><namePart type="family">Dewar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Highbarger</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>Manual of Clinical Laboratory Immunology</title></titleInfo><originInfo><publisher>American Society for Microbiology</publisher><place><placeTerm type="text">Washington DC</placeTerm></place></originInfo><part><date>2002</date><extent unit="pages"><start>772</start><end>789</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Decreased HIV transmission after a policy of providing free access to highly active antiretroviral therapy in Taiwan</title></titleInfo><name type="personal"><namePart type="given">CT</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HM</namePart><namePart type="family">Hsu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SJ</namePart><namePart type="family">Twu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MY</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YY</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Hwang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Chuang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fang CT, Hsu HM, Twu SJ, Chen MY, Chang YY, Hwang JS, Wang JD, Chuang CY. 2004. Decreased HIV transmission after a policy of providing free access to highly active antiretroviral therapy in Taiwan. J Infect Dis 190: 879–885.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>190</number></detail><extent unit="pages"><start>879</start><end>885</end></extent></part><relatedItem type="host"><titleInfo><title>J Infect Dis</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>190</number></detail><extent unit="pages"><start>879</start><end>885</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>International HIV drug resistance threshold survey to monitor transmission of HIV drug resistant strains in resource‐limited settings</title></titleInfo><name type="corporate"><namePart>HIV Drug Resistance Program, WHO and CDC</namePart></name><genre>other</genre><part><date>2004</date></part></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Molecular epidemiology and full‐length genomic analysis of HIV‐1 circulating recombinant form 07_BC strains from injecting drug users in Taiwan</title></titleInfo><name type="personal"><namePart type="given">YT</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YC</namePart><namePart type="family">Lan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YJ</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TT</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JY</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WW</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CT</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YM</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lin YT, Lan YC, Chen YJ, Liu TT, Yang JY, Wong WW, Wang CT, Chen YM. 2007. Molecular epidemiology and full‐length genomic analysis of HIV‐1 circulating recombinant form 07_BC strains from injecting drug users in Taiwan. J Infect Dis 195: 1283–1293.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>195</number></detail><extent unit="pages"><start>1283</start><end>1293</end></extent></part><relatedItem type="host"><titleInfo><title>J Infect Dis</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>195</number></detail><extent unit="pages"><start>1283</start><end>1293</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Timing the ancestor of the HIV‐1 pandemic strains</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Korber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Muldoon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Theiler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Gupta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Lapedes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BH</namePart><namePart type="family">Hahn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Wolinsky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Bhattacharya</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Korber B, Muldoon M, Theiler J, Gao F, Gupta R, Lapedes A, Hahn BH, Wolinsky S, Bhattacharya T. 2000. Timing the ancestor of the HIV‐1 pandemic strains. Science 288: 1789–1796.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>288</number></detail><extent unit="pages"><start>1789</start><end>1796</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>288</number></detail><extent unit="pages"><start>1789</start><end>1796</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Tracing the origin and history of the HIV‐2 epidemic</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Lemey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">OG</namePart><namePart type="family">Pybus</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NK</namePart><namePart type="family">Saksena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Salemi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Vandamme</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lemey P, Pybus OG, Wang B, Saksena NK, Salemi M, Vandamme AM. 2003. Tracing the origin and history of the HIV‐2 epidemic. PNAS 100: 6588–6592.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><extent unit="pages"><start>6588</start><end>6592</end></extent></part><relatedItem type="host"><titleInfo><title>PNAS</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><extent unit="pages"><start>6588</start><end>6592</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>The lack of epidemiological link between the HIV type 1 infections in Hong Kong and Mainland China</title></titleInfo><name type="personal"><namePart type="given">WL</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Xing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KH</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MC</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YM</namePart><namePart type="family">Shao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MH</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SS</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lim WL, Xing H, Wong KH, Wong MC, Shao YM, Ng MH, Lee SS. 2004. The lack of epidemiological link between the HIV type 1 infections in Hong Kong and Mainland China. AIDS Res Hum Retroviruses 20: 259–262.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>259</start><end>262</end></extent></part><relatedItem type="host"><titleInfo><title>AIDS Res Hum Retroviruses</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>259</start><end>262</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Antiretroviral‐drug resistance among patients recently infected with HIV</title></titleInfo><name type="personal"><namePart type="given">SJ</namePart><namePart type="family">Little</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Holte</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Routy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ES</namePart><namePart type="family">Daar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Markowitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Collier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RA</namePart><namePart type="family">Koup</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Mellors</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Connick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Conway</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Kilby</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Whitcomb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NS</namePart><namePart type="family">Hellmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DD</namePart><namePart type="family">Richman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Little SJ, Holte S, Routy JP, Daar ES, Markowitz M, Collier AC, Koup RA, Mellors JW, Connick E, Conway B, Kilby M, Wang L, Whitcomb JM, Hellmann NS, Richman DD. 2002. Antiretroviral‐drug resistance among patients recently infected with HIV. N Engl J Med 347: 385–394.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>347</number></detail><extent unit="pages"><start>385</start><end>394</end></extent></part><relatedItem type="host"><titleInfo><title>N Engl J Med</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>347</number></detail><extent unit="pages"><start>385</start><end>394</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>2004 HIV Sequence Database. [Online]</title></titleInfo><name type="corporate"><namePart>Los Alamos National Laboratory</namePart></name><genre>other</genre><part><date>2004</date></part></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China</title></titleInfo><name type="personal"><namePart type="given">FE</namePart><namePart type="family">McClutchan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Carr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Murphy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Piyasirisilp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Hahn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">XF</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Beyrer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Birx</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">McClutchan FE, Carr JK, Murphy D, Piyasirisilp S, Gao F, Hahn B, Yu XF, Beyrer C, Birx DL. 2002. Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China. AIDS Res Hum Retroviruses 18: 1135–1140.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>1135</start><end>1140</end></extent></part><relatedItem type="host"><titleInfo><title>AIDS Res Hum Retroviruses</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>1135</start><end>1140</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Understanding the genetic diversity of HIV‐1</title></titleInfo><name type="personal"><namePart type="given">FE</namePart><namePart type="family">McCutchan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">McCutchan FE. 2000. Understanding the genetic diversity of HIV‐1. AIDS 14: S31–S44.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>S31</start><end>S44</end></extent></part><relatedItem type="host"><titleInfo><title>AIDS</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><extent unit="pages"><start>S31</start><end>S44</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Molecular epidemiology of HIV transmission in a dental practice</title></titleInfo><name type="personal"><namePart type="given">CY</namePart><namePart type="family">Ou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Ciesielski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GF</namePart><namePart type="family">Myers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CI</namePart><namePart type="family">Bandea</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Luo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BT</namePart><namePart type="family">Korber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JI</namePart><namePart type="family">Mullins</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GF</namePart><namePart type="family">Schochetman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RL</namePart><namePart type="family">Berkelman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AN</namePart><namePart type="family">Economou</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ou CY, Ciesielski CA, Myers GF, Bandea CI, Luo CC, Korber BT, Mullins JI, Schochetman GF, Berkelman RL, Economou AN. 1992. Molecular epidemiology of HIV transmission in a dental practice. Science 256: 1165–1171.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>256</number></detail><extent unit="pages"><start>1165</start><end>1171</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>256</number></detail><extent unit="pages"><start>1165</start><end>1171</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Primary HIV‐1 drug resistance in Spain before and after the introduction of protease inhibitors</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Perez‐Olmeda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RJ</namePart><namePart type="family">Del</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Rubio</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Ruiz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Rodriguez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Leal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Clotet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Soriano</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Perez‐Olmeda M, Del RJ, Rubio A, Ruiz L, Rodriguez C, Leal M, Clotet B, Soriano V. 2001. Primary HIV‐1 drug resistance in Spain before and after the introduction of protease inhibitors. J Med Virol 63: 85–87.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>85</start><end>87</end></extent></part><relatedItem type="host"><titleInfo><title>J Med Virol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>85</start><end>87</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>A recent outbreak of human immunodeficiency virus Type 1 Infection in Southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Piyasirisilp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FE</namePart><namePart type="family">McCutchan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Carr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Sanders‐Buell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Wagner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Wolf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Lai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Beyrer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">XF</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Piyasirisilp S, McCutchan FE, Carr JK, Sanders‐Buell E, Liu W, Chen J, Wagner R, Wolf H, Shao Y, Lai S, Beyrer C, Yu XF. 2000. A recent outbreak of human immunodeficiency virus Type 1 Infection in Southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant. J Virol 74: 11286–11295.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>11286</start><end>11295</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>11286</start><end>11295</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>HIV‐1 nomenclature proposal</title></titleInfo><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Robertson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Bradac</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Carr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Foley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RK</namePart><namePart type="family">Funkhouser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BH</namePart><namePart type="family">Hahn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Kalish</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Kuiken</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GH</namePart><namePart type="family">Learn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Leitner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">McCutchan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Osmanov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Peeters</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Pieniazek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Salminen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Sharp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Wolinsky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Korber</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Robertson DL, Anderson JP, Bradac JA, Carr JK, Foley B, Funkhouser RK, Gao F, Hahn BH, Kalish ML, Kuiken C, Learn GH, Leitner T, McCutchan F, Osmanov S, Peeters M, Pieniazek D, Salminen M, Sharp PM, Wolinsky S, Korber B. 2000. HIV‐1 nomenclature proposal. Science 288: 55–56.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>288</number></detail><extent unit="pages"><start>55</start><end>56</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>288</number></detail><extent unit="pages"><start>55</start><end>56</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Comparative full‐length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection</title></titleInfo><name type="personal"><namePart type="given">YJ</namePart><namePart type="family">Ruan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Wei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AE</namePart><namePart type="family">Ling</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VB</namePart><namePart type="family">Vega</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Thoreau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SY</namePart><namePart type="family">Se Thoe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Chia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Ng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KP</namePart><namePart type="family">Chiu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ruan YJ, Wei CL, Ling AE, Vega VB, Thoreau H, Se Thoe SY, Chia JM, Ng P, Chiu KP, Lim L. 2003. Comparative full‐length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection. Lancet 361: 1779–1785.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1779</start><end>1785</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>361</number></detail><extent unit="pages"><start>1779</start><end>1785</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Characterization of a virtually full‐length human immunodeficiency virus Type 1 genome of a prevalent intersubtype (C/B') recombinant strain in China</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Su</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Graf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">von Briesen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Xing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Kostler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Melzl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Wolf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Shao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Wagner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Su L, Graf M, Zhang Y, von Briesen H, Xing H, Kostler J, Melzl H, Wolf H, Shao Y, Wagner R. 2000. Characterization of a virtually full‐length human immunodeficiency virus Type 1 genome of a prevalent intersubtype (C/B') recombinant strain in China. J Virol 74: 11367–11376.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>11367</start><end>11376</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>11367</start><end>11376</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Clinical presentations and virologic characteristics of primary human immunodeficiency virus type‐1 infection in a university hospital in Taiwan</title></titleInfo><name type="personal"><namePart type="given">HY</namePart><namePart type="family">Sun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MJ</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Hung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MY</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Hsieh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WH</namePart><namePart type="family">Sheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CT</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SY</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sun HY, Chen MJ, Hung CC, Chen MY, Hsieh SM, Sheng WH, Fang CT, Chang SY, Chang SC. 2004. Clinical presentations and virologic characteristics of primary human immunodeficiency virus type‐1 infection in a university hospital in Taiwan. J Microbiol Immunol Infect 37: 271–275.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>271</start><end>275</end></extent></part><relatedItem type="host"><titleInfo><title>J Microbiol Immunol Infect</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>271</start><end>275</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Molecular epidemiology of HIV: Tracking AIDS pandemic</title></titleInfo><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Takebe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kusagawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Motomura</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Takebe Y, Kusagawa S, Motomura K. 2004. Molecular epidemiology of HIV: Tracking AIDS pandemic. Pediatr Int 46: 236–244.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>236</start><end>244</end></extent></part><relatedItem type="host"><titleInfo><title>Pediatr Int</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>46</number></detail><extent unit="pages"><start>236</start><end>244</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Timing and reconstruction of the most recent common ancestor of the subtype C clade of human immunodeficiency virus Type 1</title></titleInfo><name type="personal"><namePart type="given">SAA</namePart><namePart type="family">Travers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Clewley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Glynn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PEM</namePart><namePart type="family">Fine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Crampin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Sibande</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Mulawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JO</namePart><namePart type="family">McInerney</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GP</namePart><namePart type="family">McCormack</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Travers SAA, Clewley JP, Glynn JR, Fine PEM, Crampin AC, Sibande F, Mulawa D, McInerney JO, McCormack GP. 2004. Timing and reconstruction of the most recent common ancestor of the subtype C clade of human immunodeficiency virus Type 1. J Virol 78: 10501–10506.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>10501</start><end>10506</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>10501</start><end>10506</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>Analysis of prevalence of HIV‐1 drug resistance in primary infections in the United Kingdom</title></titleInfo><name type="corporate"><namePart>UK Collaborative Group on Monitoring the Transmission of HIV Drug Resistance</namePart></name><genre>journal-article</genre><note type="citation/reference">UK Collaborative Group on Monitoring the Transmission of HIV Drug Resistance. 2001. Analysis of prevalence of HIV‐1 drug resistance in primary infections in the United Kingdom. BMJ 322: 1087–1088.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>322</number></detail><extent unit="pages"><start>1087</start><end>1088</end></extent></part><relatedItem type="host"><titleInfo><title>BMJ</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>322</number></detail><extent unit="pages"><start>1087</start><end>1088</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>On‐going generation of multiple forms of HIV‐1 intersubtype recombinants in the Yunnan Province of China</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Xia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kusagawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Ben</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Takebe</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yang R, Xia X, Kusagawa S, Zhang C, Ben K, Takebe Y. 2002. On‐going generation of multiple forms of HIV‐1 intersubtype recombinants in the Yunnan Province of China. AIDS 16: 1401–1407.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>1401</start><end>1407</end></extent></part><relatedItem type="host"><titleInfo><title>AIDS</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>1401</start><end>1407</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>Identification and characterization of a new class of human immunodeficiency virus Type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kusagawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Xia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Ben</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Takebe</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yang R, Kusagawa S, Zhang C, Xia X, Ben K, Takebe Y. 2003. Identification and characterization of a new class of human immunodeficiency virus Type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China. J Virol 77: 685–695.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>685</start><end>695</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>685</start><end>695</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>Molecular characterization of human immunodeficiency virus Type 1 and hepatitis C virus in paid blood donors and injection drug users in China</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Cao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Yin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Mei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Balfe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">He</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Ba</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HH</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MF</namePart><namePart type="family">Yuen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CL</namePart><namePart type="family">Lai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DD</namePart><namePart type="family">Ho</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Zhang L, Chen Z, Cao Y, Yu J, Li G, Yu W, Yin N, Mei S, Li L, Balfe P, He T, Ba L, Zhang F, Lin HH, Yuen MF, Lai CL, Ho DD. 2004. Molecular characterization of human immunodeficiency virus Type 1 and hepatitis C virus in paid blood donors and injection drug users in China. J Virol 78: 13591–13599.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>13591</start><end>13599</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>13591</start><end>13599</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>Identification and distribution of HIV type 1 genetic diversity and protease inhibitor resistance‐associated mutations in Shanghai, P.R. China</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Zhong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Kang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q</namePart><namePart type="family">Pan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Konings</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Burda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Xue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Zheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Jin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Nyambi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Zhong P, Kang L, Pan Q, Konings F, Burda S, Ma L, Xue Y, Zheng X, Jin Z, Nyambi P. 2003. Identification and distribution of HIV type 1 genetic diversity and protease inhibitor resistance‐associated mutations in Shanghai, P.R. China. J Acquir Immune Defic Syndr 34: 91–101.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>91</start><end>101</end></extent></part><relatedItem type="host"><titleInfo><title>J Acquir Immune Defic Syndr</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>91</start><end>101</end></extent></part></relatedItem></relatedItem><identifier type="istex">5D42273C171AD3003D2A55BE0DAE6AE699513D32</identifier><identifier type="ark">ark:/67375/WNG-LV07GDJL-N</identifier><identifier type="DOI">10.1002/jmv.21065</identifier><identifier type="ArticleID">JMV21065</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LV07GDJL-N/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001066 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001066 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:5D42273C171AD3003D2A55BE0DAE6AE699513D32
|texte= Molecular epidemiology of HIV‐1 subtypes and drug resistant strains in Taiwan
}}
| This area was generated with Dilib version V0.6.33. |  |